#=GF ID   DUF6548
#=GF AC   PF20185.2
#=GF DE   Family of unknown function (DUF6548)
#=GF AU   Paysan-Lafosse T;0000-0001-5663-0894
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   MGnify-UniProt clustering
#=GF GA   27.30 27.30;
#=GF TC   27.30 27.30;
#=GF NC   27.00 26.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR046678;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins is functionally uncharacterised. This
#=GF CC   family of proteins is found in bacteria. Proteins in this family
#=GF CC   are around 180 amino acids in length. They contain highly
#=GF CC   conserved motifs, YKxLD and I/LC at the N-terminal and LKxxRxxRN
#=GF CC   in the middle.
#=GF SQ   35
#=GS R5XL73_9FIRM/1-161       AC R5XL73.1
#=GS A0A143ZRW2_9FIRM/1-158   AC A0A143ZRW2.1
#=GS A0A1Y3TIF6_9FIRM/6-164   AC A0A1Y3TIF6.1
#=GS A0A834UE48_VESPE/6-85    AC A0A834UE48.1
#=GS A0A1K1PIP4_RUMFL/4-149   AC A0A1K1PIP4.1
#=GS A0A1Y4TKC9_9FIRM/1-158   AC A0A1Y4TKC9.1
#=GS A0A373BK97_9FIRM/6-168   AC A0A373BK97.1
#=GS A0A1H4DYE6_9FIRM/11-128  AC A0A1H4DYE6.1
#=GS A0A1G4W8A2_9FIRM/2-161   AC A0A1G4W8A2.1
#=GS A0A1H6QVH4_9FIRM/6-149   AC A0A1H6QVH4.1
#=GS R6DZZ2_9FIRM/6-174       AC R6DZZ2.1
#=GS R5TSD0_9FIRM/1-161       AC R5TSD0.1
#=GS R6NMA6_9FIRM/6-177       AC R6NMA6.1
#=GS R6RRF0_9FIRM/6-165       AC R6RRF0.1
#=GS A0A834N6M0_VESGE/10-85   AC A0A834N6M0.1
#=GS A0A1T4M2Y2_9FIRM/1-130   AC A0A1T4M2Y2.1
#=GS A0A1I0F9X2_9FIRM/6-184   AC A0A1I0F9X2.1
#=GS V1CGM3_9FIRM/6-190       AC V1CGM3.1
#=GS R5YY43_9FIRM/6-157       AC R5YY43.1
#=GS A0A4U7J7D2_9FIRM/1-155   AC A0A4U7J7D2.1
#=GS R5CWC5_9FIRM/6-159       AC R5CWC5.1
#=GS A0A810Q2P9_9FIRM/1-165   AC A0A810Q2P9.1
#=GS B1C312_9FIRM/6-147       AC B1C312.1
#=GS G2T341_ROSHA/7-209       AC G2T341.1
#=GS A0A1I3FXC4_9FIRM/10-126  AC A0A1I3FXC4.1
#=GS R6Q7Q8_9FIRM/1-159       AC R6Q7Q8.1
#=GS A0A1H5U213_9FIRM/6-165   AC A0A1H5U213.1
#=GS A0A1H7LFN3_9FIRM/9-128   AC A0A1H7LFN3.1
#=GS A0A1H5V1Q3_9FIRM/6-106   AC A0A1H5V1Q3.1
#=GS R5ED23_9FIRM/6-163       AC R5ED23.1
#=GS H1PKP0_9FIRM/1-161       AC H1PKP0.1
#=GS A0A1I0CH28_9FIRM/1-137   AC A0A1I0CH28.1
#=GS R6C2L9_9CLOT/7-167       AC R6C2L9.1
#=GS R5LBG8_9FIRM/6-158       AC R5LBG8.1
#=GS A0A4Z2H0T7_9TELE/11-88   AC A0A4Z2H0T7.1
R5XL73_9FIRM/1-161                  ...................MSFTESYKQLE.KLCGEIMND......DRRVSAYIDEMINTPR-GSYLVKGWDSDLKQLKHYRWIRNQIAHTPDCTEQNMCKPGDAEWLDGFYFRIMNQTDPLTLY----.................AKATAPKPTEK.AAPTP...................kTKAETYPCSQQATKSKKTSKKAIGFVIFAA.MIALAVAVIFIISKS-f.........................................
A0A143ZRW2_9FIRM/1-158              ...................MEFMNSYKRLD.NLCRDMNGI......--GITGYIEDMEIAAN-GAYYVHGWKEDYLQLKRYRHIRNRIAHENDIDEFDICSDQDEIWLRAFYQRIMTQEDPLGLY----.................YKATRLHATDK.ASSVQ....................ETYGDSPNVSNHSNTEKNIRKSVGCSIFLL.FSIVIIVLVAVVLRM-l.........................................
A0A1Y3TIF6_9FIRM/6-164              ...................NEFFEEYKRLD.RLCSDMYSS......KNGVSRYIEDMESRSCRGADSILSWNTDYKLLKHLRWIRNRIAHDTDDYQ--ISSESDLKNMRNFYERIFSGQDPIALLEKSN.................ADGGCREEEVQ.ALKDQ....................---KN-MQYSHNPNKQKSFANGCLVRVAVI.ALVFIAVGVVAAIA--fl........................................
A0A834UE48_VESPE/6-85               ..............ttvvk-----------.---------......-----------------------------------------------------------------------LDDKVAMGLSKT................pYKKKEKKKDRD.EEDKD....................EDEDEDEDKDEDEEEEEESNDVNSSSVVVV.IVVVVVVVVIVVV---rvn.......................................
A0A1K1PIP4_RUMFL/4-149              ..................r-DFLSLYIKVD.KFIKDAYSS......NEGVSEYIRQMEINCGKGYTYVQSWRNDYIELKRVRWLRNQLVHD-DIFE---GEEEDYDWLENFYNRLFTADDPLSRIRKVSq...............tIQRKPVQQTTQ.PPKPS....................TNQQ--------------------------.----------------lyrktetwygynwhsksnleyvqfk.................
A0A1Y4TKC9_9FIRM/1-158              ...................MSFMQSYKRLD.VLCRDMNGI......--GISGYIADMEQLTN-GRLFVAGWEEDYRLLKHYRHIRNRIAHDVDATEDALCTAEDAAWIEEFYGHILNQTDPLAVYCKAS.................LQQKSVRRTAE.SFSSG....................------------------------------.----------------iscappslprpncklnanlplivtllaggaavfillillflq
A0A373BK97_9FIRM/6-168              ...................IEFFEAYKRLD.VLCRDVLNC......KNGVSEYIQQMEVSHQVLGRGT-GWSEDYRMLKHIRWVRNQVAHKTSDAP--FSTEKDIEFVNAFYDRIMDQDDSFARLRKME.................LKKKHRRKQIK.NKSSE...................dLAQKEVSNISNRKVSKENSDGIRVKSVVCL.IVIFCLVAIMGTLL--yg........................................
A0A1H4DYE6_9FIRM/11-128             ..................e-RFYDAYLDFDcQLCELLGVE......KDGVQAYRMRMKEAWYEAKELIPEWESIDQRLEVIRERYQVLKQGKSKFDDVHGKDEDVVWIQIFRERLDAQADPLAKYSKLS.................FEKKKKD----.-----....................------------------------------.----------------kgifqkl...................................
A0A1G4W8A2_9FIRM/2-161              ..................k-EFIDAFKHLE.KLCNDIYGE......QHGVTLYIKEMEDTPNYMAQKVFGWDHDLKALKRVRLIRNKWAHPDDEMD---YTFEDIEFLKNFYSRVMNQQDPLAMLRQKN.................KEVRSKNKAIS.EPVIP....................--YKPQDSARAYNIEEEGAELNRLKTIAIF.FIVLSAIIIVGALG--wl........................................
A0A1H6QVH4_9FIRM/6-149              ..................v-KFFDEYKFVD.NICRDMFQS......NQGVTEYIKQMEVMDAEGSRIVVNWREKYKKLKHLRWLRNKIAHESGAPD---LTENDLIELQNFHNQLLKQVDPLAELWKK-.................---RRVYKR--.NVVKQ....................------------EYYNPESDDSAISVFILI.CIVIIVIGLFWIFAS-f.........................................
R6DZZ2_9FIRM/6-174                  ..................n-LFFEEYKKLD.KLCSDIYND......KYGISTYIKDMEDNDYIGQKAVKSWHRVYKSLKHIRWLRSQIAHEVNTTG--ISTYDDIEFIQKFYNQIFASTDPISQLERLGk...............yNQTSSFKKSVQ.DIEYRny................ynEKTFNVDHADIHISTKSENKKGSKKKIIAA.LVIITIMIMFILIS--ky........................................
R5TSD0_9FIRM/1-161                  ...................MNFIDSYKKLE.KLCNEMYGD......KHGVSLYIDEMINTPV-GSRYVKSWNEDLKQLKHYRWARNQIVHEPGCTETNMCNRDDIQWINNFYIRMMSTSDPLALYR---.................-KTIRSNRKTHsSSGGK....................SASRQCDDSQQKGKHSRFSQESHRCGVFVW.GTIIAVIVIFLFFKV-i.........................................
R6NMA6_9FIRM/6-177                  ...................NEFYEAYKKSA.SFCDDLYQKereknyKSGIKYYIEDMEHTPFSVARMIPNWNSDLKKLKYLLYLRNQLSHDINTSPGSLATSDDTLWIQSFYQRLLNQSDPLALK----.................HQLLSPNRNTN.TPAKSvs...............tpnQSMQHRTMPYNPLYANEADREPQNMHFHWT.WIVIAFIVLFFIYL--ga........................................
R6RRF0_9FIRM/6-165                  ..................v-DFFETYKKLD.RLCAQMYGL.....sGGGVTAYIDDMKDNWA-AAYGTDNWNETFNTLRRLRHMRNEMAHDEGAFDVLNCTMEDINWLNSFYYALMNGYDPLSCIR---.................KKAAEHYRQVK.PPVNN....................--TYYVRNTRYTEPLDYGQKHHDTGKVAAM.IIDIVIILLALVYYI-f.........................................
A0A834N6M0_VESGE/10-85              rlisslnvyfkndggfsrf-----------.---------......-----------------------------------------------------------------------------------.................------ENKKE.NKKRK....................KKKEKKKVKKKDKKRKEKKRKSTIIIIIII.IIILIIIIIIIIII--iki.......................................
A0A1T4M2Y2_9FIRM/1-130              ...................MEFLTVYKKLD.NLCKDLLNT......DRGISTYISIMEDKSS-AAYFIQNWSDDYKALKHYRWVRNQLAHEDNVYEEDLCTEADIQWIIRFHKRILNHQDPLALYYKTK.................RKVKTPIKPVQ.TT---....................------------------------------.----------------iikkkdsksffqkff...........................
A0A1I0F9X2_9FIRM/6-184              ..................i-IFFEEYKKLE.NICRQMYDG......NSGVTSYIEDMEDTAISIHLNIRGWDHTLDYLKRVRHIRNQLAHD-ATFDIELSTQEDIDWVRDFYDKILHTRDPLALRYQMEqp.............rkNEAKKVHDSST.KQTSQssqtm.........pinrtgQGVNEDKFTRMDNQIRHGLEKNKIAGLAMT.IFIVLIVVIVLVLLV-l.........................................
V1CGM3_9FIRM/6-190                  ...................MEFFDKYKDVD.KFCGDMLSS......DSGISEYIDQMEKTPASERRYVPSWERDYRMLKHLRYVRNQIAHANNDV---ISTEEDFFELNEFYDRLLSGNHPFALIRINSk..............raERISKHSGVKN.DGTSNtehtgysnydsrqhsydydnKIRSTDRNNYNHNSTNYGKNSGSPLKILAL.SAFVIAVLLIAYYMS-q.........................................
R5YY43_9FIRM/6-157                  ..................i-IFFEEYKKLD.NLCKDLLGS......NQGITQYVNEMEQIPFEKSKLVESWQYDYKMLKHIRWIRNNIAHNNGDSE---CSESDVQYVKNFYQRIINRTDSFSLIN-VE.................IRKAEDNQASK.NITNE....................---------NVDNVVSRDNSNNVFIGITMI.ALIIILVIFVLMIHYF..........................................
A0A4U7J7D2_9FIRM/1-155              ...................MSFFQQYKRLD.NLCKDLFHS......DKGISTYIENMEKCGYNAWRIV-GFDTDLQMLKRYRHIRNLIAHEDDANESDYCDKSDEEWIIYFHERIIRCDDPLALYRKTI.................YAPAEISKAEK.ETNKP....................-------STPIPIY-KDNPNSSIIPHAVAF.GFLIAIVVLFCMF---tk........................................
R5CWC5_9FIRM/6-159                  ...................NDFFEEYKRLD.RLCADMYSC......RNGVSEYIAQMENRFYQGQFRVPSWSSDHKMLKHVRWVRNQIAHDSGAYQ--ISEPSDLEFVLNFYERIFSGQDPLTLLRKAT................eAEAERRKRQAR.SATST....................----------PPDNESTGKPLGIVIGIGIV.ALVLTIIFAAILLRS-l.........................................
A0A810Q2P9_9FIRM/1-165              ...................MGFIDSYKRLE.KLCGDVMGC......DRPVTAYIDEMKATPH-GAYYVAGWGSDLEMLKRYRWIRNQIAHEPGCTEANMCGAGDAAWIDQFYGRIMDQTDPLALYEKEM.................KRQRAEQAQRS.RPESV....................RPAEKKPPQEPRKRESIEKAPRRKWGTVVLaFLLFAVIFLAS-----fagli.....................................
B1C312_9FIRM/6-147                  ...................IEFLEEYKRLD.RLCQDMLST......LQGVSEYINRMELLFEQGEEFVDEWTINYKMLKHLRWLRNRIVHSVEETE---CSLKEIEMITNFYHQILIQQDPLALLYKIN.................QKIYKNKTTNQ.EKNKN....................--------------------IDNSSKITML.ITIVLIIIFVLFI---agi.......................................
G2T341_ROSHA/7-209                  ..................i-IFFDEYKKLD.KLCSEMYGI.....nSGGVTCYLNDMMAVPVMQRNRIPEWNQTYDRLRELRHIRNQMAHGEGSFEDYPCSEEDVLWLFEFRSKIMHISDPLAVYRSQTeesmhatrikedfpravDQSQTEESMHA.TRAKEdfllavdqsqtegniadhqrMKMDNVEVIDQEENDSFEKKHSMLKKIAVF.GLIVLIVAAAVLIF--gn........................................
A0A1I3FXC4_9FIRM/10-126             ..................q-NFYDEYKYFD.EFLAEHLHV.....eENGVDEYVKKMKHAIYEVKDVLPEWMPTIERLEKMKARFLSLDGAKVSFDDFQGKDEDVVWIRIFLEKIDQKADPLEKYSKLK.................FTFKKRKK---.-----....................------------------------------.----------------sllqr.....................................
R6Q7Q8_9FIRM/1-159                  ...................MSFIESYKHLD.KICGEMFET......QYGVSAYIEEMLNNPH-GSYLVRGWENDLKQLKHYRWIRNQIVHEPDCYEETMCEAGDDEWLDDFYERIINQTDPLAMY----.................FQATKPHPVAK.SAQNH....................-EPARLQYTYSKQPSQPKHKSKKVVRWIVF.SIIVAIVLLYLVLKYF..........................................
A0A1H5U213_9FIRM/6-165              ..................d-EFMEAFKHLD.KICKEMFNA......EKGVTSYIDEMERISS-GPRYVPNWNYVLRRLKDLRHIRNTHSHEIGTSYGDICSPEDVQWLESFYSEIMNTTDPLAQY----.................RKATAPKPKPK.MPTST....................QYNPNDFHTFTPQYEQEEEETISGLAIFII.CLVVVAVVVGVFFAV-f.........................................
A0A1H7LFN3_9FIRM/9-128              ..................e-NFYDEYQYFD.SVLAKRFKI.....eENGVVRYIKEMKNAVIDVRDVLPEWDPTIARLQKMKVRYDSLDNAESSFDDFQGKDEDVVWIKVFLTKLESHADPLSKYSKLEf...............tY--KKRKK---.-----....................------------------------------.----------------sffqklka..................................
A0A1H5V1Q3_9FIRM/6-106              ...................MEFFDEYKKLD.VTLKNKYST......KTGVTSYIENMERFSD-GEGFVPSWREDYKALKHYRWLRNKLAHEAGED--VNLDKSDLAGLKKFFANVSKNKDPYTLYL---.................-----------.-----....................------------------------------.----------------askk......................................
R5ED23_9FIRM/6-163                  ...................NEFFEEYKHLE.RLCSDMYSC......RDGIRQYLEDMECQFSEGKKTIPHWAQDYRKLRGLRRTRNTLAHNVSEYQ--VCTEQDVENVIDFVDRIMQQQDPLAMLNLYN.................SKDEESETMDE.SE---....................--VSVPGSFYYDAPRNEKKGKQLILGVVLL.VITCVMVILVSILIS-h.........................................
H1PKP0_9FIRM/1-161                  ...................MGFMDSYKHLE.KLCGDMFGD......ERRISAYIDEMYENTE-GWDLVDGWESDLKKLKHYRWVRNRIVHEPDAYEDELCDAEDIEWLDDFYYRIIDREDPLNRY----.................YEIVRSRKSIK.HASEQ...................rMDSASYGKNSSSQCSDDKPGKILPGFLCFL.CFFFAVVILFMILG--ei........................................
A0A1I0CH28_9FIRM/1-137              ...................-----------.-----MYAA......SQGVTEYINRMEVFSNEGRYLIDKWNTDYYTLKHLRWLRNTIVHNLEETD---CSLEDLQSLKEFYQQILNRKDSLALLYMMK.................QKHLTKEKLSI.HQDKQ....................---------ILENVRYKKQNRRNLFNITIV.LIIAVLVMIVLNF---kif.......................................
R6C2L9_9CLOT/7-167                  ..................y-VFFEEYKKIS.NLCNDMLQV......QNGVTEYINELEKIAG---RREPEAQSVLRQLKRMRHLRNLLAHGEGTFEQELCSAQDVEWIRDFHQKLLTQTDPLALYNQK-.................---KRRNQSGQ.QAEQQg.................rqKEFERLQPKEVKNAGQNERESETGESVVIV.GVVLGVVIWLILWII-y.........................................
R5LBG8_9FIRM/6-158                  ...................NKFFEKYKELD.SLCKDVLNS......NQGVTQYICEMEKTSGRGRYYVHSWDYDYKMLKHVRWVRNNIAHNNGGSE---CSENDIKYVKDFYQRIMQQKDPFSIIYQRQ.................NEIKKRTVKQS.EIK--....................-------PNPYINNRKTTNKNRGYTRLAVG.IFIVIIVVLLMIMS--rl........................................
A0A4Z2H0T7_9TELE/11-88              .........rgdkrrdlrn-----------.---------......--------------------------------------------------------------------------------KKS.................NKKAEDEEGEE.EDEEEg..................eEEEGGEEEGDNDKAEERNKQKKKKKHIIII.IIIIITIIIIIIIIM-fq........................................
#=GC seq_cons                       ....................pFh-pYK+LD.pLCp-hhss......ppGVopYIccMEptst.utthl.sWppDh+tLK+hRalRNplAHpsssh-...sstpDlpalpsFYp+IhsppDPLAhh.pht.................hctpcpcpptp.p.ppp................................p.tpptpppt.hhtlhhh.hhllhllllhhhhh..h.........................................
//