#=GF ID   DUF6823
#=GF AC   PF20709.1
#=GF DE   Family of unknown function (DUF6823)
#=GF AU   Paysan-Lafosse T;0000-0001-5663-0894
#=GF AU   Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Eukaryotic microbiome clustering
#=GF GA   25.00 25.00;
#=GF TC   41.80 39.70;
#=GF NC   24.80 21.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins is functionally uncharacterised. This
#=GF CC   protein family is found in eukaryotes. There are highly
#=GF CC   conserved motifs: QQE and RFDLR.
#=GF SQ   53
#=GS A0A8J2SEE2_9STRA/47-170   AC A0A8J2SEE2.1
#=GS M1UPP6_CYAM1/77-190       AC M1UPP6.1
#=GS A0A090M308_OSTTA/49-149   AC A0A090M308.1
#=GS A0A2P6V3A5_9CHLO/52-154   AC A0A2P6V3A5.1
#=GS R1E0L6_EMIHU/56-158       AC R1E0L6.1
#=GS C1MIR0_MICPC/56-159       AC C1MIR0.1
#=GS A0A835Y752_9CHLO/44-152   AC A0A835Y752.1
#=GS A0A150GD59_GONPE/26-134   AC A0A150GD59.1
#=GS A0A383VTV1_TETOB/94-202   AC A0A383VTV1.1
#=GS B7FWS1_PHATC/50-175       AC B7FWS1.1
#=GS A0A8J4F346_9CHLO/44-152   AC A0A8J4F346.1
#=GS A0A1X6PE09_PORUM/11-121   AC A0A1X6PE09.1
#=GS A0A448YZQ2_9STRA/70-195   AC A0A448YZQ2.1
#=GS A0A250XMR0_9CHLO/44-152   AC A0A250XMR0.1
#=GS A0A7J7QH83_9CHLO/46-154   AC A0A7J7QH83.1
#=GS A0A4D9DBI6_9STRA/54-168   AC A0A4D9DBI6.1
#=GS A0A8J4CH26_9CHLO/44-152   AC A0A8J4CH26.1
#=GS A0A0D2JAW2_9CHLO/102-207  AC A0A0D2JAW2.1
#=GS A0A0M0J7B2_9EUKA/56-175   AC A0A0M0J7B2.1
#=GS A0A2P6TN18_CHLSO/48-150   AC A0A2P6TN18.1
#=GS A0A383VTM3_TETOB/46-154   AC A0A383VTM3.1
#=GS A0A6H5JXG9_9PHAE/63-182   AC A0A6H5JXG9.1
#=GS A0A835VSI6_CHLIN/44-153   AC A0A835VSI6.1
#=GS A0A1Z5KM84_FISSO/51-176   AC A0A1Z5KM84.1
#=GS R1EL16_EMIHU/67-186       AC R1EL16.1
#=GS A4RZV5_OSTLU/41-141       AC A4RZV5.1
#=GS K8EAX0_9CHLO/73-173       AC K8EAX0.1
#=GS A0A2V3J394_9FLOR/38-149   AC A0A2V3J394.1
#=GS A0A8J2WTB0_9STRA/51-159   AC A0A8J2WTB0.1
#=GS A0A1E7EU29_9STRA/31-156   AC A0A1E7EU29.1
#=GS A0A835T2U7_9CHLO/44-153   AC A0A835T2U7.1
#=GS R1DDR0_EMIHU/67-186       AC R1DDR0.1
#=GS D7FS75_ECTSI/62-181       AC D7FS75.1
#=GS I0YW86_COCSC/19-118       AC I0YW86.1
#=GS A0A8J5XNW1_DIALT/16-141   AC A0A8J5XNW1.1
#=GS A0A2K3DGG7_CHLRE/44-153   AC A0A2K3DGG7.1
#=GS A0A1Z5KNP8_FISSO/51-176   AC A0A1Z5KNP8.1
#=GS A0A835Z067_9STRA/48-167   AC A0A835Z067.1
#=GS A0A5B8MHT3_9CHLO/53-149   AC A0A5B8MHT3.1
#=GS A0A0M0JCV6_9EUKA/24-126   AC A0A0M0JCV6.1
#=GS W7TJH4_9STRA/54-168       AC W7TJH4.1
#=GS R1FE64_EMIHU/56-158       AC R1FE64.1
#=GS C1E059_MICCC/51-154       AC C1E059.1
#=GS A0A2J7ZGV2_9CHLO/15-112   AC A0A2J7ZGV2.1
#=GS K0T5V1_THAOC/40-161       AC K0T5V1.1
#=GS A0A1E7FCU3_9STRA/76-182   AC A0A1E7FCU3.1
#=GS A0A8J4F0I8_9CHLO/44-146   AC A0A8J4F0I8.1
#=GS B8BYZ0_THAPS/47-172       AC B8BYZ0.1
#=GS A0A830HMI9_9CHLO/10-124   AC A0A830HMI9.1
#=GS A0A7J7IQY8_9RHOD/89-202   AC A0A7J7IQY8.1
#=GS A0A0G4GUH0_VITBC/47-168   AC A0A0G4GUH0.1
#=GS D8TY13_VOLCA/44-152       AC D8TY13.1
#=GS E1ZI80_CHLVA/72-174       AC E1ZI80.1
A0A8J2SEE2_9STRA/47-170              ...............KDEQWRIQQDVLKRRQSKE...ATNKYFDSVDANRQKATQE.QVTKW.AFQRd...pTQDSLIGWKKLRDSGEI-GDLKTGLGTdg....kkrEGGLPIPLPSFGLggeagvgGEYDNGERFDLRLPYVD..QGYEDPD.............
M1UPP6_CYAM1/77-190                  ...............REREIAEQQRIMREKLEAR...RAGRHLEGVAERRQAVQEQ.LNAKE.KPKP.....GEDPLIAWERQREKERTAGTWKEVGYGe......epKRGIILPWPSFGI.......PRFDYGERFDLRLPYVD..EGYVDED.............
A0A090M308_OSTTA/49-149              ...............RDTTFEAQQEILRKRRSG-...--ANLGKEVAARRAKVSRF.VNKKL.PEQE.....-MRMIEKKNRDKANALSKEAI------.........KGGIPLPMASFGM.......PEFDGGERFDLRGKYVD..EGWVDES.............
A0A2P6V3A5_9CHLO/52-154              ...............KEEQYRKQQEVLARRRS--...--NSWQAEVVERRKEVSKY.MQDPV.YKKK.....----IDAEKRARFKSKKEQEEKDNPVP.........KFGIIVPLAPFGN.......PDYDQTERFDLRLPFVD..FGDPDPE.............
R1E0L6_EMIHU/56-158                  ...............KEAEWEAQQAMLARRRNPE...AMEAYQSEVEERRAEISSK.DAELK.ELQK.....-TGDIEAWEALRAEGKLQGSDELEREA.........G------ERSWGG.......EGL-VAERIDTRLPFVD..SGYVDES.............
C1MIR0_MICPC/56-159                  ...............RDTTWEAQQEILRKRRRG-...--VNVESEISSRRKKVSGF.LKGTL.SKEE.....-TEAINKKNRDKANELSKEAFKGQ---.........KGWISIPGMAIGM.......PEFDGGERFDLRGPYAD..EGWVDPD.............
A0A835Y752_9CHLO/44-152              ...............REEQYRLQQELKDKRKS--...--GAMIKEANDRRKKVAEE.LQSRK.DLRR.....------KEKEALARGEMPETLQKWKPYekei.dqkaDRGIIVPLLPFGI.......KKFDEGERFDLRSPYSD..AGWVDPD.............
A0A150GD59_GONPE/26-134              ...............KEEQWRVQQELMEKRRS--...--GQLIKEANERRKKVAET.VESRK.ELRR.....------REKEALARGEMPDTLQNWKPYdkei.dekaNSGIVVPLLPFGI.......KKYDEGERFDLRSPYSD..AGWVDPD.............
A0A383VTV1_TETOB/94-202              ...............KEEMFRAQQEMLEARRS--...--GKALDGANQRRRQVAET.VAERK.AARR.....------AEREALGRGEMPDSLKEWRNYknke.detaNSGLVVPLLPFGM.......PKYDAGERFDLRSPYAD..DGWVDPD.............
B7FWS1_PHATC/50-175                  ..............l-DEEWEKQQEILAERRKPK..aERDKYFEKVEQRRQQASAK.QKDMW.AWQTksyskGEDPIDEWKKRRADGTI-SDLENQYGDp......kkIGGIPIPGASFGVggefgvgGKFDNGGRFDLRLPYAD..QGYVDDD.............
A0A8J4F346_9CHLO/44-152              ...............KDEQWRLQQELIQKRKS--...--GQLIKEANERRKKVSEE.LASRK.DLRR.....------REKEALARGEMPDTLRGWKPYdkei.dekaNSGIVVPLLPFGI.......KKYDDGERFDLRSPYSD..AGWVDPE.............
A0A1X6PE09_PORUM/11-121              ..............r-QAEVDAQRAMLARRRDEK...AAAKYMAEVEQRRADTEAH.FQSNKlDIQP.....GEDPIEAWRRKEARGLI-KPLGYEDVP.........EGGIPMPMASFGI.......PKYDNGERFDLRLPHVE..VGYEDPD.............
A0A448YZQ2_9STRA/70-195              ..............l-DEEFEKQQAILAARRAPK..sERDKYFEKVEERRRRADKE.RQDNW.GWQTkqykkGEDPINEWKKRRESGTI-SDLDDQYGDa......kkIGGIPLPMASFGVggefgvgGKYDNGGRFDLRLPYAD..QGYVDED.............
A0A250XMR0_9CHLO/44-152              ...............KDDQFRIQQELLAARRT--...--GSLIKEANDRRRKVQET.VAERK.AARQ.....------QEKDSLAKGIIPDSLKDWKNYktrd.aeqgTSGIVIPLLPFGK.......KEYDEGERFDLRSPYAD..EGWVDPE.............
A0A7J7QH83_9CHLO/46-154              ...............KEEMFKAQQEMLEARRS--...--GKALEGANQRRKQVAET.VASRK.AARR.....------AEREALGRGEMPDSLRDWRNYknke.detaNSGLVVPLLPFGM.......PKYDAGERFDLRSPYAD..DGWVDPE.............
A0A4D9DBI6_9STRA/54-168              ...............KEEAYQKQQEILRARQNPD...KQKAYFQEVNKRRAEANKN.YKEKF.NLSKn...gKQDPAIKWMELRKKGVIGEREKYEQYGe.......tNRGIIIPQVPFGN.......TKYDEGERFDLRLPYVD..DGYVDES.............
A0A8J4CH26_9CHLO/44-152              ...............KEEQWRLQQEMIQKRKS--...--GQFIKEANERRKKVSDE.LASRK.ELRR.....------REKEALARGEMPDTLRGWKPYdkei.dekaNSGIVVPLLPFGI.......KKYDEGERFDLRSPYSD..AGWVDPD.............
A0A0D2JAW2_9CHLO/102-207             ..........aarri--------AELLEKRRT--...--GQAIKEAGERRRKVSET.MASRK.AARR.....------EEREALGRGEMPESLANWKPYkkse.daegTGGIIIPLNPLGL.......RMYDEGERFDLRSPYSD..DGWVDPD.............
A0A0M0J7B2_9EUKA/56-175              ...............KEQQFREQQEILERRRNPK...AREKYLRESEENRRVASRE.AADRI.GWQQn...pFQDPIKEWKKRKADDKV-KPLGYEDVP.........KGGIQFPMASFGVggefgtgGKYDNGERFDLRLPYVD..QGWVE--ggd..........
A0A2P6TN18_CHLSO/48-150              ...............KEEQFRKQQEVLQRRRS--...--NSWQAEVKERRAEVSRY.MQDPA.YKKQ.....----VDEEKRARFKARKEQEARDNPEP.........KFGIIVPLAPFGI.......ADYDGGERFDLRLPFVD..QGDPDEE.............
A0A383VTM3_TETOB/46-154              ...............KEEMFRAQQEMLEARRS--...--GKALDGANQRRRQVAET.VAERK.AARR.....------AEREALGRGEMPDSLKEWRNYknke.detaNSGLVVPLLPFGM.......PKYDAGERFDLRSPYAD..DGWVDPD.............
A0A6H5JXG9_9PHAE/63-182              ..............v-EENWKAQQEMLKRRNNKG...AMEKYKSRVNEKRAQADAK.-ANKW.KWQTe..ksSFDPLVAWKKMKAEGKIDEIYDEGENE.........EGGIPIPMASFGVggsfgvgGKWDEGGRFDLRLPYAD..QGYVDPD.............
A0A835VSI6_CHLIN/44-153              ...............KEAEWQRQQELMAKRKS--...--GSLIKEANDRRRKVAET.LQDRK.ALRA.....------AEKAALARGEMPETLKDWKPYekeidqkgiSGGIVVPLLPFGI.......KKYDEGERFDLRSPYSD..AGWVDPD.............
A0A1Z5KM84_FISSO/51-176              ..............l-DEQWERQQEILKNRRKPQ..aEREQYFNKVAQRRAEATAK.QEQMW.AWQKksyakGEDPLDEWKKRRADGSI-SDLDNQYGDp......kkIGGIPLPIASFGVggefgvgGKFDNGGRFDLRLPYAE..QGYVDDD.............
R1EL16_EMIHU/67-186                  ..............i-DRAYAEQLEVAARRKNPK...ASAEYMRATEKRRRESSAA.FADKF.AWQR....gKEDPLVEWKKRQKEGKL-NPLGYEDEP.........KGGIPMPMASFGVggefgvgGKYDNGERFDLRLPYAE..QGWVE--gedd.........
A4RZV5_OSTLU/41-141                  ...............RDTTWEAQQEILKKRRSG-...--ANLGKEVAARRAKVSRF.VNKKL.PAAE.....-QKAIEAKNRAKANALSKEAV------.........TGGIPLPMISLGM.......PEFDGGERFDLRGKYVD..EGWVDPE.............
K8EAX0_9CHLO/73-173                  ...............RDETFKRQQEILAKRRKG-...--GRIDEEANKRRAKVSGF.MKKTL.SKKE.....-MDEIKTENTKAANALSKEAV------.........KGGIPFPMASFGM.......PEFDGGERFDLRGPYAE..EGWVDE-k............
A0A2V3J394_9FLOR/38-149              ...............KDEAFRQQQEILARRRDAK...RQDKYFKQVRERRDTVEEH.FDNRTlKVKE.....GEDPIVEWRKMKENGFIDEDVGYTEEE.........ESGIPIPMASFGI.......PKYDRGARFDLKLPHVE..HGYTDPD.............
A0A8J2WTB0_9STRA/51-159              ...............KDEMMREQQAILANRRASGg.fITEAQEEEIRQRRAKVGEE.EDRLK.AIQQs...rEADNLDQWKSARDSGAIKTASSGLKRD.........ADSSR--MGSAGL.......--F--AERADAKMPYID..RGYVQE-t............
A0A1E7EU29_9STRA/31-156              ..............l-NDEYAKQQRILEERRAPK..sQRDKYFQKVEQRRQTADKE.RSDNW.AWQTktykkGEDPIDEWKKRRADGTI-GDLEDQYGDp......kkIGGIPLPMASFGVggefglgGKFDNGGRFDLRLPYAD..QGYVDED.............
A0A835T2U7_9CHLO/44-153              ...............KEEQWRAQQELMAKRKS--...--GVLIKEANDRRRKVAET.LQERK.ALRA.....------AEKEALARGEMPDTLQGWKPYekeidqkgiSGGIVVPLLPFGI.......KKYDEGERFDLRSPYSD..AGWVDPE.............
R1DDR0_EMIHU/67-186                  ..............i-DRAYAEQLEVAARRKNPK...ASAEYMRATEKRRRESSAA.FADKF.AWQR....gKEDPLVEWKKRQKEGKL-NPLGYEDEP.........KGGIPMPMASFGVggefgvgGKYDNGERFDLRLPYAE..QGWVE--gedd.........
D7FS75_ECTSI/62-181                  ..............v-DENWKAQQEMLKRRNNKG...AMDKYKSKVNEKRAQADAK.-ANKW.KWQTe..ksSFDPLVAWKKMKSEGKIDEVYEEGENE.........EGGIPIPMASFGVggsfgvgGKWDEGGRFDLRLPYAD..QGYVDPD.............
I0YW86_COCSC/19-118                  ...............KEDAYRAQQDVLRRRRE--...--GSWQKDVNARRAKVKKY.NTDPE.YKKK.....----IDEDKRARALAERPPDPIVN---.........AFNIIIPLAPFGI.......PEYDQGERFDLKAKYCD..NGWVDEE.............
A0A8J5XNW1_DIALT/16-141              ..............i-DEAFEAQQAILRRRRNPR...ARDAYFKDVEKKRDAETDV.WYDKL.AWQKrtddkNFNKLDEFKRRQEAGKV-KKLGYEDQQpt.....kaRWNLPLPMASFGVggefgvgGKYDNGERFDLRLPYVD..EGWVEE-k............
A0A2K3DGG7_CHLRE/44-153              ...............KEEEFRKQQELIQKRKS--...--GVLIKEANDRRRKVAET.LQERK.NLRA.....------AEKEALARGEMPETLQGWKPYekeidqkgiSGGIVVPLLPFGI.......KKYDEGERFDLRSPYSD..AGWVDPE.............
A0A1Z5KNP8_FISSO/51-176              ..............l-DEQWERQQEILRNRRKPQ..aEREQYFSKVAQRRAEATAK.QEQMW.AWQKksyakGEDPLDEWKKRRADGSI-SDLDNQYGDp......kkIGGIPLPMASFGVggefgvgGKFDNGGRFDLRLPYAE..QGYVDDD.............
A0A835Z067_9STRA/48-167              ..............m-DAAFRDQQEILARRRNKN...KMEEYKKQVEANRAVADEK.V-TRW.AWQRr..sdGKDPLTDWQKMRAEGKIPDVYEEGENQ.........EGGIPIPSASFGVggsfgvgGKWDEGGRFDLRLPYVD..QGYVDD-s............
A0A5B8MHT3_9CHLO/53-149              ...............KEKMHQQQLEILRARKDKA...KGAQNAERVKQRRAEVSKM.MRKK-.----.....---------PKRGDEKKEPRVQKYDEP.........ENSIPIPMASFGI.......PKYDGGERFDLAAPYCD..EGYVDEE.............
A0A0M0JCV6_9EUKA/24-126              ...............KEAEYRAMQEMLERRRNPA...KMAAYEAEVERRREEISAK.DAELK.ELQK.....-TGDYVAWQKMREEGKLQASDDMEREA.........G------DRSWGG.......VGL-VAERIDTKLPFID..SGYVDES.............
W7TJH4_9STRA/54-168                  ...............KEEAYQKQQEILRARQNPD...KQKAYFQEVNKRRAEANKN.YKEKF.NLSKn...gKQDPAIKWMELRKKGVIGEREKYEQYGe.......tNRGIIIPQVPFGN.......TKYDEGERFDLRLPYVD..DGYVDES.............
R1FE64_EMIHU/56-158                  ...............KEAEWEAQQAMLARRRNPE...AMEAYQSEVEERRAEISSK.DAELK.ELQK.....-TGDIEAWEALRAEGKLQGSDELEREA.........G------ERSWGG.......EGL-VAERIDTRLPFVD..SGYVDES.............
C1E059_MICCC/51-154                  ...............RDPMYEQQQEILRRRRKG-...--GNLESEVSKRRAKVSGF.MKGTL.AKEE.....-MDAIKAKNKAKADDLAKEAFKGQ---.........KGWISLPGMAIGM.......PEFDGGERFDLRAPYAD..EGWVDEN.............
A0A2J7ZGV2_9CHLO/15-112              ...............KEAEFQAQQALRQKRKS--...--GELIKEANDRRKKVAET.LADRK.ALRR.....------AEKDSLARGEMPETLKAWKPYdkea.dekaSSGIIVPLLPFGI.......KKYDDVSRL--------..-------avgg.........
K0T5V1_THAOC/40-161                  ..............l-DEEWERQQELLKLRQASP..eEREKYFKSVEDRRAQATKQ.QVDDW.AWQRkqykkGEDPIDEWKKRRKDGRI-SDLDNQYGEp......ekVGGIPLPMASFGV......gGEFGVGGKFDNGGEVNNiyLGWMEDD.............
A0A1E7FCU3_9STRA/76-182              .............rt--EQEAAQREILERRRNPE...KMEEYEQQVNEGRVKLQEE.-KDVW.DFQGki.edGYDPLTEWTRLKDEGLITTGNDLE-RD.........KGSE-----RLGS.......EGL-IDVRIDERLPYID..QGYVDE-g............
A0A8J4F0I8_9CHLO/44-146              ...............KDEQWRLQQELIQKRKS--...--GQLIKEANERRKKVSEE.LASRK.DLRR.....------REKEALARGEMPDTLRGWKPYdkei.dekaNSGIVVPLLPFGI.......KKYDD------------..-------vrvagllaswrde
B8BYZ0_THAPS/47-172                  ..............l-DEEWEKQQEMLRLRQASP..eEREKYFKQVEDRRIKATEE.QVDKW.AWQKkqyakGDDPINEWRKRRESGQI-SDLENQYGDp......keVGGIPMPMASFGVggefgvgGKFDNGGRFDLRLPYAE..QGWVDED.............
A0A830HMI9_9CHLO/10-124              dddkasknkdfrtlk-------------QQRDDAfgaTAEERIRRSQERRAETARM.MKMSN.AEKR.....--KFREKAKPERAKGPYQDEKE----Ggg....flsQGFFIIPQAPFGN.......PEMDGGERFDLKGKYVD..EGWVDES.............
A0A7J7IQY8_9RHOD/89-202              ...............REQEIEEQRRIMEEKLAAR...RAGRHLDGVVERRRAVQEH.TDAKE.KPKP.....GEDPLIAWERQREKERAAGTWKEVGYGe......epKQGIIFPWPSFGI.......PRYDYGERFDLRLPYVD..EGYVDEE.............
A0A0G4GUH0_VITBC/47-168              ...............KAERFKKQQEILQRRRNPE...KLKEYYSDLADRRAKASKLeILKKQ.AWAEr...pGETAAQRKQRIEATWESFREQGLIGKPgtst.yeepERSIPLPVAPFGL.......EKYDQGERFDLRSPWVE..SGWVNPN.............
D8TY13_VOLCA/44-152                  ...............KEEQWRLQQELIQKRKT--...--GQLIKEANERRKKVAEE.LASRK.ELRR.....------REKDALARGEMPDTLKSWKPYdkei.dekaNSGIVVPLLPFGI.......KKYDEGERFDLRSPYSD..AGWVDPE.............
E1ZI80_CHLVA/72-174                  ...............KEEQFRKQQEVLARRRT--...--NSWQAEVVDRRKEVSKY.LQNPE.YRKQ.....----VDAEKRARFKAKKEQEEKENPIP.........KFGIIVPLAPFGM.......PDYDETERFDLRLPFVD..FGDPDPE.............
#=GC seq_cons                        ...............+--pactQQElLp+RRs.......sphhcclscRRtclucp.hts+h.shpc.......t.l.ph+ct+ucGch.pslct.t...........puGIslPhssFGl.......sKaDpGERFDLRhPYsD..pGaVD.-.............
//