#=GF ID Dimeth_Pyl
#=GF AC PF09505.14
#=GF DE Dimethylamine methyltransferase (Dimeth_PyL)
#=GF AU TIGRFAMs;
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE TIGRFAMs
#=GF GA 25.00 25.00;
#=GF TC 65.70 65.60;
#=GF NC 21.60 20.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF DR INTERPRO; IPR012653;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family consists of dimethylamine methyltransferases from
#=GF CC the genus Methanosarcina. It is found in three nearly identical
#=GF CC copies in each of Methanosarcina acetivorans, Methanosarcina
#=GF CC barkeri, and Methanosarcina mazei. It is one of a suite of three
#=GF CC non-homologous enzymes with a critical UAG-encoded pyrrolysine
#=GF CC residue in these species (along with trimethylamine
#=GF CC methyltransferase and monomethylamine methyltransferase). It
#=GF CC demethylates dimethylamine, leaving monomethylamine, and
#=GF CC methylates the prosthetic group of the small corrinoid protein
#=GF CC MtbC. The methyl group is then transferred by
#=GF CC methylcorrinoid:coenzyme M methyltransferase to coenzyme M. Note
#=GF CC that the pyrrolysine residue is variously translated as K or X,
#=GF CC or as a stop codon that truncates the sequence.
#=GF SQ 74
#=GS MTBB3_METAC/3-465 AC Q8TN68.3
#=GS A0A1Y3GC86_9EURY/2-356 AC A0A1Y3GC86.1
#=GS A0A1W2DKD6_9DELT/3-355 AC A0A1W2DKD6.1
#=GS A0A1H0LJ70_9DELT/3-348 AC A0A1H0LJ70.1
#=GS A0A1I1Z023_9FIRM/4-351 AC A0A1I1Z023.1
#=GS A0A1Q9JIV3_9FIRM/1-93 AC A0A1Q9JIV3.1
#=GS A0A1Y3GCW1_9EURY/1-101 AC A0A1Y3GCW1.1
#=GS A0A415DYG6_9FIRM/1-111 AC A0A415DYG6.1
#=GS A0A133VGR5_9EURY/1-99 AC A0A133VGR5.1
#=GS R6E5B7_9FIRM/5-352 AC R6E5B7.1
#=GS L0KTA2_METHD/2-464 AC L0KTA2.1
#=GS A0A1W2CM78_9DELT/2-348 AC A0A1W2CM78.1
#=GS A0A0B7MMD8_9FIRM/1-101 AC A0A0B7MMD8.1
#=GS A0A6P1MJW0_9FIRM/5-352 AC A0A6P1MJW0.1
#=GS MTBB3_METMA/3-465 AC P58972.2
#=GS A0A0E3NZ26_9EURY/3-465 AC A0A0E3NZ26.1
#=GS A0A8J7W4I0_9FIRM/1-109 AC A0A8J7W4I0.1
#=GS A0A0B7MKZ6_9FIRM/2-349 AC A0A0B7MKZ6.1
#=GS A0A0B7MMN8_9FIRM/1-103 AC A0A0B7MMN8.1
#=GS A0A1M6F436_9FIRM/1-92 AC A0A1M6F436.1
#=GS K4LIW4_THEPS/1-101 AC K4LIW4.1
#=GS W9DXI8_METTI/3-465 AC W9DXI8.1
#=GS MTBB2_METAC/3-465 AC Q8TS72.3
#=GS A0A1W1HAS7_9DELT/1-103 AC A0A1W1HAS7.1
#=GS A0A6J4XV89_9DELT/3-159 AC A0A6J4XV89.1
#=GS A0A1H0IZA0_9DELT/2-348 AC A0A1H0IZA0.1
#=GS A0A1W2DK76_9DELT/1-103 AC A0A1W2DK76.1
#=GS M4YJT7_THEXX/1-457 AC M4YJT7.1
#=GS A0A1H0IYT7_9DELT/1-91 AC A0A1H0IYT7.1
#=GS U5Q2B5_METII/2-464 AC U5Q2B5.1
#=GS A0A0W7TKF0_9ARCH/3-356 AC A0A0W7TKF0.1
#=GS MTBB1_METMA/3-465 AC P58970.2
#=GS A0A1W2CXK7_9DELT/1-107 AC A0A1W2CXK7.1
#=GS W9DXH3_METTI/3-465 AC W9DXH3.1
#=GS A0A1W1HB41_9DELT/3-355 AC A0A1W1HB41.1
#=GS R6ER79_9FIRM/1-80 AC R6ER79.1
#=GS A0A6P1MSJ8_9FIRM/1-111 AC A0A6P1MSJ8.1
#=GS M9SER6_METAX/4-466 AC M9SER6.1
#=GS A0A8J7VYE9_9FIRM/1-100 AC A0A8J7VYE9.1
#=GS A0A1I1Z1W7_9FIRM/1-93 AC A0A1I1Z1W7.1
#=GS A0A8J7W0J8_9FIRM/3-350 AC A0A8J7W0J8.1
#=GS MTBB2_METMA/3-465 AC P58971.2
#=GS A0A1W2CKJ5_9DELT/1-88 AC A0A1W2CKJ5.1
#=GS A0A1Q9JJ37_9FIRM/4-351 AC A0A1Q9JJ37.1
#=GS D9QQJ6_ACEAZ/3-459 AC D9QQJ6.1
#=GS A0A1U7MCE8_9FIRM/1-91 AC A0A1U7MCE8.1
#=GS A0A415DYA0_9FIRM/8-355 AC A0A415DYA0.1
#=GS M4YNV1_THEXX/4-466 AC M4YNV1.1
#=GS A0A0W7TJR1_9ARCH/4-356 AC A0A0W7TJR1.1
#=GS K4LLG4_THEPS/2-349 AC K4LLG4.1
#=GS A0A0E3L794_9EURY/3-465 AC A0A0E3L794.1
#=GS A0A1H0KD90_9DELT/1-101 AC A0A1H0KD90.1
#=GS A0A6J4Y151_9DELT/1-63 AC A0A6J4Y151.1
#=GS A0A484F2L8_9EURY/3-465 AC A0A484F2L8.1
#=GS A0A1H0LIU7_9DELT/1-88 AC A0A1H0LIU7.1
#=GS A0A1H0KDM8_9DELT/2-348 AC A0A1H0KDM8.1
#=GS D7E9M1_METEZ/3-465 AC D7E9M1.1
#=GS A0A1M6F3W9_9FIRM/5-352 AC A0A1M6F3W9.1
#=GS F7XQH1_METZD/3-465 AC F7XQH1.1
#=GS L0KZ37_METHD/2-464 AC L0KZ37.1
#=GS A0A1Q6DT84_9EURY/3-357 AC A0A1Q6DT84.1
#=GS A0A8J7W1Q4_9FIRM/4-351 AC A0A8J7W1Q4.1
#=GS A0A0W7TJQ6_9ARCH/1-101 AC A0A0W7TJQ6.1
#=GS A0A1U7MCG1_9FIRM/3-350 AC A0A1U7MCG1.1
#=GS A0A0U1KZC8_9FIRM/5-462 AC A0A0U1KZC8.1
#=GS A0A0E3NZM1_9EURY/3-465 AC A0A0E3NZM1.1
#=GS A0A133VGU6_9EURY/1-350 AC A0A133VGU6.1
#=GS MTBB1_METAC/3-465 AC Q8TTA5.3
#=GS A0A0X8UZL0_THEX5/2-464 AC A0A0X8UZL0.1
#=GS A0A1W2CXN8_9DELT/2-348 AC A0A1W2CXN8.1
#=GS A0A0B7ML93_9FIRM/2-348 AC A0A0B7ML93.1
#=GS A0A1Q6DT74_9EURY/1-101 AC A0A1Q6DT74.1
#=GS A0A0W7TKQ5_9ARCH/1-101 AC A0A0W7TKQ5.1
#=GS D7EAA4_METEZ/3-465 AC D7EAA4.1
MTBB3_METAC/3-465 ....TEYALRMGDGKRIYLTKEKILSEIEAGSSNAADLGDIPDLSTDEMKKLAEILMMPGKAVSVEQGMEVPVTHDIGTIRLDGDQGNSGVGI.PSSRLVGCMTHERAFGADTMELGHIDYSFKPVKPVVSNECQAMEVCQQNMIIPLFYGAMPNMGLYYTPD.GPFENPGDLMKMFKIDKARESMEHAADHLTRDTVWVMQKLFASGADGVNFDTTAAAGDADMYGTLRAVEVLRA..Q..FPEMYIEVGMAGEMVLGMHGELEYDEVRLAGLWPHEQAPLIAKAGANVFGPVVNTNTSKTSAWNLARAVTFIKEAVKASPIPCHVNMGMGVGGIPMLETPPVDAVTRASKAMVEVAGVDGIOIGVGDPLGMPISHIMASGMTGIRAAGDLVARMEFSKNMRIGEAKEYVAKKLNVDTMDLADEHVMRELREE..LDIG..VITS.VPGAAKGIAAKMNIEKLLGIKINSCETFRA-q..
A0A1Y3GC86_9EURY/2-356 ...s-KYQTNMGDGAAIEMTKEEIRDELDKGTAAAAEQADIPQLSDDELDHLLSILTEPGKVVGVEKGNEVVFTHDIGTLRLMGDQGNSGVGI.PLSREQGVQVHERAFAADTMELGHIDYSYKPTKPIIAQEQQTLENILLSTIVPIFYGAMPNLGTYYTPD.GPFQNPNNLMAEGNMMEALESQENAVDQAIEDIGYIAKNLGKLGLDGLNLDTSGAAGDPDLKASLEITEKLKS..NpaTEHLTIEIGMAAENVLGMHGGLKYNGETLAGMWPHQLCGLVEEAGGDIFGPVVNTNASETLPWNLARAVTFVKLTMDEANIPIHVNMGMGVGGIPMFETPPVEAVTRASKAMVEVAGVDGI-----------------------------------------------------------------------..----..----.-------------------------------...
A0A1W2DKD6_9DELT/3-355 .nqi---LTRMGDGERLWMDVEDVMDDIRDGCADAAQRIGVPELSEEDQKKLFDILAEPSRIVSVNPGEEVIVSDDGTTMSFYSGQDGGGVGT.PLSRQQAVQTYERACGADTTSLGHSDYSYKPVKSIINFEANDYYNISQVTTAPFFYGAQPNMGLYFQPD.GPCPNAAELMPLGKIEEARQAQEQACDYLADDLVFVGSKLAEVGLEGLNFDTSGSAGDADFLAALQGVERLKE..K..FPDLPILMGGAGEFILGMHGELTYDDKRIAGMYTIDQVKAVEKAGANIYGMAVNTATTESVPWNLARAVTFLKATTDTAAIPVHANVGMGVCGVPMMEQPPIDAVTRVSKALVQIGKADGL-----------------------------------------------------------------------..----..----.-------------------------------...
A0A1H0LJ70_9DELT/3-348 kifs-----RYGDGTPFETTEKELMEDLVAGTQDAAERGKIDPLSQDDLDHIADIMKCRYTAVGVDPGYECVLTYDGAPIKLIR------TNV.NVDRLQALQIYEKLMGADTLEMGFVDYSYKPIKHIVTYEQPLMEQALLSTTAPIIYGAQPNLGLYSQPD.GPFPNPAELLPAGRIAEAKESYEKAVEEAVRDMVYVASAMYESGADGIILDTVGAAGDADALAGLKTAQILKA..K..YPDISIEMGMAGEFVLGMHGSLEFEGVRLAGLYNHQMLELAEQVGVDIFGTVMNTNTTESAAWNLARAITFTKSCTDIAKIPIHANMGMGVGGVTVNDHTPIDITSKASKAMVEVCRLDGL-----------------------------------------------------------------------..----..----.-------------------------------...
A0A1I1Z023_9FIRM/4-351 ...k-KYFTRMGDGSIVYMTETEIRADIEEGVADAVLRGKIDPITEEEKEHLYKIVTAPGSIVGVEPGKQVVLTNDSGAYKINV-----KSQI.PIPKEMETLIYERCLGCDSVDVGNTDYNYKTAKGVAKREASALKQALNVTTMPLFYGAMTNLGFYTKPD.GPVDNWAVLLPDGKIKEAMAAQEEAVEHAVRDVVFVAEQMYDVGADGFQLDTSGAAGDADFLAALRACEEITK..K..FPGMGVEIGMAGEFVLGMHGRLKYDGKRLAGLYPHDQVKLAEKAGASIFGAVVNTNCNKSFPWNIARVCTFIKACTNVAKIPVHANVGMGVCGVPMVEMMPSDMISRADKALVEIGKIDG------------------------------------------------------------------------..----..----.-------------------------------f..
A0A1Q9JIV3_9FIRM/1-93 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..--------------------------------------------------------------------------------------------------------------------------------------------MGGVRTAGDLVLRMELAEKMKIDQAKEYVADKLGVTVEELHDVVVMTDVRTD..LGLGlaHVEP.CAEENNGMAAKFRISEVLGIKINSVERFKE-r..
A0A1Y3GCW1_9EURY/1-101 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..----------------------------------------------------------------------------------------------------------------------------------MSLAHYAASGLGGLRTSGDLVSRVMMNKKTGIDESKEYVADKLDVSVADLSDVFVMRELRED..MDIG..VITS.VPGCAKGIEAKARIAKVLDLEIPSVKRLEN-k..
A0A415DYG6_9FIRM/1-111 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..--------------------------------------------------------------------------------------------------------------------------MGVGDPLGAEATHALAAGMGGIRTAGDLVMRLQLAKKMKINEAKAYVAEKLSVSVEELCDIVTMNDKREE..LGLGlaHVEP.NAEANAGMEAKFRIQEVLDIKVNSVERFKE-r..
A0A133VGR5_9EURY/1-99 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..----------------------------------------------------------------------------------------------------------------------------------MDVTYRMAAGMGGLRTSGDLVARTQLDKKMQIDEGKKYVAEKLGIDVTDLSDEIAMRKAREE..NGIG..LPIA.TPGKPKGFAAKKNIKELFDFDIRSIEA----lt.
R6E5B7_9FIRM/5-352 ...k-KFFTRMGDGSPVYMTEEEIRSDMKAGIDDAVLRGKIDPLSDEDFEKLYDIITMPGTVVGVEPGKQIVLTNDSGGYKINV---K--SQL.PVPKEVEVLVYERCLGCDSVDVGNTDYNYKTAKGVAKREAGALKQALNISTMPLFYGAMPNLGFYTKPD.GPVDNWAMLLPEGKIKESLAAQEEAVEHAVKDILFVAEQVYDVGADGINLDTSGAAGDADFLVALKATEEIKK..R..FPDLGVEIGMAGEFVLGMHGKLKYDGVRLAGLYPHKQVKLAEKAGASIFGAVVNTNCNKSFPWNIARVITFIKACTDVAEIPVHADVGMGVCGIPMVENMPSDVASRADKALVEIGKVDG------------------------------------------------------------------------..----..----.-------------------------------f..
L0KTA2_METHD/2-464 ....TEYALRMGDGKRIFLTKEQIRADLEAGTADAADLGSIPALTGNELDKLAEILMMPARMVGVEPGKEVPVTHDIGTIRLDGDQGNSGVGI.PTSRLAGCMVHERAMGADTMELGHIDYSYKPVKPVISQEQQAMEVCQQNMIVPLFYGAMPNMGLYYTPD.GPFENPGDLMKAFKITEAQASMEHAADHLTRDIVWIMQKMMFAGADGANFDTTGAAGDGDMFATLRAVEALRK..Q..YPDMYIEVGMAGELVLGMHGELQYDNTTLAGLWPHQQAPLAAKAGANVFGPVVNTNTSKSSAWNLARAVTFVKEAVKVSPIPCHVNMGMGVGGIPMLETPTIDAVSRASKAMVEIAGVDGIOIGVGDPMGMPITHIMTSGMSGIRAAGDLVARMEFSKNMRLNDAKDYVAKKLGVSTMDLSDEYVMRDLREE..LGIG..VITS.VAGAPKGIAAKMNIEKLLDIKINCCEKFRG-k..
A0A1W2CM78_9DELT/2-348 .tki---LTRYGDGSAVELTESELMEDLIAGTEDAAERGNIPAMTQDEMDHLADIFKCTHRVVGVDPGYECVLSYDGAPIKMLR------TNV.TSDRITALQIYEKLMGADTLEMGFVDYSYKPIKPILTFEEPLMEQALLTTTAPIMYGAQPNLGRYSQPD.GPFPNPAELMPMGKIKEAQESYELAVDEAVKDMVDVASSMYESGVDCILLDTVGAAGDADALAGLRTAEILRE..K..YPDIGIEMGMAGEFVLGMHGALEYEGVRLAGLYNHQMLELAQKAGVNIFGTVMNTSTTESTPWNLARAVTFTKACSDIADIPIHANIGMGVGGVTVHDHTPIDVTSRASKALVELCNLDGL-----------------------------------------------------------------------..----..----.-------------------------------...
A0A0B7MMD8_9FIRM/1-101 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..----------------------------------------------------------------------------------------------------------------------------------MAVAHEVAAGMGGIRTTGDLVARVQMSKAMKIKEAKEYVAGKLGVSVFDLSDSHLMKELREQ..LDIG..HVQA.RDRASYGIEAKFNIARLLDIKINSVENFKR-k..
A0A6P1MJW0_9FIRM/5-352 ...k-KFFTRMGDGSIVYMTEEEIRADIKEGIEDAVRRGKIDPLTDAETEHLYEIVTMPGNIVGVTPGMEVVSSNDSGSDKINT-----KCGI.PTSRDTNSMIHERVLGADSVDIGYSDYNYKTVKGVAKREATILKQALGRCTMPLFYGAMPNLGFYTKPD.GPVDNWAVLLPEGKIQEAMAAQEEAVDHAVRDIVYVAEQMNDVGADGFMLDTSGAAGDADFLVSLKATEIIRE..K..FPEMPVEIGMAGEFVLGMHGKLKYNGQRLAGLYPHKQVKLVEEAGASIFGVVVNTNCNKSFPWNIARVCTFVKACTDVANIPVHANAGMGVCGIPMCENLPADVVSRADKALIEIGKIDGL-----------------------------------------------------------------------..----..----.-------------------------------...
MTBB3_METMA/3-465 ....TEYALRMGDGKRIFLTKDKIIEELEAGMANASDLGEIPDLSGDEIDKLAEILMMPGKAVSVEQGMEVPVTHDIGTLRLDGDQGNSGVGI.PSSRLVGCMMHERAFGADTMELGHIDYSYKPVKPVVANECQAMEVCQQNMIIPLFYGAMPNMGLYYTPD.GPFENPGDLMKAFKIQEAWDSMEHAAAHLTRDTVWVMQKLFASGADGVNFDTTAAAGDADMYGTLHAIEALRK..E..FPDMYIEAGMAGECVLGMHGNLQYDGVTLAGLWPHQQAPLIAKAGANVFGPVCNTNTSKTSPWNLARAVNFMKAAVQASSIPCHVDMGMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGIOIGVGDPLGMPISHIMASGMTGMRAAGDLVARMQFSKNMKIKEAKEYVAKKLNVETMDLADEYVMRELREE..LDIG..VITS.VPGAAKGIAAKMNIEKLLDVKINSCNLFRKQ...
A0A0E3NZ26_9EURY/3-465 ....TEYALRMGDGKRIFLSKEKILEELEAGSADAADLGEIPALSGNEIDKVAEILMMPGKTVSVEQGMEVPVTHDIGTLRIDGDQGNSGVGI.PSSRLVGCMMHERAFGADTMELGHIDYSYKPVKPVISNECQAMEVCQQNMIVPLFYGAMPNMGLYYTPD.GPFENPGDLMKAFKIQEAWDSMEHAAEHLTRDTIWIMQRLMASGSDGVNFDTIGAAGDGDFFGSLHAIEALRK..E..FPNIYIEAGMAGECVLGMHGELKYDGTTLAGLWPHQQAPLAAKAGASVFGPVCNTNTSKTSPWNLGRAVTFMKAAVEASTIPCHVDMGMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGIOIGVGDPMGMPISHIMASGMTGIRAAGDLVARMEFSKKMRIGEAKEYVAKKLGVSTLDLSDEHVMRELREE..LDIG..VITS.VAGAAKGIAAKMNIEKLLDTKINSCDLFRKQ...
A0A8J7W4I0_9FIRM/1-109 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..----------------------------------------------------------------------------------------------------------------------------MGDPLGAEATHGIAASMGGVRTAGDMVLRMQLSHKMRINEAKQYVADKLGLTLEELCDVVTMAEVREDrgFGLG..NFEP.YAESTIGMEAKFRIAEALDIKINSVERFKE-r..
A0A0B7MKZ6_9FIRM/2-349 arvf----TRMGDGSASWLSEAEICQDLEEGMLDAADRGRIPELTDDEMERLYQIISNPQKTVSIERGNEVVATFDAGTLKLPV-----RAGI.PVGRMTTVLMHERVLCSDTMEIGNTDYSYKQLKNIVHEEATSMELTQLNCMIPVFYGAMPNLGLYTRPD.GPIDNWSELLPMGKISEARAAQEEAVEMATKDMVYVASLLYEAGADGINFDTVGASGDGDFLATLKAIEILKE..K..YPDMAIEVGMSGEFVLGMHGQLEFDGIRLAGLYPQDQARVVEKAGGTIFGAVINTNSRKTLPWNLARAVTFSKACSDASNIPVHVNAGMGVGAIPLSNTSPTDATSRVSKSLVEIGKADGL-----------------------------------------------------------------------..----..----.-------------------------------...
A0A0B7MMN8_9FIRM/1-103 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..--------------------------------------------------------------------------------------------------------------------------------MGMAITHALASGMGGMRTTGDLVARMQMSKGMKIKEAKEYVADKLGVPVLDLVDEAVVRELREE..LDIG..IVHH.LDGFAKGIEAKFRIAKLLDIEIKSVSNFI--kr.
A0A1M6F436_9FIRM/1-92 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..--------------------------------------------------------------------------------------------------------------------------------------------MGGVRTAGDLVLRMQMTHKMKIDDAKNYIADKLGVNLEQLSDAVYMSELRDD..LGIG..TQEPfVTDANYGMEAKFNISEKLGLKINSVERFKE-r..
K4LIW4_THEPS/1-101 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..----------------------------------------------------------------------------------------------------------------------------------MAIAHEVAAGMGGIRTAGDLVARVQMSKAMKIKEAKEYVAEKLGISVFDLCDSYVMKELREQ..LDIG..HVQA.RDRASYGIEAKFNIARLLDIKINSVENFKR-k..
W9DXI8_METTI/3-465 ....TEYKLRMGDGKRIFMTKEQIVADLKEGMADAADLGSIPDLSADEIDKLVDIITMPSRMVGVEQGMEVPVTHDIGTIRIDGDQGNSGVGI.PSSRLVGAMMHERAFGADTMELGHIDYSYKPAKPVIAQEMQTMEICQQNMIVPLLYGAMPNMGLYYTPD.GPFENPGDLMKAFKIEEARQSMEHSAEHLTRDIVWIMQRMMASGSDGVNFDTIGAAGDGDMYASLHAIEALRK..Q..FPDIYIEAGMAGELMLGMHGELEYDGTTLAGLWPHEQAPLVAKAGANVFGPVVNTNTSKSAAWNLGRAVTFIKAAVEASTLPCHVNMGMGVGGIPMLETPTIDAVSRASKAMVEIAGVDGIOIGVGDPMGMPISHIMTSGMSGIRAAGDLVARMEFAKGMRIGEAKDYVAKKLDVTTDDLSDEYVMRELREE..LGIG..VITS.VAGAPKGIAAKMNIEKLLDLKINSCEKFRGQ...
MTBB2_METAC/3-465 ....TEYALRMGDGKRIFLTKEKIREELEAGAANAADLGEIPALSGDEIDRLAEILMMPGKAVSVEQGMEVPVTHDIGTIRLDGDQGNSGVGI.PSSRLVGCMMHERAFGADTMELGHIDYSFKPVKPVVSNECQAMEVCQQNMIIPLFYGAMPNMGLYYTPD.GPFENPGDLMKAFKIQEAWESMEHAADHLTRDTVWIMQKLFASGADGVNFDTTAAAGDGDFYGTLHAVEALRK..E..FPAMHIEVGMAGEMVLGMHGNLQYEGVTLAGLWPHQQASLVAKAGANVFGPVVNTNTSKTSPWNLARAVTFIKEAVKVSSLPCHVDMGMGVGGIPMLETPPIDAVTRASKAMVEVAGVDGIOIGVGDPLGMPISHIMASGMTGIRAAGDLVARMQFSKNMRIKEAKKYVAKKLDVDVMDLADEHVMRELREE..LDIG..VITS.VPGAAKGIAAKMNIEKLLDVRINSCELFRKQ...
A0A1W1HAS7_9DELT/1-103 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..--------------------------------------------------------------------------------------------------------------------------------MGMSIAHIMASCMGGIRTAGDLVAWMQMTRKMKINDAKAYVAGKLGIDVFDLTDEEVMRDIRKD..LGIG..TVTS.IAGSPKGIRAKIKIAELLGIKIRSVELFKKQ...
A0A6J4XV89_9DELT/3-159 kril----TRMGDGERVSMPADEVKEELLSGTQDAAQNGEIPELTREDLEQLFGILAESGRVVSVPPGDEVVVTDDGCGKLFCSGPADGGAGL.PISRQTSILAYERGFAADTVSIGHEDYSFKSVKPIIDYEAQTYYATALATTVPFFYGAQPNLGLY----.-------------------------------------------------------------------------..-..------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..----..----.-------------------------------pni
A0A1H0IZA0_9DELT/2-348 skil----TRFGDGYKVELTEDEVKADIEEGCNDAASRAGIEPLARDEQEHIFEMFKNQDTLVGIERGREVVMTYDGMSSKIRR------AHI.VIDRVQSLQVFERALGADTLELSHIDYSFKPCKPINGFELPDLDLLLNSTVAPVYYGAMPNLGLYSQPD.GPCPNPADLLPLGKIDEARQAYEEAIEHAVSDIVFVASAMYEAGVDGINIDTVGAAGDADFLTALKATEILKE..K..YPAMGIEMGMAGEFVLGMHGNLSWRGVKLAGLYPQDQVRLAQQAGATIFGPAINIVTSGTLPWNVARSVTFCKACSEVSEIPVHANLGMGVCGIPLTLTVPVDALSRATKAHVEICRLDGL-----------------------------------------------------------------------..----..----.-------------------------------...
A0A1W2DK76_9DELT/1-103 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..--------------------------------------------------------------------------------------------------------------------------------MGMAIAHIMASCMGGIRTAGDLVAWMQMTRKMKINEAKAYVAEKLGIEVFDLTNEEVMRELRKD..LGLG..TVTS.IAGGPKGIRAKMKIAELLDIKIRSVELFKSQ...
M4YJT7_THEXX/1-457 ....------MGDGRTVYMTRENVLEDIRKGMADAADAAGVPDLNENEIEQMADVICSDERLVSVPRGHEVVMSEDGGPYKMMIDSGSSGNGI.EISRLQAILAHERTLGMDSFQLAHIDYSIKAVKPIIGYEAQAMEQINMLSTVPLLYGAMPNMGLYYAPD.GPFGNPADLMREFKMEEAMDQAEKAAAQIAADIDYVFSGMMAAGSEGWNFDTTASAGDADFVGTLNGITEVRK..K..FPNAYIEMGMAAENVLGIHGSIEYDGTPVAGLYPHQQVKLAEKAGVNIFGPVVNTNTSRSFAWNIARAVTMVKECEKVSNIPCHVNMGMGVGGIPMSECPPLDAVSRANKLMVEIAHVDGIOAGAGDPLGMSNAHVAASGMGGVRTAGDLVARMEFSKNMKLAKAKEYVAKKLGISEIEIADETVMRDLRYD..LGLG..NVTS.IPGAAKGMEAKLNIEKVLGITINSCEKFRG-t..
A0A1H0IYT7_9DELT/1-91 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..--------------------------------------------------------------------------------------------------------------------------------------------MGGVRTAGDLVARMQLNRGMRIDAAKKYVAESLGVAVSDLNDPIVMGEVRDD..KNIF..WISE.GQTTVDGIAAKYNISKLLDLDINCVNRFL--kn.
U5Q2B5_METII/2-464 ...a-EYPIRRGDGKRLYLSRQQILDDINEGIADAADIASVPNLTSDDIDFLLEILIDSNRTVGVEVGKEVVLTYDIGQIDLEGDTGNSGLGI.PISRLTGALTHERAMGADTFELAHADYSIKPVKPIIANEMQAMETAQNNLVIPYFYGAMPNMGLYYSPD.GPYGNPADLMREFKIQEARESCEAAVDHLARDIHFVSTKIMSAGADGFDFDTTASAGDGDFVATLRGVEMLRK..E..CPQAYINLGMSGELVLGIHGELEYDGQIVAGLCPHQQVKLAAKAGASVFGPVVNTNTGKSLAWNLARALTFIKECVKVSPIPCHANMGMGVGGIPMTETPSLDAMTRCSKAMVEIAGVDGIOVGVGDPAGMALPHYVSSGMGGIRTAGDLVARMEYSKSMKISEAKEYVAKKLGVSSIDLADEYVMKDLREE..LGLG..VVTA.IPGVPKGIAAKMNIERLLDTKINCCEHFRN-m..
A0A0W7TKF0_9ARCH/3-356 asvf----TRMGDGRVVYMTKEQVMDDIQAGMADGADAASAAELTDDEMQRICDIVCDPSKIVGIEPGEEVIMTKDAGEIKFSQDSGGSGIGItSIPRAAGALMYERAFAFDTLELAWMDYSIKPVKQVISEEMITYEQISQETTFPYMYGAMPNMGLYYAPD.GPYGNPTDLMREFKIEEAQDQAEKSADLLTKDIGYVTERLHSVGLEGFDFDTTASAGDAEFVATLRGAENYRK..L..DPNAYIVIGMSAENVLGIHGSIEYKGTPVAGIYPAEQAKLCEQAGANVFGAVVNTNTSKSFAWNVARSAAIIKKCTDESNIPVHANLGMGVGGIPMCELVPTDTVGRAGKILIEIAHIDGI-----------------------------------------------------------------------..----..----.-------------------------------...
MTBB1_METMA/3-465 ....TEYALRMGDGKRVFLAREKIMEEIEAGTANAADLGEIPALSADEMNKLAEILMMPGKAVSVEHGMEIPVTHDIGTIRLDGDQGNSGVGI.PSSRLVGCMMHERAFGADTMELGHIDYSFKPVKPVVANECQAMEVCQQNMIIPLFYGAMPNMGLYYTPD.GPFENPGDLMKAFKIQEAWDSMEHAAEHLTRDTIWIMQKLFASGADGVNFDTTAAAGDGDFYGTLHAIEALRK..E..FPEMYIEAGMAGEMVLGMHGNLQYDGVTLAGLWPHQQAPLVAKAGANVFGPVVNTNTSKTSPWNLARAVTFIKEAVKVSSLPCHVDMGMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGIOIGVGDPLGMPISHIMASGMTGMRAAGDLVARMQFSKNMKIKEAKEYVAKKLNVEIRDLADEYIMRELREE..LNIG..VITS.VPGSAKGIAAKMNIEKLLGIKINSCELFRKQ...
A0A1W2CXK7_9DELT/1-107 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..----------------------------------------------------------------------------------------------------------------------------MGDPVSMAITHAHASGMGGMRGAGDLVARAQMSRGMRTWEAKEYVAEKLKISVADLTDPVIMTEVRED..LQIG..QMTP.MPGCAKGIEAKFNIARELDFNINCVNRFKT-r..
W9DXH3_METTI/3-465 ....TEYKLRMGDGKRIFMTREDIIADLKEGMADAADLGAIPDLSEDEIDKLVDIVTMPSRMVGVEQGMEVPVTHDIGTIRIDGDQGNSGVGI.PSSRLVGAMMHERAFGADTMELGHIDYSYKPVKPVISQEMQTMEVCQQNMIVPLLYGAMPNMGLYYTPD.GPFSNPGDLMKAFKIQEAQESMQHAAEHLTRDTVWIMQRLMSSGADGVNFDTIGAAGDGDMYASLHAIEALRK..Q..YPDIYIEAGMAGELLLGLHGEMEYDGTVLAGLWPHEQAPLVAKAGANIFGPVVNTNTSKSAAWNLGRAVTFIKAAVKASPIPCHVNMGMGVGSIPMFETPTIDAVSRASKAMVEIAGVDGIOIGVGDPMGMPISHIMTSGMSGIRAAGDLVARMQLAKSMRIGEAKDYVAKKLDVTTDDLSDEYVMRELREE..LGIG..VITS.VAGAPKGIAAKTNIEKLLDLKINCCEKFRGQ...
A0A1W1HB41_9DELT/3-355 .kki---LTRMGDGERLWMDAEEVMDDIQDGSEDAARRLGGKPLSQEEQEKLFEILAEPSRIVSVNPGEEVIVSDDGCTMSFYSGQDGGGTGT.PLSRQQAVLTYERACGADTTSMGHSDYSYKPVKSIINFEANDYYNISQVTTAPFFYGAQPNMGLYFQPD.GPCPNAAELMPLGKIDEARASQEEACEYLTDDLEFVGSRLADIGLEGLNFDTSGSAGDADFLAALKGVERLKA..K..YPDLPILMGGAGEFVLGMHGKITYNGRQVAGMYTPDQAKAVEKAGADIFGMAVNTVTTESVPWNLARAVTFLKATTEATNLPVHANVGMGVCGVPMMEQPPIDCVTRVSKSLVQLGKADGL-----------------------------------------------------------------------..----..----.-------------------------------...
R6ER79_9FIRM/1-80 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..---------------------------------------------------------------------------------------------------------------------------------------------------------MQLAEKMKIDEAKAYVAEKLGVTVEDLYDIVTMTDKRTD..LGLGltHVEP.CKEENNGMAAKFRIADVLGIKINSVERFKE-r..
A0A6P1MSJ8_9FIRM/1-111 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..--------------------------------------------------------------------------------------------------------------------------MGVGDPLGAEAAHALAACMGGTRTAGDLVMRLQLAKKMKINEAKAYVAEKLGVSLEELCDVVTMSEKREE..LGLGlaHVEP.CAKANAGMEAKFRIQELLGIQVNSVERFKE-r..
M9SER6_METAX/4-466 ....QEFYTRMGDGKRVTMTKEQIMADLQAGTADAADMGSIPALTADDLERLADIICDKNRIVAVEPGNEVVLTYDIGQLDFTGDNGNSGNGV.DMGRLEAALIHERALGADTFELAHSDYSIKPVKPVIAMEMQTMEEIQQEIVAPYFYGAMPNMGLYYAPD.GPYGNPADLMREFKIDESMQQSELAAEHMARDIEYVGNKIISAGADGFDFDTMASAGDADFVGGLKGVEALRK..A..NPLAYINTGMAGESVMGIHGGIEFHGKTVAGLFPHQQVKMCEEAGANVFGAVCNTNTSKSLAWNMARAVTFVKECVKQASIPVHCDLGMGVGGIPMFETPPIDAVTRASKAMVEIAKCDGVOIGVGDPVGMDMAHMLASGMGGIRTAGDLVARMEYAKNMKVDKAKEYVAKKLGLSTLDIADEHVMRDLREE..LKIG..VVTG.LPGAPRGIAAKMNIEKLLDIKINSCEKFRQ-s..
A0A8J7VYE9_9FIRM/1-100 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..----------------------------------------------------------------------------------------------------------------------------------MACMHETAAGMGGIRTAGDLVARMVM-KGMKINQAKKYVADKLGCSVFDLSDSARMKEIRES..LDIG..TVLS.RTNAATGMAAKIKIAELLDIKIPSVEKFKK-l..
A0A1I1Z1W7_9FIRM/1-93 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..--------------------------------------------------------------------------------------------------------------------------------------------MGGVRTAGDLVLRMQLAKKMKITEAKEYVAAKLGVTLEELHDVVTMTELRED..RGLGlaHVEP.CAEENNGIAAKFRIAKALDIEINSVERFKE-r..
A0A8J7W0J8_9FIRM/3-350 ...d-SYFTRMGDGEGIWMSKAELEEEVQKGMEDAVKKGKSQPLDKEDIDRLLDILMMPEKNVSVERGNEGVVTFDAGTLKLPV-----RAGI.PVDRTTALLIHERILCSDTMELCHVDYSYKAIKNIIAEEAMAMESAQMNCIMPVFYGAMPNMGLYTKPD.GPVENWSVALPEGRIKDACDAQEAALEFCRDDMIYIGSKMAEAGACGIQFDTIGASGDADAIAALEAAKVLSQ..K..YPDLSITMGMANEFHLGMHGKLTFEGEKIAGQYPAKQVKSVEAAGAHSYGVVINTNSSRSFPWNLARSLTYVKEATRVAGIPVLVNAGMGVGGIPLTNTSPTDCTTRVSKVMMEIGKADGL-----------------------------------------------------------------------..----..----.-------------------------------...
MTBB2_METMA/3-465 ....TEYALRMGDGKRIFLTKDKIMEELEAGMANASDLGEIPDLSGDEIDKLAEILMMPGKTVSVEQGMEVPVTHDIGTLRLDGDQGNSGVGI.PSSRLVGCMMHERAFGADTMELGHIDYSYKPVKPVVANECQAMEVCQQNMIIPLFYGAMPNMGLYYTPD.GPFENPGDLMKAFKIQEAWDSMEHAAAHLTRDTVWVMQKLFASGADGVNFDTTAAAGDADMYGTLHAIEALRK..E..FPDMYIEAGMAGECVLGMHGNLQYDGVTLAGLWPHQQAPLIAKAGANVFGPVCNTNTSKTSPWNLARAVNFMKAAVQASSIPCHVDMGMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGIOIGVGDPLGMPISHIMASGMTGMRAAGDLVARMQFSKNMKIKEAKEYVAKKLNVETMDLADEYVMRELREE..LDIG..VITS.VPGAAKGIAAKMNIEKLLDVKINSCNLFRKQ...
A0A1W2CKJ5_9DELT/1-88 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..-----------------------------------------------------------------------------------------------------------------------------------------------MRAAGDLVARMQISQGMRLVEAKAYVAKKLGVAVKDLTDPIIMTEVRTD..LRLG..TLHA.GARSAKGIEAKHNIADLLDIDINCVRNFRK-n..
A0A1Q9JJ37_9FIRM/4-351 ...r-KYFTRMGDGSPVYMTEEEIRADMKEGMEDAVSRGKIDPLSEEDFEKLYRIITMDGTVVGVEPGKQIVLTNDSGGYKINV-----KSML.PVAKETEVLIYERVLGCDSVDIGNTDYNYKTAKGVAKREASILKQALNTSTMPLFFGGMPDLGFYTEPD.GPCGNWATLLPDGKIKEALAAQEQAVDYSVKDIVYVAEQAYDVGADGINLDTCGAAGDADFLAALKATEEIKK..R..FPELGVEIGMAGEFVLGMHGKLKYEGERLAGMYPHKQVKMAEKAGASIFGVVVNTNCNKTFPWNIARVITFVKACTDVAEIPVHADVGMGVCGTPMTENMPSDMLSRADKALVEIGKIDG------------------------------------------------------------------------..----..----.-------------------------------f..
D9QQJ6_ACEAZ/3-459 .nmv---QTRLGDGSTIEMTEDEIRADIERGIEDAVDRAEVDSLPEEEIEKLTDIYTRPSKFVSVETGNELVLTFDEGSVKLKR------LAV.SIGRIPDLQIYERVFCSDTAELAHIDYSFKPVKPIVAEEQIEMEQALLSTVLPLYYGAMPNLSLYSQPD.GAFPNPAELLPKGKVKEAQEAYEGMMEHAIKDMVFVGSKMYEAGADGINFDTTGSAGEPDFLATLKATEELKE..K..YPNISIEMGMAGEFVLGMHGDLEYNGVGLAGLYPHEQVKLAEEAGVDVFGPVVNINSSETIPWNIGRTVTMMKACAEAADIPVHANVGMGVGGVPIVETPPADSLSRASAALAEIGKQDGLOVGVGDPNGMVISHALASGMGGVRTAGDLVARMQMSENMRLDEAKEYVADKLGVEVGELTDPVIMDEVRNE..LNIG..RVQP.EAGEAKGVEAKFNISELLDIRINSVEKFKNK...
A0A1U7MCE8_9FIRM/1-91 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..--------------------------------------------------------------------------------------------------------------------------------------------MSGIRTSGDLVARVQMAKGLRIDAAKQYVADKLKISLSDLHDSSVMRDIRNQ..LNIG..ETNA.RPESADALAAKSRIAQILDIEINSVTRFNK-m..
A0A415DYA0_9FIRM/8-355 ...k-KFFTRMGDGSPVYMTEEEIRADIKAGIDDAVLRGKIDPLSEEDTERIYEIVTMPGNIVGVQPGMEIVTSNDSGSDKIST-----KCGI.STSRDTNALIHERVLGADSVDIGYSDYNYKTVKGVAKREATVLKQALTKATMPLFYGAMPNLGFYTKPD.GPVDNWAMLLPEGKIKEAMAAQEEAVDHAVRDIVYVAEQMNDVGADAFMLDTSGAAGDADLLVSLKACEIIRE..K..FPDMPVEIGMAGEFVLGMHGKLKYNGTRLAGLYPHKQVKVVEEAGASIFGAVVNTNCNKSFPWNIARVCTFIKACTDVAEIPVHANAGMGVCGIPMVENLPSDVVSRADKCLIEIGKVDGL-----------------------------------------------------------------------..----..----.-------------------------------...
M4YNV1_THEXX/4-466 ....TEYYTRLGDGKRVTMTKEAIMADLQAGTADAADMGGIPALNESQLEQLADIVMDKNRVVGVEPGNEVVLTYDIGQLDFTGDNGNSGNGV.DMGRLEAALLHERALGSDTFELAHSDYSVKPVKPVIAMEMQTMEEIQNEIIIPFFYGAMPNMGLYYAPD.GPYGNPADLMREFKIDESMQMSELASAHLTRDIEYVGNKIFAAGADGFDFDTIASAGDADFVGSLNGIELLRK..A..NPNMYINAGMAGENVMGIHGSIEYKGKSVAGMFPAQQIKMCEQAGANVFGTVCNTNTSRTLAWNLARSVTFAKSAVDAKSLPVHVDLGMGVGGIPMFETPPIDAVTRCSKAMVEVAHADGVOIGVGDPCGMDVTHYMASGMGGIRGAGDMVARMMYGKNMTIDKAKEYVAKKLGVTTMDLGDEVVMRDLREE..LKIG..VVTG.LPGAPRGIAAKLNIEKILGITINSCEKFRG-m..
A0A0W7TJR1_9ARCH/4-356 ....QEYYTRMGDGKRVTMTKEQIMADIQAGTADAADMGSIPALTDDDMARIADIIMDKNRVVSVEPGNEVVLTYDIGQLDFTGDNGNSGNGV.DMGRLEAALLHERALGADTFELAHSDYSIKPVKPVIAMEMQTMEEIQQEIVAPYFYGAMPNMGLYYAPD.GPYGNPADLMREFKIDESMQQSELASEHMARDIEYVGNKILSAGADGFDFDTMASAGDADFVGGLKGVEALRK..A..NPLAYINTGMAGESVMGIHGGIEFHGKTVAGMFPHQQVKMCEEAGANVFGAVCNTNTSKSLAWNMARAVTFVKECVKQANIPVHCDLGMGVGGIPMFETPPIDAVSRASKAMVEIAHCDGV-----------------------------------------------------------------------..----..----.-------------------------------...
K4LLG4_THEPS/2-349 ...a-EFFTRMGDGSAVWLSEAEIRRELEEGMLDAAERGRIPELTDDEMQRLFEIVTDPQKTVSIERGNEVVGTFDAGTLKLPV-----RAGI.PVDRMTTVLIHERALCSDTMELCSTDYSYKQLKNFVHEEAASMELIQLNCVIPVFYGAMPNLGLYTKPD.GPIDNWSELLPMAKIKEARAAQEEAVEMAAKDMVYIASILYEAGADGINFDTVGASGDGDFLATLKAMEILKK..K..YPDMAIEVGMAGEFVLGMHGRLEYDGVRLAGLYPHDQAKVVEKAGGSIFGAVINTNSSKSFPWNLARAVTFTKACSEASNIPVHVNAGMGVGAIPLTNTAPTDATSRASKALVEIGKADGL-----------------------------------------------------------------------..----..----.-------------------------------...
A0A0E3L794_9EURY/3-465 ....TEYALRMGDGKKLFLTKETIIEEIEAGTADAADLGEIPTLSGDEIDKLAEILMMPGKTVSVEQGMEVPVTHDIGTLRLDGDQGNSGVGI.PSSRLVGCMMHERAFGADTMELGHIDYSYKPVKPVISQECQTMETCQQNMVVPLFYGAMPNMGLYYTPD.GPFENPGDLMKAFKIQEAWESMEHAAEHLTRDTVWVMQRLFASGADGINFDTTGAAGDADMYGTLHAIEALRK..E..FPNMYIEAGMAGECVLGMHGELKYDGTTLAGLWPHQQAPLIEKAGANVFGPVCNTNTSKTSAWNLARSVTFMKAAVEASNLPCHVDMGMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGIOIGVGDPMGMPISHIMASGMTGIRAAGDLVARMEFSKNMRIGEAKEYVAKKLGVDTMDLSDEYVMRELREE..LDIG..VITS.VPGAAKGLAAKMNIEKLLDVKINSCDLFRKQ...
A0A1H0KD90_9DELT/1-101 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..----------------------------------------------------------------------------------------------------------------------------------MAITHAHASGMGGMRGAGDLVARVQMSKGMRTWEAKQYVADKLGVAVAELTDPVIMTEVRED..MNIG..QITP.LPGCAKGIEAKFNIQKALDIQINCVDRFRK-r..
A0A6J4Y151_9DELT/1-63 ...m-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..-------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEKLGISVADLSDPVIMTEVRQD..LEIG..YINP.LPGCAKGLEAKIRIGEILDIDINCIMRLKN-r..
A0A484F2L8_9EURY/3-465 ....TEYILRMGDGKRVSMTKEQIKEDTLAGAGNAVDYGLVPELSADEIDKLIEICTMPGKSVSVEYGMEIPVSHDIGTIRLDGDQGNSGVGI.PSSRLVGMMMHERAFGADTMELGHIDYSFKPVKPIVSNECQMMEVAQQNMIVPLFYGAMPNMGLYYTPD.GPFENPGDLLKAFKLEEAFASMEHSAEHLTRDIVWIMQKLMASGADGVNLDTTGAAGDADAYGTLTAVKALRE..E..FPEMYIEVGSAGESWIGMHGMLEFEGTVLAGLWPHQQVKLVEKAGASIFGPAVNTNTSRTFPWNLARSVAFTKECCKASTIPIHADMGMGVGGIPMLETPPIDAVTRASKAIVEIAGADGIOIGVGDPLGMPIAHIMASGMTGLRAGGDLVARMQLSKSMKIKEAKEYVAKKVGVDVFDLADEYAMRDVRED..LGIG..VITS.VPGAPKGIAAKMNIEKVLDTKINCCDYFRNQ...
A0A1H0LIU7_9DELT/1-88 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..-----------------------------------------------------------------------------------------------------------------------------------------------MRAAGDLVARMQMAKAMKIGDAKKYVAERLGVSIADLTDPIIMTEVRND..LKLG..TLHA.GARSAKGIEAKHNIAELLDLDINCVRNFKS-n..
A0A1H0KDM8_9DELT/2-348 akif----SRYGDGTPLELDEKELMEELHAGTEDAADRAKVSTLTDDDLKHLYEILASPYKFVSVEPGKEVLLTYDAGTLKIRR------VGV.NVDRIQALQIYEKIMGADTMELCHVDYSYKPLKPIVTMEQPILEQALLSTHIPLFYGAMPNLGLYSQPD.GPFPNPAELLPNGKIKEARESLEQTVEEAVRDIVFAGSAMYESGADGINLDSVGAAGDADFLASLMATKKLKE..K..YPDICIEIGMAGEFILGMHGELEFEGTRLAGLYAHDQVRLAAQAGATIFGPVVNTNTTETSAWNLARAITFMKACGEVAEIPIHPNMGMGVGAVPVNDHPPIDSVSRASAAMTSLVRLDGL-----------------------------------------------------------------------..----..----.-------------------------------...
D7E9M1_METEZ/3-465 ...n-GYRIRMGDSTTEYHSKDRIMEDIEAGTNDAAELGGIPALSDDDKEKIADILMSPQKMVSVDAGNEVPVTHDIGTLRIDGDQGNSGTGI.PASRLTGVMTHERAFGTDTMELGHIDYSFKPVKPVVSQECQTMEVCQQNMTVPLMYGAMPNMGLYYQPD.GPFKNPSDLMREFKLQEAKKEIEGAADELTNDMVWTVDKLYKSAADGVNFDTIAAAGDGDFYATLNAIEALRK..R..FPNMYIEAGMASESILGMHGEFEYDGTTLAGLWPHEQAPLLGKAGANLFGPVCNTSTSHSTSWNLARAVTFVKSAVDKSPIPCHVNMGMGVGGIPMFETPPVDAVTRCSKAMVEVAGVDGIOVGVGDPVGMPIAHVSASGMTGMRAGGDLVARMQLSKNMRINEAKDYVSKKLGVEPMDLSDEYVMRDLREE..LGIG..VLTS.VEGAPKGISAKMNIEELLDIKINSCEKFRNQ...
A0A1M6F3W9_9FIRM/5-352 ...k-KFRTSMGDGFIVHMTEEEIRSDIDAGVADAVKRGKISPLTEEEKNHLYNIIIMPGKVVGVEPGREVVSTNDSGSYKVSS-----KCMI.SIRRDEQAAIAERVWGCDSIDIGNTDYNYKTVKGIADREASTMRMALQKTTMPLFYGAMANLGFYTKPD.GPVENWSMLLPDGRIEEAMEAQEEAIEHSVRDIVFVAEQIYNAGGDGINLDTTGAAGDADFLAALKATEIIKK..E..YPDLAVEIGMAGEFVLGMHGKLEYDGKRLAGMYTHDQVKAVEKAGASIFGAVVNTNCNKSFPWNIGRVCTFIKACTDVAEIPVHANVGMGVCGIPMNEILHTDIVSKTDKALIEICKIDGL-----------------------------------------------------------------------..----..----.-------------------------------...
F7XQH1_METZD/3-465 ....TEYDLRMGDGKRVYHSKNQIMDDLEAGSADAADLGEISALSGDELEKLAEIIMTKSRMVGVEPGKEVPVTHDIGTLRIDGDQGNSGVGI.PSSRMIGCMMHERAFGADTMELGHIDYSFKPVKPVIAQECQAMEVCQQNMIVPLLYGAMPNMGLYYTPD.GPFENPGDLMKAFKIAEAQESIEKSADHLTRDMIWIIQHMMKSSSDGVNFDTTGAAGDGDMFATLHAVEALRK..E..FPEMYIELGMAGECVLGMHGGLEYDGKTLAGLWPHQQAPLVTKAGANVFGPVVNTNTSMSFSWNLARAVTFIKAAVEASDIPCHVDMGMGVGGIPMLETPPIDAVSRASKAMVEVAGVDGIOIGVGDPMGMPISHIMTSGMSGIRAAGDLVARMQFSKNMRIGEAKKYVADKLGVTPLDLSDEFAMREIRED..LGIG..VITS.VTGAPKGIAAKMNIEKALDIKINSCEKFRNQ...
L0KZ37_METHD/2-464 ....TEYALRMGDGKRIFLTKEQIRADLEAGTADAADLGSIPALTGNELDKLAEILMMPARMVGVEPGKEVPVTHDIGTIRLDGDQGNSGVGI.PTSRLAGCMIHERAMGADTMELGHIDYSYKPVKPVISQEQQAMEVCQQNMIVPLFYGAMPNMGLYYTPD.GPFENPGDLMKAFKITEAQASMEHAADHLTRDIVWIMQKMMFAGADGANFDTTGAAGDGDMFATLRAVEALRK..Q..YPDMYIEVGMAGELVLGMHGELQYDNTTLAGLWPHQQAPLAAKAGANVFGPVVNTNTSKSSAWNLARAVTFVKEAVKVSPIPCHVNMGMGVGGIPMLETPTIDAVSRASKAMVEIAGVDGIOIGVGDPMGMPITHIMTSGMSGIRAAGDLVARMEFSKNMRLNDAKDYVAKKLGVSTMDLSDEYVMRDLREE..LGIG..VITS.VAGAPKGIAAKMNIEKLLDIKINCCEKFRG-k..
A0A1Q6DT84_9EURY/3-357 ...e-KYTTRKGDGRKIELTKSEIREDIEEGSADAANKGGINELKEDEKDKIVSLITDPSKVVSVEKGNEVPFTHDIGTLRLMGDQGNSGVGI.PMSREQGVKTHERAFAVDTMELGHIDYSFKPAKPIIAQEQQTLEDILLSTIVPIWYGAMPNLGLYYAPD.GQFKNPNELMPEGKIKEAKEAQEKAIEQAKEDMSYIAENLRKVGLDGLNIDTTAAAGDPDFKAVLEVTEELKSnpE..TEDLAIEIGMAAEHVLGMHGDLEYNGKQLAGIFPHEQVEIVEEAGGDLFGPVCNTKTGKSLPWNLARAVTFVKETSKVSDIPIHVNMGMGVCGVPMFETPPVDAVTRASSAMVEVGNVDGI-----------------------------------------------------------------------..----..----.-------------------------------...
A0A8J7W1Q4_9FIRM/4-351 ...k-KYFTRMGDGSIVYMTEEEIRADIEKGVQDAADRGKIPPLTQAEMEHIYDIVTMPGGVVGVEPSLAVVTSNDSGSDKFST-----KCGI.PVERSVNAMFHERVLGADSVDIGLEDYNYKTVKGVAKREAAVLKNALNKTTIPLFYGAMPNLGFYTKPD.GPVDNWAVLLPEGKIKEALEAQEEAVEHAVRDIVYVAEQMYDVGADGIQLDTSGAAGDADFLVSLKATEIIRE..K..FPDMGVEIGMAGEFVLGMHGRLKYNGVKLAGLYPHQQVKLVEEAGASIFGAVVNTNCNMSFPWNIARVCTFIKACSEAASIPVHANAGMGVCAIPMCETLPADIVSRADKCLIEICKIDGL-----------------------------------------------------------------------..----..----.-------------------------------...
A0A0W7TJQ6_9ARCH/1-101 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..----------------------------------------------------------------------------------------------------------------------------------MDMAHMIASGMGGIRTAGDLVARMEYAKNMKVGAAKEYVAKKLGVSTLEIADEHVMRELRED..LGIG..VVTG.VPGAPRGIAAKMNIEKLLGIKINSCEKFRQ-s..
A0A1U7MCG1_9FIRM/3-350 ...k-KYFVRYGDGYGAEMTMDEIREEILLGTQDAAERGQIPPLTAEEQEHLLEICTMPAKFVTVEPGKEVVMTNDEGTLKVSV-----RCGL.SIDRTTALLINEKILCMDSAELAHIDYSYKPIKGIIHDEVCAMHHAQLNTIIPVFYGAMPNLGLYTKPD.GPVGNWAELLPAGKIAAAREAQEEAVEHSIRDIVTVAHKMYEAGADGINLDTVGASGDADALAAFRAVKKIRE..M..HPDFAIELGMAGEFILGMHGGLQFEGKTLAGLYPHEQVKLAEAAGVTIFGPTVNTNSSQSFPWNIARVCTFVKACSEVSNIPIHPNVGMGVCGMPLTDAVPLDAASRADKALVEICKIDGL-----------------------------------------------------------------------..----..----.-------------------------------...
A0A0U1KZC8_9FIRM/5-462 akif----TRYGDGYGTYMTKDEIRQEIKDGIQDAVSRGKLDPLTKAEEDHLFDICTMPSKNVCVDAGDEVVMTNDEGTLKVSV-----RCGL.SIDRTTGIMIDERILCMDTAELAHIDYSYKPIKTIIHDEQCAMEHAQLNSIIPIFYGAMPNLGLYTQPD.GPVGNWAELLPAGKLQEAREAQEKACELAVRDIVTVAHKMYEAGADGINLDTVGASGDADALAAFTAVQQIRQ..M..HPDFPIEMGMAGEFFLGMHGKLEFEGQKLAGMYPHNQVKIAEKAGATIFGPTVNTNSSKSFPWNLARVCTFIKACSEASTIPIHPNVGMGVCGMPITDSVPLDVGSRVDKALIEIGKADGLOIGVGDCFGMPINHAVSAGMSGIRAAGDLVARVQMAKKMRIKEAKEYVAKKLNVRVRDLSDCAVMRDIRNE..LNIG..EPNA.RPHSAFGLIAKSRIAKILDIEINSVNRFKN-m..
A0A0E3NZM1_9EURY/3-465 ....TEYLLRMGDGKRISLTKKQIFEEIEEGSANAADLGETPFLSGDELETLAEILMMPGKAVSVEQGMEVPVTHDIGTLRLDGDQGNSGVGI.PSSRLVGSMMHERAFGADTMELGHIDYSFKPVKPVVANECQAMEVCQQNMIIPLFYGAMPNMGLYYTPD.GPFENPGDLMKLFKIQKARESMEHAAEHLTRDTVWVMQRLMASGADGVNFDTTGAAGDGDMYGTLNAVEALRA..R..FPDMYIEVGMAGEMVLGMHGELEYDGTTLAGLWPHQQAPLAAKAGANVFGPVCNTNTSRTSAWNLARAVTFIKAAVSASPIPCHVNMGMGVGGIPMLETPPVDAVTRASKAMVEIAGVDGIOIGVGDPLGMPISHIMASGMTGIRAAGDLVARMQFSKNMRVGEAKDYVAKKLGVGVGDLTDEYVMRELREE..LDIG..VITS.VTGAAKGIAAKMNIEKLLGININSCEMFRKQ...
A0A133VGU6_9EURY/1-350 ...m--YETRAGNAKKIKMEKKEIESEIEDGTNEAAENAGIEALTEDEQEHLLDIIIESGGLVSVDDGDEIVLTRDGGTIRYTE--CNRYQGI.PLSKEQAVWMAERILFMDTMELGHLDYSFKRVKPVAHDEAAILENTMMLTIIPILYGSMPNLGLYYQSQgGSFPTPTDLMKEGKFEEAKETQENAKEKMLEDMRYIGKVLAKTGLDGLNIDTAAAAGDAEFYGVLEAVEYYTQ..E..L-GIPVEVGMSTEEVLGMHAELEYEGTKLAGITPHKQGKLLQKAGASIFGPAINVNSEKTFPWNLARAITYVKKCTEELEIPIHPNMGMSVGGVPVTDTPPVDAVSRAAKAMVEIANIDGI-----------------------------------------------------------------------..----..----.-------------------------------...
MTBB1_METAC/3-465 ....TEYALRMGDGKRVFLTKEKILEELEAGMANASDLGEIPDLSADEIDKLAEILMMPGKAVSVEQGMEVPVTHDIGTIRLDGDQGNSGVGI.PSSRLVGCMTHERAFGADTMELGHIDYSFKPVKPVVSNECQAMEVCQQNMIIPLFYGAMPNMGLYYTPD.GPFENPGDLMKAFKIQEAWESMEHAAEHLTRDTVWVMQKLFASGTDGVNFDTTAAAGDADMYGTLHAIEALRK..E..FPDMYIEAGMAGECVLGMHGNLQYDGVTLAGLWPHQQAPLVAKAGANVFGPVCNTNTSKTSAWNLARAVNFMKAAVQASPIPCHVDMGMGVGGIPMLETPPVDAVTRASKAMVEVAGVDGIOIGVGDPLGMPISHIMASGMTGIRAAGDLVARMQFSKNMRIGEAKEYVAKKLNVDVMDLADEHVMRELREE..LDIG..VITS.VPGAAKGIAAKMNIEKLLDIKINSCNLFRKQ...
A0A0X8UZL0_THEX5/2-464 ...a-KYYTRSGDGRRIEMTKEEIIADIQAGTADAADIATIPALTDDQMEHICDIITCQDRVVGVAPGKEVVMTYDIGQLDFTGDNGNSGNGV.DMGRLEAALLHERALGADTFELAHSDYSVKPVKPIISMEKQTMEEIQDVIVAPYFYGAMPNMGLYYAPD.GPYPNPADLMREFKIDESMASSEAAAEHLARDIEYVGTHIQAAGSDGFNFDTTGSAGDADFVGTLNGVKALRK..A..CPEAYINVGAAGESVMGIHGMIEFEGTVCAGLYPHQQAKVIAQAGANVFGAVCNTNTSKSLAWNLARSVTFIKAAVEQSPIPVHVDLGMGVGGIPMKETPPVDAVSRCNKAMVEIAKVDGVOVGVGDPVGMDIPHLMTSGMQGIRTTGDLVARMMYAKNMKLDKAKEYVAKKLGLDTVEIADECIMRDLREE..LGIG..SCTG.IPGAPRGIAAKMNIEKLLDIKINSCELFRRQ...
A0A1W2CXN8_9DELT/2-348 skif----TRYGDGTPVELSESELWEDMRAGTEDAADRANVPVLTDDDLKYMYDILASPYSFVSCERGKEVILTYDAGTLKIRR------VGV.NVDRIQALQVYEKIMGADTMELCHVDYSYKPIKPIITMEQPIMEQALLSTHIPLLYGAMPNLGLYSQPD.GPFPNPAELLPMGQIKEARESLEMTVEEAVRDIVFTGSAMYESGADGINLDSVGAAGDADFLASLMACQKLKE..K..YPDICIQIGMAGEFILGMHGELEYDGVRLAGLYPQDQVVLAKKAGATIFGPVVNTNTTESTPWNLARAVTFMKACGEVAEIPIHPNMGMGVGAVPVNDHPPIDTVSRASAAMTSLCKLDGL-----------------------------------------------------------------------..----..----.-------------------------------...
A0A0B7ML93_9FIRM/2-348 ekvf----TRMGDGSAVWLSKEEVRHELEEGANDAADRGKIPSLTQEELDNLFDICTRPEKIVSVDRGNEVIVTFDAGTLKMVR------IGV.PVHRSQSIHIHERALGSDTMELAHIDYSYKAIKPIVHEEMYDMEQAQLATIIPLFYGAMPNVGLYTQPD.GPVPNWSELLPLGKIAEAQAAQEDAVTHAEKDMVYVGSNLYEAGADGINFDTTGASGDADFLATLRAIRALKE..K..YPELPIEMGMSGEFVLGMHGELYFDDVRLAGLYPHDQVKVAEKAGVTIFGAVVNTNSSKSFPWNIARAVTFVKACTEAAIIPVHVNVGMGVGAIPVFDTPPPDVVSRASKALVEIGKADGL-----------------------------------------------------------------------..----..----.-------------------------------...
A0A1Q6DT74_9EURY/1-101 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..----------------------------------------------------------------------------------------------------------------------------------MNIAHYAASGLGGIRTAGDLVARCQMRENMKIDEAKNYVAKKLDVDTQDLSNVNVMRDLREE..LDIG..VITS.LPGAAKGVEAKSKIADVLDIEIPSVNRLKNK...
A0A0W7TKQ5_9ARCH/1-101 ....-----------------------------------------------------------------------------------------.---------------------------------------------------------------------.-------------------------------------------------------------------------..-..----------------------------------------------------------------------------------------------------------------------------------MAVAHSLCSGMGGIRTSGDLVGRMQLGKSMKINAAKDYVAKKLGVDRADLAVEGVMRDVREE..FGIG..TITA.VPGTPKGIAAKMNIEKLLGIKINSCEHFREQ...
D7EAA4_METEZ/3-465 ...n-GYRIRMGDSTTEYHSKDRIMEDIEAGTNDAAELGGIPALSDDDKEKIADILMSPQKMVSVDAGNEVPVTHDIGTLRIDGDQGNSGTGI.PASRLTGVMTHERAFGTDTMELGHIDYSFKPVKPVVSQECQTMEVCQQNMTVPLMYGAMPNMGLYYQPD.GPFKNPSDLMREFKLQEAKEEIEGAADELTNDMVWTVDKLYKSAADGVNFDTIGAAGDGDFYASVQAIEALRK..R..FPNMYIEAGMASESVLGMHGEFEYDGTTLAGLWPHEQGPLVAKAGANLYGPVCNASTGHSTSWNLARAVTFIKSAVESTPIPCHVNMGMGVGGIPMFETPPVDAVTRCSKAMVEVAGVDGIOVGVGDPVGMPIAHVSASGMTGMRAGGDLVARMQLSKNMRINEAKDYVSKKLGVEPMDLSDEYVMRDLREE..LGIG..VLTS.VEGAPKGISAKMNIEELLDIKINSCEKFRNQ...
#=GC seq_cons ........hRhGDGt.h.hscpplht-l.tG.tsAsphutls.Lstp-.pplhpIhh..tphVulp.G.El.ho.D.uthch.........tl.s.sR..sh.haE+hhs.Doh-lu..DYshKshKslht.E...hc.h...hhhPhhYGA.PNhGhY.tPD.GPh.N.s.Lh..h+lt-u.tt.E.uht.hhpDh.ahhpthhtsG.-Gh.hDT.uuuGDuDhhssLpshp.l+t..t...Pth.lphGhuuE.hhGhHGtlpaps..lAGhastpQs.hhtpAGsslFGsshNsssspo.sWNluRshsahKtssp.s.lPhHsshGMGVsulPh.pt.s.DhhoRsspshhplsthDGl...................htGhRssGDLVhRh.hsctM+lttAKtYVAcKLslt..-LsD.hhMp-lRp-..htlG...hps.hstts.GhtAKhpItchLshpIsssp.Fct....
//
