#=GF ID   Diphtheria_R
#=GF AC   PF01324.23
#=GF DE   Diphtheria toxin, R domain
#=GF PI   Diphtheria_tox; 
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Griffiths-Jones SR;0000-0001-6043-807X
#=GF SE   Sarah Teichmann
#=GF GA   25.00 25.00;
#=GF TC   25.00 265.00;
#=GF NC   24.10 23.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF WK   Diphtheria_toxin
#=GF RN   [1]
#=GF RM   7833808
#=GF RT   Refined structure of monomeric diphtheria toxin at 2.3 A
#=GF RT   resolution. 
#=GF RA   Bennett MJ, Eisenberg D; 
#=GF RL   Protein Sci 1994;3:1464-1475.
#=GF RN   [2]
#=GF RM   8573568
#=GF RT   Crystal structure of diphtheria toxin bound to nicotinamide
#=GF RT   adenine dinucleotide. 
#=GF RA   Bell CE, Eisenberg D; 
#=GF RL   Biochemistry 1996;35:1137-1149.
#=GF DR   INTERPRO; IPR022404;
#=GF DR   SCOP; 1ddt; fa;
#=GF DR   TC; 1.C.7;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   C-terminal receptor binding (R) domain - binds to cell surface
#=GF CC   receptor, permitting the toxin to enter the cell by receptor 
#=GF CC   mediated endocytosis.
#=GF SQ   5
#=GS A0A1W6JQW4_9CAUD/406-559  AC A0A1W6JQW4.1
#=GS Q6NK15_CORDI/406-559      AC Q6NK15.1
#=GS K6UNZ7_9MICO/109-261      AC K6UNZ7.1
#=GS A0A1W6JRA5_9CAUD/406-559  AC A0A1W6JRA5.1
#=GS A0A1W6JR77_9CAUD/406-559  AC A0A1W6JR77.1
A0A1W6JQW4_9CAUD/406-559             ..SPGHKTQPFLHDGYAVSWNTVEDSIIKTG------FQ-----GESGHDIKITAENTPLPIAGVLLPTITGK-LDVNKSKTHISVNGRKIRMQCRAIDGNVTFCRPKSPVYVGKGVHANLHVAFHRSNSEKIQSNEILSDSIGILGYQKIVDHTKVNS-KLSLFFEIK
Q6NK15_CORDI/406-559                 ..SPGHKTQPFLHDGYAVSWNTVEDSIIRTG------FQ-----GESGHDIKITAENTPLPIAGVLLPTIPGK-LDVNKSKTHISVNGRKIRMRCRAIDGDVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNS-KLSLFFEIK
K6UNZ7_9MICO/109-261                 ea--TDSVRPAVSLGLRAGWKTEEDAKLHIGSPYGMKFQRIVLSAEEGKEI-------PFVRAAV---AVDSKFLKINGPRSFVVQNGIKTPMACFETEGNLAFCRPSRPIFLSSSSPATLHLSYVTNEHE---NGTIKNPTVDILG-QRIVENKVITANKVSLVYKVD
A0A1W6JRA5_9CAUD/406-559             ..SPGHKTQPFLHDGYAVSWNTVEDSIIKTG------FQ-----GESGHDIKITAENTPLPIAGVLLPTITGK-LDVNKSKTHISVNGRKIRMQCRAIDGNVTFCRPKSPVYVGKGVHANLHVAFHRSNSEKIQSNEILSDSIGILGYQKIVDHTKVNS-KLSLFFEIK
A0A1W6JR77_9CAUD/406-559             ..SPGHKTQPFLHDGYAVSWNTVEDSIIKTG------FQ-----GESGHDIKITAENTPLPIAGVLLPTITGK-LDVNKSKTHISVNGRKIRMQCRAIDGNVTFCRPKSPVYVGKGVHANLHVAFHRSNSEKIQSNEILSDSIGILGYQKIVDHTKVNS-KLSLFFEIK
#=GC seq_cons                        ..SPGHKTQPFLHDGYAVSWNTVEDSIIKTG......FQ.....GESGHDIKITAENTPLPIAGVLLPTITGK.LDVNKSKTHISVNGRKIRMQCRAIDGNVTFCRPKSPVYVGKGVHANLHVAFHRSNSEKIQSNEILSDSIGILGYQKIVDHTKVNS.KLSLFFEIK
//