#=GF ID   Diphtheria_T
#=GF AC   PF02764.18
#=GF DE   Diphtheria toxin, T domain
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Griffiths-Jones SR;0000-0001-6043-807X
#=GF SE   Sarah Teichmann
#=GF GA   27.00 27.00;
#=GF TC   27.40 27.00;
#=GF NC   26.40 26.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF WK   Diphtheria_toxin
#=GF RN   [1]
#=GF RM   7833808
#=GF RT   Refined structure of monomeric diphtheria toxin at 2.3 A
#=GF RT   resolution. 
#=GF RA   Bennett MJ, Eisenberg D; 
#=GF RL   Protein Sci 1994;3:1464-1475.
#=GF RN   [2]
#=GF RM   8573568
#=GF RT   Crystal structure of diphtheria toxin bound to nicotinamide
#=GF RT   adenine dinucleotide. 
#=GF RA   Bell CE, Eisenberg D; 
#=GF RL   Biochemistry 1996;35:1137-1149.
#=GF DR   INTERPRO; IPR022405;
#=GF DR   SCOP; 1ddt; fa;
#=GF DR   TC; 1.C.7;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Central domain of diphtheria toxin is the translocation (T)
#=GF CC   domain.   pH induced conformational change in this domain
#=GF CC   triggers insertion  into the endosomal membrane and facilitates
#=GF CC   the transfer of the  catalytic domain into the cytoplasm.
#=GF SQ   26
#=GS A0A0A2VBY4_BEABA/495-612  AC A0A0A2VBY4.1
#=GS A0A0D9NU82_METAN/498-622  AC A0A0D9NU82.1
#=GS A0A7W7CB56_9PSEU/82-218   AC A0A7W7CB56.1
#=GS A0A1W6JR77_9CAUD/229-394  AC A0A1W6JR77.1
#=GS A0A8J3FUK7_9PSEU/256-413  AC A0A8J3FUK7.1
#=GS E9DRF6_METAQ/389-494      AC E9DRF6.1
#=GS A0A1W6JRA5_9CAUD/229-394  AC A0A1W6JRA5.1
#=GS A0A3B0B7P5_9ACTN/229-385  AC A0A3B0B7P5.1
#=GS E9EI25_METAQ/491-612      AC E9EI25.1
#=GS A0A542Q245_9ACTN/634-796  AC A0A542Q245.1
#=GS A0A0D9PEF4_METAN/249-386  AC A0A0D9PEF4.1
#=GS A0A2A9P4S9_9HYPO/182-281  AC A0A2A9P4S9.1
#=GS K6UNZ7_9MICO/9-97         AC K6UNZ7.1
#=GS J5JQT1_BEAB2/495-611      AC J5JQT1.1
#=GS A0A4U0NVY7_9ACTN/299-454  AC A0A4U0NVY7.1
#=GS A0A2X0IP61_9ACTN/239-409  AC A0A2X0IP61.1
#=GS A0A1M4ZWA4_9BACL/252-410  AC A0A1M4ZWA4.1
#=GS A0A0P4RJ06_9ACTN/486-592  AC A0A0P4RJ06.1
#=GS A0A1G9SDF8_ALLAB/93-261   AC A0A1G9SDF8.1
#=GS A0A086ALZ4_9FLAO/450-610  AC A0A086ALZ4.1
#=GS A0A0B2WV66_METAS/306-430  AC A0A0B2WV66.1
#=GS A0A0D9PBJ1_METAN/174-304  AC A0A0D9PBJ1.1
#=GS Q6NK15_CORDI/229-394      AC Q6NK15.1
#=GS A0A2N6N8B3_BEABA/493-610  AC A0A2N6N8B3.1
#=GS A0A1W6JQW4_9CAUD/229-394  AC A0A1W6JQW4.1
#=GS A0A7W7CHP1_9PSEU/69-236   AC A0A7W7CHP1.1
A0A0A2VBY4_BEABA/495-612             .......................................................arqrskesfdnlleefdy----------------------------------KSVVKHDQLYKELN.E.RLPEFNPVSRTERI.TGLS.AKFg.......eGALAVAG...IA.LygkAVADVFSSD-ASVLDKAAV..VTSILPGIGCAVQLA.DSIEHGHV----.----------..-----..-...------------------------dathtalc.........................
A0A0D9NU82_METAN/498-622             .............................................................skesfddlltdf--------------------------------KYKSVVKHDQLYKELN.E.RLPEFNPVSRTERI.AGLS.AKFg.......eGALAVAG...LA.LygkAVADVFSSDTSSVLDKAAV..VTSILPGVGCAVQLA.DSVEHGNVDA--.----------..-----..-...------------------------ghtalcfaedallvsg.................
A0A7W7CB56_9PSEU/82-218              .............................eealksqkvakgdaravvagkvaavgkqvgkssalakfkevlkp------------------------------------------------.-.--------------.----.---.........SKGVIAL...WA.V...SALYTLAQEDVSTVDKAEA..VLAIVPILGPLFSFG.NSYRKEDVEGMV.ISTVALAATL..IAFLC..P...PVGAGIGVGLAVYQVVRA------fcp..............................
A0A1W6JR77_9CAUD/229-394             .........................................................................LDWDAIRDKTKAKIESLKENGPIKNKMSESPNKTVSEEKAKQYLEEFH.Q.TALEHPELSELKTV.AETN.SVF.........AGANYAA...WA.V...NVAQVIDSKTADNLEKTTA..ALSILPGIGSVMGIA.DGAVHHNTEEIV.AQSIALSSLM..IAQAI..P...LVGELVDIGFAAYNFVESIINLFQ.................................
A0A8J3FUK7_9PSEU/256-413             .........................................................................LDRKKIETRAKQVISKLAQDGDLRRELPRR---TTTGHAHEEVRGVLA.K.SRG------ALHEI.HGAAtTVA.........MPLATVA...WV.E...DMARVFREKNATTLDKAAT..VSEIVPVAGQVLGMA.DGIAHRDAETVA.VNAVVLAAIA..VSQAV..P...VVGELVDLGLTAYAVVDVVVRLF-g................................
E9DRF6_METAQ/389-494                 .................................................svvkqgqlynelnarlpefstprp------------------------------------------------.-.-----EKIAGLTTK.IG-E.GAL.........AVAGLAL...YG.K...AVADVFSSD-ASVLDKAAV..VTSILPGIGCAVQLA.DDAERGHGHV--.----------..-----..-...------------------------dvaqtalcstedal...................
A0A1W6JRA5_9CAUD/229-394             .........................................................................LDWDAIRDKTKAKIESLKENGPIKNKMSESPNKTVSEEKAKQYLEEFH.Q.TALEHPELSELKTV.AETN.SVF.........AGANYAA...WA.V...NVAQVIDSKTADNLEKTTA..ALSILPGIGSVMGIA.DGAVHHNTEEIV.AQSIALSSLM..IAQAI..P...LVGELVDIGFAAYNFVESIINLFQ.................................
A0A3B0B7P5_9ACTN/229-385             .........................................................................VDWDKVEEKAKATAKKVAQDAEHVEKLPKRS-------PKGPTWGEAH.S.TAE--LSHAKVREV.SGAH.VAA.........SAAGVGT...WV.Y...GMAKTFSDKDATTLDKVAV..TGAVVPGLGQALGIA.DGIQHGDPEAIA.VNAVALAALA..AAQVV..P...VVGEVVDAVLLTEQLVEVLVDVF-r................................
E9EI25_METAQ/491-612                 .......................................................aqqrskesfdnlltdfny----------------------------------KSVVKHDQLYKELN.D.RLPEFNTVSRTERI.AGLS.AKLg.......eGALAVAG...LA.LygkAVADVFSSD-ASVLDKAAV..VTSILPGVGCAVQLA.DSVEHGNV----.----------..-----..-...------------------------dvghtalcfted.....................
A0A542Q245_9ACTN/634-796             .........................................................................MDGEKVTKGAQSVADTLKGHGNLQPLVKRTRAEPRTQQYLPPTRQQID.D.AIS-----AAQRVH.PGVD.TAMkh.....lgSAQALAG...FA.L...DVSQ--GEPLRAAADVTAM..LPRIGPGLGNALGLA.DSIVHDDPEGIA.VNAIGLGAFI..VAQAI..P...VIGELADLGFAAYALIETLKSMFA.................................
A0A0D9PEF4_METAN/249-386             kekenndpsvektedgeliavakekskesfdglleefnygsvvkqdklygelnarlpefsaprveriagfask------------------------------------------------.-.--------------.----.--Lg.......eSALAIGGlvlYG.K...AVADVFSSEDASVLDKAAV..VTSILPGIGCAVQLA.DD----------.----------..-----..-...------------------------eqrgqvdvthtal....................
A0A2A9P4S9_9HYPO/182-281             .............................................praldgksmsrtdlrmrltkltqsklgi------------------------------------------------.-.---------KLRKF.GGTS.AAAk......siAAASIGV...WI.A...DMAEVFSSQESSTTDRIAA..ATSIVPGVGCV----.------------.----------..-----..-...------------------------trsmqmaqwnledvaad................
K6UNZ7_9MICO/9-97                    .......................................................................gg------------------------------------------------.-.--------------.----.---.........-------...--.V...AVAQAFTDPKADALTKTAA..TLSVVPGLGQALGIA.DGIKHENTEEIV.VQSISLAGLL..AAQAI..P...VVGEAVDFGLLVYQLVETIVDL--at...............................
J5JQT1_BEAB2/495-611                 .......................................................arqrskesfdnlleefdy----------------------------------KSVVKHDQLYKELN.E.RLPEFNPVSRTERI.TGLS.AKFg.......eGALAVAG...IA.LygkAVADVFSG-DASVLDKAAV..VTSILPGIGCAVQLA.DSIEHGH-----.----------..-----..-...------------------------vdaghtal.........................
A0A4U0NVY7_9ACTN/299-454             ...................................raaaasvcelakdkardilseagnevslpqrdsdglsk------------------------------------------------.Q.EITATAEATRSKLG.TGVH.GAV.........SAAMVAD...WA.H...DVARTFADPKATKLDKAAA..VTAIAPVIGQAVNIA.DGIQHHDKKTIV.VNSLVLAAVV..AAQAV..P...AVGEVVDAAIVADFVVEKLVG---wft..............................
A0A2X0IP61_9ACTN/239-409             .................................vnwkdaydrsmniaqdidgsaefrataparpaagkampea--------------------------------------DVTRLVSTSE.D.FLEKSTKTSG----.--VK.KALkainnqkmiSWGSLLS...NA.L...ANSHTWSDKNATNLDKAYA..VVGGVPVLGEVIGIA.SGIDKQDAESIA.VNTLSLVGIV..AATVC..P...PLGATVEFVMIGYTAIKLML----swft.............................
A0A1M4ZWA4_9BACL/252-410             .........................................................................LDWEKIKTESQRIVKQIIEEHPELQSHSKN-----AVTDKEKLQKIYN.D.YAPKIDKLSSLKE-.-GVS.RAT.........TALNIAS...WA.A...GLAETFSNKNADGLDKAAA..VTAIIPGLGQAVGIA.NGIEKHDGEAIA.INSIALSALV..VAQAI..P...IVGEIADVVGAGLILAGGLAQLIQ.................................
A0A0P4RJ06_9ACTN/486-592             ................................................................slnegwsnl------------------------------------------------.-.--------------.---N.EAL.........TPAMAMA...WL.E...STARAFTSDS-TALDKAAT..SMALVPVVGQLLGIA.DSAIHKDPAGVA.ANVLVL----..-----..-...------------------------lqvasefagqpelamifgigafltiavqgikdl
A0A1G9SDF8_ALLAB/93-261              .......................................nilsksekatttlaasndykssmkgfsesfaklr--------------------------------KAAAETKKPIPTADIK.KlLTPHLDKVSTVKDF.KKYF.TNLk.......pSQGSAAT...WL.V...NLAATVANEESSKADVAVA..AAGIIPVVGQVAAIA.NSVSQGDVEGTV.TSAIALAANI..-----..-...------------------------aiavgagplgtailaglavyslgkafia.....
A0A086ALZ4_9FLAO/450-610             ..............ivkrkaknlvedfmkkrqvdnifkpqfvdsyriakitprsqvvifkkttkvlkqalkps------------------------------------------------.-.--------------.----.-RM.........DALEIYN...WG.K...NLIHVFDSD-ADDFTKASA..ALGIIPVVGDILGII.DDIRLGNAEQAI.IGSFVLGALV..TGAVIggPvgvVIGAVVGIVFAIINIKSII-----edfin............................
A0A0B2WV66_METAS/306-430             ...............................................mekqqylyrelrarlprlkglsrpqr------------------------------------------------.-.-------IARLTTK.VG-G.RAM.........AVAGLGF...YT.Q...AVMDVFSSDTASFLEKAAV..VTSILPVIGCVVQLA.DDMEQGRVDQVQtVSCLAQDILLfpVALAM..Q...VVGG--------------------vgawlea..........................
A0A0D9PBJ1_METAN/174-304             ....................................................kdaeskgptvektqdgeliae-------------------------------ASKKSKESFNRLLEDYNfS.TVAKQDKLIAGFTN.KIAG.GAL.........AAAGLAL...YG.K...AVADVFSS-NASILDKAAV..VTSILPGIGCAVQLAaDEAER-------.----------..-----..-...------------------------ghasathtalcftqdallvaa............
Q6NK15_CORDI/229-394                 .........................................................................LDWDVIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFH.Q.TALEHPELSELKTV.TGTN.PVF.........AGANYAA...WA.V...NVAQVIDSETADNLEKTTA..ALSILPGIGSVMGIA.DGAVHHNTEEIV.AQSIALSSLM..VAQAI..P...LVGELVDIGFAAYNFVESIINLFQ.................................
A0A2N6N8B3_BEABA/493-610             .......................................................arqrskesfdnlleefdy----------------------------------KSVVKHDQLYKELN.E.RLPEFNPVSRTERI.TGLS.AKFg.......eGALAVAG...IA.LygkAVAEVFSG-DASVLDKAAV..VTSILPGIGCAVQLA.DSIEHGHV----.----------..-----..-...------------------------dathtalc.........................
A0A1W6JQW4_9CAUD/229-394             .........................................................................LDWDAIRDKTKAKIESLKENGPIKNKMSESPNKTVSEEKAKQYLEEFH.Q.TALEHPELSELKTV.AETN.SVF.........AGANYAA...WA.V...NVAQVIDSKTADNLEKTTA..ALSILPGIGSVMGIA.DGAVHHNTEEIV.AQSIALSSLM..IAQAI..P...LVGELVDIGFAAYNFVESIINLFQ.................................
A0A7W7CHP1_9PSEU/69-236              ..........................................tcdmsakqiekllpnlqdetaalraaamsdp--------------------------------AAQAMTSGQRTTADIT.K.IIENATKISKNPAVkKLTD.KAS.........TFADFAS...RSnT...GTGAALGEQTVLEYAKAAIylALSFRPPLGDLLSLA.EAISSGNIEQGI.VAVIGLTAFA..IGLAF..P...PLGAIISVGLAIYG----------vgklvwsyf........................
#=GC seq_cons                        .......................................................................t........................................h..hht.hp.p.hh.....huphcph.tths.ssh.........uutslAu...au.h...uVAcVFuucsAosLDKAAs..ssSIlPGlGsslslA.Duhp+tss-thh.htslsLs..h......................................................................
//