#=GF ID   DisA
#=GF AC   PF19226.4
#=GF DE   DisA glycoprotein
#=GF AU   Karlin D;0000-0002-3033-7013
#=GF SE   David Karlin
#=GF GA   27.00 27.00;
#=GF TC   28.20 27.60;
#=GF NC   26.90 21.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   24155369
#=GF RT   Powerful sequence similarity search methods and in-depth manual
#=GF RT   analyses can identify remote homologs in many apparently
#=GF RT   "orphan" viral proteins.
#=GF RA   Kuchibhatla DB, Sherman WA, Chung BY, Cook S, Schneider G,
#=GF RA   Eisenhaber B, Karlin DG;
#=GF RL   J Virol. 2014;88:10-20.
#=GF DR   INTERPRO; IPR043638;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry corresponds to a putative viral glycoprotein [1].
#=GF SQ   8
#=GS A0A1U7EIU8_9VIRU/34-381   AC A0A1U7EIU8.1
#=GS A0A023Q224_9VIRU/74-418   AC A0A023Q224.1
#=GS A0A1L3KJW4_9VIRU/37-395   AC A0A1L3KJW4.1
#=GS A0A023Q224_9VIRU/378-589  AC A0A023Q224.1
#=GS A0A1L3KKD7_9VIRU/61-401   AC A0A1L3KKD7.1
#=GS A0A2L2P6U1_9VIRU/36-374   AC A0A2L2P6U1.1
#=GS W5VG83_9VIRU/46-418       AC W5VG83.1
#=GS A0A088D9X0_9VIRU/52-410   AC A0A088D9X0.1
A0A1U7EIU8_9VIRU/34-381              ................................................................................MLDIELIGKLYSLQPFSDFKVYEANAWNKLIGYH.CPSGQTVYPLEHSFLKD.LYTCIPKPKV....LNSQYLVYR.....IKPsSHDNVTVQCKNRYyNV......SVAFCQIESYRFLIDNKGDTWFTSDYCLSNRYMTDNDGKELFTVSHTSTDYSVTFE.FPPPECP...FY--PYDVYYEKS.....LPATVCI.....DSSPEF.------...KSCVt....gaKCEVHPPYELLPVSTHSELHFKVNGTCSVAFMTFT.EPTT-----------..----..ITYHIKSALSTSFIDAVLHALLSLLRPLIDALLELVTYIIDTLVTIFTSSE.FVAIYQKIYHLILSVLQN............................VFDY.IIDVA...VPKIMDLFYESTLK.TKFIILTFIYVYFKYTKFIYALSVCVVVCLFF-s..............................
A0A023Q224_9VIRU/74-418              ................................................................................LWQLKYHSNVYDSELSKEIVVHTANAWNKFIGYH.CPPNHYKHVLQHEFFSD.VYVCVKIPQP....LKKIYTAYS.....LVQ.AYDIIALRCYSTPvNTid..hfYITIVDVDQWYLLKDGGGSEYLISKYCLNYWYQIDSHGNELFDLKFTVSKGVVTFH.LPKHSCS...-------------.....-PLKIDF.....SSANNIlNVQIRGgrtLECI.......KRQLFRNYNYNCNIPYKNLTFTHN--KLMLYRTND.CPSTLYESVESED--..----..ISIHVESSSGASPFSFITTALLQVMKPVLDFVLDSLMTIINEFVTIYESPE.FIEIFTRIFDTFAKFVRI............................ILDF.ITKP-...--EIMNLFVHI---.---------------------------------letalkiiqsvldffkkprlkvvflriimii
A0A1L3KJW4_9VIRU/37-395              ...............................................................................n-VVFQHEFDILDKHLSSEVQIYSTNFYSHIVGAN.CPVGFHRQDINHYTFSD.IFACIYHGYTdiysLPVKYRAYS.....LRL.TSNVIDRYS----.--......TIQYINLHEFLVLKNDTG-YYLSTRFCFNEYPWKDINGTIQPHLYFENHDTFVKF-.YVSNSCL...LRYLTTDAEHLTYyifsqIPSLFDLevktpNSAVDFfRVGFVK...YHWL.......---------------HHTL--SPGDLPYMDYNATH.SITKHCYSVEYCVAVyyPVQRlfTTIAIQSAHANSFVHSLTHAILSILKPILVEILSLMSFLFGSIIDLIFSSE.FIDLYKLFFDNFIKALHQ............................ILTF.IFTN-...FRLLIYYLLTNHIY.FSMGLFLFLLIYIRYGMLVYSFIFVLLLSSLVR...............................
A0A023Q224_9VIRU/378-589             peimnlfvhiletalkiiqsvldffkkprlkvvflriimiiedfvvttldyifksdsvnnilskgltfiekiikmltrfi----------------------------------.-----------------.----------....---------.....---.-------------.--......--------------------------------------------------------.-------...-------------.....-------.....------.------...----.......-----------------------------------.---------------..----..----------------------KQAKGTIEEVIKLVFSLIEQIVNLIIGDEqIIKIFVKFVTLIEHTLMQiigyllksnllrdlinsvftllvhvsniIFDF.ISLTI...VPQVIHVFMNLSFK.VKIMFAVFLICYIKSSKFFWSIVIALIFSCFI-g..............................
A0A1L3KKD7_9VIRU/61-401              ............................................................scisvvktntllevdcqlpq---------------------------------H.CGVLHHRKMPQGWFGQE.VILCYSFHQT...tLGGALKVST.....MDF.SPSSFTYESPNGPlTV.....eDWTSVDFFSHVYLLNSNDRYSLIPRICLDHYTSSNDDQPQSVQFEFTESQVCVHQSlHPETDCE...-PEWYESMEKLIVs..ydYPVAYRGn..pyELVTHI.RYGNQD...PNVI.......-NYVSSNKLNHVFSVIDGKTYSSAVGLSHMYLHGIsSPENYIVLVDPSPLK..VNQS..FCYPIQSVY-KNPLSAVINSIIDALEPIILKLLSILEQYLEKFLKI-----.FIKALLIFLKLFYELIDN............................LLTQeIITALl.cSAAVYLYFKDYVITfISFCLFCFLLYYI--------------------f..............................
A0A2L2P6U1_9VIRU/36-374              ................................................................................QVTEDRYRTFLDYYDTADVKAYDLSWASKFFKDPvCHNGWVLHLLSNSAFRDeYYLCVRTEGNkkrlIETTQLRFSdqqqwIFSdADNQVGV------.--......IVLELDIPNKYIFYKDGDDLYMTTPMCMSNHYYLTDDKIFPPEPPIENKKNFIKY-.FYTYQCR...PVRVHNTLKQ---.....LPIEVKW.....------.RVAGGQgysPEYVvfledafKSNLLRQLDQDAFVPTDNLYYSPD------YNVTI.MDTPSVYAVKYLNHL..PDYEiiYFEHITSNF-----------FLDLIEFVLDRVISLIVTILSTIFNF-----.--------------VLEK............................INQY.VFSNIpyyFKSFYEFFFSLDPY.VKFLIMSFVLIYIKTTKFIKTIFLVFLLTLFT-y..............................
W5VG83_9VIRU/46-418                  ...............................................................................l-LSFDFEYNIYGKYVEDDIKVYHANAWSKFIGSH.CPPNHHKVSLQHHIFSE.LYVCIHVPTV....LKNPHSVYK.....INK.NYNEVLVSCYLPGgDEfaietiRVDIPDLDKFRII-EFNGKNFLTSQYCISDRYGLTSDHKEVLQVNYTVTDNTISFQ.FPKGECRkdsQLIWDIDSLHPGY....yLPFVINI.....TASTNM.------...HKCLtyyytpyDTELDTNVTVLPLTPTEHLIWAVDVSPIIV-----.-DARNLTRVWSSINYypPPSD..TVIHIGSAITNSPFNFISSAILAILRPIIDILLDSLIYILSTLMEIFESSE.FLEIVNRLFDFVYLLIKN............................IFEF.IVKVI...YPRLLDIVLSFSTK.CKFLFVVFIITYIKTGKFFVTCIITFFVNMCMR...............................
A0A088D9X0_9VIRU/52-410              ................................................................................FLTFKKFSTIYRSELFTDFKIYHANAWNKFLGVS.CAGNHVPYALTHHIFSE.IYVCLPFPPV....LEPIYTAYE.....LVP.RERNFFIPCGMTG.EKst..faNFEPMNYKDYLVLQDPKGKFHLSSKYCVGHMYQIGLNNKEILTVNYTVTDYSVTID.YPSSYCN...VFPLPIKFLDFTL.....LPIVVRV.....KSTLDV.------...IDCL.......--RVERSSNVVAGRPMYEL--AIDDVTLLRYNTTT.NGTHNFAYTYKSRHS.yP--T..KTFHISAAANVNPFTWVTTGLLTLLTPILDFLLNSFLYCFESLLNIFESTP.FLNLFDRLLHFIYNIISL............................ISKF.IATHI...FPKILTFIKNIPIR.YKFLLVFLFVMYLKTTKFIFSCCVTALIHLCIK...............................
#=GC seq_cons                        .................................................................................lshch..slhs....s-hplYpsNhasKhlG.p.CsssahhhsLpHphFp-.lYlCl.hsts....LpshapsYp.....lh..s.splsl.s.....p.......plp.hslcpahlLhcssGchaLoocaClsphY.hssctpp.hplpaTsocssVpap.aPpspCp....h.h..sh.p.h......lPhhlch.....pussph..........hcsl........ppl.pshp..sh.shcpLhausss...hhY.ssh.psop.hh.V..p.....s..p..hshHIpSuhsss.hshlhpulLslL+PllDtlLsllhhllsollsIh.SsE.Flclap+hhchhhpllcp............................IhcF.Ihssl...hsplhphFhshshp.hKFhlhsFllhYIKhsKFhhohhlshllshhh................................
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