#=GF ID DotA
#=GF AC PF11388.12
#=GF DE Phagosome trafficking protein DotA
#=GF AU Pollington J;0000-0002-8158-8998
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE Pfam-B_001493 (release 23.0)
#=GF GA 25.00 25.00;
#=GF TC 25.40 41.50;
#=GF NC 23.40 20.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 16423685
#=GF RT The Legionella pneumophila global regulatory protein LetA
#=GF RT affects DotA and Mip.
#=GF RA Shi C, Forsbach-Birk V, Marre R, McNealy TL;
#=GF RL Int J Med Microbiol. 2006;296:15-24.
#=GF RN [2]
#=GF RM 9632267
#=GF RT Legionella pneumophila DotA protein is required for early
#=GF RT phagosome trafficking decisions that occur within minutes of
#=GF RT bacterial uptake.
#=GF RA Roy CR, Berger KH, Isberg RR;
#=GF RL Mol Microbiol. 1998;28:663-674.
#=GF DR INTERPRO; IPR021528;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC DotA is essential for intracellular growth in Legionella [1].
#=GF CC DotA is thought to play an important role in regulating initial
#=GF CC phagosome trafficking decisions either upon or immediately after
#=GF CC macrophage uptake [2].
#=GF SQ 27
#=GS A0A0W0VPZ8_9GAMM/467-578 AC A0A0W0VPZ8.1
#=GS A0A0W0VHR9_9GAMM/455-563 AC A0A0W0VHR9.1
#=GS A0A378I541_9GAMM/475-597 AC A0A378I541.1
#=GS A0A222NZT7_9GAMM/479-595 AC A0A222NZT7.1
#=GS A0A0W0XZF2_9GAMM/456-564 AC A0A0W0XZF2.1
#=GS A0A078KQA5_9GAMM/472-580 AC A0A078KQA5.1
#=GS A0A098G030_9GAMM/486-604 AC A0A098G030.1
#=GS A0A098GHT5_TATMI/456-571 AC A0A098GHT5.1
#=GS A0A433K4P6_9GAMM/502-601 AC A0A433K4P6.1
#=GS A0A6F8T9X6_9GAMM/463-575 AC A0A6F8T9X6.1
#=GS A0A0W0V2W0_9GAMM/472-574 AC A0A0W0V2W0.1
#=GS A0A0W0YSV7_9GAMM/469-583 AC A0A0W0YSV7.1
#=GS A0A0W0Z5I8_LEGSP/484-588 AC A0A0W0Z5I8.1
#=GS A0A078KU97_9GAMM/468-573 AC A0A078KU97.1
#=GS A0A0W0TLP6_9GAMM/485-589 AC A0A0W0TLP6.1
#=GS G9ESC7_9GAMM/474-580 AC G9ESC7.1
#=GS A0A378LQN8_9GAMM/509-627 AC A0A378LQN8.1
#=GS A0A0W0R0A3_9GAMM/496-610 AC A0A0W0R0A3.1
#=GS A0A3S0V681_9GAMM/451-558 AC A0A3S0V681.1
#=GS A0A0W0Y028_9GAMM/463-567 AC A0A0W0Y028.1
#=GS W0BHK6_9GAMM/481-583 AC W0BHK6.1
#=GS A0A0W0ZQ79_9GAMM/502-615 AC A0A0W0ZQ79.1
#=GS A0A0W0THF1_9GAMM/481-589 AC A0A0W0THF1.1
#=GS Q5ZS33_LEGPH/485-589 AC Q5ZS33.1
#=GS A0A0W1ADC9_9GAMM/484-593 AC A0A0W1ADC9.1
#=GS A0A0W1AF93_9GAMM/474-578 AC A0A0W1AF93.1
#=GS A0A0W0VBN6_9GAMM/465-582 AC A0A0W0VBN6.1
A0A0W0VPZ8_9GAMM/467-578 ...................TDTGTGLNGS.KVD..LSQLNNAF.................-VGGK..CS.tG.........ETPSvyLCNWMNG..........DPT...LI.NQVIGLINGANLgsp......ldmpGSSAIPG--....LQAGTSD.AQTGA.FSSTVYGFLQNSMMVQLPD.QPGQSPPQ...
A0A0W0VHR9_9GAMM/455-563 ...................MDEKTGLEKS.SFS..PGKLLAAFte.............asPGTYN..CT..S.........TYPD..LCYWLNK..........DQN...KV.RAVVGLIQGGIG.............NISLVSEPQ....LKNLNQN.VVKGI.ESSTVYGFTTNSTIIRVPG.QPGITPL-r..
A0A378I541_9GAMM/475-597 .................id--TTANLSSS.TVQ..PTDLSNIFskgssnsgsssssssddSGVSN..CS..G.........TRKD..LCVWLHG..........DET...PI.NNLLSLINGSNG............vAKATLNPPD....LSANGLQ.LSTDA.SASTVYGYINNAVILQIPN.QPGMTPPT...
A0A222NZT7_9GAMM/479-595 ..................s-DSDTGMDQT.EFS..TQNLQSAF.................AQGGQ..CG.gP.........PYGV..LCEWVNG..........DTT...VV.DQVIGLIDGSNVsstsp...kpslpAGGGISDIV...kGTSTTAQ.AETGA.YSSTAYGFIVNSLMVNLAE.QPGQTPP-d..
A0A0W0XZF2_9GAMM/456-564 ...................TDTNTGLEGS.QFD..SQIPLNAF.................SQNKQ..CS..G.........TYAA..LCQWLGG..........NQT...AI.QNMVGLINGSTLv..........gpNNPPLSPPT...fGNNAAQK.AQSGV.LSSTVYGFINNSVMVNLPG.QPGLNPPQ...
A0A078KQA5_9GAMM/472-580 ...................TDTNTGLDSS.SID..VSSLLTPL.................-SSPG..CN..G.........TFPS..LCTWLSK..........YPSglsAM.QSLTMLIDNYNPa...........aATPAIILSV....IPSASST.PVLGN.GSATTVGFINNSVLITLPG.QPGMTPP-a..
A0A098G030_9GAMM/486-604 dqvdstvsfngsktgmqgg----------.---..--------.................GPQNI..CK.dP.........KYGP..VCAWFGS..........NAT..aML.NQVQALIDGTFStedpk..npgvaqQGDATPAPKf.gkTDIQGSS.AVTSV.GSASVNGFVTNSLMIQLPG.QPGIAPLQ...
A0A098GHT5_TATMI/456-571 ...................TDSNTGLDGS.SFD..ASLPGSAF.................GSNGNlgCS..G.........NYAN..LCVWLTGgipsqkllkdASD...SV.ANVISLINGSGV.............-VPTLSTPT....FNATSTK.AIPPP.GANTVFGFVNNSSMVNLPG.QPGLTPPQ...
A0A433K4P6_9GAMM/502-601 ...................FDTESGLDNS.TTT..DPTVST-V.................-SSTT..IG..K.........LYNS..FVSAALN..........GQS...RV.KLIANLIQGSPE.............ATKPTF--T....STQQTLN.AQTDS.KSISVYGFVDNSLMVRPAG.QPGA----ynq
A0A6F8T9X6_9GAMM/463-575 ...................TDTGTGLDSS.TFG..FNGIAS--.................---GT..CN.aD.........SYAL..LCTWFGN..........SAA...LL.VQVQALIDGTYVsaga....ggvpiPGTAAKKPKl.dsSSIAAST.VDKTL.TSSSVYGFVNNSMMMQVQG.QPGLEPLQ...
A0A0W0V2W0_9GAMM/472-574 ..................p-EQGSGLSGS.SFN..ATKLTDAF.................GSNNT..CQ..G.........TRAA..LCTWFNG..........KSM...VL.QYLQGSITGPTG.............--SNIPNPT....DPSSQIK.IVTGT.QSATVWGFINNSLTMKTPG.QPGIDP--gf.
A0A0W0YSV7_9GAMM/469-583 ...................FDKNTGLDSS.SFD..LTELTSSF.................GQGGS..CV..G.........TYAK..LCTWFGG..........NSS...YL.NAVQSLINGAYLsskn....gvpiaNNNPVKAPD...lKPNPKRE.LVSGQ.ESSTVYGFINNSVMVQLPG.QPGLQPLQ...
A0A0W0Z5I8_LEGSP/484-588 ...................TDKDTGLDSS.SFK..IENIIKSF.................GSNNK..CK..D.........PYQD..ICEWMQT..........NQA...PM.NNVVSLINGASV.............LSRPQDPPD....VTSLDHK.AVSGA.GSSTVYGFIDNSLLVNLPG.QPGLKPPQ...
A0A078KU97_9GAMM/468-573 ...................TDTNTGLDSS.TID..TSNLSASF.................VGGTG..CSttA.........PFNN..LCTWLSG..........NQG...TV.STIITAINGSTA.............GNNPIPAN-....VSPTAHQ.AVGSL.GSSTATGYINNSVMVNLPG.QPGMAPP-s..
A0A0W0TLP6_9GAMM/485-589 ...................TDTSSGLDSNtSFD.vVASLSSPF.................-SSQG..CS..Q.........QYAP..LCAWFQG..........SST...RI.DQINALISGAIG.............NTPGINMP-....SIGKNNP.VTVGP.MADTVYGYINNASALQLPN.QPGLAPLT...
G9ESC7_9GAMM/474-580 ...................IDSNTGLEKS.SFD..AAKLVKAF.................-KDGQ..CT..S.........DYAP..LCAWFGG..........VAT...PL.GYVQTLINAGNTa...........tNTSPIQKPT...mSGSPRRN.AILTQ.AATSVYGLANNSIMVQLPG.QPGLKPLT...
A0A378LQN8_9GAMM/509-627 ...................VDGNSGLDGS.KFN..PKIMVSPFst............ssdGKSVS..CT.aGdtqdlpsgqSLAN..LCEWLGE..........SNEg.kQLaLNVQSLITADPS.............-KDKLPA--....-LSSDMK.AKGGT.ESSTVFAFLNNALMIQTPG.QPGVQT--ln.
A0A0W0R0A3_9GAMM/496-610 ...................TDTNTGIEGS.TYK..GQQLVS--.................-----..CS..G.........NYSI..VCDWFQN..........DLF...QL.QSITTLVNGNTPppswvgtpppsspVPSNIPTPSlkpgNPPPAPP.VYSGA.NASTVYGFTSNSNALKLPD.QPGQKPLQ...
A0A3S0V681_9GAMM/451-558 ...................FDENTGLEKS.KFN..VSMLTNAF.................GTGKQ..CT..Gt.......eTYQM.fMCELFGG..........DVT...KV.QPVVYLITGGGS.............-VPAINAQD...lSPGKTRA.VTDGL.ASSTVYGFTNNSTIIQLPG.QPGQKPL-s..
A0A0W0Y028_9GAMM/463-567 ...................TDSDSGLDSS.SAD..ISTMTNAF.................GGDGT..CK..G.........QYSE..LCQWYQG..........DDK...YV.KHIAGLIDGSTV.............LNSGLDVPT....FNSISHK.AVTGL.GSSTTYGYISNASMVQLPG.QPGIV---tap
W0BHK6_9GAMM/481-583 ...................VDKDSGLKNC.TFP..LSGLTQ--.................---LQ..CS..G.........STPP.vLCELFNN..........NPS...YV.AQVAYLIAGGGE.............GVNSVSAAD....YSFSSLNvQDTNF.NDSTVYGFTTNSSIVTTPNqQPGLSG--pn.
A0A0W0ZQ79_9GAMM/502-615 ...................TDSETGLEKS.TFS..ASAVTSPFvp............sedGKTIT..CG.pGdmt..nnnkDFSQ..LCKWFGQ..........DNT...QV.LEVHALIT----.............SDPNAKNPP....SLGNKMT.VDSGQ.SSSTVYGFLNNSFMMSNPE.QPGVKPLT...
A0A0W0THF1_9GAMM/481-589 ...................VDTGSGLNES.SFD..ENLPLTPF.................-SNGS..CV..G.........TYAT..LCEWLDG..........DSS...PI.KAVIGLINGSTFl...........pSKEIIHSPPt.vdPNTSGLV.AISGP.GSSTVNGFITNSILVNLPG.QPGMTPPQ...
Q5ZS33_LEGPH/485-589 ...................FDTGTGLDKS.SFD..PTQLTKPF.................G--KT..CQ..D.........PYSL..LCTWFQN..........KSD...KL.IQIQSLIDGVPA............lGQDGVKQPD...lSDNPQRQ.SVSGP.LSSTVYGFVNNSMMVQLPG.QPGIKPLT...
A0A0W1ADC9_9GAMM/484-593 ...................IDSNTGLGGS.AFT..ATALTSAFp..............gqGSNSQ..CDpdA.........PYAN..LCTWFGK..........DQT...KL.TNVVNLITGGGS.............--ASLPSPS...yPPGDSLT.ADTNKpTSSSVYSFINNSTLLKTVG.QNDIKPLT...
A0A0W1AF93_9GAMM/474-578 ...................FDTNTGLNTS.TFD..PTNLVSSF.................TSNNS..CS..G.........QYSL..LCTWFQG..........DKT...PL.DKVQSIINGASL.............-DDMVSKPS...mKDDAKRP.VVGNQ.QSSTVYGFINNSVMVQLPG.QPGIAQPQ...
A0A0W0VBN6_9GAMM/465-582 ...................TDSGTGLGES.IFPtiLPAVTSGF.................ASNNT..CS.pG.........QSAPnyLCQWMQG..........DPA...PI.NAVVGLIDGSNVgqer.....vnfpASKDIAGLN....TGGQDVS.AAKGA.ASSTVYGFLHNSMMVQLPG.QPGQNPPQ...
#=GC seq_cons ...................hDosTGL-sS.oFs..sstlsssF.................sssss..Cs..u.........sYus..LCpWhss..........sss...hl.ppVhuLIsGuss.............sssslssPs....ssssstp.sssGh.tSSTVYGFlsNShhlpLPG.QPGlpP.p...
//
