#=GF ID DrrA_P4M
#=GF AC PF14860.10
#=GF DE DrrA phosphatidylinositol 4-phosphate binding domain
#=GF AU Eberhardt R;0000-0001-6152-1369
#=GF SE Jackhmmer:Q29ST3
#=GF GA 26.20 26.20;
#=GF TC 29.40 27.30;
#=GF NC 25.60 24.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 20176951
#=GF RT Structural mechanism of host Rab1 activation by the bifunctional
#=GF RT Legionella type IV effector SidM/DrrA.
#=GF RA Zhu Y, Hu L, Zhou Y, Yao Q, Liu L, Shao F;
#=GF RL Proc Natl Acad Sci U S A. 2010;107:4699-4704.
#=GF RN [2]
#=GF RM 20616805
#=GF RT High-affinity binding of phosphatidylinositol 4-phosphate by
#=GF RT Legionella pneumophila DrrA.
#=GF RA Schoebel S, Blankenfeldt W, Goody RS, Itzen A;
#=GF RL EMBO Rep. 2010;11:598-604.
#=GF DR INTERPRO; IPR028057;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain binds to phosphatidylinositol 4-phosphate. It is
#=GF CC found in Legionella pneumophila DrrA, a protein involved in the
#=GF CC redirection of endoplasmic reticulum-derived vesicles to the
#=GF CC Legionella-containing vacuoles [1,2].
#=GF SQ 35
#=GS A0A098G3D5_9GAMM/337-447 AC A0A098G3D5.1
#=GS A0A0W0TLF4_9GAMM/506-587 AC A0A0W0TLF4.1
#=GS A0A0W0XW72_9GAMM/494-595 AC A0A0W0XW72.1
#=GS A0A0W0TZ20_9GAMM/180-262 AC A0A0W0TZ20.1
#=GS G9EKI0_9GAMM/1-49 AC G9EKI0.1
#=GS A0A6F8T857_9GAMM/129-236 AC A0A6F8T857.1
#=GS Q5ZWI4_LEGPH/213-318 AC Q5ZWI4.1
#=GS A0A0W0YVQ3_9GAMM/360-464 AC A0A0W0YVQ3.1
#=GS A0A0W0WH13_9GAMM/294-402 AC A0A0W0WH13.1
#=GS G9EMR5_9GAMM/194-296 AC G9EMR5.1
#=GS A0A378M2J1_9GAMM/119-217 AC A0A378M2J1.1
#=GS A0A0W0ZNX1_9GAMM/384-497 AC A0A0W0ZNX1.1
#=GS A0A0W1AIZ4_9GAMM/1-56 AC A0A0W1AIZ4.1
#=GS DRRA_LEGPH/538-640 AC Q5ZSQ3.1
#=GS A0A0W1ACG7_9GAMM/207-310 AC A0A0W1ACG7.1
#=GS A0A0W0TS70_9GAMM/23-120 AC A0A0W0TS70.1
#=GS G9EKK5_9GAMM/1-86 AC G9EKK5.1
#=GS A0A078KTJ3_9GAMM/1013-1105 AC A0A078KTJ3.1
#=GS A0A433JGK0_9GAMM/1924-2023 AC A0A433JGK0.1
#=GS A0A0W0Y666_9GAMM/507-611 AC A0A0W0Y666.1
#=GS A0A0W1AD05_9GAMM/295-407 AC A0A0W1AD05.1
#=GS G9ERP3_9GAMM/464-566 AC G9ERP3.1
#=GS A0A0W0XXU0_9GAMM/147-250 AC A0A0W0XXU0.1
#=GS A0A0W1AC27_9GAMM/52-156 AC A0A0W1AC27.1
#=GS A0A0W1A7G5_9GAMM/810-875 AC A0A0W1A7G5.1
#=GS A0A078L2I8_9GAMM/474-517 AC A0A078L2I8.1
#=GS A0A378LY42_9GAMM/745-857 AC A0A378LY42.1
#=GS A0A0W0XQN7_9GAMM/296-401 AC A0A0W0XQN7.1
#=GS A0A098G693_9GAMM/596-706 AC A0A098G693.1
#=GS Q5ZSB6_LEGPH/326-430 AC Q5ZSB6.1
#=GS A0A0W0V8A7_9GAMM/495-606 AC A0A0W0V8A7.1
#=GS A0A0W1A4Q3_9GAMM/340-425 AC A0A0W1A4Q3.1
#=GS A0A0W1AGC3_9GAMM/294-399 AC A0A0W1AGC3.1
#=GS A0A078L153_9GAMM/223-328 AC A0A078L153.1
#=GS A0A0W1ABC9_9GAMM/54-151 AC A0A0W1ABC9.1
A0A098G3D5_9GAMM/337-447 ......dhkkrtvdlsnvsfq----.-----Kp.......eSSEEFKNFKSKYGNLKGDHLKTKILEDFRQQIEE....TT.SKKELADLKTK..IEASYEYD..VLKKAQGWFTGK...VG.IK....TSSEKALADMFKQQEKFLSN--td................
A0A0W0TLF4_9GAMM/506-587 ..........ytsgceglrdv----.------.........------------------ALKRKILEMVTEALLR....AE.NREGYNKVLDT..LESSGALG..ILRTGQGFYSRM...FN.AQ....TSPMAALEAIKAEVS-------kdk...............
A0A0W0XW72_9GAMM/494-595 ....................y-TNR.HHFWPA.........-----TIAKGQFANLRGDPLKQAILADFKRQIEA....CT.SDNGLKQCSSR..LRESSEFQ..VLTMAQDRFTYF...FR.WLpwvkTSSEKAFEKMLNDQGSYLSL--sk................
A0A0W0TZ20_9GAMM/180-262 ..........epytsgckglr----.------.........----------------DVALKRKILEILAEALLR....AE.TPEQYQEALSK..LDSSGAVS..ILTTGMGFSSRI...FQ.LQ....TSSSDALTAIEEE---------vwek..............
G9EKI0_9GAMM/1-49 ....................m----.------.........----------------------------------....--.---------QE..LKSKPEYK..ILEKGQGIATKV...FG.LE....TSSVKAFNKMVDEQGKNLSKKE..................
A0A6F8T857_9GAMM/129-236 ....................a-KDR.IHLFKAtl....nsnKNQNCTFLNEEEKKLTGDALKGKILDKFKNELES....SV.GPEKFKEVVAK..ITASPEYQ..IIKTSQGLASKI...LG.LE....TDSHKTLRDMISQRKTELN---ige...............
Q5ZWI4_LEGPH/213-318 ...................ig--SR.FHLFTAk......vdEKTGDQSFKDRYSQVKGDILKRAIINNLKNDIEK....ID.NLDDLKDFIKK..FKQSSEYM..TLSKAQGLFTKV...TG.IK....TDSQRAVEEIFSKALKDLQSP-k.................
A0A0W0YVQ3_9GAMM/360-464 ....................s-TGR.AHRYSV.........SAETMKTIKQEFQQLKGDHLKREILLDFKSQIEN....IS.TIEELQKFETEniKNKSESYK..ILATSQDLTTRI...LH.LE....TDSVKALKHMINEKRVVLNT--dl................
A0A0W0WH13_9GAMM/294-402 .....................KEDR.KHTFHEv......saEDFKSQEYKQEYRGIRGDALKRTILKELKDALED....VK.TEEELEEIKSN..FFKSPEMK..IIDKPQGRATRMlghFG.LK....TDAHKAAEEIFKKAEEKISKF-s.................
G9EMR5_9GAMM/194-296 ...................ag--GR.FHAYKV.........SGTKFAGLPEHLQKFKGDHLKSQILLDFKMQLMD....AK.THQEVDDLVTE..FQKKVEYD..VLTTGQGFISLR...FH.RP....TSSLRAFEHMVNERKQDISTE-k.................
A0A378M2J1_9GAMM/119-217 ...................vk--GR.IHALNI.........---DRSKLSPELRKLSGDALKTAILLKVKNDLDK....LT.EPQAIEKYKSD..FLDKPEYD..VLKSAQGLVTYF...FK.RD....TSSITAFNLLIAEAIKN-----cttp..............
A0A0W0ZNX1_9GAMM/384-497 ....................e-KPR.KHDYEVtt.....etVVNASQEFKSRYQNMKGDELKTHILLNFKSKIEQ....FK.TTEEIQEYLKA..FKDTNEYK..TLEIGQGAFTRVahkLG.LKkwitTDSVDAIDKIVKDTMKKIEEK-g.................
A0A0W1AIZ4_9GAMM/1-56 ....................d----.------.........----------------------------------....--.--EAVRSFKKE..SKEITEYQ..VLCASQGITSHL...FG.LK....TSSLKALEQIIADAYK------lakerq............
DRRA_LEGPH/538-640 ....................d-EGR.EHRYTA.........STENFKNVKEKYQQMRGDALKTEILADFKDKLAE....AT.DEQSLKQIVAE..LKSKDEYR..ILAKGQGLTTQL...LG.LK....TSSVSSFEKMVEETRESIKSQE..................
A0A0W1ACG7_9GAMM/207-310 .kglhykfattpnspgrdhge----.------.........----YTATSENYKGLQGDALKTKILSDFRDAIAG....-K.SAKEIQNIYDD..FKTKPEYT..ILATGQGWATRF...FH.WK....TSSIIALNAIKEEAA-------aen...............
A0A0W0TS70_9GAMM/23-120 ...........vaytdlkpgf----.------.........-------YQNECQGLFGVDLKRKILEIAVTELLE....AQgDRKKIGETLDA..LCDSGALA..ILEKGQGFTSRM...FPcIK....TSAAKSLKSILDEISNPLKS--me................
G9EKK5_9GAMM/1-86 .................mssa----.------.........-----------EHGLKGDLLKTKILLDFRISLMN....IT.DLEHFDLVIKR..FEQSKDYT..ILKTGQGLITRF...FN.LE....TSSVRAVKEIIAEVRQEIQQK-p.................
A0A078KTJ3_9GAMM/1013-1105 ...................gh--SR.LHLAPA.........-----KSNDPKYEHLKGDVLKRKILLDFKHKLES....CS.NEDDLRAVISE..IKGSKEYA..ILDKAQTWQA--...--.PT....PDAKNALENMIADSELE-----lgis..............
A0A433JGK0_9GAMM/1924-2023 .....dprnhryivevdhlpe----.------.........---------------KGDQLKGKILKNLRKALNLaiadSS.SLQELDSEITR..IKKDYEFElnTLKTAQDITTWL...FG.LR....TDSFKAFEKMCKDAREIV----ikna..............
A0A0W0Y666_9GAMM/507-611 ....................n-SGR.LHLYNKa.......aVAEGMNLVKAELQGLRGDALKRGILDAYKEKIAA....CG.TKEELEDLRKA..YDQSDDKK..IIESSQGLMSSI...RK.LE....TSSQKEMKAMFESADERVKEF-e.................
A0A0W1AD05_9GAMM/295-407 ...................tv--NR.VHTFHEasa..edlgYADDFKKIKEEFMGIKGDALKRVIIKELKDSLES....ID.TLEDLARRKLS..FYDSPKMK..ILDIAQGKTTSIlgpLG.LK....TSSHDAVAQLFKDAEKRIQNQE..................
G9ERP3_9GAMM/464-566 .............fythasnt-QSR.FHMFGA.........-------NSQQYRAFHGDLLKTKILSIFKEKLQS....CS.SPIELQNKVLE..IKNCDEYR..ILAQGQGLITRG...LG.LE....TSSIKALNKMIEDIGRSLSDS-p.................
A0A0W0XXU0_9GAMM/147-250 ....................e-ANR.THLFKAtl....nlsKTQNCFFLDNEEKKLTGDALKGKILEKFRIELEN....CI.TSDDFKDTVNR..IRGSEEYQ..IIKKSQGLGFRE...--.--....TDSHKALRSMISQRGSDLNV--pe................
A0A0W1AC27_9GAMM/52-156 ...................ai--GR.PHVFGD.........TAKGFKDIKAELAHLKGEQLKREILFDFKKEVDK....LT.TLEELTSFEQRtiIQKSHAYQ..ILEKQQGFLSRL...SS.TE....TDSVKALKKMVHEKREALRF--es................
A0A0W1A7G5_9GAMM/810-875 .....................KNCR.FHLFAA.........--KIDAQKYPKYQEKKGDVLKTEILKNFKKSLEG....-K.NKTEI------..--------..------------...--.--....----------------------xxxxklthknirsikrkk
A0A078L2I8_9GAMM/474-517 ....................g-KSR.SHLIPV.........IPVKYQGPKRQYYGLVGDNLKRAILDDFKDSLEE....--.-----------..--------..------------...--.--....----------------------..................
A0A378LY42_9GAMM/745-857 ryehfatsnqenrevatmatc----.------.........-ADLNQSFKERYKQCQGDHLKSTILKDFYEDLEN....AE.TEREVDDVVNR..YKKDGRYD..ILAKAQNNTMQV...LG.MT....TTSAKAFESLITERMESINAQ-k.................
A0A0W0XQN7_9GAMM/296-401 ....................r-KNR.LHFFHEv......svNDASHDRFKNQYKGIKGDALKRAILNGLKDELAE....AE.TEEALLDIITR..FLKSPEMA..ILDKAQGKLTHS...FN.LK....TDSHKAAEKLFEAAKKRIND--aa................
A0A098G693_9GAMM/596-706 ..................nth---Y.EHATHIte.....nnRWYFCQASSDKFRDLKGDCLKTRLLLDFKSELTTyaqmCT.SKEQFDKHVEE..LKQSKEYE..VLATGQGQVTKI...FG.LE....TSSVKAFNNIAAELRDGIDD--ls................
Q5ZSB6_LEGPH/326-430 ....................k-KFK.KHSHEVg.......vNRFFSPKKQEIYEGLKGDGLKKVILKELRDSLAE....IR.TMEQLEEKKLE..FLASPEMQ..ILAEGQDKTTKA...LN.LK....TSSRKKVMVIFKEAEERILNS-p.................
A0A0W0V8A7_9GAMM/495-606 ....................g-NSR.KHASPVsldnlevkgDFHKVHDLKAKYKGVMGDALKTSILLDFKTQLEN....CN.TREDLEKKITE..IEASPAYH..VLKKGQGITTQL...LR.LK....TSSIDALEKLIKTRRDELPD--tg................
A0A0W1A4Q3_9GAMM/340-425 .............svklikqe----.------.........---------------KRNPSKHSILKNLQQKLAE....ID.SLDELYRHRIA..FKKGEDYK..LLLKNQHSIYNL...FG.RS....INFKKEVKQLYHQAASRILDNE..................
A0A0W1AGC3_9GAMM/294-399 ....................r-ESR.AHTFHEv......ssDDFQSPSFKKQYQSIKGDALKRTILRELKYSLDQ....MD.NLEELQQLKHQ..FLRSPEMQ..ILDKAQGQWTSR...FH.LK....TDSHKAVERLFASAEKRIKEE-i.................
A0A078L153_9GAMM/223-328 ..................kds---RwYHAFKA........tTKDTSQAFKDKHKDQIGDHLKNSILEDFRKQIED....APfDLPEFKTFVTT..LRNTEGYA..ILKTGQGCLTTF...FD.WE....TSSVAAFNEMVAEKIKQIGQ--ie................
A0A0W1ABC9_9GAMM/54-151 ....................d-KGR.THLWEA.........-----KSFKQQYHALKGDALKTTILNDFKSKIVN....CS.SRQELEDAVEN..IRASNDFK..ILAQAQGLVTHH...FN.LK....TSSVEALERIIEDKFTELRSS-s.................
#=GC seq_cons ....................p..sR..Hhh................pthpppaptl+GDsLKppILpcaKppLpp....hp.ohc-lpchhpc..hcpSs-Yp..ILppuQGhhTph...hs.lc....ToSh+Alcphhp-ttpplpp....................
//
