#=GF ID   E2-ntca
#=GF AC   PF20298.2
#=GF DE   Prokaryotic E2 domain
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Aravind L
#=GF GA   27.50 27.50;
#=GF TC   28.70 28.10;
#=GF NC   26.70 23.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0208
#=GF RN   [1]
#=GF RM   32868406
#=GF RT   Identification of Uncharacterized Components of Prokaryotic
#=GF RT   Immune Systems and Their Diverse Eukaryotic Reformulations.
#=GF RA   Burroughs AM, Aravind L;
#=GF RL   J Bacteriol. 2020; [Epub ahead of print]
#=GF RN   [2]
#=GF RM   18276160
#=GF RT   Anatomy of the E2 ligase fold: implications for enzymology and
#=GF RT   evolution of ubiquitin/Ub-like protein conjugation.
#=GF RA   Burroughs AM, Jaffee M, Iyer LM, Aravind L;
#=GF RL   J Struct Biol. 2008;162:205-218.
#=GF DR   INTERPRO; IPR046891;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is an E2 domain observed in certain prokaryotic Ubiquitin
#=GF CC   systems found as secondary effectors in nucleotide-activated
#=GF CC   effector conflict systems [1-2].
#=GF SQ   18
#=GS A0A7V7TXZ2_9HYPH/16-122  AC A0A7V7TXZ2.1
#=GS Q9A4X4_CAUVC/26-133      AC Q9A4X4.1
#=GS A0A1I0WJG2_9RHOB/40-121  AC A0A1I0WJG2.1
#=GS A0A1I7KIQ2_9BURK/15-123  AC A0A1I7KIQ2.1
#=GS A0A1I1CDY8_9PSEU/32-143  AC A0A1I1CDY8.1
#=GS A0A7W3FKQ4_9GAMM/17-122  AC A0A7W3FKQ4.1
#=GS A0A0H3C9Z5_CAUVN/26-133  AC A0A0H3C9Z5.1
#=GS A0A518RFA7_9SPHN/1-62    AC A0A518RFA7.1
#=GS A0A3S0A7C3_9HYPH/17-123  AC A0A3S0A7C3.1
#=GS A0A1E7RDF3_9GAMM/14-115  AC A0A1E7RDF3.1
#=GS A0A501PH16_9PROT/14-121  AC A0A501PH16.1
#=GS A0A4Y4CWT6_ZOORA/15-122  AC A0A4Y4CWT6.1
#=GS A0A0R3QBR8_9BILA/68-178  AC A0A0R3QBR8.1
#=GS A0A126V6B5_9RHOB/14-121  AC A0A126V6B5.1
#=GS A0A4R2P6D0_9SPHN/15-118  AC A0A4R2P6D0.1
#=GS Q89TV2_BRADU/18-118      AC Q89TV2.1
#=GS A0A519J3H3_9CAUL/12-108  AC A0A519J3H3.1
#=GS B4RIT4_PHEZH/15-118      AC B4RIT4.1
A0A7V7TXZ2_9HYPH/16-122             .......gefirgdag-----------RMFASVRPLLDSGASGpTFLLEIAEVS.DT-LIA.REA.APVNLPCFCPERHINSGGTFCL.YWDEDEPLS.FSTRPDIELWWGKLLIFLHRQIVAGRLRRWP-g........
Q9A4X4_CAUVC/26-133                 ................HEASVISRSGNVLFVLVRLRRPSGKIV.RYHLTI-EVD.DPEPDV.RET.TPTHLPVYCPNRHINGGGYFCL.SFPEADPLP.IADASSAADWWKRLLKYLNLQEATSSLRRWPS.........
A0A1I0WJG2_9RHOB/40-121             ...........ggfwl---------------------------.--MLEVSEHG.G-VAVS.EVQ.DQRQLPEFCLERHINPDSTFCV.FFRSEHP--.LEDTEAAKTWWSYLAVYLANQVYAKKRGIWP-l........
A0A1I7KIQ2_9BURK/15-123             ................YNAAAEHVSAVSVILRFNLALSDGRTV.PYEIEVKQVG.DRKAMA.KER.QPINLPEFCPQRHINSDGSFCL.YWREVSNLD.ISDEETAHAWWGILWKFLTLQARVKKARRWPN.........
A0A1I1CDY8_9PSEU/32-143             ..........lgvpra-----------RIEGIVKVARPDGRVD.SFELSIHYPNlDPFALP.DTFdAVGRFPRNEPDRHIEPNGRFCL.WLPQTEPVDdFQRPGGLRRYISRVEEFLVLQRLYDVRR----khnilphwp
A0A7W3FKQ4_9GAMM/17-122             ....atlhraagggra---------------EISVTRPGGAVH.VFTLAISIAG.EHVSAK.EAP.GHHQLPQFCPDRHINPNQSFCL.GWGDGKPGH.IIDEAAARQWWSTVYRFLAHQISANVRRVFP-g........
A0A0H3C9Z5_CAUVN/26-133             ................HEASVISRSGNVLFVLVRLRRPSGKIV.RYHLTI-EVD.DPEPDV.RET.TPTHLPVYCPNRHINGGGYFCL.SFPEADPLP.IADASSAADWWKRLLKYLNLQEATSSLRRWPS.........
A0A518RFA7_9SPHN/1-62               ..............mv---------------------------.----------.------.---.PGTDLPARCPERHVQFDKTFCL.---GLRYLT.VRSVSDAENWWTQLHQFIRCQMVAERTRVWP-p........
A0A3S0A7C3_9HYPH/17-123             ...............w-F-NQTKDSSRAIEGHAVVAVANGVGRtVADLRITDRS.GKVTVS.ETV.VGMAFPARCSERHIEWDGSFCIgY---RAGLG.IRTVDEAVVWWGLLEQFLRLQRVASRTRRWPA.........
A0A1E7RDF3_9GAMM/14-115             ...............k-KISIQQKNENTIIFELKFYTDAGDAR.IVELEVHAVN.D--VLK.VKA.TNGRYPSLCPNRHINSGGFFCLgLYEDLATLP.IEK------WVRTVQKFLEAQYKCELNGVWPI.........
A0A501PH16_9PROT/14-121             .......wvtmqessq---------ERVKILVSPPSMGTATQR.DFYLELRSSN.QRGVRVfEQK.NHKQFPDCCIERHINYDSSFCV.Y-RGS-EEN.LEDQDRAIAWWSNLAVYLNNQIYAEKYGLWP-l........
A0A4Y4CWT6_ZOORA/15-122             ..............fg--GALTRSPDTSAILDLPVKLVDGRII.PYKLLLKQKG.DR-VTA.QEE.TPQHLPPFCPERHINPDGTFCL.YFTGTTCLN.VIDEESARAWLETVYRYLKLQERVRLKRRWPN.........
A0A0R3QBR8_9BILA/68-178             daalidvpsssiasdp-------------VLDVAVTSADSRRT.IYRLVLAARG.G-EVTA.REH.TPSKLPGFCPQLHINGDGTFCL.GWNGAGLLA.VEDEASARLWWARLHGYLRLQQRARRLGHWP-d........
A0A126V6B5_9RHOB/14-121             ..........wvdvla-------RKRRVLEVKAHSQKDSGAPGeLYFISIETVGaDSIKAF.ETS.AHRRLPKCCIERHINDDTSFCL.YL--NSTRP.VFSEQDAWSWWAMLGRYLSNQDFASKHGLWP-r........
A0A4R2P6D0_9SPHN/15-118             ..............wf---EVERQGHQKLIGVAKVPQTPWAGG.GLRLSIGGVR.SP-HVG.EET.PGTALPARCPERHLQEDRTFCV.---GLRRLE.VDGPDAADRWWEQLRQWIRCQGVAERTGVWP-p........
Q89TV2_BRADU/18-118                 ........pvhafeaq--------------VDVVATRSSGAFTrVFELRVVQVA.DQIAVF.ERP.VGGTLPACCPERHINPDGSFCI.---GLRAGD.GITGASATAWWEKLHVFILCQETAAEAGFWP-g........
A0A519J3H3_9CAUL/12-108             .crtvnqvrgdaahgp-----------------------WAES.PVDLTILSAP.CP-IVR.ETQ.PGTRFPAFCPDRHIQGDRTFCV.---GLGRRP.VDSLRRARAWWADLDQYLACQAIAEATRLWP-p........
B4RIT4_PHEZH/15-118                 ..............wf----AIQNTDGDIIGDAHPRDTIWEAN.GIRLRIFSRS.DRLGAA.EVT.PGTLLPVRCAERHIQADQTFCL.---GLDALP.VETGDDAKVWWTHMEQWLQVQSIAAQTGRWPA.........
#=GC seq_cons                       ..............hh............h.h.ststhssGths.sacLpltpss.-..sss.cpp.ssspLPshCP-RHINsDuoFCL.hh.stpsLs.lpstssAcsWWspLtpaLphQthApppthWP..........
//