#=GF ID EAD7
#=GF AC PF19960.3
#=GF DE Effector-associated domain 7
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF SE Aravind L
#=GF GA 32.00 32.00;
#=GF TC 32.50 32.70;
#=GF NC 31.30 31.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0041
#=GF RN [1]
#=GF RM 32101166
#=GF RT Highly regulated, diversifying NTP-dependent biological conflict
#=GF RT systems with implications for the emergence of multicellularity.
#=GF RA Kaur G, Burroughs AM, Iyer LM, Aravind L;
#=GF RL Elife. 2020; [Epub ahead of print]
#=GF RN [2]
#=GF RM 34061031
#=GF RT Bacterial death and TRADD-N domains help define novel apoptosis
#=GF RT and immunity mechanisms shared by prokaryotes and metazoans.
#=GF RA Kaur G, Iyer LM, Burroughs AM, Aravind L;
#=GF RL Elife. 2021; [Epub ahead of print]
#=GF DR INTERPRO; IPR045435;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Effector-associated domains (EADs) are predicted to function as
#=GF CC adaptor domains mediating protein-protein interactions. The EADs
#=GF CC show a characteristic architectural pattern. One copy is always
#=GF CC fused, typically to the N- or C-terminus, of a core component of
#=GF CC a biological conflict system; examples include VMAP, iSTAND, or
#=GF CC GAP1. Further copies of the same EAD are fused to either
#=GF CC effector or signal-transducing domains, or additional EADs. EAD
#=GF CC pairs are frequently observed together on the genome in
#=GF CC conserved gene neighborhoods, but can also be severed from such
#=GF CC neighborhoods and located in distant regions, indicating the
#=GF CC EAD-EAD coupling approximates the advantages of collinear
#=GF CC transcription requirements. Profile-profile searches unify EAD7
#=GF CC with the Death superfamily of domains [2].
#=GF SQ 36
#=GS D7BTR8_STRBB/116-179 AC D7BTR8.1
#=GS A0A160T190_9CHLR/1-52 AC A0A160T190.2
#=GS A0A160T2K1_9CHLR/8-71 AC A0A160T2K1.2
#=GS A0A160T7D2_9CHLR/99-155 AC A0A160T7D2.1
#=GS A0A160T2V7_9CHLR/10-72 AC A0A160T2V7.2
#=GS Q89Y78_BRADU/413-474 AC Q89Y78.1
#=GS A0A2T1C0D1_9CYAN/8-71 AC A0A2T1C0D1.1
#=GS A0A160T2L5_9CHLR/15-76 AC A0A160T2L5.2
#=GS A0A161K300_9CHLR/12-73 AC A0A161K300.2
#=GS V4JSY8_9GAMM/270-334 AC V4JSY8.1
#=GS A0A161K3V4_9CHLR/13-73 AC A0A161K3V4.1
#=GS A0A170PHW1_9CHLR/15-76 AC A0A170PHW1.2
#=GS A0A160T1A6_9CHLR/8-71 AC A0A160T1A6.2
#=GS A0A161K3X5_9CHLR/435-496 AC A0A161K3X5.1
#=GS A0A170PHX8_9CHLR/14-75 AC A0A170PHX8.2
#=GS A0A251X7X4_9GAMM/11-72 AC A0A251X7X4.1
#=GS I3CJ70_9GAMM/38-100 AC I3CJ70.1
#=GS A0A161KAB4_9CHLR/233-294 AC A0A161KAB4.2
#=GS A0A160SXN5_9CHLR/16-77 AC A0A160SXN5.2
#=GS A0A160T984_9CHLR/9-70 AC A0A160T984.1
#=GS A0A090AJE8_9GAMM/11-72 AC A0A090AJE8.1
#=GS A0A160SZ55_9CHLR/8-69 AC A0A160SZ55.2
#=GS K9UL02_CHAP6/147-206 AC K9UL02.1
#=GS I3CJ68_9GAMM/300-361 AC I3CJ68.1
#=GS A0A160T9K4_9CHLR/220-281 AC A0A160T9K4.1
#=GS A0A2T1C037_9CYAN/8-71 AC A0A2T1C037.1
#=GS A0A160T8B9_9CHLR/135-196 AC A0A160T8B9.2
#=GS A0A1R1SMP5_9ACTN/142-205 AC A0A1R1SMP5.1
#=GS A0A1R1SNF0_9ACTN/16-79 AC A0A1R1SNF0.1
#=GS A0A160T9R9_9CHLR/6-67 AC A0A160T9R9.1
#=GS A0A160T0G7_9CHLR/33-96 AC A0A160T0G7.2
#=GS A0A160T3G7_9CHLR/102-163 AC A0A160T3G7.2
#=GS A0A160T6Q4_9CHLR/15-76 AC A0A160T6Q4.1
#=GS A0A170PEM5_9CHLR/6-67 AC A0A170PEM5.2
#=GS D7BTS2_STRBB/46-109 AC D7BTS2.1
#=GS A0A161JZJ2_9CHLR/118-178 AC A0A161JZJ2.1
D7BTR8_STRBB/116-179 ...VRRLVMDALD.DDELGALCLDHfpSVYDQFAQG.MSKSQKTLRLIEYCARRDRLPDLVRRVGEVNP.....
A0A160T190_9CHLR/1-52 ...----------.MDELQMVAFAL..GVDWDELKG.TTKSLKTVALIQYADRRGEMSGLLALLSEERP.....
A0A160T2K1_9CHLR/8-71 ...LRQFIIQFFS.DEELETLAFDYfpEAANDFGSG.MSKGRKVIALIGHCERRGRLDDRHAAVGRERA.....
A0A160T7D2_9CHLR/99-155 ...LHTALCRRHS.LDSLRTLCFRL..GLDYDDLPG.ESKAGRARELILALEREGRVGEL---------fler.
A0A160T2V7_9CHLR/10-72 ...LRNLFIDRFS.DDELADLAFAL..GMNIKDLGE.DTTKGKARELAAYVVRHEWVAKLIAEVG----pkerp
Q89Y78_BRADU/413-474 ...LFDELCTAFD.MEEFKNLCFLL..GVDIDEIPG.DRKSARVRELILLFERRDTLHVLEEAVDERT-r....
A0A2T1C0D1_9CYAN/8-71 ...LSELIQQALT.KDEFADLVFTHfpTVNSQFTEG.QFQSQRIRLLLEYIDTRREPEKLLALIKSLNP.....
A0A160T2L5_9CHLR/15-76 ...LRKQMVASFS.LDELRDLCFDL..GVRDDNLSG.DTIDAKTTALLEYLNQRHLLVELITHLNFIRP.....
A0A161K300_9CHLR/12-73 ...LVKLFVERFD.NNELEDLAFSL..GVNFDDISG.NTRSAKARELALYLNRRSLMDELRQKGPVERP.....
V4JSY8_9GAMM/270-334 ...LFECIDTVLTtEDELRAFCFEHfpEVYRNLREI.DRRPHITRELIGYVLARAQTDALWQLLQMRS-y....
A0A161K3V4_9CHLR/13-73 qak----LTTYFN.GEEVETIAFVL..GIDYDSLRG.ATKPTKVNSLLYDVARNGRLPELLAHVGDSR-r....
A0A170PHW1_9CHLR/15-76 ...IHHQMVERFS.LEELQSLAFDL..GVDWGQLAP.GNKSTKTTELLELLNRRTKLPQLLARLEKLFP.....
A0A160T1A6_9CHLR/8-71 ...IRRFLIDTFN.DDELTTLCFDHfpEVFQEFAAG.MTLGRKALQLVDYCRRRERVAELLDILRRERP.....
A0A161K3X5_9CHLR/435-496 ...LRRALDDGYN.DSELRDVCFEL..GIDYEELPG.DNQSAKARELVLYAQRRNLLAQLVAHVMRERP.....
A0A170PHX8_9CHLR/14-75 ...LLRQIDSLFS.LEDVQTLCLSL..GFDYENLPG.RTREGLIRELMRCLLDQDRLQALVDLARVQRP.....
A0A251X7X4_9GAMM/11-72 ...LRRFFLQQFD.KDEIKGFYFAL..QIEIDHLEA.SSREKLMADLLHHLQRQSRLPELLTQAMLLRP.....
I3CJ70_9GAMM/38-100 ...LHYCLTHSFA.FHEIQTLIFFL..NIDQDEFSGiEAKSRLIETLIQYCERHNITQVLINLIKNERP.....
A0A161KAB4_9CHLR/233-294 ...IRHYLLAHYS.VEQLQQFAADL..GIDWEQLAA.GDKKDKTRDLLLYLYRRNRIDDLLQAMRAA--aa...
A0A160SXN5_9CHLR/16-77 ...LRENIASRFT.LDELQLLCVRL..GIDYEELRT.GAKSVVVLGLVQYIVRRGRVSDLIRALYVERP.....
A0A160T984_9CHLR/9-70 ...LRNLILNHFD.PEELNSLMFEL..GIRKGDISG.ATISARVEELVAYCQRQGQLEVLYAECVRLRP.....
A0A090AJE8_9GAMM/11-72 ...LIDLLMEHFN.ITELKGLYTRL..GIDSDRIDS.SSKETLIMDLLSYLERRLQISTLIDIGKKQRP.....
A0A160SZ55_9CHLR/8-69 ...LLHFLVQHYT.LDGLKTLCFNL..FVDFENLSG.DTKNAKARELILQLERAGRLSDLEAALGREQP.....
K9UL02_CHAP6/147-206 ...LRQLVEKALT.DDELLNLCNDF..KV--AVTQG.QTKDQRIRTLVEYIERQGKQSELLTEIEQLNP.....
I3CJ68_9GAMM/300-361 ...LQKCFNQYFS.FREVKSVIFKL..NIDEDELEN.TTKRRLVETLIVYCEQREQTEQLVQILKAERP.....
A0A160T9K4_9CHLR/220-281 ...LYYLLNRAFS.VDEMRDLCLRM..HIDFEELPG.RTKSNKFGELMGYCQRRGQLSVLVAHVLAERP.....
A0A2T1C037_9CYAN/8-71 ...LQQLLKQALS.AEDLNELCSTYfpEVYAQFTNG.QVISHQRRLLLEYAQRHREIPKLLAAVREINP.....
A0A160T8B9_9CHLR/135-196 lai---QLARAFN.LDELRDLEFRL..GVPDGALAG.ETIATRTRELVRFCRRRGMVDELRAAAQELRP.....
A0A1R1SMP5_9ACTN/142-205 ...VRRLVAEALD.DDELTALCLDHfpAVYGQFAQG.MSKSQKTIRLIEYCARRDRLPDLVRRVGEVNP.....
A0A1R1SNF0_9ACTN/16-79 ...VRALVDRALS.EDEIRDLCFDHypEVYRELAAA.MSRRECIRRLVAWCHARQQLGALVARVAELN-a....
A0A160T9R9_9CHLR/6-67 ...LRDLLVNHFN.LSELINLSFDL..GIDAENLAG.QTKEDKARELISYCARRGTLPGLIERCEQLRP.....
A0A160T0G7_9CHLR/33-96 ...LRQFLMLFFN.DDELEDFCLDYfaDVAQEFTIG.MTKSQKVRLLIGHGDRRGRREHLLAALAKERP.....
A0A160T3G7_9CHLR/102-163 ...LHRLLVEYFN.NEELDSLALEA..GIAPESYSG.STRPARALALVQVASRHDRLEELVRVARRERP.....
A0A160T6Q4_9CHLR/15-76 ...LLEQIRALFS.DSELRDLCLDL..AVDYENLPG.AGKGDKARELILLMQRLNRLPDLVGRATELRP.....
A0A170PEM5_9CHLR/6-67 ..f-LDILDDALT.EAELSELCRRF..GVAFAAFPG.ATKRDRTREFLGYVRRQGRMAGLAEATVALRP.....
D7BTS2_STRBB/46-109 ...VRALIDRALS.EDEIRDLCFDHypEVYRELAAA.MSRRECIRRLVAWCHDRRELGALVARVAEIN-a....
A0A161JZJ2_9CHLR/118-178 ..l-ARTIENRFS.LDEMTNLAFEL..GM-DGSVTG.DTQATRAVSLVNVAKRRGLLVRLIELCRAERP.....
#=GC seq_cons ...LpchlhptFs..-ELpsLsFcL..ulsh-plsG.po+sp+sccLltaspRRsplspLlstltp.RP.....
//
