#=GF ID EAD8
#=GF AC PF19961.3
#=GF DE Effector-associated domain 8
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF SE Aravind L
#=GF GA 27.00 27.00;
#=GF TC 27.50 27.60;
#=GF NC 26.80 26.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0041
#=GF RN [1]
#=GF RM 32101166
#=GF RT Highly regulated, diversifying NTP-dependent biological conflict
#=GF RT systems with implications for the emergence of multicellularity.
#=GF RA Kaur G, Burroughs AM, Iyer LM, Aravind L;
#=GF RL Elife. 2020; [Epub ahead of print]
#=GF RN [2]
#=GF RM 34061031
#=GF RT Bacterial death and TRADD-N domains help define novel apoptosis
#=GF RT and immunity mechanisms shared by prokaryotes and metazoans.
#=GF RA Kaur G, Iyer LM, Burroughs AM, Aravind L;
#=GF RL Elife. 2021; [Epub ahead of print]
#=GF DR INTERPRO; IPR045437;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Effector-associated domains (EADs) are predicted to function as
#=GF CC adaptor domains mediating protein-protein interactions. The EADs
#=GF CC show a characteristic architectural pattern. One copy is always
#=GF CC fused, typically to the N- or C-terminus, of a core component of
#=GF CC a biological conflict system; examples include VMAP, iSTAND, or
#=GF CC GAP1. Further copies of the same EAD are fused to either
#=GF CC effector or signal-transducing domains, or additional EADs. EAD
#=GF CC pairs are frequently observed together on the genome in
#=GF CC conserved gene neighborhoods, but can also be severed from such
#=GF CC neighborhoods and located in distant regions, indicating the
#=GF CC EAD-EAD coupling approximates the advantages of collinear
#=GF CC transcription. Profile-profile searches unify EAD8 with the
#=GF CC Death superfamily of domains [2].
#=GF SQ 69
#=GS B4VT08_9CYAN/9-107 AC B4VT08.1
#=GS A0A8J7BJU6_9CYAN/9-123 AC A0A8J7BJU6.1
#=GS B4VR58_9CYAN/5-99 AC B4VR58.1
#=GS A0A0S6VXF5_9BACT/5-100 AC A0A0S6VXF5.1
#=GS A0A0V7ZN16_9CYAN/7-109 AC A0A0V7ZN16.1
#=GS A0A0V7ZP75_9CYAN/151-269 AC A0A0V7ZP75.1
#=GS K9V0R6_9CYAN/16-116 AC K9V0R6.1
#=GS A0A0S6VT01_9BACT/5-99 AC A0A0S6VT01.1
#=GS A0A139XHF3_9CYAN/7-107 AC A0A139XHF3.1
#=GS A0A160T2V7_9CHLR/91-190 AC A0A160T2V7.2
#=GS A0A844MB14_9CYAN/7-107 AC A0A844MB14.1
#=GS R4LTX0_9ACTN/5-90 AC R4LTX0.1
#=GS A0A160T0G1_9CHLR/8-107 AC A0A160T0G1.2
#=GS A0A081C631_9BACT/5-100 AC A0A081C631.1
#=GS A0A081C7P4_9BACT/1-98 AC A0A081C7P4.1
#=GS A0A081BP47_9BACT/211-306 AC A0A081BP47.1
#=GS A0A0S6VU15_9BACT/3-97 AC A0A0S6VU15.1
#=GS A0A0V7ZQ63_9CYAN/12-127 AC A0A0V7ZQ63.1
#=GS A0A011MKH4_9PROT/2-95 AC A0A011MKH4.1
#=GS A0A844MAE1_9CYAN/18-112 AC A0A844MAE1.1
#=GS B2J8D1_NOSP7/6-100 AC B2J8D1.1
#=GS A0A0S6VTD4_9BACT/5-100 AC A0A0S6VTD4.1
#=GS A0A139XH75_9CYAN/1-81 AC A0A139XH75.1
#=GS A0A161K300_9CHLR/106-201 AC A0A161K300.2
#=GS K9QNL5_NOSS7/6-100 AC K9QNL5.1
#=GS A0A372GFU1_9ACTN/5-97 AC A0A372GFU1.1
#=GS A0A367R276_9NOSO/9-122 AC A0A367R276.1
#=GS B4W431_9CYAN/1-51 AC B4W431.1
#=GS K9WZT2_9NOST/7-106 AC K9WZT2.1
#=GS A0A081C893_9BACT/175-270 AC A0A081C893.1
#=GS A0A8J7CH79_9CYAN/5-99 AC A0A8J7CH79.1
#=GS K9V0E8_9CYAN/6-101 AC K9V0E8.1
#=GS A0A0S6VPM8_9BACT/250-345 AC A0A0S6VPM8.1
#=GS R4LNX9_9ACTN/7-107 AC R4LNX9.1
#=GS A0A139XHC0_9CYAN/8-90 AC A0A139XHC0.1
#=GS A0A563VL84_9CYAN/693-791 AC A0A563VL84.1
#=GS A0A1Z4NC26_9CYAN/5-100 AC A0A1Z4NC26.1
#=GS A0A0V7ZQM1_9CYAN/12-127 AC A0A0V7ZQM1.1
#=GS A0A5S4FNR9_9ACTN/7-107 AC A0A5S4FNR9.1
#=GS B4VXV2_9CYAN/7-101 AC B4VXV2.1
#=GS A0A5B9WCN9_9BACT/410-502 AC A0A5B9WCN9.1
#=GS A0A844MB11_9CYAN/1-65 AC A0A844MB11.1
#=GS A0A139XH76_9CYAN/6-100 AC A0A139XH76.1
#=GS A0A844MFI7_9CYAN/9-123 AC A0A844MFI7.1
#=GS A0A0S6VQ31_9BACT/2-92 AC A0A0S6VQ31.1
#=GS A0A856M697_9CYAN/5-108 AC A0A856M697.1
#=GS A0A011NPS4_9PROT/2-94 AC A0A011NPS4.1
#=GS A0A139XH95_9CYAN/6-100 AC A0A139XH95.1
#=GS A0A2K8U8M8_9GAMM/10-109 AC A0A2K8U8M8.1
#=GS A0A160T3P9_9CHLR/111-210 AC A0A160T3P9.2
#=GS A0A8J6Y164_9CYAN/7-106 AC A0A8J6Y164.1
#=GS A0A197SJ66_9ACTN/6-100 AC A0A197SJ66.1
#=GS A0A1Z4SAW8_9NOSO/9-122 AC A0A1Z4SAW8.1
#=GS A0A2K8U8I9_9GAMM/190-289 AC A0A2K8U8I9.1
#=GS B4VT06_9CYAN/172-285 AC B4VT06.1
#=GS A0A081C1U1_9BACT/17-112 AC A0A081C1U1.1
#=GS B4VIY7_9CYAN/1-93 AC B4VIY7.1
#=GS B4VIY6_9CYAN/6-102 AC B4VIY6.1
#=GS K9X0D2_9NOST/898-989 AC K9X0D2.1
#=GS K9PCH3_9CYAN/328-442 AC K9PCH3.1
#=GS A0A170PH88_9CHLR/20-121 AC A0A170PH88.2
#=GS A0A844MTX5_9CYAN/7-101 AC A0A844MTX5.1
#=GS A0A1Z4SAW4_9NOSO/6-107 AC A0A1Z4SAW4.1
#=GS A0A081C1B2_9BACT/210-305 AC A0A081C1B2.1
#=GS A0A7W7VGY5_9PSEU/6-100 AC A0A7W7VGY5.1
#=GS A0A0V7ZZ75_9CYAN/332-446 AC A0A0V7ZZ75.1
#=GS A0A1Z4SHL5_9NOSO/330-444 AC A0A1Z4SHL5.1
#=GS A0A1Z4NC28_9CYAN/7-106 AC A0A1Z4NC28.1
#=GS A0A844MAJ9_9CYAN/6-100 AC A0A844MAJ9.1
B4VT08_9CYAN/9-107 ...kkkc-----QLQQIITKSSLL.QT...ADERRNFLSIC..-..........GLDSSCGSVQ..LDQP.SDKFFISLWSTLSKAYTTv...eNSER.SALVVFLEYISr.ldSSL.HEED.............KNFIQDIIGNY.....................
A0A8J7BJU6_9CYAN/9-123 ......k-KDVVPLTLALNAFALRvND...AIDRRRVLESA..G..........IDIALLSNLK..LGAT.SNIFAPALVAEFQRYCISn...qHLDY.HPLVSLLKHLCd.laPIY.GLADqdivlftrlaeqgQENLKALAAR-s....................
B4VR58_9CYAN/5-99 ......n-DSIEKLLPLLRPYLRD.--...ENERRAYLIRA.lG..........MDTPVLNRLV..LNTP.VDSFITNMVTELVRLGKI.....STGK.LALCALLEVIR....KDM.GLDN.............QAKVDTLLQQL.....................
A0A0S6VXF5_9BACT/5-100 .....gk--LQKEIIDLLLSLPNI.QD...SDGQKAFISRA..A..........IESKLENQLP..FGKP.ASDFVPLLVRVALKYEKS.....DDGR.YPLEAILQTAK....EYV.GIDK.............QQHYDNLIQRL.....................
A0A0V7ZN16_9CYAN/7-109 .......QADIDKLVNVLAGLAAT.SFtspQDFFRDLVSRA..N..........LRQQLVYSLAgvWTGN.PIHDARRLINWALVRDIN....pNDQRfTTLGSILQPLL....SEA.GFND.............AKLIVSLII--iy...................
A0A0V7ZP75_9CYAN/151-269 .......DNDKEYLITTISRLATN.STtssKEYFKALVNQL..N..........LPEKWRNSIAdiWTGD.TNTDTSKLVNWVEQKKSYpneseKPGY.TVLGSLIEKLL....EET.GDRHflemiisyelitdKSVLDNLRNNY.....................
K9V0R6_9CYAN/16-116 ......t-PDFQRIIKIVSNLPGFgTT...VYERRRFVEGA.fGg.......eaKANTILVQLN..LDGL.PMNVAVELVNFLCKFGQV.....AYGK.EALGVFLNYIQ....LYT.GEED.............TSFIQDVFQRY.....................
A0A0S6VT01_9BACT/5-99 ....pif---LKELSAFLTPLPPF.QD...EPSRRALLINA..-..........GFSDLLAQIS..CGGT.TANFVPIVVNYLANYGTR.....ADGR.HALAHLLEEVA....RNV.GNDK.............QARIQEFLAKL.....................
A0A139XHF3_9CYAN/7-107 .......QPDFQRLTRIVQNLPDF.AN...VRDRRDFLTGA.fGg.......dpKAEVILARLD..WEGS.PMSFSVRIVTFLSQFGQV.....AYGK.EALAVFLNHIQ....NYIgDGDD.............KDFILGLFQTY.....................
A0A160T2V7_9CHLR/91-190 ......d-DDRSRLVDILANNYDMqMG...PSARYGLMDRA..-..........GLRERLKFID..LAGA.PLSLAYSIVSDLEPLGILp...gQPSF.HALGALINYILq..lPDT.TTDD.............ARILAELLVKY.....................
A0A844MB14_9CYAN/7-107 .......QPDFQRLTRIVQNLPDF.AN...VRDRRDFLTGA.fGg.......dpKAEIILARLD..WEGS.PMSFSVRIVTFLSQFGQV.....AYGK.EALAVFLNHIQ....NYIgDGDD.............KDFILGLFQTY.....................
R4LTX0_9ACTN/5-90 ......d-AVRTEIAEVLKPHLTR.--...LDDREALVRPA..L..........LGTRLDTALQ..WEGP.ADRFTTDLVRLL------.....--PA.PALAAVVRAAR....RRL.GADS.............VAILEDLCSRL.....................
A0A160T0G1_9CHLR/8-107 ......l-PDRQKLARIIANLNEMtMG...AAARFGWLDRA..-..........GLRRFVPGTN..LDAA.PITLAGVLVGKLEPYGMLp...nQPNY.HALGALVSLALt..ePDL.AQDD.............AQFLAGLLVKY.....................
A0A081C631_9BACT/5-100 .....gt--LRNKIIDFLQSLPNI.GD...IRGRQAFIYSV..G..........LDSKLQDQIV..FDEP.PAQFIPLLVKRLLDYGQI.....SDKR.NALEAVLKVAK....NYV.GLDR.............KAYCDELLAEL.....................
A0A081C7P4_9BACT/1-98 ......m-AIEQEIVTWLERHSDI.LDlkeTSGRKAFLFKA..-..........DLTDLQNKLK..LEET.TAIFCSDLVQRLRNYGAL.....SDGR.DPLTAVLEAAK....TMV.GRDK.............QAECDALIARL.....................
A0A081BP47_9BACT/211-306 ......n-AIKAKIMKLLPSLNIL.RQ...ESERFGLIRAA..M..........LDQAAANQID..ASQA.LGSFVPNTVELLAGYGTL.....EDGR.HALEALLIAAR....DLG.GKEF.............KQQCDAIFQEW.....................
A0A0S6VU15_9BACT/3-97 .....pt--LQRDIINFLRPLPQF.ES...ENSRKALLITA..-..........GLNNIISSLD..LRGS.AGEFVPLLVRRLEAFGVA.....ADDE.PALVVLLRSLA....RDM.GQEK.............KAAIREFCARL.....................
A0A0V7ZQ63_9CYAN/12-127 ......t-NDIIQLETAFVSLLNQiDT...VAGRRSILLAA..G..........IDNYFISELN..LNLN.IREFTNILVSKFIDIPISs...qRPCY.HPLIVFLDYLLqqpqRKY.NLDDealeilnkvyvigQHKIKNLLTEL.....................
A0A011MKH4_9PROT/2-95 .....dd--FLPRAARLLQPHLGE.ER...RGARLALAFHG..-..........SNRAILDGIS..QRGS.SSDFTVRCVSRLLDRGCV.....-GSR.HALSLLLEVVR....GEA.GDEL.............QASFQTLIGE-l....................
A0A844MAE1_9CYAN/18-112 ......a-NIINELVQLLRPFLED.--...ERNRRPFLVFA.lG..........NDAPVLQHIS..WGGA.VASFIPDMMCKLVDYGEV.....APGK.QALWALLEYVR....SQV.GVDV.............QQRIDHLR---pll..................
B2J8D1_NOSP7/6-100 ......a-EDRKQLITLLKELPEL.AT...ERSRQQILELA..-..........GLKQVIPMIN..LSGA.SFVAVSEIVSYLSNYGRL.....TYDH.EALGLFLNTLK....SLT.GAQQ.............QEFLDMLLTKY.....................
A0A0S6VTD4_9BACT/5-100 ......a-KLKTKISNFLRSLPNI.DD...SNGRRAFIYSV..G..........LDSQLQDHIS..FNQP.VAEFIPLLIANLFDYGKL.....NDGR.YALEALLETAK....EHV.GQDK.............KDYCERLIREL.....................
A0A139XH75_9CYAN/1-81 ......m-----------------.EN...EYQRRGYLRKA.lG..........MNAPVLNRLC..WNLP.VDAFIGDMFEKLVEFGEI.....SSGK.PAICALLKVVR....EEV.GVDV.............QATIDTLIVE-f....................
A0A161K300_9CHLR/106-201 ......f-RDIQKLGPILAAHTLF.QT...PDGRQSLLYNA..-..........GLSRVI-HLD..LNGN.AYAVASSLLAKVNEYGEI.....EPGD.TAIGRLLAYIAa..dPAL.PPAD.............KSVITAIAAK-n....................
K9QNL5_NOSS7/6-100 ......v-EDRKQLITLLKDIPEL.AT...ERSRQQILEQA..-..........DLKQLLPMID..ISGA.TFVAVSEIVSYLSNYGRL.....TYEQ.EALGRFLNTVK....GFV.GMQQ.............QHFLDKLLTKY.....................
A0A372GFU1_9ACTN/5-97 ...deqf----GRAVRVIARLPML.AT...ERDRQAIVIAT..-..........GFQSLLPVID..ISGS.PISASTMLLDALRRRGRL.....PDGR.TAFAAFLTALA....EMMeG---.............-----------avaddlmaive..........
A0A367R276_9NOSO/9-122 .......QKDVAPLTRSLIQVLMQ.NN..iASDRYSLLDNA..G..........IDSALIGNLR..LDSQ.PNVLAQALVAEFRRYRVDs...rRLDY.HPMVNLLAHLCe..fAEIyRLSDedftlfsrlvregQENFKALK---np...................
B4W431_9CYAN/1-51 ......m-----------------.--...-----------..-..........----------..----.-ATFIPEMVEKLADYGEI.....APGK.QALWALLECVR....SHS.GLDT.............QQRIDKLLPR-i....................
K9WZT2_9NOST/7-106 ......p-PDFQRLTRVVQNLPDF.AN...VRDRRRLVVGA..Leg......vpQADVILARLD..LDGA.PMGVSVEIVRFLSQFGQV.....AYGK.EALAVFLNYIQ....PYT.GDQD.............KDFIIELFQKY.....................
A0A081C893_9BACT/175-270 ......f-AFHTRMVEFLLTLPNL.DD...SYAQRAFLNSA..G..........LDPQLQQRIH..VADP.PSQFFHLLVPMLSQYGTL.....KDGR.HALQAILEAAK....AYV.GKEG.............QAQCEELLREL.....................
A0A8J7CH79_9CYAN/5-99 .....ps--TINELVEILVPLVNG.--...DIKRQSLLIAA.lG..........IGAPVLQQID..YSGA.PLEFIIHLLTVLAQYGEV.....TAGK.QALVALLEYVQ....TQV.GLDV.............QQRIDKLFDKL.....................
K9V0E8_9CYAN/6-101 ......s-SIIQELVEILTPYMIN.--...DRDRHSLLIAA.lG..........NNATVLQQIT..WSGA.VATFIPDMAYKLVSYGEI.....APGK.QALWVLLDYVR...sQRV.GLDV.............QQRIDKLLDRL.....................
A0A0S6VPM8_9BACT/250-345 ......p-ALTQEIVAFLVALPDI.HD...RLKQQAFLLSA..G..........LDAELFNQLH..IGEP.PTSFINALISNCMTYGQL.....NDGR.HALIAVMNAAK....QLV.GKNR.............QADADTLIQQ-i....................
R4LNX9_9ACTN/7-107 ......a-EDFERVVAILATMPDF.RT...AQQRADLLTDV.fAg.......tpRGDDVITSLD..LDGT.PRAVAVRVVQRLQLFGQD.....EPGR.EALGVLLNKML....SYLgGGGS.............AQVLRSVLVRY.....................
A0A139XHC0_9CYAN/8-90 ......p-NTINELVQLLQPFLED.--...ERDRRPFLVLA.lG..........HSLPVLERLI..WSGS.VATFIPDMICKLADYGEV.....ATGK.QALY-------....---.----.............-----------cqvlldycdltqd........
A0A563VL84_9CYAN/693-791 dliqfey---------ALQNLFASiDS...IAGKKSILKNS..G..........IDDYFIANLD..FNLK.IREFISILTSQFIDYRISs...hEKDN.HPLILFINYLT....KQY.----.............-----------skynisdgeiaiferil....
A0A1Z4NC26_9CYAN/5-100 .....gk--LMQELLNFLQQHLTD.--...KNDCKSYLSLL.fG..........TNQSILNQIQ..WDNT.LNNIIINVLVKLDAYGTM....pDSGQ.TALCGFFNLIS....ENV.GSDV.............RINIDRLLE--fi...................
A0A0V7ZQM1_9CYAN/12-127 .....ln--HTIELESALQNLFINiDG...VAGRRGILRNA..G..........IDNHFIANFD..FNLG.INEFTTILVSKFKDYSVS....rKNPS.HPLVKLLSYILr.qpQKY.NLDDedikifteilsigR----------kkieafqtntte.........
A0A5S4FNR9_9ACTN/7-107 ......p-EDFGRAAGILSTMPEF.QT...AQNRVDLVTDV.fAg.......tpRKDDVVSSLN..LDGA.PRAVAVRVVERLQTFGQD.....EPGR.ETLGVLVNKLL....SYLgGGDD.............AEFLRGLLRRY.....................
B4VXV2_9CYAN/7-101 ......p-NTINELVELLQPFMED.--...ERSRRSILILA.lG..........NDASVLQRIT..WNGT.VTTFIPEMVEKLADYGEI.....APGK.PALWALLECVR....SHS.GIDR.............QQRIDKLRPR-i....................
A0A5B9WCN9_9BACT/410-502 .....ld----EELRLLLRPLMGD.--...RDNRRARLTRA.fS..........NYPGLLDRIN..LDGE.TGVFLSNLINTLREYGEV.....ERGE.PALHRLLVPIK....EEV.GVRD.............RERIEEILR--sh...................
A0A844MB11_9CYAN/1-65 ......m-----------------.--...-----------..-..........-NTPVLNRLC..WNLP.VDAFIGDMYVKLVEFGEI.....SPGK.PAICALLKVIR....EEV.GVDV.............QAIIDTLIVE-f....................
A0A139XH76_9CYAN/6-100 ......g-EIIQELSRVLRPFMWD.--...KQQRQSYLVMA.lG..........TNANVLNRLV..WDTS.VDVFIPQMVKELVAFEEI.....ASGK.PALCILLEVIR....ENV.GVDI.............QPKIDNLLQQ-i....................
A0A844MFI7_9CYAN/9-123 ....qsn---VIPLTKALIKVLNDkPN...ASDRLTLLNNA..G..........INSAWIGNLR..LESQ.PNTLAPSLVAAFKAYRISr...gQPDY.HPMVKLLEHLSe.fiESY.GLSDeevdlfsrlidqgQENFKALKVR-s....................
A0A0S6VQ31_9BACT/2-92 ......e-NIIQELSEFLTPLPCF.AN...EPSRRAVLINA..-..........GLSDLLPSVN..LSGS.AYDCVASLLDHFAKSGQI.....----.EEQIALLQEVY....KSV.GGEK.............KKEITRLIA--ll...................
A0A856M697_9CYAN/5-108 ......s-DIIQKLLRLLRPLMQS.--...ESQRRGYLMRS..AqsaaaklslgMDTPVLNRLL..FNQP.VDTFITDMLRELVTLSET.....TACE.PALCALLEVIR....KDG.GPDL.............EVSIDELLQ--gi...................
A0A011NPS4_9PROT/2-94 tplerat--------RLLQPQ---.MG...SERRDTLLTLAfhG..........ELRPLYDAID..QAGA.SDAFTVACVRTLLERGCV.....-GSR.HALSLLLEVAQ....SRA.GDEK.............RADFAELIAEL.....................
A0A139XH95_9CYAN/6-100 ......g-EIIQELSRVLRPFMWD.--...KQQRQSYLVMA.lG..........TNANVLNRLV..WDTS.VDVFIPQMVKEIVTFGEI.....ASGK.PALCTLLEVIR....ENV.GVDI.............QPKIDNLLRK-i....................
A0A2K8U8M8_9GAMM/10-109 ....pva----ETLRDLLARLPLW.QQ...ERDRRALLEFA..L..........AGHPALADFR..HDGQ.PLTVACELVTRLQHHGYAa...lATGT.HPVCALLRELRt.rgEHG.NPDT.............AARGAVLA---rff..................
A0A160T3P9_9CHLR/111-210 ......v-PDRQRLVDLLAGGPWLlGD...ATARRALLDIA..-..........GLGRFAAGLN..LNGA.AREVAAMLVTRLEPYGFLp...dRPTH.HALGALLDYLAg..lPDT.PPDD.............GQWLSSIIRRY.....................
A0A8J6Y164_9CYAN/7-106 .......QPDFQRLTRIVQNLPDF.AN...VRDRRRLVAGA..Lqg......vaQADVILARLE..LDGT.PMGVSVEVVRFLSQFGRV.....AYDK.EALAVFLNYIQ....PYT.GDED.............KDFIVELFQNY.....................
A0A197SJ66_9ACTN/6-100 ......v-EERQRLVTLLTAVPVL.GS...PSGRAEILALA..-..........GLGGLVPHID..LEGP.TLVAVSRIVTHLSAYGRV.....SYDH.EALGLLLNVIA....TLT.GKEQ.............QDFLAALLLR-h....................
A0A1Z4SAW8_9NOSO/9-122 .......QEDVIPLTKALTIVLRQnNT...ASDRQTLLENA..G..........IKSALIGNLR..LESQ.PNILAPALVAEFRRYRVDs...rWLDY.HPMVSFLEHLCd.faEDY.PLSQ.............QD---------vtlfrrlveqgqnnlqafker
A0A2K8U8I9_9GAMM/190-289 ....erq---RSPLRDLLVALPDW.DL...LAVRRGFVAAA..-..........LGEHPAARLT..WEGD.GFTVAGELVSKLKYYSAAp...lPDVR.HAVCALLAEAR...tR--.----.............-----------kwdqapaigdavrrlaaaf..
B4VT06_9CYAN/172-285 .....xx---VTPLMLALNRFAIKvND...ASERQEVLESA..G..........VDIALLSNLK..LGAT.PTKFAPALVAAFKIYPISn...rRLNY.HPMVSLLKYLCe.laPLY.GLADqdvalfsrlveqgQENFKALAAR-n....................
A0A081C1U1_9BACT/17-112 ......p-PVHEEIVKFLLSIPNI.QD...QKTIQGLISNA..G..........LGIQLQNQLD..ITGS.PVQIFNLVVPILLKYGKL.....DDGR.YALEAFLETTK....QCV.GTDK.............RAYCDILIKKL.....................
B4VIY7_9CYAN/1-93 ......m-KLKPQLLRFLVRMPTT.QT...VRERKALLAYL..-..........GFERLSSKIK..WDNSnNFVFFTELVELLT-----.....SEGK.SELLSFLNNLVe..iEWI.GLED.............QQKLRCLIAD-i....................
B4VIY6_9CYAN/6-102 ......n-EDRQQLIALLKDIPEL.SN...ERSRRQFLAEA..-..........GLTPLLPRLD..LSGS.PFVAISEIITNLLNYGRL.....SYDR.EALGVFLNALKi..fNIV.GVQQ.............QQFVDRLLTDY.....................
K9X0D2_9NOST/898-989 ......m-SLRSQLIDFLLNSSIL.NT...ERERQTLLLYF..-..........GYDSLIKKIT..LAGT.PQQFTVHLIQVLE-----.....LEGR.DTLLNFIDNLA...nSDFlGIEN.............KEKLTRLSAD-i....................
K9PCH3_9CYAN/328-442 .......QQDVTPLIMALNLFALKvNV...ASDRQNFLENA..G..........VDLAFLSRLK..FDTQ.PGTFAQSLVSAFKSYQISh...kSFNS.HPLVNVLKHLCe.laSLY.GLKDqdielftrlvekgQENFRALAVR-n....................
A0A170PH88_9CHLR/20-121 ......a-DERQRLIRLLSELPLI.LTg.gADGRLAFLNSN..-..........GLLELSTRLP..MADN.AQLFAGLLVITAEGQGEPl..ahRPGY.HALGAVCDGVLq..lDDA.PRDD.............RPFLAQLIARY.....................
A0A844MTX5_9CYAN/7-101 ......a-NDRKQLIDLLINIPEL.LT...ERGRRQILEIA..-..........GLDDFSKRID..LSGD.PKTVVSQIVSVLSSYGRI.....NEYQ.TALELFLTTIK....EYI.GYEQ.............QAFIDQLLDKY.....................
A0A1Z4SAW4_9NOSO/6-107 .....tq--EKAQLQKFLVNNTLL.RTa.dENFRGVLLANS..-..........GLDKYRSRIA..LNRS.LQEFVLSLCAILSENRNEv...dSSAK.LPLIVFLEYISe.sdDNL.STQD.............QEFIQKVIIK-w....................
A0A081C1B2_9BACT/210-305 .....vs--LRRQIIEFFLSIPDI.YN...PGKPQALVQSA..N..........LDSQLLNQIS..FAGA.PGQFFNLLLPILIQYGRL.....NDGR.YALQAVLEAAK....QFV.GPDR.............KAVCDNLIREL.....................
A0A7W7VGY5_9PSEU/6-100 ......v-EDRQRLVRLLSDVPGL.AT...EESRRDLLVLA..-..........GLDELAANID..VSGP.PPEAVARIVHHLAGYGHA.....SSGP.HALGLFCNLVK....GFV.GAER.............QAVLADLLT--gy...................
A0A0V7ZZ75_9CYAN/332-446 .......QKDIPSLIIALNKFALKvSV...ANDRYNALETA..N..........IDDAFLSNIR..FDTG.SNIFAQSLVAAFKNYQVSn...qNLSY.HPLINFLKSLTd..lALIyGFRDqdielfnrlvekgQENFEALKAR-n....................
A0A1Z4SHL5_9NOSO/330-444 .......QQDVSSLTLALNDFASNvLV...PSDRLNFLQNS..G..........VDSAFLSNLR..FDTS.PNTFAQSLVSGFKSYQISh...kNFDY.HPLLNVTKSLCe..lESIyGLKEqdvelftrlvekgQENFKALAAR-n....................
A0A1Z4NC28_9CYAN/7-106 .......QPDFQRLIRIVSNLPDF.AN...VRDRRRLVAGA..Leg......vpKANIILAQLD..LDGN.PKNVAVEVVHFFANFGQV.....AYGK.EALGVFLNYIQ....FST.SDED.............TSFIQDLFQIY.....................
A0A844MAJ9_9CYAN/6-100 ......g-EIIQELSRVLRPFMWD.--...KQQRQSYLVMA.lG..........TNANVLNRLV..WDTS.VDVFIPQMVRELVAFGEI.....NSGK.PAVCTLLEVIR....ENV.GVDI.............QQTIDNLLQKI.....................
#=GC seq_cons ..........hpcLhphLpshsth.ts...tpsRpshLttA.............hsssllspls..hsus.stsFssplVstLtpaGph.....ssu+.pALsslLphlp....p.h.Gh-p.............pphlppLhtc......................
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