#=GF ID EC042_2821
#=GF AC PF18740.5
#=GF DE EC042_2821-like Restriction Endonuclease-like domain
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Burroughs AM;0000-0002-2229-8771
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF SE Iyer LM
#=GF GA 24.90 24.90;
#=GF TC 25.00 25.30;
#=GF NC 23.80 24.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0236
#=GF RN [1]
#=GF RM 23768067
#=GF RT Comprehensive analysis of the HEPN superfamily: identification
#=GF RT of novel roles in intra-genomic conflicts, defense,
#=GF RT pathogenesis and RNA processing.
#=GF RA Anantharaman V, Makarova KS, Burroughs AM, Koonin EV, Aravind L;
#=GF RL Biol Direct. 2013;8:15.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This entry represents a Restrictions Endonuclease-like fold
#=GF CC fused to a HEPN-like domain Pfam:PF12358 (EC042_2821) [1].
#=GF SQ 95
#=GS A0A3N0BZJ6_9MICC/219-295 AC A0A3N0BZJ6.1
#=GS D0WFB0_SLAES/225-320 AC D0WFB0.1
#=GS A0A7X6S2W9_9LACO/1-33 AC A0A7X6S2W9.1
#=GS A0A1C0BS63_9FIRM/226-321 AC A0A1C0BS63.1
#=GS A0A4D5ZQ79_9VIRU/227-318 AC A0A4D5ZQ79.1
#=GS A0A3A5H529_9ACTN/244-320 AC A0A3A5H529.1
#=GS R5HJF8_9MOLU/228-313 AC R5HJF8.1
#=GS R5ZD98_9FIRM/182-273 AC R5ZD98.1
#=GS A0A133XRK7_9ACTN/1-72 AC A0A133XRK7.1
#=GS A0A4D5ZGU2_9VIRU/227-318 AC A0A4D5ZGU2.1
#=GS A0A8H2MAF0_9FIRM/230-321 AC A0A8H2MAF0.1
#=GS F8E1A2_CORRG/252-334 AC F8E1A2.1
#=GS A0A0M3TBZ6_9ACTN/89-171 AC A0A0M3TBZ6.1
#=GS A0A7K3M1V0_9ACTN/1-78 AC A0A7K3M1V0.1
#=GS A0A4D5ZHW3_9VIRU/227-318 AC A0A4D5ZHW3.1
#=GS A0A4D5ZMP1_9VIRU/227-318 AC A0A4D5ZMP1.1
#=GS A0A4D5ZKI0_9VIRU/227-318 AC A0A4D5ZKI0.1
#=GS A0A7D5BFU7_9CAUD/228-327 AC A0A7D5BFU7.1
#=GS C3PJW2_CORA7/236-332 AC C3PJW2.1
#=GS A0A0R2CPU9_9LACO/241-332 AC A0A0R2CPU9.1
#=GS A0A7Y9RXI1_9ACTN/244-321 AC A0A7Y9RXI1.1
#=GS A0A4D6A5F7_9CAUD/228-324 AC A0A4D6A5F7.1
#=GS A0A6A0B5N0_9LACT/7-98 AC A0A6A0B5N0.1
#=GS A0A4D5ZJ35_9VIRU/227-318 AC A0A4D5ZJ35.1
#=GS B0RZZ1_FINM2/234-325 AC B0RZZ1.1
#=GS A0A4D5ZWS9_9VIRU/228-324 AC A0A4D5ZWS9.1
#=GS A0A1F1UXB9_9CORY/235-332 AC A0A1F1UXB9.1
#=GS Q5YPN3_NOCFA/88-164 AC Q5YPN3.1
#=GS R9KX54_9ACTN/231-334 AC R9KX54.1
#=GS S2ZEY4_9CORY/17-113 AC S2ZEY4.1
#=GS V7HSP1_9LACO/228-323 AC V7HSP1.1
#=GS G4CU90_9ACTN/244-323 AC G4CU90.1
#=GS A0A061A8S2_9MOLU/238-333 AC A0A061A8S2.1
#=GS A0A4P8L2Q7_9DELT/35-109 AC A0A4P8L2Q7.1
#=GS A0A4D5ZKT3_9VIRU/228-324 AC A0A4D5ZKT3.1
#=GS A0A1I4GIB7_9FIRM/227-321 AC A0A1I4GIB7.1
#=GS A0A410DYS3_9CLOT/224-311 AC A0A410DYS3.1
#=GS A0A6M5IVG2_9MICO/244-320 AC A0A6M5IVG2.1
#=GS A0A0M2H0P5_9MICO/244-321 AC A0A0M2H0P5.1
#=GS C7N391_SLAHD/227-322 AC C7N391.1
#=GS A0A1S2U0B1_9GAMM/326-427 AC A0A1S2U0B1.1
#=GS Q6NK57_CORDI/1-82 AC Q6NK57.1
#=GS A0A5C5XT78_9BACT/237-323 AC A0A5C5XT78.1
#=GS A0A4R7J6X3_9ACTN/242-318 AC A0A4R7J6X3.1
#=GS A0A4D5ZVI3_9VIRU/228-324 AC A0A4D5ZVI3.1
#=GS E0QN77_9ACTO/80-176 AC E0QN77.1
#=GS Q5DZS9_ALIF1/188-267 AC Q5DZS9.1
#=GS C6LMF6_9FIRM/227-321 AC C6LMF6.1
#=GS A0A4D5ZIQ3_9VIRU/228-324 AC A0A4D5ZIQ3.1
#=GS A0A3N6Z5R7_9ACTN/77-155 AC A0A3N6Z5R7.1
#=GS G7M3W1_9CLOT/228-315 AC G7M3W1.1
#=GS A0A133XV76_9ACTN/251-284 AC A0A133XV76.1
#=GS A0A2Z4Q9I4_9CAUD/243-339 AC A0A2Z4Q9I4.1
#=GS J9VXG3_LENBU/237-334 AC J9VXG3.1
#=GS A0A1G5FRE0_9FIRM/229-320 AC A0A1G5FRE0.1
#=GS A0A239TIB3_9FIRM/229-328 AC A0A239TIB3.1
#=GS A0A449BJ56_9MOLU/238-333 AC A0A449BJ56.1
#=GS A0A6G9QJ90_9GAMM/331-429 AC A0A6G9QJ90.1
#=GS A0A2N6SND8_9LACT/227-318 AC A0A2N6SND8.1
#=GS A0A3P1UKV8_9ACTO/242-318 AC A0A3P1UKV8.1
#=GS A0A0J1G8E1_9FIRM/228-322 AC A0A0J1G8E1.1
#=GS A0A062XCW8_9LACO/227-318 AC A0A062XCW8.1
#=GS A0A1G8I3F4_9VIBR/327-427 AC A0A1G8I3F4.1
#=GS A0A0N9RUA4_9CAUD/229-321 AC A0A0N9RUA4.1
#=GS A0A288QSC9_9LACO/229-323 AC A0A288QSC9.1
#=GS F4LRV0_TEPAE/229-327 AC F4LRV0.1
#=GS R9NEH3_9FIRM/118-210 AC R9NEH3.1
#=GS A0A1E5E2K6_9VIBR/327-427 AC A0A1E5E2K6.1
#=GS A0A4D5ZUI9_9VIRU/228-324 AC A0A4D5ZUI9.1
#=GS W5Y4Z0_9CORY/243-339 AC W5Y4Z0.1
#=GS A0A4D5ZXU9_9VIRU/227-318 AC A0A4D5ZXU9.1
#=GS A0A4D5ZGK8_9VIRU/227-318 AC A0A4D5ZGK8.1
#=GS A0A4R2LD86_9FIRM/228-322 AC A0A4R2LD86.1
#=GS K2KHT2_9GAMM/327-427 AC K2KHT2.1
#=GS A0A3A9CUM5_9BACT/227-321 AC A0A3A9CUM5.1
#=GS M5J4Q9_9LACO/228-324 AC M5J4Q9.1
#=GS A0A4D5ZEM4_9VIRU/260-351 AC A0A4D5ZEM4.1
#=GS A0A418Q4Q0_9CORY/244-326 AC A0A418Q4Q0.1
#=GS A0A316DHR3_9FLAO/242-316 AC A0A316DHR3.1
#=GS A0A094ISX3_9GAMM/324-418 AC A0A094ISX3.1
#=GS A0A4Q2EKE7_9ACTN/244-322 AC A0A4Q2EKE7.1
#=GS A0A2M9H6C5_9BIFI/245-345 AC A0A2M9H6C5.1
#=GS A0A4R2KS59_9CLOT/226-313 AC A0A4R2KS59.1
#=GS A0A380K796_9STRE/226-317 AC A0A380K796.1
#=GS A0A1H9BXI5_9LACT/227-319 AC A0A1H9BXI5.1
#=GS F9VIB3_ARTSS/152-239 AC F9VIB3.1
#=GS A0A662ZIC1_9GAMM/153-248 AC A0A662ZIC1.1
#=GS A0A087AR43_9BIFI/232-330 AC A0A087AR43.1
#=GS A0A8E4VQ66_9CAUD/229-321 AC A0A8E4VQ66.1
#=GS A0A4Q8UDK4_9MICC/244-319 AC A0A4Q8UDK4.1
#=GS A0A0R2ENK0_9LACO/231-327 AC A0A0R2ENK0.1
#=GS A0A4D5ZLP8_9VIRU/228-324 AC A0A4D5ZLP8.1
#=GS A0A0H4LRS6_9LACO/227-318 AC A0A0H4LRS6.1
#=GS A0A4D6AXU9_9CAUD/227-318 AC A0A4D6AXU9.1
#=GS A0A7I7RRG2_9MYCO/244-323 AC A0A7I7RRG2.1
A0A3N0BZJ6_9MICC/219-295 ........................DPNKTHPYSMKKLLERVND----.....-....--.--.......----..RREGRPLNTYDYQVVCWKENLKD.EAKYAWKHSNAA.....-.SYVWSGDAVHFLAS--------------fdddyydnc........
D0WFB0_SLAES/225-320 ........................DPINKYKYRTKAAVKFIKGKLKK.....E....GI.SI.......YVSG..--EEKEFNTFHFGVFVDFYEMKG.NEAYSYNFSLPG....eQpSWGYSQQAIDLMLQELIKNPTRVVDSMR.................
A0A7X6S2W9_9LACO/1-33 .....................mgs-----------------------.....-....--.--.......----..-----------------------.------------.....RvEYTYSQQLIDFIFSEIKKRPNLFVNEV-l................
A0A1C0BS63_9FIRM/226-321 ........................DPNKTHAYTTKKCIELINGKLKK.....E....GI.YL.......TYKD..-NKKAKFNSYHFSNFCKHFEIKE.KTDFCYVNTIHS.....SpSYSYSNKAINFIFEELKKDPENILNHIK.................
A0A4D5ZQ79_9VIRU/227-318 ........................DPSETHKYSYANIISVVNDRLNK.....K....NI.KL.......----..-NYKSGFNQYVLTLVIDFYSIKS.DEKYSYCHKIGK.....SeHYTYSQKFVDFIISEIEKDPQHFVESLK.................
A0A3A5H529_9ACTN/244-320 ........................DPNQTHPYSMKELLARANK----.....-....--.--.......----..KRTGRLLTSYDHQAICWKENLRT.NARFAWKHGAAA.....-.THVWSGDAVSHFA---------------slsdaycdav.......
R5HJF8_9MOLU/228-313 ........................DIDKTHPYTATEVIKKIKETL--.....-....EL.SL.......----..-GPNHKFTSNKFQDICKRKGLKN.NQDYCYQFPYSK....tK.IYKYSDITIEYISQ--------------vyieefknkkv......
R5ZD98_9FIRM/182-273 ........................DPANTHKYTFNNVITVVNSRLSK.....S....NI.NL.......----..-GYKKGFNSYVLNLFIEFYDIKN.NIKYSYKHSLGN.....StSYTYSERLVNFIIEEIKKNPDGFVESLK.................
A0A133XRK7_9ACTN/1-72 .......................n-----------------------.....-....NV.KI.......YVNN..-AEKDKFTNNDFQLFADQYGYKE.KSQFCYKHEVGN.....StTRTYSQTVIAQIVEALMRN-NHLIEELK.................
A0A4D5ZGU2_9VIRU/227-318 ........................DPSETHKYSYANIISVVNDRLNK.....K....NI.KL.......----..-NYKSGFNQYVLTLVIDFYSIKS.DEKYSYCHKIGK.....SeHYTYSQKFVDFIISEIEKDPQHFVESLK.................
A0A8H2MAF0_9FIRM/230-321 ........................DPADTHKYAHGLVITAVQERLKK.....K....NI.TI.......----..-GYKQGFNSYVLNLFINFYNIKS.NPKYTYCHIVGN.....NkSYTYSQSCVEFIVKEIEKDPLNIVESLK.................
F8E1A2_CORRG/252-334 ........................DPNDTHPFSAGELVERANE----.....-....--.--.......---V..RKHGRKLTMHDLTCMAWRHGLRE.DTKYAWRGKHNP.....-.SWVWSGDALSFLKNQTDEDFDRVR----eeyk.............
A0A0M3TBZ6_9ACTN/89-171 ........................DPNDTHPFSAGELVERANE----.....-....--.--.......---V..RKNGRKLTMHDLKCMAWRHGLRE.NTKYAWRGKHNP.....-.SWVWSGDALSFLKNQTDEDFDRVR----eeyk.............
A0A7K3M1V0_9ACTN/1-78 ....................mler-----------------------.....-....--.--.......-VNK..KRSGRRLNSYDHQAICGKDNLRD.DKRYAWKHSNSA.....-.SHVWSGETVAYLVSLSDEQ---------ydkaraaysehqkaerv
A0A4D5ZHW3_9VIRU/227-318 ........................DPSETHKYSYANIISVVNDRLNK.....K....NI.KL.......----..-NYKSGFNQYVLTLVIDFYSIKS.DEKYSYCHKIGK.....SeHYTYSQKFVDFIISEIEKDPQHFVESLK.................
A0A4D5ZMP1_9VIRU/227-318 ........................DPSETHKYSYANIISVVNDRLNK.....K....NI.KL.......----..-NYKSGFNQYVLTLVIDFYSIKS.DEKYSYCHKIGK.....SeHYTYSQKFVDFIISEIEKDPQHFVESLK.................
A0A4D5ZKI0_9VIRU/227-318 ........................DPSETHKYSYGNIISVVNDRLNK.....K....NI.KL.......----..-NYKSGFNQYVLTLIIDFYSIKT.DEKFAYCHKIGK.....SeHYTYSQQFVDFIITEIEKDPLNFVESLK.................
A0A7D5BFU7_9CAUD/228-327 ........................DPNKTHPYTQKNCVKEINKILSR.....E....KI.DFe....hfSVFT..KEIRSNFNTADFQLFLKFYSLKA.QERYSYRHVIGE.....HsQYTYSRAIIDFILTEIKKNPQKTIEHLK.................
C3PJW2_CORA7/236-332 ........................DAASYYPYTVGNAVKEVRNRLRK.....S....KT.TI.......YFRG..--EEKLFNRWHFNLFNKVFQFRE.DARYAHDRSTAGe...pNsSWTYSQRAIEFIVAQLEKEPGTCIDALQ.................
A0A0R2CPU9_9LACO/241-332 ........................DPSNTHKYSYNSVITAVNIRLNN.....K....NI.KL.......----..-DYSKGFNQYILKLVIDFYSIKK.NELYAYEHVIGN.....QqIYTYSQQFIDFIVSEIKQNPSKFVESLR.................
A0A7Y9RXI1_9ACTN/244-321 ........................DPNTTHPYSLKDLLKLVNK----.....-....--.--.......----..RRSGRDLTTYDHTALCWDEKLRE.NPKYSWKHSNAP.....-.APMWSNDAATH-----------------lagltddyvddvk....
A0A4D6A5F7_9CAUD/228-324 ........................DPNAVYPLTTKEVIKIVNKRLRA.....K....GI.LL......tKIVS.gEKQKRPFTTNDLQLFNAFYDIKK.DGRYCYHYKIGN.....-.RYSYAPAFCEFIIEEIERNPETFVENLK.................
A0A6A0B5N0_9LACT/7-98 .....................klv---DTHKYSYESVVISVQERLKK.....R....QI.KL.......----..-GYEKGFNTYVLSLVIDFYHIKF.NEKYAYEHVIGK.....QhHFTYSQQFIDFIVSEIEKAPNNFVESLK.................
A0A4D5ZJ35_9VIRU/227-318 ........................DPSETHKYSYANIISVVNDRLNK.....K....NI.KL.......----..-NYKSGFNQYVLTLVIDFYSIKS.DEKYSYCHKIGK.....SeHYTYSQKFVDFIISEIEKDPQHFVESLK.................
B0RZZ1_FINM2/234-325 ........................DPADTHKYSFNSVVTAVQERLKR.....K....NI.VL.......----..-SYEKGFTAYVLTQFINFYNIKE.NDKYCYKHKIGN.....NnSYTYSQQFIEFIVDEISKDPLNIVESLK.................
A0A4D5ZWS9_9VIRU/228-324 ........................DPNAIYPLTTREVIKIVNRYLKS.....K....GI.LL......tKIVG.gEKQKKTFTTNDLQLFNTFYDIKT.NQRYCYHYKIGN.....-.RYGYSQILCDFIIEEIERNPETFVENLK.................
A0A1F1UXB9_9CORY/235-332 ........................DAVSFYPYTAGNATKKIDSLLKK.....R....GI.TF.......CFNG..-SVKEKFTTYAFQLFTKAYEMKG.DERFSYDRKTAGe...kTsNWIYSEAAVEFIAHQVEKDPGHCLDQLR.................
Q5YPN3_NOCFA/88-164 ........................DPNQSHPYNQTELLDKVNQ----.....-....--.--.......----..RRKGRRLTSYDYQVPCWKEKLRD.NPKYAWKHEHSP.....-.TYLWSGDAVSYLA---------------glddevydqa.......
R9KX54_9ACTN/231-334 ......................ev--KNKYPYRPSGVVKAICERLAK.....S....NV.VLmq..dgsDTRA.rTKNRRPFNLYMFGLFTSFYGMKT.DSRYSYDNSLEG....eAsSFIYSQQAVDLIWDKIRENPEGVIDRLK.................
S2ZEY4_9CORY/17-113 ........................DSSSYYPFTAKGCINEVRKRLKR.....A....RI.TI.......KWKG..--EDVTFNKFHFDLFVRVFSMKS.NAKFAYDRKAKNe...kAsSWIYSQQAIDFIVRYLTKDPMNCLDQLR.................
V7HSP1_9LACO/228-323 ........................DPNAIFTFAQRKVIDSVNKRLKK.....K....HI.LL......dKIKN.gEPVKDKFTSNDFQLFIKFYDIKN.NESMCYHYNIGN.....-.RYGYSQKVVDFIIDEIEKNHSII-----lhik.............
G4CU90_9ACTN/244-323 ........................DPNETHPYSATQLIARANR----.....-....--.--.......---A..RKNGRKLTSYDLTCMAWKHNMRD.NSKFAWRGTHSP.....-.THVWSGDALSFLKNQTDEE---------fdrvra...........
A0A061A8S2_9MOLU/238-333 ........................DSSITHPLSNKQVLFHVNQELTK.....L....NI.QI.......TPVS..NGAKTHFTTFTFNLYNKYYKIKD.IPEFAYKHKLGE.....NcSYTYSLELIQKIISDICSDPD-IFKK--ik...............
A0A4P8L2Q7_9DELT/35-109 ...........fkalqglrkllte-----------------------.....-....--.--.......----..-LHGRKFTSHAFEAVIWHNNIKE.NSRLCWISEEGV.....-.LTKYSREVIAMIRRLSKKQVDDAISA--yk...............
A0A4D5ZKT3_9VIRU/228-324 ........................DPNAIYPLTTREVIKIVNRHLKS.....K....GI.LL......tKIVG.gEKQKKTFTTNDLQLFNTFYDIKT.NQRYCYHYKIGN.....-.RYGYSQILCDFIIEEIERNPETFVENLK.................
A0A1I4GIB7_9FIRM/227-321 ........................DPNDTHKYSMKACLKELNKRIAR.....D....GI.QL.......LYNG..--ETVELNQYHFKLFNSYFKIKE.NEKFCYVYQISA.....QpQYSYSQQAIDFIYDEIKKAPSTLLDDLK.................
A0A410DYS3_9CLOT/224-311 ........................DPNNTHKYNMRSCNNEINKRLKS.....L....GI.NL.......----..-----KFNRYHFELFCEYYRIKE.NPKLCFIYKINS.....SpNYSYSIKTIDFIVDEIKKDPKNIIESLR.................
A0A6M5IVG2_9MICO/244-320 ........................DPNQTHPFSATKLLEKVNE----.....-....--.--.......----..KRTGRKLTSRDHQALCWQDQLRE.NPKYAWKHTIGA.....-.SHSWSGETVSYMASLTD-----------eqydga...........
A0A0M2H0P5_9MICO/244-321 ........................DPNQTHPYSATKLLEKVNE----.....-....--.--.......----..KRTGRKLTSRDHQALCWQDQLRE.NPKYAWKHTIGA.....-.SHSWSGETVAYMVSLSD-----------eqydsar..........
C7N391_SLAHD/227-322 ........................DPINKYIYRTKKGTEFIRRKLSK.....E....GI.TL.......LVKG..--EPKEFNTFHFGIFVDFYNMKG.NDTYSYNLSLGG....eQpSWGYSQLAIDLMLQEIRRGPKHVIDSMR.................
A0A1S2U0B1_9GAMM/326-427 ........................DREKSHPYLESSAIKKLNDRLKE.....QcseeA-.-Lnk..flvARCK..KSGKPTINQHCFRAVVDKLKVKN.ANN-EYHHKNCN....pE.LHYYSDSFIDLVVKKV-IDGQNFIANAK.................
Q6NK57_CORDI/1-82 .......................m-----------------NKRLKK.....A....KV.QI.......QFRD..-SKKNKFTSHDFQLFIKAYAMKG.DPRFSHDRKASNe...vNpSWTYSQQAIKHIADELIKDPEKCLDRLK.................
A0A5C5XT78_9BACT/237-323 vdrkvdpnkshpklqkhvlsdigr-----------------------.....-....--.--.......----..ELKGVRFTSYTFQAIVWDHDIKN.NPQYYWKPEHGG.....-.SSQYSPQLIAFVRSLTKTEIETAIENY-r................
A0A4R7J6X3_9ACTN/242-318 ........................DPNQTHPYSATELLQRVNA----.....-....--.--.......----..KRAGRELNSRDHQALCWKEHLRD.DPRMAWKHGNAA.....-.THVWSGDAVNHMAK--------------ledgyydqv........
A0A4D5ZVI3_9VIRU/228-324 ........................DPNAIYPLTTREVIKIVNRYLKS.....K....GI.LL......tKIVG.gEKQKKTFTTNDLQLFNTFYDIKT.NQRYCYHYKIGN.....-.RYGYSQILCDFIIEEIERNPETFVENLK.................
E0QN77_9ACTO/80-176 ........................DLQNKYPYTARKVWEEVNRQLQK.....H....GV.TF.......TYRD..-RIQDKFNNHHWTIMVKFYNLKT.DPRYGYNRATKGe...kAlSYVYSQQTVELIVDSIRRNPHVLT----dll..............
Q5DZS9_ALIF1/188-267 ........................DLNTTHPFTTKAAIEQMNR----.....-....--.--.......----..EQSKVVLNQHSFQAICYKHKIKA.NNNSEYHNYTD-.....-.IHRYSAKFINWVIKNIKEQD--------swlqqal..........
C6LMF6_9FIRM/227-321 ........................NPNETHKYNAKACIKEINKRLKK.....N....KI.AM.......LYNG..K--EAELNMYHFQNFTAYFCLKE.NERMCFTYQISA.....QpQYSYSQQAIDFIYGEIEKAPSTILDNLK.................
A0A4D5ZIQ3_9VIRU/228-324 ........................DPNAIYPLTTREVIKIVNRYLKS.....K....GI.LL......tKIVG.gEKQKKTFTTNDLQLFNTFYDIKT.NQRYCYHYKIGN.....-.RYGYSQILCDFIIEEIERNPETFVENLK.................
A0A3N6Z5R7_9ACTN/77-155 ........................DPNQTHPYSATALLAKVNE----.....-....--.--.......----..KRTGRKITTYDHQAICWKESLRE.DTKYAWKHSNGA.....-.SHVWSGDAVSHLASLTDR----------qydelra..........
G7M3W1_9CLOT/228-315 ........................DPNSTHKYNMKSCNKEINKRLKT.....L....GI.NL.......----..-----KFNKYHFELFCKYYSLKK.NPKLCYTYNVNS.....SpNYSYSLQTIDFIVEEIKKDPKNVIQNLR.................
A0A133XV76_9ACTN/251-284 ........................DPKNSHPYSTTQCIVEINKRLRK.....N....NV.KI.......YVNN..-----------------------.------------.....-.----------------------------ae...............
A0A2Z4Q9I4_9CAUD/243-339 ........................DAISYYPFRVSACVDKVNGKLKG.....K....GT.KI.......RFRG..-DEVPQFNKFHFDLFAKGHHFKG.DQRFSYNRNGPD....eTpYYVYSQHTVEFIVQRLREEPETYLDKL-s................
J9VXG3_LENBU/237-334 ........................DPKNTHPFSYSEVVNQINKWISR.....K....KI.NF.......QVTI.sHGIRVAFNKSDLDLFIKFYEIKT.NIDYAYKHVLGN.....NnQYTYSQKAINLIEKEIKDNPQRIISILK.................
A0A1G5FRE0_9FIRM/229-320 ........................DPSNTHKYSYQSVITVVSEKMHK.....D....NL.HI.......----..-DYPKGFNAYVLNLLMDFYDIKT.NQLYAYKHTIGN.....QeQYTYSQQFIDFVIGEIKKNPNTFVESLK.................
A0A239TIB3_9FIRM/229-328 ........................DMQLSCPYNTKRCIEIINSWIKK.....D....NL.NFi....npNCKN..EEKKHTFNSFHFSLFVKFYNLKE.NNKYCYKYTRNK.....QpNYTYSNQALDLIYTEIKKDPENIIQSLK.................
A0A449BJ56_9MOLU/238-333 ....................dsgi----SHPLSTKQVLDCVNSELLK.....L....DI.KI.......APIS..DGSKTNFTTYTFNLYNLFYNIKE.IPEYSYKHILGN.....RwSYTYSYELVQKIIDDICND-QEIFKKIK.................
A0A6G9QJ90_9GAMM/331-429 ........................NPEKSHPFTRSKLLSSVLEKLQK....yD....DV.KLg....rcLVYT..AGAKPSLNTNCIDACIHKLKWKS.NDNEYHHYIKVS.....D.RHLYSMSAVDELVKRITE-NENFVRE--ak...............
A0A2N6SND8_9LACT/227-318 ........................DPSDTHKYSFNSVITAVQERLTR.....R....NI.RL.......----..-DYKNGFNSYVLNEFIKFYDIKL.ESKYTYKHKIGK.....ElRYTYSQQFIEFIIEEIKKNPVNFVDSLK.................
A0A3P1UKV8_9ACTO/242-318 ........................DPNQSHPYNATELLARVNA----.....-....--.--.......----..KRKGRTLNSRDHQALCWKENLRD.DPRMAWKHKKGQ.....-.SYNWSGDAVRHMTEL-------------sdahydea.........
A0A0J1G8E1_9FIRM/228-322 ........................DLNNTHKYTAKACIAKIKENLSK.....E....NI.KL.......SYNG..--DEAKFTSFHFTNFCKHFGLKE.NDKYCYVHKQFS....mP.QYSYSQQAIDFILEELKKDPDNILDNIK.................
A0A062XCW8_9LACO/227-318 ........................DPSDIHKYSYNNIITAVNERLKK.....K....NI.QL.......----..-KYKSGFNTYVLSLFIEFYNIKS.DSKYAYRHCIGN.....QtSYTYSQQLVEFIVSQIKKDPNNFVESLK.................
A0A1G8I3F4_9VIBR/327-427 ........................DPEKTHTFTQKTAIDAINKTLNA.....N...yDIaKLek...clVARD..KKGNPTINSHCFQAAVSKLNWKA.TCNKHHHYQKIS.....N.THIYSQDAVDELVRQIT-TKDNFIAQ--ak...............
A0A0N9RUA4_9CAUD/229-321 ........................DPNDKYRLSFNNVIKGVNKQLKA.....K....NL.KF.......NYYD.kANDKNEFNQYTLSLIIKFYNLKF.DDKYAYHFANLT.....-.--RYSQQIVDFIVKEIKNDP-NIINNIK.................
A0A288QSC9_9LACO/229-323 ........................NPAETHMYSHNDLVNEIMRRIRK.....Q....KI.NF.......EYQS.kERIRRDFTSSLLTLFMNFYDMKA.DGKYAFKHVIGN.....SeRYSYSQAAAEFVVSEIKK----------irkillr..........
F4LRV0_TEPAE/229-327 ........................DPKETHKYTTGKCVDILNKWIER.....D....GL.AF.......QSLSpaKGKDNTFNAYHFRLFTDFYNLKS.DIKYCYEFNLHS.....QpTFTYSQATINLIYSEIKKDPENIIQHLK.................
R9NEH3_9FIRM/118-210 ........................DPNTTHKYSTTSCVKEICTRLTR.....L....GI.EL.......KYNG..--ESKKFNNYHFNLFCKYYGIKN.NPKLCYKHQLTG.....-.TYGYSIQTIDFIVDEIKKDSDNIIQNLK.................
A0A1E5E2K6_9VIBR/327-427 ........................DPETSHKYSQATAIKVINELLN-.....D....KY.DMgkltrclVARD..KKNVPDFNSNCFQAVIKKLKWKL.SNNEFHHHQALA.....N.KHIYSHQAVEEIVKRITEN-ESFL----keak.............
A0A4D5ZUI9_9VIRU/228-324 ........................DPNAVYPLTTKEVIKIVNKRLRA.....K....GI.LLt.....kIVNG..EKQKRPFTTNDLQLFNAFYDIKT.NERYCYHYKIGN.....-.RYGYAQAFCEFIIEEIERNPETFVENLK.................
W5Y4Z0_9CORY/243-339 ........................DAISYYPFRVSACVDKVNGKLKG.....K....GT.KI.......RFRG..-DEVPQFNKFHFDLFAKGHHFKG.DQRFSYNRNGPD....eTpYYVYSQHTVEFIVQRLREEPETYLDKL-s................
A0A4D5ZXU9_9VIRU/227-318 ........................DPSETHKYSYANIISVVNDRLNK.....K....NI.KL.......----..-NYKSGFNQYVLTLVIDFYSIKS.DEKYSYCHKIGK.....SeHYTYSQKFVDFIISEIEKDPQHFVESLK.................
A0A4D5ZGK8_9VIRU/227-318 ........................DPSETHKYSYANIISVVNDRLNK.....K....NI.KL.......----..-NYKSGFNQYVLTLVIDFYSIKS.DEKYSYCHKIGK.....SeHYTYSQKFVDFIISEIEKDPQHFVESLK.................
A0A4R2LD86_9FIRM/228-322 ........................DPNNTHKFTAKHCIAIIRDHLNK.....N....NI.EL.......FYNG..--VTTKFNSFHFNNFCRYFGIKC.NEKYCYIHRQFS.....QpQYSYSQQAIDFIIEELAKDPLHILDKIK.................
K2KHT2_9GAMM/327-427 ........................DPDKSHPFSQKGLMKAVNERLWQ.....Dl..dDE.ALrk...klPKQN..QQGKPALNSHCIQACIMKLGWKKnNNDFHYHSKMSD.....-.RHQYSDAAVVALVKKIKKDDS-------fvarsk...........
A0A3A9CUM5_9BACT/227-321 .......................r-PELIFKYSTKTSIETITSIIKR.....Q....KI.TL.......QYHN..--EPVIFNKYHFSNLIKYYGIKD.NSKFCWKYTVGN.....TdFFRYSQQAIDFLAEELKRDPLHILDNIK.................
M5J4Q9_9LACO/228-324 ........................DPSAIYIYTTKKVIQLVNKRLKK.....D....NI.LL......sKMKK.gEKIKSVFTTNDFQLFIKFYGIKE.NSKYSYLYTIGN.....-.RYGYSIKVIDFIVEEIKKRPDTIIETLK.................
A0A4D5ZEM4_9VIRU/260-351 ........................DPSETHKYSYANIISVVNDRLNK.....K....NI.KL.......----..-NYKSGFNQYVLTLVIDFYSIKS.DEKYSYCHKIGK.....SeHYTYSQKFVDFIISEIEKDPQHFVESLK.................
A0A418Q4Q0_9CORY/244-326 ........................DPNETHPYSATELIDRVNR----.....-....--.--.......---S..RKIGRKLTSHDLTCMAWKYHLRE.DGMYVWRGKHNQ.....-.TCVWSGAALNFLKNKTDEEYE-------rvrkeyk..........
A0A316DHR3_9FLAO/242-316 ..............elypfrfeql-----------------------.....-....--.--.......----..-KSELGLNQYELRCILWKLNVKG.DKKYHTSIQIGK....tNeTHKYSQKFVDSVKAVLKRYPNWLTE---tis..............
A0A094ISX3_9GAMM/324-418 ........................DAEKTHPYRQTDVIKAINERLEEhysdeQ....RA.EF.......LVSK..KNGQPTFNPNCFQSVAHKLKWKN.GNNKFHHFLAKA.....N.THLYSEAAINTIIEKIT-----------siqgy............
A0A4Q2EKE7_9ACTN/244-322 ........................DPNQTHPFSMTELLDKVNE----.....-....--.--.......----..RHEGRKLTTYDYQAICWKEPLRE.NTKYAWKHSSGA.....-.SHVWSGDAVSYLAAMTDDQ---------ydsirv...........
A0A2M9H6C5_9BIFI/245-345 ........................DPTQRYPFRMKEVLSLVNRQLRK.....R....HI.RF.......TSRG..-DQDARFNNWHFSLFSKCYGMKQ.DERFAFNRASPAenragHpYYIYSNATVDFIVGEIAKDPEHIVEKL-n................
A0A4R2KS59_9CLOT/226-313 ........................DPNDTHKYTTKACIKEINKRLKR.....E....DI.DI.......----..-----EVNKYHFTLFCKYYEIKE.NAKLCYVHKIHA.....QpTYSYSMQTTDFIFEEIKKDPENIIQNIK.................
A0A380K796_9STRE/226-317 ........................DPNDKYKLTRKNVIDSINKQLQT.....K....KI.SF.......NYQT..VKGDKGFNEYTLNLFMDFYNLKQ.DNKYCYQFGTVR.....-.--RYSQQLVDFILEKIKIDAD-II----nkil.............
A0A1H9BXI5_9LACT/227-319 ........................DPSDTHKYSFKSVIKSVNERLQR.....Y....NI.KI.......----..KDYPKPINHYVLNLIIDFYSIKE.DEKYCYKHTIGN.....NiHHTYSQQFVDFIISEIRKNPDSFVTSLK.................
F9VIB3_ARTSS/152-239 .....................ndv---DLYKYSKKSLCREINNVLKS.....L....GI.EF.......----..-----KIDSQSFELFDRVYGIKE.NKEYCLISNVNN....rP.SYRYSSRVLNFIVGLIQKNPNNIKEVLK.................
A0A662ZIC1_9GAMM/153-248 ........................NPNDTHKYNAKSCIEAINNKLRK.....D....GT.YP.......MCK-..-GQNVKINNFHFMNFVKYFDLKS.NERMCFVFDKQA....kQpQYRYSQQVIDFIYEEIKKNPETILDDLR.................
A0A087AR43_9BIFI/232-330 ........................NPADTHRYTYHNVIDAVNTRLAA.....S....GT.VM.......HYVS.gGREHTEFNSYTLQLFIRFYDLKS.DERYAYKYVIGD....eApRWTYSQHMIDFIVGEIVKAPDEIIGSLK.................
A0A8E4VQ66_9CAUD/229-321 ........................DPNDKYTLSFNNVIQGINKQLKA.....K....NL.EF.......NYFD.kKDGKNEFNNYTLSLIIKFYNLKN.DDKYSYHFANVT.....-.--RYSQQIVDFIVKEIKHDP-NIINNIK.................
A0A4Q8UDK4_9MICC/244-319 ........................DPNKTHPYSMKELLKRVKA----.....-....--.--.......----..RRPGRELNTYDYQVVCWKEDLKN.ESKYAWKHSNAA.....-.SYVWSGDAVSFLAS--------------ldddyfdk.........
A0A0R2ENK0_9LACO/231-327 ........................DPNSTHPLTNARVIALVNKRLKK.....D....KI.LIt.....kKYKD..GSQTVKFTTNDFQLFNKFYNIKS.KPKYTYHITIGN.....-.RYSYSTKVVDFIIEEIKKDPEHIIQNLK.................
A0A4D5ZLP8_9VIRU/228-324 ........................DPNAIYPLTTREVIKIVNRHLKS.....K....GI.LL......tKIVG.gEKQKKTFTTNDLQLFNTFYDIKT.NQRYCYHYKIGN.....-.RYGYSQILCDFIIEEIERNPETFVENLK.................
A0A0H4LRS6_9LACO/227-318 ........................DPSDTHKYSYNSVITAVNERLNK.....Q....NL.KL.......----..-NYTPGFNQYVLSLIIDFYDIKR.MPQYSYEHIIGK.....QhNFTYSQQFIDFIMDEIKKDPKNFVESLK.................
A0A4D6AXU9_9CAUD/227-318 ........................DPSETHKYSYGNIISVVTDKLNK.....D....NI.KL.......----..-GYKNGFNQYVLNLVIDFYSIKQ.DEKWAYCHKIGK....lE.SYTYSQQFVDFIVSEIKKDPQNFVESLK.................
A0A7I7RRG2_9MYCO/244-323 ........................DPNVTHPFSLKELLDRVNA----.....-....--.--.......----..KRKGRTLTTYDHQVLSWKEDLRS.KETYAWKHSKGV.....-.SYAWSPAAVTHLVSLTDEDYD-------rvrae............
#=GC seq_cons ........................DPspoH.YohppllptlNcpLpp.....p....sl.th..............ptpppFNsashplhspaaslKs.sp+YsYcaphus.....t.pasYSpphl-FIlpcIc+sPpphlppl+.................
//
