#=GF ID   EGL-1
#=GF AC   PF11430.12
#=GF DE   Programmed cell death activator EGL-1
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF SE   pdb_1ty4
#=GF GA   21.20 21.20;
#=GF TC   21.40 33.00;
#=GF NC   20.20 21.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   15383288
#=GF RT   Structural, biochemical, and functional analyses of CED-9
#=GF RT   recognition by the proapoptotic proteins EGL-1 and CED-4. 
#=GF RA   Yan N, Gu L, Kokel D, Chai J, Li W, Han A, Chen L, Xue D, Shi Y; 
#=GF RL   Mol Cell. 2004;15:999-1006.
#=GF DR   INTERPRO; IPR021543;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Initiation of programmed cell death in C.elegans occurs by the
#=GF CC   binding of EGL-1 to CED-9 which disrupts a complex involving
#=GF CC   CED-4/CED-9 and allows CED-4 to activate CED-3, a caspase. It is
#=GF CC   the C terminal domain of EGL-1 which is involved in the
#=GF CC   formation of the complex with CED-9. The formation of the
#=GF CC   complex induces structural rearrangements in CED-9 and EGL-1
#=GF CC   adopts an extended alpha-helical conformation [1].
#=GF SQ   20
#=GS G0MQX1_CAEBE/238-256    AC G0MQX1.1
#=GS A0A2G5TNC3_9PELO/73-92  AC A0A2G5TNC3.1
#=GS A0A2G5SZG2_9PELO/51-70  AC A0A2G5SZG2.1
#=GS G0NM76_CAEBE/79-98      AC G0NM76.1
#=GS A0A8R1ERM6_CAEJA/12-30  AC A0A8R1ERM6.1
#=GS EGL1_CAEEL/67-86        AC O61667.2
#=GS A8WY25_CAEBR/70-89      AC A8WY25.1
#=GS A0A261BIE4_9PELO/68-86  AC A0A261BIE4.1
#=GS A0A2G5SZ39_9PELO/9-28   AC A0A2G5SZ39.1
#=GS A0A260ZTL9_9PELO/73-92  AC A0A260ZTL9.1
#=GS G0MQX1_CAEBE/181-200    AC G0MQX1.1
#=GS B6IM60_CAEBR/51-70      AC B6IM60.1
#=GS Q9TY06_CAEEL/53-72      AC Q9TY06.1
#=GS G0MQX1_CAEBE/298-317    AC G0MQX1.1
#=GS G0MQX1_CAEBE/124-143    AC G0MQX1.1
#=GS A0A261BZR9_9PELO/69-87  AC A0A261BZR9.1
#=GS A0A8R1DSP5_CAEJA/69-87  AC A0A8R1DSP5.1
#=GS E3MP30_CAERE/60-78      AC E3MP30.1
#=GS E3LTJ5_CAERE/75-94      AC E3LTJ5.1
#=GS E3M1A5_CAERE/71-89      AC E3M1A5.1
G0MQX1_CAEBE/238-256               HNIGVKQAVMCDNFDKEMM-.
A0A2G5TNC3_9PELO/73-92             HDIGTKLAVMCDAFDAEMMS.
A0A2G5SZG2_9PELO/51-70             HAIGKQLRQLCDDFDKEMM-a
G0NM76_CAEBE/79-98                 YKIGTQLAAMCDDFDAEMMS.
A0A8R1ERM6_CAEJA/12-30             -EIGARIATMCDEFDAELMS.
EGL1_CAEEL/67-86                   YEIGSKLAAMCDDFDAQMMS.
A8WY25_CAEBR/70-89                 HDIGTKLAAMCDAFDAEMMS.
A0A261BIE4_9PELO/68-86             -EIGTKLVAMCDDFDVKIMS.
A0A2G5SZ39_9PELO/9-28              HAIGKQLRQLCDDFDKEMM-a
A0A260ZTL9_9PELO/73-92             HEIGTKLVAMCDEFDAQMMS.
G0MQX1_CAEBE/181-200               HNIGMKLAKMCDDFDDEMM-a
B6IM60_CAEBR/51-70                 HTIGKQLSKLCDDFDKEMM-a
Q9TY06_CAEEL/53-72                 YNIGRKLTVMCDEFDSELMS.
G0MQX1_CAEBE/298-317               YDIGTKVANMCDDFDAKLMS.
G0MQX1_CAEBE/124-143               HDIGTKLAAMCDDFDDKIMS.
A0A261BZR9_9PELO/69-87             -EIGTKLAAMCDDFDAKMMS.
A0A8R1DSP5_CAEJA/69-87             -EIGARIATMCDEFDAELMS.
E3MP30_CAERE/60-78                 -EIGTKLTTMCDGFDAKMMS.
E3LTJ5_CAERE/75-94                 YEIGTKLVAMCDDFDAQMMS.
E3M1A5_CAERE/71-89                 -EIGTKLAAMCDDFDAKMMS.
#=GC seq_cons                      a-IGoKLAsMCDDFDAcMMS.
//