#=GF ID EKAL
#=GF AC PF17986.5
#=GF DE EMP3-KAHRP-like N-terminal domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE Osborne A
#=GF GA 25.00 25.00;
#=GF TC 25.00 25.00;
#=GF NC 24.90 24.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF WK KAHRP
#=GF RN [1]
#=GF RM 27777305
#=GF RT Expansion of Lysine-rich Repeats in Plasmodium Proteins
#=GF RT Generates Novel Localization Sequences That Target the Periphery
#=GF RT of the Host Erythrocyte.
#=GF RA Davies HM, Thalassinos K, Osborne AR;
#=GF RL J Biol Chem. 2016;291:26188-26207.
#=GF DR INTERPRO; IPR040805;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is the N-terminal domain which is found at the N terminus
#=GF CC of the erythrocyte cytoskeleton-associated protein (EMP3) and
#=GF CC the knob-associated histidine-rich protein (KAHRP). KAHRP found
#=GF CC in protozoan parasites such as Plasmodium falciparum, is
#=GF CC involved in both rigidifying the host cell and the formation of
#=GF CC cytoadherent knob structures [1].
#=GF SQ 41
#=GS A0A024WDU8_PLAFA/337-384 AC A0A024WDU8.1
#=GS A0A0L0CWN9_PLAFA/143-195 AC A0A0L0CWN9.1
#=GS A0A679L6R9_PLAKH/75-127 AC A0A679L6R9.1
#=GS A0A1A8YK93_9APIC/85-137 AC A0A1A8YK93.1
#=GS W7K550_PLAFA/337-384 AC W7K550.1
#=GS A0A1A8ZJ05_9APIC/888-941 AC A0A1A8ZJ05.1
#=GS A0A1D3JE02_9APIC/49-101 AC A0A1D3JE02.1
#=GS A0A0L1ICB9_PLAFA/143-195 AC A0A0L1ICB9.1
#=GS A0A1D3TFQ7_PLAMA/74-126 AC A0A1D3TFQ7.1
#=GS A0A1D3TLT7_9APIC/846-899 AC A0A1D3TLT7.1
#=GS A0A1A8VIX3_9APIC/67-119 AC A0A1A8VIX3.1
#=GS A0A1A8WBC1_9APIC/33-85 AC A0A1A8WBC1.1
#=GS A0A024VWA3_PLAFA/122-169 AC A0A024VWA3.1
#=GS K6UZS3_PLACD/742-795 AC K6UZS3.1
#=GS A0A1A8YH51_9APIC/69-121 AC A0A1A8YH51.1
#=GS A5K449_PLAVS/746-799 AC A5K449.1
#=GS A0A1A8W9C0_9APIC/820-873 AC A0A1A8W9C0.1
#=GS A5KBG6_PLAVS/80-132 AC A5KBG6.1
#=GS Q9TY99_PLAF7/143-195 AC Q9TY99.1
#=GS A0A024WX12_PLAFA/339-386 AC A0A024WX12.1
#=GS A0A1D3JJP3_PLAMA/79-131 AC A0A1D3JJP3.1
#=GS A0A1A8X256_PLAMA/67-119 AC A0A1A8X256.1
#=GS A0A1A8WEZ4_9APIC/85-137 AC A0A1A8WEZ4.1
#=GS A5KA28_PLAVS/16-68 AC A5KA28.1
#=GS A0A024VX71_PLAFA/132-184 AC A0A024VX71.1
#=GS W4J612_PLAFP/143-195 AC W4J612.1
#=GS A0A0L7KKR3_PLAFX/143-195 AC A0A0L7KKR3.1
#=GS A5KBG7_PLAVS/79-131 AC A5KBG7.1
#=GS A0A024WZA3_PLAFC/106-158 AC A0A024WZA3.1
#=GS A0A024WXN9_PLAFA/52-104 AC A0A024WXN9.1
#=GS W7K236_PLAFO/119-171 AC W7K236.1
#=GS A0A679L3Z0_PLAKH/80-132 AC A0A679L3Z0.1
#=GS A0A024WF22_PLAFA/143-195 AC A0A024WF22.1
#=GS A0A1D3JJE5_PLAMA/80-132 AC A0A1D3JJE5.1
#=GS W7JJQ7_PLAFA/143-195 AC W7JJQ7.1
#=GS K6UCL9_PLACD/80-132 AC K6UCL9.1
#=GS A0A1A9A4E3_9APIC/31-83 AC A0A1A9A4E3.1
#=GS A0A1D3KX12_9APIC/70-122 AC A0A1D3KX12.1
#=GS A0A1D3SQZ2_PLAMA/913-963 AC A0A1D3SQZ2.1
#=GS A0A679KY73_PLAKH/682-735 AC A0A679KY73.1
#=GS A0A1D3UB13_9APIC/69-121 AC A0A1D3UB13.1
A0A024WDU8_PLAFA/337-384 ...alg-------ELDEYEERYEKKRYYLKEDGEGDLKDVEEKLEETGYGFREKFP---tt..
A0A0L0CWN9_PLAFA/143-195 rearpg------GGFKAYEEKYESKHYKLKENVVDGKKDCDEKYEAANYAFSEECPYTV....
A0A679L6R9_PLAKH/75-127 ......VEEIIPAGYKEYTENYEVKRFKLKESVDNGKRECDEKYEASGYGFKEGAPYE-m...
A0A1A8YK93_9APIC/85-137 .....i-KEVINGGFKEYEEKYESKHYKLSENVEDGNKDCDEKYEAANYGFREKCPYE-m...
W7K550_PLAFA/337-384 ...alg-------ELDEYEERYEKKRYYLKEDGEGDLKDVEEKLEETGYGFREKFP---tt..
A0A1A8ZJ05_9APIC/888-941 ..fken----DEGELEEYIETEGTKTYKLKNSVKDGKQVHDETFEKSIYGFRDKLP---vkdv
A0A1D3JE02_9APIC/49-101 .....i-KEVINGGFKEYEEKYESKHYKLSENVEGDNKDCDEKYEAANYGFREKCPYE-m...
A0A0L1ICB9_PLAFA/143-195 rearpg------GGFKAYEEKYESKHYKLKENVVDGKKDCDEKYEAANYAFSEECPYTV....
A0A1D3TFQ7_PLAMA/74-126 .....i-KEVIHSGYKEYQERYDIKRHKIVQDEEKGFKDCDETYEGSNYGFTDKRPY--ts..
A0A1D3TLT7_9APIC/846-899 ...fke---NEEGELAEYIETEGTKTYKLKNSVKDGKQVHDETFEKSIYGFRDKLP---vkdv
A0A1A8VIX3_9APIC/67-119 ......VTEITHGGFKEYEEKYESKHYKLKENVNDGNKECDEKYEAANYGFREKCPYEV....
A0A1A8WBC1_9APIC/33-85 .....i-NETIHGGYKEYEEKRESRRHTLTEDMSDFCGNCDEKYEGAKYGYRERCPYS-s...
A0A024VWA3_PLAFA/122-169 ...alg-------ELDEYEERYEKKRYYLKEDGEGDLKDVEEKLEETGYGFREKFP---tt..
K6UZS3_PLACD/742-795 ....lk--ENNAGDIEEYIETHETKRYKLEADVKDGIKEYDLKFEKAGYGYREKLP---vtev
A0A1A8YH51_9APIC/69-121 ......VTEITHGGFKEYEEKYESKHYKLKENVNDGNKECDEKYEAANYGFREKCPYEV....
A5K449_PLAVS/746-799 ...lke---NDTGEVEEYIETHETKRYKLKADVKDGVKEYDEKFEKASYGFREKLP---vtev
A0A1A8W9C0_9APIC/820-873 ...fke---NEEGELAEYIETEGTKTYKLKNSVKDGKQVHDETFEKSIYGFRDKLP---vkdv
A5KBG6_PLAVS/80-132 ......VKEVTRGGFKEYEEKYESKHYKLKENVEDGNKDCDEKYEAANYGFREKCPYEV....
Q9TY99_PLAF7/143-195 rearpg------GGFKAYEEKYESKHYKLKENVVDGKKDCDEKYEAANYAFSEECPYTV....
A0A024WX12_PLAFA/339-386 ...alg-------ELDEYEERYEKKRYYLKEDGEGDLKDVEEKLEETGYGFREKFP---tt..
A0A1D3JJP3_PLAMA/79-131 ......VKDITHGGLKEYKENFENKRYKLTENEKDGNKDCDEHYEAANYGFKEKCPYEV....
A0A1A8X256_PLAMA/67-119 ......VKEITHGGFKEYEEKYESKHYKLKENVESGNKNCDEKYEAANYGFREKCPYEV....
A0A1A8WEZ4_9APIC/85-137 .....i-KEVINGGFKEYEEKYESKHYKLSENVEGDNKDCDEKYEAANYGFREKCPYE-m...
A5KA28_PLAVS/16-68 ......VTEFKSGGLKEYQENYETKHYKLKENVVDGNKECDEKYEAAQYGFKEKCPYDV....
A0A024VX71_PLAFA/132-184 rearpg------GGFKAYEEKYESKHYKLKENVVDGKKDCDEKYEAANYAFSEECPYTV....
W4J612_PLAFP/143-195 rearpg------GGFKAYEEKYESKHYKLKENVVDGKKDCDEKYEAANYAFSEECPYTV....
A0A0L7KKR3_PLAFX/143-195 rearpg------GGFKAYEEKYESKHYKLKENVVDGKKDCDEKYEAANYAFSEECPYTV....
A5KBG7_PLAVS/79-131 ......VEEITPAGFKKYDENYESKLFKFMESVDNGKRDCDEKYEGSRYGFRESSPYEV....
A0A024WZA3_PLAFC/106-158 rearpg------GGFKAYEEKYESKHYKLKENVVDGKKDCDEKYEAANYAFSEECPYTV....
A0A024WXN9_PLAFA/52-104 rearpg------GGFKAYEEKYESKHYKLKENVVDGKKDCDEKYEAANYAFSEECPYTV....
W7K236_PLAFO/119-171 rearpg------GGFKAYEEKYESKHYKLKENVVDGKKDCDEKYEAANYAFSEECPYTV....
A0A679L3Z0_PLAKH/80-132 ......VKEVTRGGFKEYEEKYETKHYTLKENVDENNKDCDEKYEAANYGFREKCPYEV....
A0A024WF22_PLAFA/143-195 rearpg------GGFKAYEEKYESKHYKLKENVVDGKKDCDEKYEAANYAFSEECPYTV....
A0A1D3JJE5_PLAMA/80-132 .....v-KEKIYCGFKEYEENYEMKHYKLKENAEDGNKNCDEKYEATNYTFKEKCPYEI....
W7JJQ7_PLAFA/143-195 rearpg------GGFKAYEEKYESKHYKLKENVVDGKKDCDEKYEAANYAFSEECPYTV....
K6UCL9_PLACD/80-132 ......VKEVTRGGFKEYEEKYESKHYKLKENVEDGNKDCDEKYEAANYGFREKCPYEV....
A0A1A9A4E3_9APIC/31-83 .....i-NETIHGGYKEYEEKCESKRHTLTEDISDLCANCDEKYEGTKYGYRERCPY--sr..
A0A1D3KX12_9APIC/70-122 ......VTEITHGGFKEYEEKYESKHYKLKENVNDGNKECDEKYEAANYGFREKCPYEV....
A0A1D3SQZ2_PLAMA/913-963 .kendf------GELQEYVEAHDTKHYKLKADMKEGKKEFDESFEKSTYGFREKLP---vk..
A0A679KY73_PLAKH/682-735 ....lk--ENEAGDLVEYIETHTTKHYELKTDVKDGIKQYDEKLENASYGFREKLP---vkev
A0A1D3UB13_9APIC/69-121 .....i-NETIHGGYKEYEEKRESRRHTLTEDMSDFCGNCDEKYEGAKYGYRERCPYS-s...
#=GC seq_cons .....h......GGaKEYEE+YEoKHYKLKEsVpDGpK-CDEKYEAAsYGFREKCPYp.....
//
