#=GF ID EME1-MUS81_C
#=GF AC PF21292.1
#=GF DE EME1/MUS81, C-terminal
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF SE ECOD:EF17371
#=GF GA 27.40 27.40;
#=GF TC 27.40 27.40;
#=GF NC 27.30 27.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0198
#=GF RC Paper describing PDB structure 2ziu
#=GF RN [1]
#=GF RM 18413719
#=GF RT Crystal structure of the Mus81-Eme1 complex.
#=GF RA Chang JH, Kim JJ, Choi JM, Lee JH, Cho Y;
#=GF RL Genes Dev. 2008;22:1093-1106.
#=GF RC Paper describing PDB structure 4p0p
#=GF RN [2]
#=GF RM 24733841
#=GF RT Crystal structures of the structure-selective nuclease
#=GF RT Mus81-Eme1 bound to flap DNA substrates.
#=GF RA Gwon GH, Jo A, Baek K, Jin KS, Fu Y, Lee JB, Kim Y, Cho Y;
#=GF RL EMBO J. 2014;33:1061-1072.
#=GF RN [3]
#=GF RM 24692662
#=GF RT Human MUS81-EME2 can cleave a variety of DNA structures
#=GF RT including intact Holliday junction and nicked duplex.
#=GF RA Amangyeld T, Shin YK, Lee M, Kwon B, Seo YS;
#=GF RL Nucleic Acids Res. 2014;42:5846-5862.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC EME1 and MUS81 form a complex that acts as a structure-specific
#=GF CC endonuclease, playing an important role in rescuing stalled
#=GF CC replication forks and resolving the meiotic recombination
#=GF CC intermediates in eukaryotes [1,2]. Both consist of a central
#=GF CC nuclease domain (Pfam:PF02732), two repeats of the
#=GF CC helix-hairpin-helix (HhH) motif and a linker helix. This entry
#=GF CC represents the C-terminal HhH domain of EME1 and MUS81 [1,2].
#=GF CC Similar to EME1-MUS81, human MUS81-EME2 cleaves 3'-flaps,
#=GF CC replication forks and nicked Holliday junctions, and exhibits
#=GF CC limited endonuclease activity with intact Holliday junctions.
#=GF SQ 2506
#=GS A0A8I3NNG9_CANLF/490-546 AC A0A8I3NNG9.1
#=GS A0A453D8J3_AEGTS/641-713 AC A0A453D8J3.1
#=GS A0A8B8QHR0_9MYRT/431-498 AC A0A8B8QHR0.1
#=GS A0A444ZXN2_ARAHY/467-538 AC A0A444ZXN2.1
#=GS A0A482XCR8_LAOST/716-782 AC A0A482XCR8.1
#=GS A0A0C4F8G0_PUCT1/610-686 AC A0A0C4F8G0.1
#=GS A8PXW2_MALGO/236-303 AC A8PXW2.1
#=GS A0A6P4F883_DRORH/351-414 AC A0A6P4F883.1
#=GS T1KMB6_TETUR/432-499 AC T1KMB6.1
#=GS A0A3B6B6S1_WHEAT/246-318 AC A0A3B6B6S1.1
#=GS F1RU20_PIG/475-542 AC F1RU20.5
#=GS A0A3F3QF41_9EURO/548-616 AC A0A3F3QF41.1
#=GS EME1_PONAB/486-559 AC Q5NVA9.1
#=GS A0A8C9G3I3_PAVCR/273-346 AC A0A8C9G3I3.1
#=GS A0A7K5SQG3_9FRIN/70-143 AC A0A7K5SQG3.1
#=GS A0A2R6XQY4_MARPO/569-637 AC A0A2R6XQY4.1
#=GS A0A8U0T997_MUSPF/399-466 AC A0A8U0T997.1
#=GS U5H504_USTV1/733-805 AC U5H504.1
#=GS A0A5N6ILC6_9EURO/397-465 AC A0A5N6ILC6.1
#=GS A0A3P9B388_9CICH/461-534 AC A0A3P9B388.1
#=GS A0A7L0QFU1_SETKR/70-143 AC A0A7L0QFU1.1
#=GS R7UL09_CAPTE/19-92 AC R7UL09.1
#=GS A0A8E0QRK7_9EURO/579-647 AC A0A8E0QRK7.1
#=GS A0A7K9YLB1_9GALL/432-505 AC A0A7K9YLB1.1
#=GS A0A8B7UZS9_CASCN/309-380 AC A0A8B7UZS9.1
#=GS A0A2I4ETD4_JUGRE/479-557 AC A0A2I4ETD4.1
#=GS A0A1J1I4G6_9DIPT/239-308 AC A0A1J1I4G6.1
#=GS G1MG23_AILME/475-542 AC G1MG23.1
#=GS A0A851APX0_SULDA/70-143 AC A0A851APX0.1
#=GS A0A8M1GI64_URSMA/442-509 AC A0A8M1GI64.1
#=GS A0A6P5E0Y8_BOSIN/296-367 AC A0A6P5E0Y8.1
#=GS A0A8C4N6R9_EPTBU/138-211 AC A0A8C4N6R9.1
#=GS A0A8H6FI40_9LECA/534-602 AC A0A8H6FI40.1
#=GS A0A139WMN6_TRICA/346-391 AC A0A139WMN6.1
#=GS A0A673HIH3_9TELE/542-609 AC A0A673HIH3.1
#=GS T1GFA5_MEGSC/308-365 AC T1GFA5.1
#=GS U4U3N2_DENPD/410-483 AC U4U3N2.1
#=GS G1R1P5_NOMLE/474-541 AC G1R1P5.1
#=GS L5KGI6_PTEAL/200-271 AC L5KGI6.1
#=GS A0A8D0E4M5_SALMN/497-564 AC A0A8D0E4M5.1
#=GS A0A452ETQ1_CAPHI/488-531 AC A0A452ETQ1.1
#=GS H3B5I6_LATCH/492-565 AC H3B5I6.1
#=GS A0A7K5TQ69_CEPOR/70-143 AC A0A7K5TQ69.1
#=GS A0A2I4C9L1_9TELE/519-586 AC A0A2I4C9L1.1
#=GS A0A8C4D347_9TELE/299-368 AC A0A8C4D347.1
#=GS A0A3M6U4C9_POCDA/507-563 AC A0A3M6U4C9.1
#=GS A0A2K6TJD9_SAIBB/481-554 AC A0A2K6TJD9.1
#=GS S9YGY1_CAMFR/351-424 AC S9YGY1.1
#=GS A0A7K8UZ77_9STRI/199-270 AC A0A7K8UZ77.1
#=GS A0A7K9H7J6_9AVES/70-143 AC A0A7K9H7J6.1
#=GS A0A7K7EWC8_CHIMN/70-143 AC A0A7K7EWC8.1
#=GS A0A0D2X1T9_CAPO3/552-623 AC A0A0D2X1T9.1
#=GS T0NJG3_CAMFR/474-541 AC T0NJG3.1
#=GS A0A670XZ14_PSETE/248-321 AC A0A670XZ14.1
#=GS A0A3P8TR59_AMPPE/471-544 AC A0A3P8TR59.1
#=GS A0A1U7X3G6_NICSY/310-381 AC A0A1U7X3G6.1
#=GS A0A453D8A7_AEGTS/540-612 AC A0A453D8A7.1
#=GS A0A087GSK9_ARAAL/463-534 AC A0A087GSK9.1
#=GS A0A7L0NQP9_9PASS/70-143 AC A0A7L0NQP9.1
#=GS K7F6K3_PELSI/398-469 AC K7F6K3.1
#=GS A0A482V8G2_9CUCU/111-184 AC A0A482V8G2.1
#=GS A0A8C9LWA9_9PRIM/474-534 AC A0A8C9LWA9.1
#=GS A0A665VSG7_ECHNA/493-560 AC A0A665VSG7.1
#=GS H2TXA7_TAKRU/521-588 AC H2TXA7.3
#=GS A0A3Q2E6K7_CYPVA/374-447 AC A0A3Q2E6K7.1
#=GS A0A8C6YXU4_NOTPE/236-309 AC A0A8C6YXU4.1
#=GS A0A668SD54_OREAU/542-609 AC A0A668SD54.1
#=GS MUS81_ASHGO/530-598 AC Q754C9.1
#=GS EME1A_ARATH/445-516 AC Q84M98.1
#=GS A0A4Z2CIG2_9TELE/355-424 AC A0A4Z2CIG2.1
#=GS A0A164XP94_DAUCS/463-534 AC A0A164XP94.1
#=GS A0A6J1Y572_ACIJB/331-402 AC A0A6J1Y572.1
#=GS A0A1M8A8P8_MALS4/628-698 AC A0A1M8A8P8.1
#=GS A0A034WR16_BACDO/345-412 AC A0A034WR16.1
#=GS A0A7K5F687_PROAR/70-143 AC A0A7K5F687.1
#=GS A0A6J3HZQ1_SAPAP/481-554 AC A0A6J3HZQ1.1
#=GS A0A091I1R6_CALAN/302-375 AC A0A091I1R6.1
#=GS A0A1S4CTY3_TOBAC/544-615 AC A0A1S4CTY3.1
#=GS A0A1E4TVJ0_PACTA/495-563 AC A0A1E4TVJ0.1
#=GS A0A8J6KRK1_MICOH/480-553 AC A0A8J6KRK1.1
#=GS A0A8C0AZ69_9AVES/178-249 AC A0A8C0AZ69.1
#=GS A0A8C5XNF8_MICMU/473-540 AC A0A8C5XNF8.1
#=GS A0A6J3RQL2_TURTR/474-541 AC A0A6J3RQL2.1
#=GS A0A7K6LZA0_PANBI/70-143 AC A0A7K6LZA0.1
#=GS A0A7K8PB64_COCCO/70-143 AC A0A7K8PB64.1
#=GS A0A6I9IQX0_VICPA/489-562 AC A0A6I9IQX0.1
#=GS A0A8B8CRE4_CRAVI/487-560 AC A0A8B8CRE4.1
#=GS A0A8C9L8D1_PAVCR/391-462 AC A0A8C9L8D1.1
#=GS A0A6P6KLM5_CARAU/561-628 AC A0A6P6KLM5.1
#=GS D8LWQ8_BLAHO/233-301 AC D8LWQ8.1
#=GS A0A8D2JNL1_SCIVU/265-336 AC A0A8D2JNL1.1
#=GS A0A2K6TYR8_SAIBB/474-541 AC A0A2K6TYR8.1
#=GS A0A024WD72_PLAFA/253-284 AC A0A024WD72.1
#=GS A0A1Y1W793_9FUNG/678-744 AC A0A1Y1W793.1
#=GS A0A8J5BNP6_9DIPT/224-294 AC A0A8J5BNP6.1
#=GS A0A6V7H5R7_9HYME/391-423 AC A0A6V7H5R7.1
#=GS H0XLQ7_OTOGA/483-549 AC H0XLQ7.1
#=GS A0A8C0FKF9_BUBBB/235-308 AC A0A8C0FKF9.1
#=GS A0A8J6KRK2_MICOH/475-542 AC A0A8J6KRK2.1
#=GS A0A8C9E427_PHOSS/457-530 AC A0A8C9E427.1
#=GS A0A7K8AAK9_9CORV/70-143 AC A0A7K8AAK9.1
#=GS A0A7J8IYJ0_MOLMO/290-361 AC A0A7J8IYJ0.1
#=GS A0A3Q3FF40_9LABR/449-518 AC A0A3Q3FF40.1
#=GS A0A4Y7J5A8_PAPSO/490-563 AC A0A4Y7J5A8.1
#=GS A0A7M5VC03_9CNID/498-568 AC A0A7M5VC03.1
#=GS A0A6J1SB97_FRAOC/558-623 AC A0A6J1SB97.1
#=GS A0A448YK89_BRENA/499-574 AC A0A448YK89.1
#=GS A0A1A6HDU3_NEOLE/286-357 AC A0A1A6HDU3.1
#=GS A0A0D3DW29_BRAOL/447-518 AC A0A0D3DW29.1
#=GS A7TRE8_VANPO/550-616 AC A7TRE8.1
#=GS A0A8H6C426_CANAX/537-608 AC A0A8H6C426.1
#=GS MUS81_CANAL/537-608 AC Q59NG5.1
#=GS A0A6P6JED9_CARAU/309-378 AC A0A6P6JED9.1
#=GS A0A3P8ZRS5_ESOLU/362-431 AC A0A3P8ZRS5.2
#=GS A0A7K5GGK9_9AVES/70-143 AC A0A7K5GGK9.1
#=GS A0A7K5DB20_9TYRA/70-143 AC A0A7K5DB20.1
#=GS W5KUW1_ASTMX/501-568 AC W5KUW1.2
#=GS A0A8C3IGX4_CHRPI/520-587 AC A0A8C3IGX4.1
#=GS A0A835L7P0_SPOEX/526-592 AC A0A835L7P0.1
#=GS A0A8K0C8H2_9COLE/554-626 AC A0A8K0C8H2.1
#=GS A0A3Q1FEC6_9TELE/354-423 AC A0A3Q1FEC6.1
#=GS A0A550C8T9_9AGAR/539-602 AC A0A550C8T9.1
#=GS A0A0L8IAV2_OCTBM/139-206 AC A0A0L8IAV2.1
#=GS A0A7J6YK01_9COLE/411-482 AC A0A7J6YK01.1
#=GS H2ZQR2_CIOSA/28-100 AC H2ZQR2.1
#=GS A0A7K9WSN7_9PASS/70-143 AC A0A7K9WSN7.1
#=GS A0A8P0P8X1_CANLF/490-548 AC A0A8P0P8X1.1
#=GS A0A5N7CXV6_9EURO/568-636 AC A0A5N7CXV6.1
#=GS G3HBN8_CRIGR/290-361 AC G3HBN8.1
#=GS A0A1L9V8Y1_ASPGL/448-518 AC A0A1L9V8Y1.1
#=GS A0A8C7C8H2_NEOVI/257-328 AC A0A8C7C8H2.1
#=GS A0A0V1GR66_9BILA/365-436 AC A0A0V1GR66.1
#=GS A0A7K5IRV2_TOXRE/70-143 AC A0A7K5IRV2.1
#=GS A0A7L2JQR6_CINMU/70-143 AC A0A7L2JQR6.1
#=GS A0A6J3I9N6_SAPAP/481-548 AC A0A6J3I9N6.1
#=GS A0A834KD34_VESPE/528-592 AC A0A834KD34.1
#=GS A0A3Q1AMY9_AMPOC/471-544 AC A0A3Q1AMY9.1
#=GS V4SKL4_CITCL/465-536 AC V4SKL4.1
#=GS A0A852KII8_UROIN/70-143 AC A0A852KII8.1
#=GS A0A5E4A1R2_MARMO/376-443 AC A0A5E4A1R2.1
#=GS A0A6J2JXF2_BOMMA/209-278 AC A0A6J2JXF2.1
#=GS A0A8B6DNC2_MYTGA/687-754 AC A0A8B6DNC2.1
#=GS T1J8L5_STRMM/14-79 AC T1J8L5.1
#=GS A0A4Y2N148_ARAVE/312-385 AC A0A4Y2N148.1
#=GS A0A8C4BG32_9TELE/504-571 AC A0A8C4BG32.1
#=GS A0A2T7D0W8_9POAL/520-592 AC A0A2T7D0W8.1
#=GS A0A7L0PQN9_9AVES/201-272 AC A0A7L0PQN9.1
#=GS A0A3P9C0E4_9CICH/349-418 AC A0A3P9C0E4.1
#=GS A0A158NHB2_ATTCE/365-437 AC A0A158NHB2.1
#=GS A0A3P7GNT5_HYDTA/320-373 AC A0A3P7GNT5.1
#=GS A0A1X7VU46_AMPQE/366-439 AC A0A1X7VU46.1
#=GS A0A8H3FJJ7_9LECA/528-596 AC A0A8H3FJJ7.1
#=GS A0A814AFQ1_9BILA/391-458 AC A0A814AFQ1.1
#=GS E1B7C9_BOVIN/285-356 AC E1B7C9.1
#=GS A0A397HSQ6_9GLOM/536-604 AC A0A397HSQ6.1
#=GS A0A8D2EPG3_THEGE/474-541 AC A0A8D2EPG3.1
#=GS A0A5J5MU21_MUNRE/285-356 AC A0A5J5MU21.1
#=GS A0A3Q7PK53_CALUR/530-596 AC A0A3Q7PK53.1
#=GS A0A7K9X5F2_9GRUI/70-143 AC A0A7K9X5F2.1
#=GS A0A4W4H2C8_ELEEL/538-605 AC A0A4W4H2C8.1
#=GS A0A1D2MRA5_ORCCI/438-503 AC A0A1D2MRA5.1
#=GS A0A317UZX9_9EURO/588-657 AC A0A317UZX9.1
#=GS A0A8V5HFR8_MELUD/418-491 AC A0A8V5HFR8.1
#=GS A0A8J5DPV5_9DIPT/355-421 AC A0A8J5DPV5.1
#=GS A0A3Q1JNC9_ANATE/479-552 AC A0A3Q1JNC9.1
#=GS A0A8I5ZKR0_RAT/480-515 AC A0A8I5ZKR0.1
#=GS A0A6P6TMA4_COFAR/694-765 AC A0A6P6TMA4.1
#=GS A0A6J3Q0W9_TURTR/178-239 AC A0A6J3Q0W9.1
#=GS A0A8C5SFB1_LATLA/517-584 AC A0A8C5SFB1.1
#=GS A0A7K7GJI5_ERIRU/70-143 AC A0A7K7GJI5.1
#=GS A0A813TT35_9BILA/177-243 AC A0A813TT35.1
#=GS A0A0D1YX84_9EURO/569-637 AC A0A0D1YX84.1
#=GS A0A836JUJ6_9HYME/361-425 AC A0A836JUJ6.1
#=GS H2RHN9_PANTR/292-363 AC H2RHN9.2
#=GS A0A1U7RT11_ALLSI/217-290 AC A0A1U7RT11.2
#=GS A0A6J3K719_9HYME/528-593 AC A0A6J3K719.1
#=GS A0A0N0U2Z2_9HYME/1-63 AC A0A0N0U2Z2.1
#=GS A0A7L2Y056_9PASS/70-143 AC A0A7L2Y056.1
#=GS M3XIM6_LATCH/520-593 AC M3XIM6.1
#=GS A0A7K8K2K4_9GRUI/70-143 AC A0A7K8K2K4.1
#=GS A0A1U7UIK3_CARSF/286-357 AC A0A1U7UIK3.1
#=GS A0A4Z2DH68_SCHJA/724-791 AC A0A4Z2DH68.1
#=GS A0A2H3DRV9_ARMGA/437-508 AC A0A2H3DRV9.1
#=GS A0A8D0F8V9_STROC/464-537 AC A0A8D0F8V9.1
#=GS A0A445KQM9_GLYSO/427-498 AC A0A445KQM9.1
#=GS A0A151JRI3_9HYME/366-438 AC A0A151JRI3.1
#=GS A0A2I0WW31_9ASPA/514-586 AC A0A2I0WW31.1
#=GS G3Q4N8_GASAC/534-601 AC G3Q4N8.1
#=GS A0A7L4NAJ1_9AVES/70-143 AC A0A7L4NAJ1.1
#=GS A0A1X2H3Z1_SYNRA/708-775 AC A0A1X2H3Z1.1
#=GS G3VN31_SARHA/483-556 AC G3VN31.2
#=GS A0A2J7RPL4_9NEOP/262-335 AC A0A2J7RPL4.1
#=GS A0A0V0TX26_9BILA/391-462 AC A0A0V0TX26.1
#=GS A0A1S4H039_ANOGA/387-453 AC A0A1S4H039.1
#=GS A0A1V4KW68_PATFA/439-512 AC A0A1V4KW68.1
#=GS A0A7N2M013_QUELO/568-639 AC A0A7N2M013.1
#=GS A0A6P7ZDJ5_9AMPH/737-804 AC A0A6P7ZDJ5.1
#=GS A0A084VYF6_ANOSI/383-449 AC A0A084VYF6.1
#=GS A0A8V5HH25_MELUD/156-229 AC A0A8V5HH25.1
#=GS A0A6H5IAG1_9HYME/393-455 AC A0A6H5IAG1.1
#=GS A0A6J3H2C1_SAPAP/337-383 AC A0A6J3H2C1.1
#=GS A0A1A7ZD06_NOTFU/329-398 AC A0A1A7ZD06.1
#=GS A0A7L4HC93_PODST/317-387 AC A0A7L4HC93.1
#=GS A0A4U1FKW9_MONMO/489-562 AC A0A4U1FKW9.1
#=GS A0A7K7SIU2_9TYRA/70-143 AC A0A7K7SIU2.1
#=GS A0A376B5G3_9ASCO/624-692 AC A0A376B5G3.1
#=GS A0A2P8YPK1_BLAGE/441-506 AC A0A2P8YPK1.1
#=GS A0A7I8VPZ2_9ANNE/297-369 AC A0A7I8VPZ2.1
#=GS A0A3Q2VEJ2_HAPBU/543-610 AC A0A3Q2VEJ2.1
#=GS A0A8C9XNK2_SANLU/449-522 AC A0A8C9XNK2.1
#=GS I3KVR8_ORENI/195-264 AC I3KVR8.2
#=GS H6C6E7_EXODN/585-653 AC H6C6E7.1
#=GS A0A8C5NF71_9TELE/371-444 AC A0A8C5NF71.1
#=GS A0A024WUL0_PLAFA/253-284 AC A0A024WUL0.1
#=GS A0A5D2XK03_GOSMU/454-525 AC A0A5D2XK03.1
#=GS A0A093LUC9_EURHL/248-319 AC A0A093LUC9.1
#=GS A0A8J6K633_ELECQ/305-366 AC A0A8J6K633.1
#=GS A0A5E4EVF6_PRUDU/165-234 AC A0A5E4EVF6.1
#=GS A0A671G2P9_RHIFE/482-555 AC A0A671G2P9.1
#=GS A0A8B9U429_9AVES/271-344 AC A0A8B9U429.1
#=GS A0A8J2JSR1_9HEXA/518-585 AC A0A8J2JSR1.1
#=GS A0A2K6TYU7_SAIBB/492-559 AC A0A2K6TYU7.1
#=GS A0A8B7R0T2_HIPAR/484-557 AC A0A8B7R0T2.1
#=GS A0A6P6HC60_PUMCO/487-560 AC A0A6P6HC60.1
#=GS A0A6P7SEG8_OCTVU/406-479 AC A0A6P7SEG8.1
#=GS A0A7K6Z2F6_ALCTO/70-143 AC A0A7K6Z2F6.1
#=GS A0A8B7RSS4_HIPAR/308-379 AC A0A8B7RSS4.1
#=GS A0A7K7DL87_PHEME/70-143 AC A0A7K7DL87.1
#=GS Q7PRC7_ANOGA/228-301 AC Q7PRC7.4
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