#=GF ID Effector_1
#=GF AC PF04518.16
#=GF DE Effector from type III secretion system
#=GF PI DUF582;
#=GF AU Mifsud W;0000-0002-9805-6461
#=GF AU Eberhardt R;0000-0001-6152-1369
#=GF SE Pfam-B_2447 (release 7.5)
#=GF GA 23.80 23.80;
#=GF TC 23.80 23.90;
#=GF NC 23.10 23.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 19682078
#=GF RT Identification of Chlamydia trachomatis CT621, a protein
#=GF RT delivered through the type III secretion system to the host cell
#=GF RT cytoplasm and nucleus.
#=GF RA Hobolt-Pedersen AS, Christiansen G, Timmerman E, Gevaert K,
#=GF RA Birkelund S;
#=GF RL FEMS Immunol Med Microbiol. 2009;57:46-58.
#=GF RN [2]
#=GF RM 21078856
#=GF RT Identification of a family of effectors secreted by the type III
#=GF RT secretion system that are conserved in pathogenic Chlamydiae.
#=GF RA Muschiol S, Boncompain G, Vromman F, Dehoux P, Normark S,
#=GF RA Henriques-Normark B, Subtil A;
#=GF RL Infect Immun. 2011;79:571-580.
#=GF DR INTERPRO; IPR007606;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This is a family of effector proteins which are secreted by the
#=GF CC type III secretion system [1,2]. The precise function of this
#=GF CC family is unknown.
#=GF SQ 19
#=GS A0A656KDX7_CHLPS/37-152 AC A0A656KDX7.1
#=GS A0A0N4XZY2_NIPBR/14-100 AC A0A0N4XZY2.1
#=GS A0A655MX95_CHLTH/1-97 AC A0A655MX95.1
#=GS A0A656K7V5_CHLPS/33-389 AC A0A656K7V5.1
#=GS A0A3Q8XNH6_9HYPH/32-214 AC A0A3Q8XNH6.1
#=GS A0A656KDX3_CHLPS/26-387 AC A0A656KDX3.1
#=GS O84626_CHLTR/452-829 AC O84626.1
#=GS A0A655MWL2_CHLTH/1-110 AC A0A655MWL2.1
#=GS O84717_CHLTR/358-765 AC O84717.1
#=GS A0A656KCG8_CHLPS/1-54 AC A0A656KCG8.1
#=GS A0A384KD17_PLAKH/71-265 AC A0A384KD17.1
#=GS A0A5D4GNE1_9HYPH/32-214 AC A0A5D4GNE1.1
#=GS A0A655MYM4_CHLTH/477-873 AC A0A655MYM4.1
#=GS A0A3S0A7R9_9HYPH/33-212 AC A0A3S0A7R9.1
#=GS O84625_CHLTR/450-835 AC O84625.1
#=GS A0A655N042_CHLTH/1-168 AC A0A655N042.1
#=GS O84718_CHLTR/17-390 AC O84718.1
#=GS A0A656KD07_CHLPS/1-115 AC A0A656KD07.1
#=GS O84624_CHLTR/477-873 AC O84624.1
A0A656KDX7_CHLPS/37-152 ..........................................lpmst-----.....---............----------...---------FVTNLQT........DYQGvklfnns...ttnlnpefFLNSIEL..MTKSTTSVMTRSDYqRVVDAMNAGIKQ.IQVQINQWTqestklmAQKASMDPTQLNYFKS.......MSEGKDIFVKTAPIQMVYS---..------------------------------------------------------....---------------------------------------------------...----------------------------------------------------------------.......------------------...------------------------------------------------------------------..............................
A0A0N4XZY2_NIPBR/14-100 ..................................rqleadgrewakk-----.....---............----------...----------------........----..................-------..--------------.------------.---------.......----------------.......----------------------..------------------------------------------------------....-----NRVLSRYEKFLADKEKEQEKSQKDIKEAMAALTAFFDQLAEIQNDK...DITQNNAKELTRKLTG------------------------------------------------.......------------------...------------------------------------------------------------------sltrkqsqiasf..................
A0A655MX95_CHLTH/1-97 ..............................................m-----.....---............----------...----------------........----..................-------..--------------.------------.---------.......----------------.......----------------------..------------------------------------------------------....---------------------------------------------------...-------------------------------------------------DEAFTAKIGSKE---.......FDTWIQQLTTFESAVIEG...GRNGVMPGGEQQVLQSLESKQQDYTSFNQNQQLALQMESAAIQQEWTMVAAALALMNQIFAKLIRR..............................
A0A656K7V5_CHLPS/33-389 ..........................................ttmeg--IVT.....ANGqfkpgntingqeESYTIYSQQN...GSGVKINPQLLNR---........GNIG..................FLPQITG..AANRNAETTARAYF.QFKGLAGVQITQ.LQSKIEASK.......EQLKDYQSLKAGLYKD.......QLYAQSNELQAMALPSAVASVL..IDRYMPKEVGFLNGIYDQLYYSNLGSSVGNAMIDAISEYVNAATYFNFASYVGQqpavGEKGKDVFPGTADSARNKLETERQKAAAYLKSTQDAETVLEEQLKRVTEDP...KISNEQRTRIIDSLNNYRDNLNAISGSLVLLQNYLAPLSV--SDGD---------VAGTFKVTG......gEEQWQARLEILEDALVSG...LSGNAISGGMFPLQATIQSDQQSYADMGQNYQLELQMHLTSMQQEW--------------------..............................
A0A3Q8XNH6_9HYPH/32-214 ............................vpahaqffggrivydptny-----.....---............----------...----------------........----..................-------..--------------.------------.---------.......----------------.......----------------------..------------------------------------------------------....--------------------------SQNLLSAARALEQINNQVTSLANEA...QMLLYQARNLTSLPTSMISEIEGNFSEMKSLLGEAERLAYSVQDIESQFSSTYRDFAGDKT--GeqlvaaaRERWQQSLSAYEHSLKAG..aTAVGNIDGTQAQTRSLVGASQSAVGI----------------------------------------lqatqagnellavqasqiadltaml.....
A0A656KDX3_CHLPS/26-387 ..............................vspaevaadytkmneva-----.....---............SHLKIMQDLLk.eASELGLRREFVSSLNR........DFLD..................TGFEIAV..MQTVLTE---KENK.ELRKQANKIFQEhLERTSPQAL.......TTAPELAPVEGSI---.......--------VNKMPFQSAFAYIL..LDKYIPAQETALYALGRELNLSGYAQNLFSPLLEVIKTFNSAPIIYNLGSYISQ....-TSGTANFKFGYQMIVDRYEEERLQLRNDIKSAENAQALLKQISKNIQGND...TLTDDQKKQLQDIVSGYDSELVIMLTQMKNLMLNLNSLIF--MPGNNEYEASYKIMGSDFSII-.......------TLQDLEHKVVDGeidVATGTAKGGLLNFFNTCLADVQNYGDLAQTHQLMLELQMRAMQQEWSLVAASLKLMHNVYRTLIS-s.............................
O84626_CHLTR/452-829 ......................................qdilqvcsl----QgfvtlANG............DRYELFSYND...-SGEAVCDEIALGD--........GFHK..................VLGTMLA..VALSQAEVFKQECD.RFILQADSEKNM.IHKRMVQGE.......QKSLFLTKMQTELNAG.......KTIAQTKEVEASPLPSAVASVL..IDHYMPKEVEFLEKISSRLYYGNKGSDIGNTILDAISLYVNSATYFGFANYIGQppvvGKTRENIFAGSADNAKAKLDEEKKQVDVFLEITEAAKTTVTNQQSAVTNDD...KLSTEQKAKIKAELTQYTDMLNAISNSLTSLKTQLAPLSVSTVEGVD----------GVFEVKNgip.genGKNWRLVLQTLEDTVVSG...EVGSPTNIGMFQMQALVHLNQQAYADMGQNFQLELQMHLTSMQQEWMVVATSLQLLNQIYLGLARN..............................
A0A655MWL2_CHLTH/1-110 ..............................................m-----.....---............----------...----------------........----..................-------..--------------.------------.---------.......----------------.......----------------------..------------------------------------------------------....---------------------------------------------------...----------------------------------------GVRDGNQGGNDTGTDPKGTFHVFG......gQDQWQARLEILEDALVSG...LPSNIISGGLFPVQASVQSDQQAYADMGQNYQLEMQMHMTAMQQEWTVVATSLQILNQIYLGLTRK..............................
O84717_CHLTR/358-765 .........................kkdvfnnaqasftdytnflnqe-----.....---............--IQYWTPRE...TSSFNISNQALQTFKNkp....saDYNGvylfdnkgletnlfnptfFFDVVSL..MTADPTKTMSRQDYnKVITASESSIQK.INQAITAWElaiaecgTKKAKLEPSSLNYFNA.......MVEAKKTFVETSPIQMVYSSLM..LDKYLPNQQYILETLGSQMTFSNKAARYLNDIIAYAVSFQTADVYYSLGMYLRQ....--MNQQEFPEVISRANDTVKKEIDRSRADLFHCKKAIEKIKELVTSVNADT...ELTSSQRAELLETLASYAFEFENLYHNLSNVYVMVSKVQISGVSKPDEVDEAFTAKIGSKE---.......FDTWIQQLTTFESAVIEG...GRNGVMPGGEQQVLQSLESKQQDYTSFNQNQQLALQMESAAIQQEWTMVAAALALMNQIFAKLIRR..............................
A0A656KCG8_CHLPS/1-54 ..............................................l-----.....---............----------...----------------........----..................-------..--------------.------------.---------.......----------------.......----------------------..------------------------------------------------------....---------------------------------------------------...----------------------------------------------------------------.......------------------...-------------FTQIQSDQQNYTTQGQTQQLNLQNQMTNVQQEWTLVSTSMQVLNQILSKLV--ge............................
A0A384KD17_PLAKH/71-265 nqnsetiiqryrefiearrgegkgnvgcssrremydplgclseverk-----.....---............----------...----------------........----..................VESEVST..ETVTQMA-AERAFD.RMKDTASHRMNQ.AGADMVEKS.......TGKTSVEGMDQKYVIL.......KKQISKEFIHQVFLPHVESQIMyhLKTYTPNQIVNIFHIYSYLYYYDQKKEMVNALLDYLQ-----------------....---------------------------------------------------...----------------------------------------------------------------.......------------------...------------------------------------------------------------------yrldcfsvhdvllvleplyllnrtnnfniy
A0A5D4GNE1_9HYPH/32-214 ............................vpahaqffggrivydptny-----.....---............----------...----------------........----..................-------..--------------.------------.---------.......----------------.......----------------------..------------------------------------------------------....--------------------------SQNLLSAARALEQINNQVTSLANEA...QMLLYQARNLTSLPTSMISEIEGNFSEMKSLLGEAERLAYSVQDIESQFSSTYRDFAGDKT--GeqlvaaaRERWQQSLSAYEHSLKAG..aTAVGNIDGTQAQTRSLVGASQSAVGI----------------------------------------lqatqagnellavqasqiadltaml.....
A0A655MYM4_CHLTH/477-873 ..............................stisdentviqkvrnkw-----.....TEL............TKQKFFSSFN...-STMPSEEELKKNYITnknsvyqaNFGN..................FVDNVITrnLNLSDAVTKAQSMLtEFQGKATEYLSK.FQQEINELN.......RTYDTLDPAKASFNTStgstpslRAQAVDSWIDSTSLGSAFIHLI..LNTQIPKQENFLNPLIQEVNFNNVAANAVNDLLSITNNFSTSSVYYNLSSYLVE....SKEGENLFCGDFFEFMGALAKEHEYIVRDINSCYRAEAFGEALLARVEALAqghKVTDAQANSMRTQANLYLSFIRIIVEQLAVLDSLLRSLNYEVEKKDNNYDK------DKYKITG.......PTDWISTLASLEGYAANG...FDNASPSGGLGPMHTLVQTDQHDYLTQSQTQQLNLQNQMTNIQQEWTLVSTSMQVLNGILSHLA--ae............................
A0A3S0A7R9_9HYPH/33-212 ...............................haqffggrivydptny-----.....---............----------...----------------........----..................-------..--------------.------------.---------.......----------------.......----------------------..------------------------------------------------------....--------------------------SQNLLSAARALEQINNQVTSLANEA...QMLLNQARNLTSLPTSMISEIEGNFSEMKSLLGEAERLAYSVQDIESQFASTYRDFVGDKTAEQlv..aaaRERWQQSLSAYEHSLKAG..aTAVGNIDGTQAQTRSLVGASQSAVGIL---------------------------------------qatqagnellavqasqiadltaml......
O84625_CHLTR/450-835 ...............................................NKIVQ.....ENGkfkat..vdgieRQYTIFGPPEndtSSNKATLNLILLNF--........GSIG..................FLPNITL..AANNHAETSARAFF.KFRALAQVESTK.LDGTLQGSE.......NFLQKINQLRTDLFSY.......QLLAQSYEIRSLPLPSAVASVL..IDRYMPQEIDYLTQMKSDLYYSNFGSSVGNAMIEAIAQFVNGATYFNFASFAGQq.pmTAMAQDTFPGSKETAETKLALEKQQAKLYLQYATQALKVVQEQMERVQNDK...VITNEQRLRITDALKGYADNLNAISGSLVLLQVYLNPLSVGVRDGNQGGNDTGTDPKGTFHVFG......gQDQWQARLEILEDALVSG...LPSNIISGGLFPVQASVQSDQQAYADMGQNYQLEMQMHMTAMQQEWTVVATSLQILNQIYLGLTRK..............................
A0A655N042_CHLTH/1-168 ..............................................m-----.....---............----------...----------------........----..................-------..--------------.------------.---------.......----------------.......----------------------..------------------------------------------------------....----------------------------FLEITEAAKTTVTNQQSAVTNDD...KLSTEQKAKIKAELTQYTDMLNAINNSLTSLKTQLAPLSVSTVEGVD----------GVFEVKNgip.genGKNWRLVLQTLEDTVVSG...EVGSPTNIGMFQMQALVHLNQQAYADMGQNFQLELQMHLTSMQQEWMVVATSLQLLNQIYLGLARN..............................
O84718_CHLTR/17-390 .......................ietaaprerrvspaevaadytqlh-----.....EAA............TYLQVFQDLLn.dAHQLGLNKEFVESLRQ........DFLK..................TGSEMSL..MQALWTE-------.ESQREARKRERK.ELQQQLESKvlgpqalTTAEELHPVDDSI---.......--------VNKMPFQSAFAYIL..LDKYIPAQEEALYALARELSFSGYAQTLFSPVLELVKSFNNAPIVYNLGSYIGQ....-TAGTANFKYGYQMVLDRYETETGQLRKDIKNAENAKQQLAQIIKNIEANN...SLTTEHKTQLKDMANGYIQTLDVCISQMQELSTGLRGLSF--IPGRDEYSPAYEIMGSSFSVV-.......------TLQNLEGKVVDGeinISSGETKGGLLNFFTYFLADVQNFGDLAQTNQLMLELQMRAMHQQWSLVTASLKLLHNVYRTLAS-s.............................
A0A656KD07_CHLPS/1-115 .............................................ms-----.....---............----------...----------------........----..................-------..--------------.------------.---------.......----------------.......----------------------..------------------------------------------------------....---------------------------------------------------...--------------------------------IFLNNMQFQPVDNPNDIDKAFKILVNSKE---.......SEDWPRFLASFESFVIEG...GENGVVPGGEQQILQSLEAAQLNFTTFNQNQQLALQLESSAIQQEWTMVSAALALMNQIFAKLTRR..............................
O84624_CHLTR/477-873 ..............................stisdentviqkvrnkw-----.....TEL............TKQKFFSSFN...-STMPSEEELKKNYITnknsvyqaNFGN..................FVDNVITrnLNLSDAVTKAQSMLtEFQGKATEYLSK.FQQEINELN.......RTYDTLDPAKASFNTStgstpslRAQAVDSWIDSTSLGSAFIHLI..LNTQIPKQENFLNPLIQEVNFNNVAANAVNDLLSITNNFSTSSVYYNLSSYLVE....SKEGENLFCGDFFEFIGALAKEHEYIVRDINSCYRAEAFGEALLARVEALAqghKVTDAQANSMRTQANLYLSFIRIIVEQLAVLDSLLRSLNYEVEKKDNNYDK------DKYKITG.......PTDWISTLASLEGYAANG...FDNASPSGGLGPMHTLVQTDQHDYLTQSQTQQLNLQNQMTNIQQEWTLVSTSMQVLNGILSHLA--ae............................
#=GC seq_cons ..............................................h...............................................................................................................................................................................................................................................................................l..s.tA.t.htt..ttlts.t...ph...pttphht..s.h...h....tph..l...ht.lth...ph.p..t.......ushp...........ppW..pLpshEptlhsG...hssushsGG.h.h.s.ltusQpsass.sQs.QL.hp.p.tshQQEW.hVssuhtlhptlh.tLh................................
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