#=GF ID   Endonuc-BsobI
#=GF AC   PF09194.14
#=GF DE   Restriction endonuclease BsobI
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1dc1
#=GF GA   25.00 25.00;
#=GF TC   25.80 40.60;
#=GF NC   24.00 20.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF WK   Restriction_endonuclease_BsobI/AvaI
#=GF CL   CL0236
#=GF RN   [1]
#=GF RM   11250198
#=GF RT   Restriction enzyme BsoBI-DNA complex: a tunnel for recognition
#=GF RT   of degenerate DNA sequences and potential histidine catalysis. 
#=GF RA   van der Woerd MJ, Pelletier JJ, Xu S, Friedman AM; 
#=GF RL   Structure. 2001;9:133-144.
#=GF RN   [2]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR015277;
#=GF DR   SCOP; 1dc1; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Members of this family of prokaryotic restriction endonucleases
#=GF CC   recognise the double-stranded sequence CYCGRG (where Y = T/C,
#=GF CC   and R = A/G) and cleave after C-1. They catalyse the
#=GF CC   endonucleolytic cleavage of DNA to give specific double-stranded
#=GF CC   fragments with terminal 5'-phosphates [1].
#=GF SQ   49
#=GS A0A0M2UYI1_9BACT/6-322    AC A0A0M2UYI1.1
#=GS A0A1B8QBY4_9GAMM/1-294    AC A0A1B8QBY4.1
#=GS A0A1E5QFZ5_9CYAN/4-322    AC A0A1E5QFZ5.1
#=GS B1WTV7_CROS5/14-331       AC B1WTV7.1
#=GS A0A073CJS7_PLAAG/16-102   AC A0A073CJS7.1
#=GS A0A7V8VG93_9BACT/7-320    AC A0A7V8VG93.1
#=GS A0A1Z4NDY7_9CYAN/3-57     AC A0A1Z4NDY7.1
#=GS K9V2C5_9CYAN/4-322        AC K9V2C5.1
#=GS A0A1J1LGW1_9CYAN/7-125    AC A0A1J1LGW1.1
#=GS A0A2V1IQ78_9BACT/4-318    AC A0A2V1IQ78.1
#=GS B1XKE2_SYNP2/4-317        AC B1XKE2.1
#=GS I3IHR3_9BACT/5-294        AC I3IHR3.1
#=GS K9QXP1_NOSS7/4-322        AC K9QXP1.1
#=GS A0A1E5IGK7_ENDTX/1-64     AC A0A1E5IGK7.1
#=GS A0A085HHS8_9GAMM/1-291    AC A0A085HHS8.1
#=GS A0A1Q4R7Q0_9CYAN/3-316    AC A0A1Q4R7Q0.1
#=GS B7KA59_GLOC7/4-316        AC B7KA59.1
#=GS H1WIJ3_9CYAN/1-192        AC H1WIJ3.1
#=GS A0A1E5IGR8_ENDTX/1-126    AC A0A1E5IGR8.1
#=GS A0A1E5ILQ9_ENDTX/2-107    AC A0A1E5ILQ9.1
#=GS A0A0S4KNL7_9BACT/6-318    AC A0A0S4KNL7.1
#=GS A0A139X6D4_9CYAN/3-316    AC A0A139X6D4.1
#=GS K9T2W3_9CYAN/4-322        AC K9T2W3.1
#=GS B4VSI6_9CYAN/7-200        AC B4VSI6.1
#=GS A0A0M1JQW0_9CYAN/4-322    AC A0A0M1JQW0.1
#=GS K9PDH7_9CYAN/4-322        AC K9PDH7.1
#=GS A0A0B7I1H9_9FLAO/1-315    AC A0A0B7I1H9.1
#=GS R6SNX0_9BACE/3-318        AC R6SNX0.1
#=GS B0JY57_MICAN/14-332       AC B0JY57.1
#=GS A0A1V6M1C3_9BACT/4-76     AC A0A1V6M1C3.1
#=GS S0EWR4_CHTCT/6-318        AC S0EWR4.1
#=GS A0A1E5IGY8_ENDTX/1-102    AC A0A1E5IGY8.1
#=GS A0A1E5IGT3_ENDTX/1-102    AC A0A1E5IGT3.1
#=GS A0A072NL17_9DEIO/1-226    AC A0A072NL17.1
#=GS A0A6M4AZ26_9SPHN/21-312   AC A0A6M4AZ26.1
#=GS A0A1Z4S8V1_9NOSO/13-331   AC A0A1Z4S8V1.1
#=GS A0A2A6RMY7_9CHLR/6-318    AC A0A2A6RMY7.1
#=GS A0A0W0VJ20_9GAMM/3-319    AC A0A0W0VJ20.1
#=GS T2A1_NOSS1/3-315          AC P0A457.1
#=GS A0A081C633_9BACT/7-324    AC A0A081C633.1
#=GS A0A1U7IN62_9CYAN/4-316    AC A0A1U7IN62.1
#=GS H1WIJ2_9CYAN/4-132        AC H1WIJ2.1
#=GS A0A1I0EXG2_9FIRM/3-319    AC A0A1I0EXG2.1
#=GS A0A7X3SKT2_9FIRM/4-316    AC A0A7X3SKT2.1
#=GS I0I3G2_CALAS/6-318        AC I0I3G2.1
#=GS A0A1E5IGR0_ENDTX/1-126    AC A0A1E5IGR0.1
#=GS A0A7C8EHK3_9BACT/4-322    AC A0A7C8EHK3.1
#=GS A0A073CJS7_PLAAG/101-134  AC A0A073CJS7.1
#=GS A0A521FDH6_9BACL/6-321    AC A0A521FDH6.1
A0A0M2UYI1_9BACT/6-322               .....lpr----LKSSKDLETTYEAVRAGFVKQALEKNRQATQYVEEARALKVAA.S.TAKTPSDLLIIPDIQSALLTAAGVSEKANNHLLQRDKEEAIKGLID..NFLEPAGKKFVEELVFRFLLIRGDTLGGSMRNIGGILAQRKLTRSIISALKVAGKSYEWL...HSETNA..WVPMT.ESNAEIEIFVKGISWK.S.DS.QSRTALFNLFVPIV...GNNVDLCLFNRESKDFSNKKIARdi.liSPPSY.IALGELKGGIDPAGADEHWKTARTHLNRIQDSFKKMG.H.K.PNLFFIGAAIEAKMAVEIWNLLKKGILSNAANLTDDNQIASVSRWLCNL................
A0A1B8QBY4_9GAMM/1-294               .....mrt----IQNYSDLTSSQTDTVNGFIWQATEKLNRSNQYFANAHYFL--N.N.YIMPENNMMTDNIMRAFLLSACMLSNKSLGHLSITEQDAIIRNSID..FNSIYNNRIYREKLVYRYFLTCGDTLGGVMRNAIGQAAQNVLTSEIIDTLVGWGI-----...------..---TP.IEGRNRANKITRLSWE.Y.NN.LSKTIFFDQKPSFL...GNSVDFVVTQGPINTP---GSLH.....DINSI.NACGELKGGVDPAGADEHWKTARAALRRIEDMYTQNN.L.NpPELYFIGAAIENSMAREIFQDLQTGKLHGAANLMKPQQLREVVELII--r...............
A0A1E5QFZ5_9CYAN/4-322               ........YRNHLQSSDDLVTTYEATRAGFVALALEKNRRATPYVAEARALQEAA.S.QAKIPSDLLSIQGIGMGLLTAAGLSDKSLAHLMPEDKIDAINGLIR..NFLEPAGASFVEELVFRFLLTRGDTLGGSMRNAGGALAQRKLTRAILSTLIIAGQRYHWQ...HSKSKR..WIAMT.NDDTEIELSLRGLSWE.S.EL.GRRTLIYNLNIPLV...KSNVDLCLFNLAPEALPANKSSKik.piEVEPYtIALGELKGGIDPAGADEHWKTAQAALNRIRQAFANAG.H.S.PLTFFVGAAIEKRMAGEIWNQLESGMLSNAANLNEENQVASISRWLCSL................
B1WTV7_CROS5/14-331                  ........YKKHLSSWESLVTSYEQTRAGFISLALEKNRKATPFVEEAKALKSIA.S.TIESPIELINITQIKSALLTASGVSDKAKKYLTENDKNEAIKRLIE..NFLEPAAKDFVDELGYRFLLTRGDSLGGIIRNLGGVLGERKMTRMLIATLSIQGISYCYL...HSKSKE..WIVGS.QDDADVEIFLKGLSWN.K.SN.QARTLIYNLTVPIV...KKNVDLCLLDAKPEQFMRRNNKNsc.hyFPSNY.IALEELKGGIDPAGADEHWKTANSALNRIKKAFLSND.L.H.PKTFFIGAAIEKAMAKEIFNQLDAKHLSNAANLTDDNQLISLCEWLINL................
A0A073CJS7_PLAAG/16-102              ........YLQHLTSSDDLITDYQATRSGFVILALEKNRRATPFIEQARTLKLFA.S.QAKMPADLVNITDIQPALLTAAGLSEKAIKYLEIQDKIE-------..------------------------------------------------------------...------..-----.----------------.-.--.--------------...-----------------------.....-----.-------------------------------------.-.-.-------------------------------------------------................
A0A7V8VG93_9BACT/7-320               ........YRNHLHSSDDLVTTYAATRAGFVAQALEKNRRAVPYIAEARALQEAA.S.QAQTPVDLLHIPGIEAGLLAAAGLSEKALVHLQEEDKRQAIENLIQ..NFLEPAGEKFVEELVFRFLLTRGDKLGGSMRNIGGILAQRKLTRAVLSTLRIAGIPYRWQ...HTKTRQ..WVDMT.DDDSEIEFSLRGLSWK.N.AD.SSRTLIYNLTVPLV..yNSNVDICLFNLNPDELVSTQYTS.....-ATSY.IALGELKGGIDPAGADEHWKTARTALDRIRQAFADHA.H.S.PYLFFIGAAIEKRMATEIWDQLERGVLTNAANLNDDHQITSISRWLCNL................
A0A1Z4NDY7_9CYAN/3-57                gksriltl-----------------------------------------------.-.----------------------------------------------..------------------------------------------------------------...------..-----.----------------.-.--.--------------...-----------------------.....-----.-------------------------------------.-.-.--YFFVGSAIAKRMASEIWHQLEDQTLSNAANPTQDRQVASISRWLCSL................
K9V2C5_9CYAN/4-322                   ........YRNHLQSSDDLVTTYEATRAGFVALSLEKNRRANPYIAEARALQAAV.N.QAKSPADLLKIQGIEMGLLTAAGLSDKSLAHLAPEDKIDAINGLIK..NFLEPEGANFVEELVFRFLLTRGDTLGGSMRNVGGALAQRKLTRAILSTLTIAGQKYHWQ...HSKTKK..WIAMT.NDDAEIELCLRGLSWK.S.DF.GRRTLIYNLNIPLV...KSNVDICLFNLAPEALPANKSSKie.pvEVEPFtIALGELKGGVDPAGADEHWKTAQAALNRIRQAFADAG.H.S.PLTFFVGAAIERRMSGEIWQQLESGMLSNAANLNEENQVASISRWLCSL................
A0A1J1LGW1_9CYAN/7-125               ........YLQHLTRSEDLITEYQATRSGFVALALEKNRRATPFIEQARTLKLFA.S.QATIPTDLLAITDIQPALLTAAGLSDKSIKYLEIQDKIDAIQGLIK..NFLEPAGANFIEELVFRFLLT---------------------------------------...------..-----.----------------.-.--.--------------...-----------------------.....-----.-------------------------------------.-.-.-------------------------------------------------gleq............
A0A2V1IQ78_9BACT/4-318               .....lli----IRSAQELITSRTQTRSGFIEAALAKNKKGRPYIEQARTLRAYA.L.AAENPQALLGIDAIRPALLTASGLSDKAFKYFTEADKTEAIRALIK..NFLEPAGDEFAEELTYRFLLIKGDSLGGSMRNYVGELAQMKLVRKLLSLLAIREIPYYVLskqQKKNNG..WTSGSyEADFTAASEIAAIQWS.H.DG.KNRLLFFNTKIPLV...NNNVDICLFDGDCLSFDFGRIVN.....HPQKA.LMFGELKGGIDPAGADEHWKTGNSALARIRSAFR--P.T.P.VCTSFIAAAIEAKMATEIWDQLSDSTLSFAANLTDDGQLTSYCAWTLSL................
B1XKE2_SYNP2/4-317                   ......nn--QFVNNSSDLVTTKDARRSGFLEYALRRNKESIPFIDKAKALQVSL.QkNTKCAEDILKLYDIRETLIEAAGVSVKAKAHLDDMDKNEILAGFVK..EVLAPCGKKYIDEIVYRYLLTLGDALGGKMRNIVGSIAEEKFVRFIVAQLQVHDIEFELF...PK-RSQ..WISNK.NYRAEMAARTKALRWK.N.KT.TYRSLIFNINVPQV...KKNIDIVLLNDKIEGVTSSILANi..lnDKNKY.LAIGELKGGIDPAGADEHWKTANTALSRVRDSFK---.N.K.IHLFFIGAAIETSMSAEIYEQCQTGELSNAANLTVDNQLSALCEWLIT-q...............
I3IHR3_9BACT/5-294                   .....nlp---HVKSSKDLETTYEAVRAGFVAQALEKNRQATPYVEEARALKVAA.S.TAKTPSDLLNIPDIQSALLTAAGVSDKANNHLLSKDKEEAIKGLID..NFLEPAGKKFVEELVFRFLLIRGDTLDGSMRNIGGVLAQRKLTRSIISALKIAGKSYELL...HSETNT..WIPMS.ENDAEIEIFVKGISWK.K.DN.ESRTALFNLFVPIV...GNNIDLCLFNCAPKNFSNKKIGKdt.tnSPHAY.IALGELKGGIDPAGADEHWKTAWTALSRIQDAFAKSR.H.K.PYLFFIGAAIESKMATEIW------------------------------yl..............
K9QXP1_NOSS7/4-322                   .......h-RHHLQSSDDLVTTYEATRAGFIALALEKNRRATPYVAEARILQEAA.S.QAEKPADLLNVKGIEMGLLTAAGLSEKSLAHLMAEDKIEAINGLIR..NFLEPAGTNFVEELVFRFLLTRGDTLGGSMRNIGGALAQRKLTRAILSTLTIAGQKYQWQ...HSKTKK..WIAMT.NDDTDIELSLRGITWE.S.EF.GNRTLIYNLTVPLV...KSNVDLCLFNLAPKELVANQSSAidpsvVAPYA.IALGELKGGIDPAGADEHWKTAQAALNRIREAFSRVG.Y.S.PLTFFVGSAIAKRMAGEIWSQLENGTLSNAANLNEEHQVASISRWLYG-l...............
A0A1E5IGK7_ENDTX/1-64                ....mlln-----------------------------------------------.-.-AKIAESLLKISEIRTALLSASGLSD----YFTEKDKNKVTLSLIK..KFLEPAGKYFADDAVYRYL-----------------------------------------...------..-----.----------------.-.--.--------------...-----------------------.....-----.-------------------------------------.-.-.-------------------------------------------------................
A0A085HHS8_9GAMM/1-291               .....mls----VTSPNDLVTTKEDRVQGFSWQAIEKVNRAHTFIECAKYFREHC.H.TIKSVECIRNDLMLTEYIIASCMLSRKSLNHLPINIQNEIIESLV-..DFSKLTDSQYLLELERRYFLTCGDSLGGTMRNVVGQHAQEILTESIFNKLVLYKK-----...------..---NP.ERVRNKAGKTTQIIWE.-.--.-DRRVFFDQKPRFI...NNSIDIIVVRGKSA--ISG-LLE.....APEDY.VCCGELKGGIDPAGADEHWKTAKTALQRISDVFDRIN.IpK.PNLVFLGAAIEMAMANEIFFLLQKNWLAGAANITNAPQLNEVIDII---ik..............
A0A1Q4R7Q0_9CYAN/3-316               ......nn--QFVSNSDDLVTTRDARRSGFLEYALRRNKESLPFIDKAKALRVSLeN.ETKCAEDILQLADLRDTLIEAAGVSVKAKAHLDDTDKTEILAGFVK..EVLAPCGNKYIDELIYRYLLTLGDALGGRMRNIVGSIAEEKFVRFIIAQLRIHNIEFELF...PKR-SK..WISST.DYVAGMAARTKALRWT.K.NT.SHRSMIFNINVPQV...KKNIDIVLLDDKIDGVTSSILANt..lnDAQNY.LAIGELKGGIDPAGADEHWKTANTALGRVRDSFK---.T.K.VQLFFIGAAIENSMSSEIYGQCQKGELSNAANLTVDNQLSALCEWLIT-q...............
B7KA59_GLOC7/4-316                   ........YHNHLQSSDNLITTPEAARAGFVTLALEKNRRATPYIVEARALQTAA.S.NAKRPAELLEIKEIEKGLLTAAGLSDKSLKHLNWEDKVEAINGLIR..NFLEPAGEKFIEELVFRFLLTRGDTLGGSMRNVGGALAQRKLTRAILSTLTIAGISYHWL...HLKTKK..WAAMT.NDDSEIELSLRGIYWE.S.DR.GSRTLIYNLNVPIS...NSNVDMCLFNLTPTELLNSKYTI.....-VESY.IALGELKGGIDPAGADEPWKTARTALDRIREAFSTLG.H.S.PHTFFVGAAIERKMAEEIWSQLYNGTLSNAANLNQENQVASISLWLCNL................
H1WIJ3_9CYAN/1-192                   ........-----------------------------------------------.-.----------------------------------------------..-----------------------------MRNIGGVLAQRKLTRAILATLSIAGTKYSWQ...DSRSKK..WLYMT.NNDTEIELYLRGISWE.N.KL.GKRTLIYNLTVPII...NSNVDLCLFNMASTELVINKSTE....iNLQSI.LALGELKGGIDPAGADEHWKTAQAALNRMRQALYQVG.Y.S.PYIFFVGAAIATRMAAEIWEQLENGTLHNAANLNQENQVASISRWLCDL................
A0A1E5IGR8_ENDTX/1-126               .......m-----------------------------------------------.-.----------------------------------------------..-----------------YFLNKGDSPDGSMCNIAGILAQQKLIRTLLSNLSIMGIDYQWF...SSKTEN..WENKH.ADDFAIEENLKALSWI.SsKG.KSRVVAFNLNIPVV...RNNADICLFKSAAYLYKEGNIA-.....-----.-------------------------------------.-.-.-------------------------------------------------ddlknrkaalippel.
A0A1E5ILQ9_ENDTX/2-107               ....flna-----------------------------------------------.-.--KIAKSLLKISEIGTALLSVSGLSD----YFTEKDKNKVTLSLIK..KFLEPAGKYFADDAVYRYLLNKCDSLCGSMRNIVETLTRQKLIRTLLFQL----------...------..-----.----------------.-.--.--------------...-----------------------.....-----.-------------------------------------.-.-.-------------------------------------------------vdnwvltidgsa....
A0A0S4KNL7_9BACT/6-318               ........YREHLQSSSDLVTTYEATRAGFVTLALEKNRRATPHVAEARALQEAA.S.KARTPADLLAIKGIESGLLTAAGLSDKSLIHLLPDDKAEAINGLIK..NFLEPAGTKFVEELVFRFLLTRGDALGGSMRNIGGALAQRKLTRAIISTLTIAGIRYKWQ...HSKTKK..WADMT.DDDSEIELSLRGLSWE.S.GG.KSRTLIYNLTVPLV...KNNVDMCLFNLNPEELEATAYKS.....-AKSY.IALGELKGGIDPAGADEHWKTARAALDRIREAFSKAR.H.S.PRTFFVGAAVEKKMADEIWGQLKKGLLTNAANLNEPNQIASISRWLCTL................
A0A139X6D4_9CYAN/3-316               ........YYNHLHSSNDLVTTYEEVRAGFVALALERNRKATPFLEQARSLKIRT.H.QVKKPQDLLQMQDIRPALLAAAGISDKAAGYLQEQDKIDAIEGLIK..NFLEPVGEEFLEELVYRFLLTRGDTLGGMMRNIGGVLAERKFTRAVISALRLSAISYKWL...DKESKS..WLDQP.EEDTDIELRVKGLSWVpE.NK.EHRTLMYNIVVPIV...RKNIDICLFNCNPIQVNTSLLKN.....-PNAY.IALGELKGGIDPAGADEHWKTANSALERIRSSFKKHS.L.N.PCTFFVGAAIENSMAEEIWHQLNSGKLSNAANLTYADQVASLCAWLITL................
K9T2W3_9CYAN/4-322                   ........YLNHLQSSDDLVTTYEATRAGFVALALEKNRRATPYVAEARALQAAA.N.QVRNPADLLNVQGIEMGLLTAAGLSDKSLAHLTAEDKIDAINGLIK..NFLEPAGANFVEELVFRFLLTRGDTLGGSMRNVGGALAQRKLTRAILSTLTIAGQSYHWQ...HSKTKK..WIAMT.NDDAEIELSLRGLSWE.S.DL.GRRTLIYNLNIPLV...KSNVDLCLFNLAPEALPANKSSKie.pvEVEPYtIALGELKGGIDPAGADEHWKTAQAALNRIRQAFADAG.H.S.PLTFFVGAAIERRMAGEIWEQLQSGMLSNAANLNEENQVASISRWLCSL................
B4VSI6_9CYAN/7-200                   ........YYQHLNASNDLVTPYAAVRAGFVALALEKNRRATPFVEQARVLKAAA.S.RIKTPMELVDLEDIQPALLTAAGVSDKAARYLDIHDKIAAIRGLIE..NFLEPAGAKFIEELVFRFLLIRGDTLGGSMRNVGGVLAQRKLTRMLLSTLTVAGKSYQWL...HSSMNR..WASMT.DEDSDIELHLKGLSWK.S.NE.QNS-----------...-----------------------.....-----.-------------------------------------.-.-.-------------------------------------------------sfnttah.........
A0A0M1JQW0_9CYAN/4-322               ........YLNHLKSSDDLVTTYEATRAGFVALALERNRQAAPYIAEAKALQAAA.S.QAVSAADLLKIKDIEVGLLTAAGLSQKSLNYLTPEDKIDAINGLIQ..NFLEPAAANFVEELVFRFLLTRGDTLGGSMRNIGGALAQRKLTRAILSTLKIAGRQYSWQ...DSRTKQ..WIAMT.NDDIEIELSLRGINWQ.S.EG.ENRTLIYNLKVPLV...RSNVDLCLFNLPPTELVVNKSSKiqpseTAPSI.IALGELKGGIDPAGADEHWKTAQAALNRIREAFSKVG.Y.F.PNTFFVGSAVAKRMADEIWHQLEEGTLTNAANLNQENQVASIARWLCNL................
K9PDH7_9CYAN/4-322                   ........YQNHLQSIDDLITTYEAIRAGFVALALEKNRRATPFVAEARALKEAA.S.QAESPIELLKIKGIEMGLLTAAGLSDKSLAHLMSEDKVEAVNGLIK..NFLEPAGANFPEELVFRFLLTRGDTLGGSMRNIGGVLAQRKLTRAILSTLTIAGTKYHWQ...HSKSKK..WIAMT.NNDSEIELSLRGISWE.S.EI.GNRTLIYNLTVPLV...RSNVDLCLFNLAPAELAANKSSTiepsvVAPYV.IALGELKGGIDPAGADEHWKTAQAALNRIREAFSRVG.H.S.PLTFFVGSAIARRMAGEIWNQLENGTLSNAANLNQEKQVASISRWLCSL................
A0A0B7I1H9_9FLAO/1-315               ....mnhv----IIKSEDLVTSREQTRAGFIAFALEKNRRSTPIIESAKSLKILA.S.KAKTAKDLLNISEIKPALLTAAGLSDKALNYFNEGDKEKAILGLIE..NFLEPVGTYFVDEVVYRYLLIRGDSLGGSMRNIVGALAQQKLVRALLSNLSVSNTNYQWL...NNKSKK..WENKP.TNDFSIEEQLKALSWK.N.STgANRVLAFNLNIPIV...KNNIDICLFNADTEIYANGEIVK.....TPHRI.VMLGELKGGIDPAGADEHWKTGNTALNRIRESFAKQN.L.K.IETSFVAAAIEKKMATEIFTQLQNKILSNAANLTIDKQLVGYCDWILKL................
R6SNX0_9BACE/3-318                   ......ee--LYIKCAEELVTSHEQTRAGFIEAALAKNYKAKPYIEQAKTLKSLA.S.CVSTPAELLNIPEIRNCLLTASGLSDKSLKYFTEEDKDEAIKKLIS..EFLEPTGATFVDELVYRFLLIKGDSLGGSMRNYVGLIAQMKLIRKLLSLLSMQKISFMVLfknDKKENK..WQSLDyEHIFDKADEVAAIQWN.N.KQ.GSRILFFNATIPLV...KNNIDICLYQGGIEDFDSGNIVK.....KDDKA.ILLGELKGGIDPAGADEHWKTGSSALERIREAFA--G.H.S.IKTSFIAAAIEKKMATEIYTQLQDGTLQNAANLTVDGQLTAYCNWMINL................
B0JY57_MICAN/14-332                  ........YLLHLNQSCDLETTYEAIRSGFIALALEKNQRATPLIAEARTLKIIA.Q.TVNNPRDLLNIPDIQAALLTASGISDKAKNYLHSQDKVEAIQELIV..NFLEPAGTNFVEELVYRFLLIRGDTLGGIMRNAGGSLAQSKFTRSLLATLRVAGIAYDWL...NSSNNQ..WREAE.EMTPNLEILVRGVSWL.N.NS.QPRTIIYNVNVPIV..nNNNIDLCLLKCDSTQLANQKIKKqt.lqSADLY.IALGELKGGIDPAGADEHWKTARTALQRIDDAFRKIS.K.H.PYTFFIGAAIETKMAREIYQQLETKKLTNAANLTNDNQLVSIMRWLCHL................
A0A1V6M1C3_9BACT/4-76                ....wfse-----------------------------------------------.-.----------------------------------------------..--------------------------GGSIRNIGGVLAQRKLTRSIISALRVAGKSYEWL...HSETNT..WIPMS.EYDAGIGIFCKRIPLE.K.RQ.RK------------...-----------------------.....-----.-------------------------------------.-.-.-------------------------------------------------qyc.............
S0EWR4_CHTCT/6-318                   ........YHDHLESSEDLVTTYEATRTGFVALALEKNRRATPFVVEARALQEAA.S.KAKTPIDLLNINGIETGLLTAAGLSDKALVHLQSEDKIEAIKSLIK..NFLEPAGEKFVEELVYRFLLTRGDALGGSMRNIGGALAQRKITRAIVSTLRIAGIEYRWQ...HLMTRQ..WIDVS.GDDAEIELSLRGLSWR.I.QG.KHRTLIYNLTVPLV...KSNVDMCLFSLDPQELQATEFKI.....-PESY.FALGELKGGIDPAGADEHWKTARAAIDRIRQAFSKAG.Y.S.PHTFFIGAAIERRMADEIWNQLETGLLSNAANLNNHRQVASISRWLCGL................
A0A1E5IGY8_ENDTX/1-102               ......mn----IKIPEGLVTSREQTRTGFILFALEKNRRSPPVIESTKSFKILL.L.NAKAAKSLLKISEIRNALLTVSGLSDKALNYF----KDKAVLSLIK..KFLEPCRQVF--------------------------------------------------...------..-----.----------------.-.--.--------------...-----------------------.....-----.-------------------------------------.-.-.-------------------------------------------------crrs............
A0A1E5IGT3_ENDTX/1-102               ......mn----IKIPEGLVTFREQTRTGFILFALEKNRRSTPVIESTKSFKILL.L.NAKAAKSLLKISEIRNALLTVSGLSDKALNYF----KDKAVLSLIK..KFLEPCRQVF--------------------------------------------------...------..-----.----------------.-.--.--------------...-----------------------.....-----.-------------------------------------.-.-.-------------------------------------------------crrs............
A0A072NL17_9DEIO/1-226               ....mall-----------------------------------------------.-.-----------------------------------------REFIE..ATLLPAGSRFREEVVYRYLLMQGDAFGGSMRNLIGARAKRRLAEYVMAAVDLAGHRVAVQ...LAGRQH..FV-PY.DPQAMTAHEVRALAWA.ApDG.SPRLLAYDRKAPVVgqrGNNLDVLLLRSTPAALAAALHD-.....-PERY.LACGELKGGIDPAGADEHWKTARAALDRVAERLP---.-.Q.VPTFFVGAAIEPSMAAELAARLAAGTLSRAANLGRPQQVAALANWLVQL................
A0A6M4AZ26_9SPHN/21-312              .vqtvpnp--------QSLVTTRRDTVEGFRWQAQEKGRRANEFHAIADHFSRFA.N.RINSVADIEADQRLYQFALGACALSAKGSRQLGPALCSQIISATIElpRLKE---PEYLAELERRYLLTCGDALGGSMRNVIGQRAQNELSDHICSYLERAQIR----...------..WHAD-.---RNGNGKITSIMWE.-.--.-ARTLIFDRKPKFI...NKNIDFILLNSGR--FDPSVLEQ.....-PRSI.LACGELKGGIDPAGADEHWKTARSALERVRQAFAERKcA.A.PALFFVGAAIEQSMADEIYGQLQDGSLAAAANLHNKMQVNELTQVLVG-l...............
A0A1Z4S8V1_9NOSO/13-331              ........YRNHLKSIDDLVTTYEATRAGFVALALEKNRRATPYIAEARALQEAA.G.EAENAADLLKVKGIEMGLLTAAGLSDKSLAHLMPEDKIEAINGLIK..NFLEPAGANFVEELVFRFLLTRGDTLGGSMRNVGGALAQRKLTRAILSTLTIAGNKYHWQ...HSKTKK..WIAMT.NNDSEIELSLRGISWE.S.EI.GNRTLIYNLTVPLV...RSNVDLCLFNLAPSELVANKSSAiepsvVAPYV.IALGELKGGIDPAGADEHWKTAQAALNRIREAFAKVG.H.S.PLTFFVGSAIAKRMAGEIWNQLENGTLSNAANLNQENQVASISRWLCKL................
A0A2A6RMY7_9CHLR/6-318               ........YLEHLRSEEQLVTSYAARRAGFVALALEKNRKATPYVQEAKALYVAA.S.KATTPTDLLRIPDIQAGLLTAAGLSDKALNHLQPEDKLEAVQGLIK..NFLEPAGDKFIEELIYRFLLIRGDTLGGSMRNVGGVLAQRKLTRALIASLNISGLSYRWL...EHRSKR..WYDKT.QDDVDVEFSARGLAWS.H.SQ.GQRTLIYNLTIPFI...RNNVDLCLFNDNPAQIMMTEYRH.....-PDTY.LALGELKGGIDPAGADEHWKTARTALDRIRTGFKDVN.L.K.PHTFFVGAAIERKMAGEIWAQLQVGLLSNAANLNEYDQVASISRWLCRL................
A0A0W0VJ20_9GAMM/3-319               .......f-TNHLNNFESLITPYSEIRAGFIAMALEKNKRATPFIEEAKALKVIA.S.QARFPKQLIDFENIQESLLTASGISDKARNHLTPDDKKLAILGLIE..NFLDPAGTSFVDELVYRFLLTRGDSLGGAMRNLAGTLGEWKFTRILLSTLSIYHKEFHYL...DLKTRQ..WIKSS.N-QPELERSIKGVFWE.T.DG.NPRTLIYNINVPIV...KKNVDLCLLNSSYQDVSFHKNKVss.hqQALTY.IALGEIKGGIDPAGADEHWKTANSALNRIRNSFSLSS.C.N.PKTFFIGAAIEKAMAQEIFHQLNEGIISNAANLTNEQQMVSICSWLVEL................
T2A1_NOSS1/3-315                     ........YQYHIQSNDDLVTPYQEVRAGFVALALERNRKATPFVEQARALKIRV.S.QIERPQDLLQMRDIRPTLLAASGVSDKAAGHLQEQDKVDAIEGLIQ..NFLEPAGENFVEELVYRFLLTRGDTLGGSMRNVGGILAERKFARYIISALTLSNTSYKWL...DKNSKT..WLNQP.DDDTDIELRLRGLSWN.L.EG.RNRTFIYNVNVPIV...RKNIDICLFDCRQNEIEKNIISN.....-PNIY.IALGELKGGIDPAGADEHWKTANSALARIRTAFDRHS.L.K.PYTFFVGSAIEKSMAEEIWHQLNSGILTNAANLTQPDQVASLCAWFIQL................
A0A081C633_9BACT/7-324               ........YTSHISSSDSLVTPYAAIRAGFVALALEKNRKATPFVAEARALQVSA.S.QANTPQELLEMESIKASLLTAAGVSDKAANHLTEADQKETIQGLID..NFLEPAGKEFVEELVYRFLLTRGDTLGGSMRNLAGALGERKLTRAIISTLSIAGRPYSWL...HSKTMQ..WLPMS.DDDTDIEFNLRGLQWS.Y.QH.QPRTFVYNLTVPLV...KKNVDLCLFHCEPEDMVFGKQKDsi.hyKPEKY.LALGELKGGIDPAGADEHWKTANSALQRIRTGFAKKS.L.T.PYTFFIGAAIEKSMAKEIFHQLENRTLTNAANLTNEEQLISICKWLIQL................
A0A1U7IN62_9CYAN/4-316               ........YRQHLESSEDLITTYQATRAGFVALALEKNRRATPYIAEARVLQEAA.S.QAENPADLLNIKGIEMGLLTASGLSDKSQKYLMPEDKLEAINGLIK..NFLEPAGEKFVEELIFRFLLTRGDTLGGSMRNVGGALAQRKLTRAILSTLTIAGISYHWQ...HLKSQK..WVAMT.NDDSEIELSLRGISWE.G.ES.GIRTLIYNLTVPLF...RSNVDMCLFNLAPSDLVASKFNL.....-VESY.LALGELKGGIDPAGADEHWKTARAALDRVREAFSRVD.Y.S.PCTFFIGAAIERRMAGEIWHQLENGILTNAANLNQENQVASISRWLCTL................
H1WIJ2_9CYAN/4-132                   ........YLNHLKSSNDLVTTYEAVRAGFVALALERNRRATPYVAEAQALQEAA.S.QATYPADLLNIRGIDIGLLTAAGLSQKSLKYLMPEDKIDAINGLIK..NFLEPAGANFVEELVFRFLLTRGDSLGGQC------------------------------...------..-----.----------------.-.--.--------------...-----------------------.....-----.-------------------------------------.-.-.-------------------------------------------------vtlge...........
A0A1I0EXG2_9FIRM/3-319               .......f-NSFITSAESLVTTHEQTRAGFLSIALEKNKVGDPYVKNALAFKAMV.S.HTTSPDDFWCMPNIRPFLLTAAGLSDKSMNYLTEDDQTAAIKELIE..KFLKPAGADYIDEATYRYLLIKGDAVGGTMRNKIGALGQEKLIRAIFSSMDVQGIDCYWLs.gDDKTFT..WKRKA.VGQADIESQVKALHWK.N.TN.GDRILAFNMTIPTV...KKNVDICLYKSNTTEYDKGKIVR.....RPERA.IMLGELKGGIDPAGADEHWKTGNTALIRIRDSFSAAG.YpG.IKTSFIGAAIANAMAVEIYDQLQDEVLSNAANLTDVNQLVEYCNWIIQL................
A0A7X3SKT2_9FIRM/4-316               ........YNRFITSAESLVTTHEETRAGFLSIALEKNRVGDPFVKNALAFKAMA.A.HTCRAEDLLNLPEVRPFLITAAGLSDKSLSYLDEDDQTMAIKELID..KFLKPSGEAYIDEATFRYLLIKGDAVGGAMRNKIGVLGQERFIRAIYSSMSVRGMVCDCV...STNSKY..WREID.GNDAGTETNVKALHWR.N.TR.GERILVFNSKIPTV...NKNVDICLFSSGIADYDG--IVR.....HDERA.IMFGELKGGIDPAGADEHWKTGNSALNRIRESFTKAG.YpK.IKTSFIGAAIQHSMAEEIYKQLEDGTLSNASNLTNNNQLIEYCNWLIEL................
I0I3G2_CALAS/6-318                   ........YQNHLRSSDDLVTSYEATRAGFVALALEKNRRSTPYVAEARALQQAA.L.QARTPVDLLAIEGIEAGLLTAAGLSDKALVHLLPEDKVEAINSLIK..NFLEPAGEKFVEELVFRFLLTRGDTLGGSMRNIGGVLAQRKLTRAIISSLRIAGIAYRWQ...HSKTRQ..WADMA.DDDSEIELSLRGLSWE.N.NG.KLRTLVYNLTVPLV...KNNVDICLFNLGPDELQATRYQS.....-AGSY.LALGELKGGIDPAGADEHWKTARAAFDRIREAFSKTK.H.S.PHTFFIGAAIEKKMASEIWDQLERGLLTNAANLNDPNQIASVSRWLCML................
A0A1E5IGR0_ENDTX/1-126               .......m-----------------------------------------------.-.----------------------------------------------..-----------------YFLNKGDSSDGSMCNIAGILAQQKLIRTLLSNLSIMGIDYQWF...SSKTEN..WENKH.ADDFAIEENLKALSWI.SsKG.KSRVVAFNLNIPVV...RNNADICLFKSAACLYKEGNI--.....-----.-------------------------------------.-.-.-------------------------------------------------addlknrkaalippel
A0A7C8EHK3_9BACT/4-322               ........YKKHIGSPADLVTPYEATRAGFIDIALEKNRKATPFVEEAKALRVAA.S.KAKKPEELLKTDKIFGALMTAAGLSDKSQNHLAKKDKRKAVMNLLE..NFLKPAGEKFVEELVYRFLLTRGDTLGGMMRNIAGVIGERKFIRSLLSVLSIQKREYFWL...HGKSLS..WIKNS.LDDAGIENNVKGLNWG.T.KA.KARTLLMNITVPFV...GKNVDLCLLKYNPRVIGKEKTKIrevisSPECY.IVLGELKGGIDPAGADEHWKTANSALDRIRKSFSEKG.K.A.PNTFFIGAAIENSMAKEIYDQLTQKILTNAANLTNDTQVISLCEWLVE-v...............
A0A073CJS7_PLAAG/101-134             .......i-----------------------------------------------.-.----------------------------------------------..------------------------------------------------------------...------..-----.----------------.-.--.--------------...-----------------------.....-----.-------------------------------------.-.-.----------------EIWHQLETERLENAANLTNDQQIASICRWICHL................
A0A521FDH6_9BACL/6-321               .......f-EKHLKTANDLQTTYAEYRAGFIAFALEKNKRSTPYIERARALKSAA.S.SAETPEELLEIHDIQDALLYASGISDKAKKFLTDVNKKESIENLIE..NFLKPAGDEFIDELVFRYLLFQGDSLGGSMRNIAGALAQQKLTRSIIAALDIANIPYKWL...DSRNKKynWLDKP.EDDYDIEIFAKGISWN.H.NG.TPRTLVYNINVPLV...RKNVDICLFDCEPDIYVSQKINK.....QPKRY.LLLGELKGGIDPAGADEHWKTANTALSRIRDKFQEKG.L.R.PKTIFIGAAIEKSMAIEIWNQLQSDLLTNSANLTKAEQVSSLCRWLIHL................
#=GC seq_cons                        ...........alpssp-LlToaptsRuGFlthALEKNR+usPaltpA+sLp.hA.s.pscpst-LLplptIp.uLLTAuGLSDKuhtaL..pDK.cAIpuLIc..sFLEPAGppFl-ELVaRaLLh+GDoLGGoMRNlsGsLAQcKLsRsllSsLpltshpYpa....ppcspp..Whshs.ppcsplEhpl+ulpWp.p.pt.ttRslhaNlplPhV...ppNlDlCLhp.sstth.ttt.tt......st.h.lslGELKGGIDPAGADEHWKTApsALpRI+puFtt.t.h.p.s.haFlGAAIpppMAtEIapQLppthLoNAANLsptpQlsulspWlhpL................
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