#=GF ID   Endonuc_Holl
#=GF AC   PF10107.13
#=GF DE   Endonuclease related to archaeal Holliday junction resolvase
#=GF AU   COGs;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   COGs (COG4741)
#=GF GA   23.80 23.80;
#=GF TC   23.90 39.00;
#=GF NC   23.40 23.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0236
#=GF RN   [1]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR019287;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This domain is found in various predicted bacterial
#=GF CC   endonucleases which are distantly related to archaeal Holliday
#=GF CC   junction resolvases.
#=GF SQ   87
#=GS A0A7T3RCC1_9SPIR/22-128  AC A0A7T3RCC1.1
#=GS S3MQV1_9GAMM/19-151      AC S3MQV1.1
#=GS A0A1E7R2U7_9GAMM/22-151  AC A0A1E7R2U7.1
#=GS A0A1Z9Z2U8_9GAMM/24-151  AC A0A1Z9Z2U8.1
#=GS A0A2W7RNN7_9BACT/35-167  AC A0A2W7RNN7.1
#=GS A0A1M6MEY7_9BACT/47-207  AC A0A1M6MEY7.1
#=GS Q4J7V0_SULAC/14-174      AC Q4J7V0.1
#=GS V2TLT0_9GAMM/19-151      AC V2TLT0.1
#=GS F2NW62_TRES6/32-139      AC F2NW62.1
#=GS A0A2W7RZS1_9BACT/32-162  AC A0A2W7RZS1.1
#=GS Q9WZB4_THEMA/15-173      AC Q9WZB4.1
#=GS F5YKY3_TREPZ/27-143      AC F5YKY3.1
#=GS A0A1G6HHW9_9GAMM/21-151  AC A0A1G6HHW9.1
#=GS A0A2W4IH74_9BACT/10-75   AC A0A2W4IH74.1
#=GS S6A2W6_9SPIR/36-137      AC S6A2W6.1
#=GS D2EE91_PARA4/23-138      AC D2EE91.1
#=GS A0A2S2FIH6_9GAMM/17-151  AC A0A2S2FIH6.1
#=GS E1RKJ5_METP4/9-172       AC E1RKJ5.1
#=GS A0A840SFA9_9SPIR/4-110   AC A0A840SFA9.1
#=GS A0A510DUP8_9CREN/13-184  AC A0A510DUP8.1
#=GS A7I604_METB6/23-148      AC A7I604.1
#=GS A0A2U3MWD5_9GAMM/17-151  AC A0A2U3MWD5.1
#=GS Q73JG2_TREDE/22-129      AC Q73JG2.1
#=GS M7U407_9ARCH/31-126      AC M7U407.1
#=GS Q2FTI0_METHJ/18-179      AC Q2FTI0.1
#=GS F5Y820_LEAAZ/26-143      AC F5Y820.1
#=GS F0KFF6_ACICP/18-151      AC F0KFF6.1
#=GS A0A0A0X0W9_9SPIR/33-140  AC A0A0A0X0W9.1
#=GS A0A241W3T7_9GAMM/18-151  AC A0A241W3T7.1
#=GS H7EHI5_9SPIR/48-153      AC H7EHI5.1
#=GS A0A1P8F8D7_9CHLR/18-144  AC A0A1P8F8D7.1
#=GS I4B863_TURPD/27-148      AC I4B863.1
#=GS A0A5B8UMG3_9BACT/68-203  AC A0A5B8UMG3.1
#=GS A0A550D3I4_9CREN/17-176  AC A0A550D3I4.1
#=GS A0A2W4IPA8_9BACT/24-126  AC A0A2W4IPA8.1
#=GS A0A2V2MY93_9EURY/10-164  AC A0A2V2MY93.1
#=GS A0A1Q6DU34_9EURY/10-164  AC A0A1Q6DU34.1
#=GS L0HG19_METFS/23-147      AC L0HG19.1
#=GS A0A133U8T0_9EURY/10-123  AC A0A133U8T0.1
#=GS A0A1T4MLH9_9SPIR/31-141  AC A0A1T4MLH9.1
#=GS A0A133UVA4_9EURY/10-123  AC A0A133UVA4.1
#=GS K9SF15_9CYAN/16-173      AC K9SF15.1
#=GS A0A2H5V2Q0_9ARCH/27-172  AC A0A2H5V2Q0.1
#=GS T0LCY0_9ARCH/30-190      AC T0LCY0.1
#=GS A0A2V1HQM2_9GAMM/17-151  AC A0A2V1HQM2.1
#=GS W7KH98_9CREN/11-184      AC W7KH98.1
#=GS A0A7T8ERC0_9CAUD/15-139  AC A0A7T8ERC0.1
#=GS A0A5N8YLJ1_9CHLR/34-122  AC A0A5N8YLJ1.1
#=GS D9Q0H0_ACIS3/14-152      AC D9Q0H0.1
#=GS N6VUY6_9ARCH/31-126      AC N6VUY6.1
#=GS A0A212QLY8_9CHLR/9-167   AC A0A212QLY8.1
#=GS Q8PS30_METMA/8-159       AC Q8PS30.1
#=GS Q8ZUL3_PYRAE/12-179      AC Q8ZUL3.1
#=GS A0A7W9SSR2_9BACT/19-119  AC A0A7W9SSR2.1
#=GS F6BCI4_METIK/1-125       AC F6BCI4.1
#=GS A0A328EEF2_9BACT/21-124  AC A0A328EEF2.1
#=GS F4LPU4_TREBD/43-145      AC F4LPU4.1
#=GS A0A7J9YXZ7_9ACTN/20-135  AC A0A7J9YXZ7.1
#=GS A0A5N8YUU5_9CHLR/24-121  AC A0A5N8YUU5.1
#=GS E3NWN6_CAERE/12-145      AC E3NWN6.1
#=GS Q8TKK5_METAC/23-174      AC Q8TKK5.1
#=GS V2UW14_9GAMM/17-151      AC V2UW14.1
#=GS A0A1T4LYM8_TREPO/44-151  AC A0A1T4LYM8.1
#=GS C6A2V0_THESM/11-169      AC C6A2V0.1
#=GS A0A172U222_9BACT/1-159   AC A0A172U222.1
#=GS V2UBT7_9GAMM/17-151      AC V2UBT7.1
#=GS A0A498H6P0_9EURY/9-159   AC A0A498H6P0.1
#=GS A0A1T0CPZ3_9GAMM/13-196  AC A0A1T0CPZ3.1
#=GS K9RU23_SYNP3/6-169       AC K9RU23.1
#=GS A0A385C7Q7_9GAMM/17-151  AC A0A385C7Q7.1
#=GS A0A7J6ZD38_9COLE/18-149  AC A0A7J6ZD38.1
#=GS A0A1H9HXU5_9SPIR/39-144  AC A0A1H9HXU5.1
#=GS A0A0W0GHF9_9CHLR/16-144  AC A0A0W0GHF9.1
#=GS N8XJX5_9GAMM/17-151      AC N8XJX5.1
#=GS A0A2R6T6M2_9ARCH/28-162  AC A0A2R6T6M2.1
#=GS B5Y695_COPPD/14-189      AC B5Y695.1
#=GS L0AB69_CALLD/19-151      AC L0AB69.1
#=GS A0A328EI90_9BACT/24-125  AC A0A328EI90.1
#=GS A0A1B2M2H3_9GAMM/17-151  AC A0A1B2M2H3.1
#=GS Q3Z792_DEHM1/20-145      AC Q3Z792.1
#=GS Q9HL33_THEAC/13-166      AC Q9HL33.1
#=GS E7NV65_TREPH/3-109       AC E7NV65.1
#=GS A0A288DCE4_9BACT/25-125  AC A0A288DCE4.1
#=GS A0A0E3NY84_9EURY/10-163  AC A0A0E3NY84.1
#=GS A0A1D2RBE3_9ARCH/31-138  AC A0A1D2RBE3.1
#=GS Q6F7K3_ACIAD/12-145      AC Q6F7K3.1
#=GS A0A1S8CTB1_9GAMM/18-151  AC A0A1S8CTB1.1
A0A7T3RCC1_9SPIR/22-128             ...........................vvqklrdsa----------------------------------.---------..................----------...-...---...-...-...--GI.......K.......K...AR...NDA..VKR.....SRAVLGGQFGEQLAPFL..PDF..PCNPGDARFIGKPVDYIAFPG...T....A.....E.....G...rS..V....E....EILLIEVKSG-TSALSAREKEIREAVKKGRVRYVEYR-i..
S3MQV1_9GAMM/19-151                 .....................fllmsssrnsrikae----------------------------------.---------..................----YERYIA...E...LEL...E...H...QQQL.......V.......K...AR...RSS..VNT.....SRAVLKGKMAEQFAPLL..PEF..QYLPSDAKFLGDPVDYIIFDG...Y....Sd...fRd..gdG....R..A....Ed..iDVIFIDIKSG-GARLSKGQQAIAEAIAQGRVRFETLR-i..
A0A1E7R2U7_9GAMM/22-151             .............................fyltkvq----------------------------------.---------..................--QMKAEFSY...ElseLQR...E...H...EQQL.......A.......Q...AK...KRS..VNT.....SRAVLKGKMAEQFAPLF..PEF..EYLPSDAKFLGDPIDYVVFSG...Y....Sd..yrE.....G....L..L....DedelEVVFIDIKSG-QARLTKGQQAIAHAIKHGRVRFETIH-i..
A0A1Z9Z2U8_9GAMM/24-151             ...................fgrlqqlkaehqyemse----------------------------------.---------..................----------...-...LMR...E...H...DAAL.......T.......L...AR...KRS..VNT.....SRAVLKGKMAEQFAPLF..PEF..DYLPSDAKFLGDPVDYVVFSG...Y....Se..yrEgl.cdA....E..D....I....EVIFIDIKSG-QARLTKGQQAIAQAIEEGRVRFETVR-i..
A0A2W7RNN7_9BACT/35-167             ..............lkdadlfylnnfsasgkvaqqe----------------------------------.---------..................----------...-...MLE...D...L...KQQR.......K.......E...LK...ERAanMTKrpqltAKAVNIGFILERIAPAF..PHF..PFQHNDCRSLFDPIDYIIFEG...L....H....kS.....G....I..V....N....KIIFTDIKTG-AAKLKNNQKAIKALIESKNVKFQIY--e..
A0A1M6MEY7_9BACT/47-207             ..................retffrkeiediqsklnd---------------TYKNIPILANQQFDEFKNN.EIESLRAVL..................SAAAAKTALA...D...LEA...W...K...TKYE.......M.......F...YR...QDA..INR.....SQSVILGKVTEHLIPFH..QNF..PFNPKEARFIGSPIDMIVFEG...I....E.....N.....E....D..V....V....DIYILEIKTG-KSSLSKRQRLIRDAVENDRVSWRELN-v..
Q4J7V0_SULAC/14-174                 ....................................IIVLIIISYSRRINKIQEESKRQAQEMFSQWTQQ.HSNELRTQI..................EQSVEMKYKA...M...LEQ...W...T...IQKE.......S.......E...IR...KDA..VTK.....SINTLLGKISEEFAPIFiaQKY..SISPKDFRHLGSPVDFVAFKG...L....S.....D.....E....S..E....P....EIIFFEIKTGKSSALTERERKIRDAIVAKRVKYEVIN-l..
V2TLT0_9GAMM/19-151                 .....................tiflssfrngkiqae----------------------------------.---------..................----YEQYIA...E...LEL...E...H...QEAL.......A.......E...AR...KRS..VNT.....SRAVLKGKMAEQFAPLF..PEF..EYLPADARFLGDPIDYVVFNN...Y....Sd..frD.....G....E..A....HadeiEVVLIDIKSG-GARLTKGQQAIARAIQAGRVRFEMIR-i..
F2NW62_TRES6/32-139                 ............................rivqklkn----------------------------------.---------..................----------...-...---...-...-...VSEF.......K.......K...QR...KDA..VNR.....SRSVLCGQFSEQIAPFL..PGF..PCNPGDVRFVGKPVDFVAFPG...C....A....eG.....G....D..I....E....EIYFIEVKSG-QSKLSPREKQIKLAVEQGRVKYFEYR-i..
A0A2W7RZS1_9BACT/32-162             .................lsdcqiyvkkkpepdwlqq----------------------------------.--------I..................EA--AQQRIN...R...AEE...K...L...DEKE.......A.......E...IR...EKA..RDA.....GRKE-AEKMIKKIDTIF..QPL..KLNPDDSKVIFHPVDFVVFNG...M....K.....S.....G....Q..L....K....NVLFLD-KVQKQTD-KRLQQSIQKVIEKGNYEWVTLR-v..
Q9WZB4_THEMA/15-173                 ....................................ILTRNLLKMSREIQELRGKIESNAMKMFEEWKKS.EWELQRRVL..................EANLKREYEV...K...FQE...W...K...MEEE.......K.......R...IR...EDA..INK.....SKSVIMGQVTEHLIPFF..PEF..RYNPKDARFIGTPVDFVVFDG...L....S.....E.....G....N..L....R....RIVFVEVKTGKTGNLNTRERQVRDVVEKREVYWEKLH-y..
F5YKY3_TREPZ/27-143                 ...........................rrmglsqgr----------------------------------.---------..................--------RQ...E...RAD...W...E...SGKL.......A.......G...IV...KAR..LKA.....SRAVLGGLVSEQIAPML..PDF..PFDPGDCRFVGKPVDFIVFRG...M....N.....E.....K....N..I....T....EVIFLEVKSGTGKNLNEQERRLRDAVQAGRVRWAEF--di.
A0A1G6HHW9_9GAMM/21-151             .........................wfyltkiqqlh----------------------------------.---------..................-----ASYQY...E...ISE...I...R...REHD.......Q.......AlalAR...KRS..VNT.....SRAVLKGKMAEQFAPHL..PEF..DYLPSDAKFLGDPVDYVVFSG...Y....Sd..frEgl.cdA....E..E....I....EVVLIDIKSG-TARLTKGQQAIAQAIDDGRVRFETIH-i..
A0A2W4IH74_9BACT/10-75              ......................laisleqiftflsf----------------------------------.---------..................----------...-...YKQ...W...D...-REL.......A.......A...IK...KKS..VSQ.....SKSSILGEVSEKVMPLL..PEF..PYHTKDLVFLGKG--------...-....-.....-.....-....-..-....-....--------------------------------------v..
S6A2W6_9SPIR/36-137                 .................................lnn----------------------------------.---------..................----------...-...---...-...-...KSKI.......K.......A...ER...ADA..VKR.....SRAVLNGQLGEQIAPFL..PDF..PSDPAEIRFIGKPVDYIAFNG...A....S.....E.....G....F..I....T....DITFIEIKTG-NSALSPVERSLKDAINAGRVKYTEYR-v..
D2EE91_PARA4/23-138                 ..............................vlkyll----------------------------------.---------..................--------KK...K...IDQ...W...E...KYEM.......Q.......K...AL...EKT..VNI.....QRPILKGKISEQLFPIL..YEK..EGDLSELRFLGNPIDYIKFDG...L....Sn..lsE.....T....G..K....V....KIKFIEIKTG-NAKLNKNEEAVKKAVQDKEVYWEEIT-i..
A0A2S2FIH6_9GAMM/17-151             ..................lttwvlsstrngkikaey----------------------------------.---------..................-----ERYIA...E...LEL...E...H...QQAL.......A.......T...AK...KRS..VNS.....SRAVLKGKMAEQLAPIM..PQF..QYLPSDAKFLGDPIDYVVFDG...Y....T.....EfrddgGa..aE..N....I....EIVLIDIKSG-GARLSKGQQAIAQAIREGRVRFETIR-i..
E1RKJ5_METP4/9-172                  ....................................LLFIVILVLFYNYSKIKGQIEQQARVIFDSWSQK.KSEDIDRWKtt..............elERLSSEKARI...Q...FEN...W...R...LAEE.......Q.......N...IR...TDA..IKR.....SQSVTRGKVTECLIPFF..PDF..PYNPKDARFLGTPVDLIVFDG...L....S....dE.....D....E..I....Q....EVAFIEIKTGKTANLSKRERAVRDCIRGGRVQYYTIH-q..
A0A840SFA9_9SPIR/4-110              ..........................lvqkvkdvnl----------------------------------.---------..................----------...-...---...-...-...---I.......K.......R...ER...NDA..VKR.....SRAVIGGQFGEQVAPYL..PDF..PCNPGDARFIGKPVDFIAFKG...C....A....dK.....D....E..V....E....EILFVEVKSG-SSTLSRRERQIKSAVEEGRVRFVEYR-i..
A0A510DUP8_9CREN/13-184             .............illlvilyyskriselnkrinet------------QVRAQQQAQQLAQQYFNTWIQQ.NLQQARLQM..................EQSIRREYEA...Q...LEE...W...K...QQNE.......K.......N...IR...KDA..VLR.....SVNTLLGRISEEFAPLFltEKY..QVNPKDFRHLGTPVDFIAFKG...L....S.....D.....D....A..D....P....EIIFIEIKSGKSSTLSERERRVREAIRKSKVRYEVVN-l..
A7I604_METB6/23-148                 .............................lfmraqf----------------------------------.---------..................-RTVEARYRA...D...LER...W...K...AESA.......A.......E...IR...KDS..VNR.....SRFTLKGRIAEQMAPLL..PSF..GYLPADARFIGSPVDYIIFDG...L....SsvadeK.....G....S..D....I....RIIFMDVKQG-SATLSRTQRVIKKAVEEKAVTWQTLH-l..
A0A2U3MWD5_9GAMM/17-151             ..........................lttivlsntr----------------------------------.---------..................NGKIKAEYEQyiaE...LEL...E...H...QQAL.......A.......H...AQ...KRS..VNT.....SRAVLKGKMAEQLAPIM..PEF..HYLPSDAKFLGDPVDYVIFDG...YtdyrD....gD.....G....S..A....Dd..iEVVLIDIKSG-GARLTKGQVAIQDAIRQGRVRFETIR-i..
Q73JG2_TREDE/22-129                 .............................gkykers----------------------------------.---------..................----------...-...---...L...N...LKRV.......N.......E...AR...KDA..VKR.....SRAVLNGQLSEQLAPFF..PDF..PANPTEIRFIGQPVDYIAFNG...A....S.....Q.....G....T..I....T....DISFIEIKTG-SAALSPVERALKDAIEKKKIKYIEYR-a..
M7U407_9ARCH/31-126                 ......................vvvhlrnkiekits----------------------------------.---------..................----------...-...---...-...-...----.......-.......-...--...---..KKQ.....SLSTTYGMITEQFAPFM..KDY..PFSPERFRFIGNPIDGIQFE-...-....-.....-.....-....-..N....D....RIVFVEFKAH-ESRLSPVQNRIKKLIKNGSVDWFEFR-m..
Q2FTI0_METHJ/18-179                 ....................................IFLLLIIALLLIIVHIWRRADKRARMLFESWKRD.EYARWKTWIqe..............eaDARADVQAEA...R...YRD...W...Q...RWEE.......Q.......K...IR...QDA..IRR.....SHSVIRGKITEHLIPWF..SEF..SYHPSDARFLGSPVDFIVFDG...L....S.....E.....G....C..L....K....EIVIVEVKTG-SGSLSPRERSVARIIEEGKIRFEVIR-k..
F5Y820_LEAAZ/26-143                 ...........................grkmglhqg----------------------------------.---------..................-------RRQ...E...RAE...W...E...GGRV.......E.......E...IV...KAR..LKQ.....SRAVLGGLVSEQMAPLL..PDF..PFDPGDCRFIGKPVDFIVFKG...M....N.....A.....K....A..I....D....EVIFLEVKSGASRTLNDQEKRLRDAVLAGRVSWAE---fdv
F0KFF6_ACICP/18-151                 .........................ttlilsntrng----------------------------------.---------..................--RIKAEYEQyiaE...LEL...E...H...QQAL.......T.......Q...AQ...KRS..VNT.....SRAVLKGKMAEQFAPVL..PEF..QYLPSDAKFMGDPVDYIIFDG...YtdfrD....gD.....G....T..A....Ed..iNIILLDVKSG-GARLTKGQQAIAQAVQQGKVRFETLR-i..
A0A0A0X0W9_9SPIR/33-140             ...........................gkliasrhl----------------------------------.---------..................----------...-...---...-...-...AAEI.......K.......M...AR...EDA..VKR.....SRAVLNGQLSEQFAAFF..PGF..PADPTEIRFVGKPVDFVAFPG...L....S.....T.....G....T..V....D....EVLFVEVKTG-NAALSKVERSLRDAVEKKNVRYTEYR-i..
A0A241W3T7_9GAMM/18-151             ...........................ttlilsnsr----------------------------------.---------..................NGRIKAEYEQ...Y...IAE...L...E...LKHQ.......Qd....liH...AQ...KRS..VNT.....SRAVLKGKMAEQLAPIL..PEF..PYLPSDAKFLGDPIDYVIFKG...Y....TdlrdgA.....G....Q..V....Dd..lEIILIDIKSG-GARLTKGQLAIAEAIKQGRIRFETIR-i..
H7EHI5_9SPIR/48-153                 ........................rgkkmnyadiag----------------------------------.---------..................----------...-...---...-...-...----.......-.......-...ER...RDA..VKK.....SRAIIGGQVAEQVAAFL..PGF..PCNPGDVRFVGKPVDFVGFPG...A....S.....E.....G....K.pI....E....EVLIIEVKTG-KSQLTQREKEIRAAVESGRVRYVVYR-p..
A0A1P8F8D7_9CHLR/18-144             ...........................itinyylir----------------------------------.---------..................-----RRFES...R...FKQ...W...Q...AQEQvywqnevG.......R...AS...KQA..VIQ.....SRAVLGGKFTEQMTPYL..PEF..KYDPTEARFIGSPIDFVVFPG...L....A.....A.....G....D..P....K....EVVIVEVKSGKNCALTPSEKKIQELIEDGMVRWEIIE-r..
I4B863_TURPD/27-148                 ....................mrlaryraesayveil----------------------------------.---------..................--------RQ...K...EAE...W...G...EGEE.......Q.......R...-R...KLA..IAR.....SRQIIGGNFSEQLAPYL..PDF..PFDPTEARFIGKPVDFLVFKG...L....S.....Q.....G....A..V....Q....EVVFVEVKSG-GSKMNRNEASLKAAIDDKRVRFIEYR-v..
A0A5B8UMG3_9BACT/68-203             ...............................aiqel----------------------------EKFKQT.EIDSIKTNL..................EQVSLQAAAN...V...LQQ...W...K...MNEE.......A.......K...IR...QDA..ISR.....SYAVNLGKISEHLVPFH..GKF..PFNPNDARFIGSPVDLLIFDG...A....S....eN.....R....E..D....I....NIYFAEIKTG-KSRLTELQRRIQSAVKDGRTYWIQIN-p..
A0A550D3I4_9CREN/17-176             ....................................VLVATLVYYSRKIKRIQQQAEQQTQTMFQQWVQQ.HSDQLRKQI..................EQNTQVKFQA...E...LEK...W...K...LEYE.......K.......Q...IR...KDA..LLK.....SANTILGRIGEEFAPFLiaDRY..NVNPKDFRHLGSPVDFIAFKG...L....S.....D.....D....K..E....V....EIIFFEVKTG-NQNLNTNERKVRDAVNAKRVRYEVIN-f..
A0A2W4IPA8_9BACT/24-126             ..............................flhfhr----------------------------------.---------..................----------...-...---...-...-...--KL.......A.......A...IK...KKS..VSQ.....SRSSILGEVSEKVMPLL..PEF..PYHTKDLVFLGKGVDYVVFDG...L....S.....R.....G....K..L....K....EIIFLEIKSG-ASQLNSNEMMIRNYLSSCPVRYEVMR-v..
A0A2V2MY93_9EURY/10-164             ...................................l-LLILLIWISYSYYRLKTSIEERARTLHNRWRDQ.DLSL----F..................QSQVEQQADE...K...IRI...W...K...NDEE.......R.......N...IR...QDA..IKR.....SREVIHGKVTEHLIPFF..SSF..RWNPADARFLGSPIDFVVFDG...L....S.....E.....G....E..L....R....EIVFVEVKSGVRPTLTPRERSVERCIKRGDIDFTVIH-h..
A0A1Q6DU34_9EURY/10-164             ..................flvillinlglitaitiy------------------YSYKTQKNIEKKYEKR.K-EDLKNEL..................EQSIKKEYQA...K...LQK...W...K...NKEE.......K.......K...IR...NDA..VNR.....SNFVLKGKVAEKFTPLL..KEF..NHDVKNTKFLGDPIDYIAFDI...T....E.....-.....T....N..-....P....KIYFIEIKTG-KSSLNKTQKTIKKAIKKNNVYWETHR-i..
L0HG19_METFS/23-147                 ............................ffrarvvi----------------------------------.---------..................---FKERARN...D...LDR...W...K...QECT.......E.......A...IR...KDS..VNR.....SRSTLKGKIAEQMAPFL..PGF..PYSAADARFIGSPVDFIVFDG...Y....St..akD.....G....DfgE....V....SIVLVEVKQG-KGKLTRGESLVRRAVEGGRVSWKTVT-i..
A0A133U8T0_9EURY/10-123             ................................ffkg----------------------------------.---------..................------RAKT...W...YKE...W...K...TEYE.......S.......Q...IR...KDA..VDR.....SRAVLKGKVGEQFAPFF..SAF..DYEPSDARFIGSPVDYIIFEG...H....S.....E.....E....N..P....K....GVTFADIKTGKNSKLNPMQRGFKRAVERGKVSWETIR-l..
A0A1T4MLH9_9SPIR/31-141             ....................wkagrisaelkfrrvl----------------------------------.---------..................----------...-...---...-...-...----.......K.......T...ER...ADA..VNR.....SKAVLSGLAAEQIAPFL..PNF..PCNPADCRFVGKPVDFVAFST...E....N.....D.....G....E..V....K....EILFIEVKNG-TSQLSKREREIKKCVEEKKVRYIEYR-t..
A0A133UVA4_9EURY/10-123             ................................ffkg----------------------------------.---------..................------RAKT...W...YKE...W...K...TEYE.......S.......Q...IR...KDA..VDR.....SRAVLKGKVGEQFAPFF..SAF..DYEPSDARFIGSPVDYIIFEG...H....S.....E.....E....N..P....K....GVTFADIKTGKNSKLNPMQRGFKRAVERGKVSWETIR-l..
K9SF15_9CYAN/16-173                 ....................................ILATCVAFLALLTYKLSSNLSNRARSLYQEWRAN.DYENLLQEQ..................KAIALREAEV...S...LQE...W...K...SKKE.......K.......T...IR...NDA..ISR.....SKSAIAARVREQFSPYF..PNM..SFNPKDARFIGSPIDLVIFDG...L....D.....N.....G....K..V....E....NIIFVEVKTG-SSSLSERQKLIREAIQLKKVIWSELR-i..
A0A2H5V2Q0_9ARCH/27-172             ........lvlvvilfyrysiirakysilveqveal----------------------------------.---------..................RGQVEAKAQL...L...LNE...W...K...KKEE.......D.......R...LR...EDA..IKR.....SMYTIIGKVGEHLAPIIifSKY..GINPKDFRFIGTPVDFIAFKG...L....S.....E.....G....S..L....T....EIYFFEVKSGETKVLTERERQIKDVIESKRVKWELIH-l..
T0LCY0_9ARCH/30-190                 ...............................vlklk------LLMEQERLSAQKTAEETAKTLFNQWAEA.SIKTIRNQI..................TETLKKDYEV...Q...LES...W...K...KQEE.......K.......K...IR...EDA..IQK.....SINTLLGKIGEEFSPVLlaNKY..GINLKDFRHLGTPVDFVAFKG...L....S....dG.....S....S..E....V....EVLFLEIKSGKSSGLVGRERMVRDAVKSKRVSYEVVN-l..
A0A2V1HQM2_9GAMM/17-151             ...............................ltyal----------------------------------.----LSNLR..................NGKIQAEYEV...Q...ISE...L...K...RKHQ.......K.......E...LRltqSRS..VNS.....SRAILKGRMAEQFAPIF..PEF..EYLPSDAKFLGDPVDYIVFNG...Y....NafrdgD.....Gr..aD..E....I....EVVLIDIKSG-NARLTKGQQAIADAIRKGRIRFETIR-v..
W7KH98_9CREN/11-184                 .............lllviiaivvhysrkinkiqqqa---------QEQVNKIQQQAQQIAQSMFSQWVQQ.YSNETRKQI..................EQSTEAKYKA...E...LEQ...W...K...LQVE.......E.......E...IR...RDA..ITK.....SINTLLGKIGEEFAPLLvaEKY..GVNPKDFRHLGTPVDFVAFKG...L....S.....D.....D....S..D....P....EVIFIEVKTG-KGSLTDREKKIRDAIASKRVRYEVV--sl.
A0A7T8ERC0_9CAUD/15-139             ...........lvylmnmakaeirkledlivekele----------------------------------.---------..................----------...-...---...-...L...VEEV.......K.......K...AR...KDS..KFR.....SSAVNWGKSIEHFVPFM..TKF..PVPPEDVVFLGMPIDYVGFTD...T....E.....S.....S....K..K....C....KVHFIEVKSG-VSFMSTKQKNIKKAIEEGRIEFHEI--av.
A0A5N8YLJ1_9CHLR/34-122             .................................gls----------------------------------.---------..................----------...-...---...-...-...----.......-.......-...-R...EGS..LRR.....SESTRYGQITEQFMPFI..SDY..PYDSKQFRFLGSPIDGVQFE-...-....-.....-.....-....-..E....D....KIVMIEFKSA-GSQLSTRQRRIRNLVREGKVDFQEIR-v..
D9Q0H0_ACIS3/14-152                 ...................laeliiivvqtvrlala----------------------------------.--QRSLKTL..................EMNIDKLADA...R...ARE...M...A...AAIV.......D.......R...AR...EDA..AKR.....SSAVTAGKIYEQLAPIL..PGF..KFNPKDVRFLGSPVDFVVFDG...L....E.....D.....G....K..R....V....YVRFVELKSG-DSKLTDREKAVKDAVESCRVSFEVVK-a..
N6VUY6_9ARCH/31-126                 ......................vvvhlrnkiekits----------------------------------.---------..................----------...-...---...-...-...----.......-.......-...--...---..KKQ.....SLSTTYGMITEQFAPFM..KDY..PFSPERFRFIGNPIDGIQFE-...-....-.....-.....-....-..N....D....RIVFVEFKAH-ESRLSPVQNRIKKLIKNGSVDWFEFR-m..
A0A212QLY8_9CHLR/9-167              .............................iltlgia------AYFFYRYLSLKAEIPSLLQRKFDEWRQR.YEDQIRRES..................KELALQEAQN...Q...FER...W...K...QEFE.......E.......Q...IR...QDA..IQR.....SQAVVRGRVTEQLAPCL..PDF..PFNPQDARFIGSPVDFVVFDG...L....S.....E.....G....E..I....R....RVVFVEVKTG-RSKLSSRERRVAEVIAARQVEWWEY--rp.
Q8PS30_METMA/8-159                  ...................................f-LALLIVYLFIKYIKLKGRVESRARDLYESWQAR.EM-------..................DRQVSEKADT...L...FRT...W...K...LDEE.......K.......K...IR...QDA..IKK.....SEAVIRGKVTEHLIPYF..PDF..EYNPKDARFLGTPVDFIVFDG...L....S.....E.....G....A..M....N....KVVFVEVKSGKTGALSQREKLVRECINRGKVSYEIIH-n..
Q8ZUL3_PYRAE/12-179                 ....................................VLALVLYHERAKVRLIQQEFEMQKRALEEQLRRE.IAAREELLRrel............avkEEQLRKEAEL...K...LAE...W...I...KEKE.......R.......E...IR...EDA..IRR.....SVAVLLGRVGEQMAPLLmsREL..NFDPRDCRYIGTPVDYVVFKG...L....S....dR.....G....E..V....E....EILFVEVKTGKSSSLSERERAVRKAVENKRVRWVTYN-l..
A0A7W9SSR2_9BACT/19-119             ...................ialarrirqlserldaa----------------------------------.---------..................----------...-...---...-...-...----.......-.......-...--...-DF..QQR.....SLSTTYGRITEQWFPLM..DQY..PYDPQGFRFLGTPIDGVQFE-...-....-.....-.....-....-..D....D....RIVFVEFKTN-KSQLSKLQKHYRELVEAGEVYFEEFR-f..
F6BCI4_METIK/1-125                  ....................................-------------------MEQRARQLFEEWKDK.EL-------..................EKLSKQKADM...L...FED...W...K...RKYE.......K.......K...IR...KDA..IEK.....SKSVIIGKVTEHFAPFL..PEF..KYNPKDARFIGSPVDFIVFDG...L....D.....E.....G....D..L....K....KIVFLDVKTG-KSPLSKREKLIKKIVESKK--------s..
A0A328EEF2_9BACT/21-124             .............................vqirrig----------------------------------.---------..................----------...-...---...-...-...--VE.......K.......K...IR...QDA..VRG.....SRNAITGEIYEKILPSM..PNF..PYAPKDMVFVGKGTDYIIFDG...L....S.....E.....G....D..L....R....EIIFLEIKSG-KSRLNANEKMIKKILDEKIVRFAEMR-v..
F4LPU4_TREBD/43-145                 ...............................lgsdr----------------------------------.---------..................----------...-...---...-...-...--RI.......R.......S...ER...RDA..VRR.....SKSVVTGLVSEQLAPFL..PGF..PCNPADVRFVGKPVDFIGFCS...D....S....gG.....D....R..V....E....EVLFIEVKTG-SGSLSARERSVKQAVEAGRVRYIEYR-i..
A0A7J9YXZ7_9ACTN/20-135             .....................vavsharyraiyryh----------------------------------.---------..................----------...-...---...-...-...DADL.......R.......A...AR...TDA..ARR.....SRSVLSGKAGEQLGPLV..PQFcdRFDASEARFIGAPIDYVIFDG...L....G.....R.....G....E..L....R....EVVLVEVKTG-TSRLNANERQVELAIREGRVGFEVLR-l..
A0A5N8YUU5_9CHLR/24-121             ...................wiifqrtllkvrelthq----------------------------------.---------..................----------...-...---...-...-...----.......-.......-...--...---..-NR.....SLSTRYGKLTEQFMPFI..AKY..PFDPHKFRFIGSPIDGVQFE-...-....-.....-.....-....-..E....D....RILLIEFKSA-TSHLSSRQRQIRDLVEDGKVEFLEMR-l..
E3NWN6_CAERE/12-145                 .........................ttivlsstrng----------------------------------.---------..................--KIKAEYEQ...Y...IAElelE...H...QQTL.......A.......S...AQ...KRS..VNT.....SRAVLKGKMAEQLAPIM..PEF..RYLPSDAKFLGDPIDYVVFDG...Y....TdfrdgE.....G....L..A....Ed..iEVVLIDIKSG-GARLTKGQQAIAQAIQDGRVRFETIR-i..
Q8TKK5_METAC/23-174                 ...................................f-LALLIVYLLVKYIKLKGRVESRARDLYEAWQTR.EM-------..................ERQVSEKADT...L...FRT...W...K...LDEE.......K.......K...IR...QDA..VKK.....SEAVIRGKVTEHLIPYF..PDF..EYNPKDARFLGTPVDFIVFDG...L....S.....E.....G....K..M....N....KVVFVEVKSGKTGVLSQREKLVRECIDRGRVSYEIIH-n..
V2UW14_9GAMM/17-151                 ...............................ltyal----------------------------------.----LSNLR..................NGKIQAEYEV...Q...ISE...L...K...RKHQ.......K.......E...LRlaqSRS..VNS.....SRAILKGRMAEQFAPIF..PEF..EYLPSDAKFLGDPVDYIVFNG...Y....NafrdgD.....Gr..aD..E....I....EVVLIDIKSG-NARLTKGQQAIADAIRKGRIRFETIR-v..
A0A1T4LYM8_TREPO/44-151             .............................mlaerna----------------------------------.---------..................----------...-...---...-...L...HKQL.......K.......E...GR...KDA..VKR.....SRAVIGGQMAEQIAPFL..PDF..PCNPADVRFIGKPVDFIAFPG...M....A....eG.....K....C..I....E....EIVLVEVKTG-TSQLSEREKEIKSAAEKGNVRYVEYR-i..
C6A2V0_THESM/11-169                 ....................................VLIVLVFILWYKYSELKGQMERKARELFEEWRSK.ELETQKRVL..................EEGIRKNYES...E...FKK...W...K...LEEE.......K.......R...IR...EDA..IKK.....SKAVIMGQVTEHLIPYF..PDF..KYNPKDVRFIGTPVDFIVFDG...M....T.....D.....G....D..I....K....RIVFVEVKTGKTGGLTSREKQVKVVVEKREVSWEKIH-y..
A0A172U222_9BACT/1-159              ...............................meltl------AQHKNTLIDLELQVHQLAAQKFEEYKTT.LLQTEQDRI..................HSEQKVVAEA...Y...FEQ...W...K...MEYE.......M.......V...IR...QDA..IKK.....SQAVTIGKVTEHMVPYF.sGVF..PYNPKEARFIGSPIDLIVFDG...M....E....tT.....P....E..N....I....SIHFIEVKTA-TSTLSPKQRAIKYAILNKRVEWKELR-v..
V2UBT7_9GAMM/17-151                 ...................lttiilshsrngrikae----------------------------------.---------..................----YEQYIA...E...LEL...E...H...QQAL.......A.......Q...AQ...KRS..VNT.....SRAVLKGKMAEQMAPIM..PQF..EYLPSDAKFLGDPVDYIVFDG...YtdfrD....gD.....G....R..A....Ed..iQVVLIDIKSG-GARLTKGQQAIAEAIQQGRLRFETIR-i..
A0A498H6P0_9EURY/9-159              ...................................a-LLLLLIYIAWRYARVAGEVERRARSLFDEWRST.EM-------..................QRLVDEKAEL...L...FRE...W...K...ITEE.......K.......S...IR...RDA..VTR.....SEAVIRGKVTEHLIPYF..PDF..TYNPKDARFLGTPVDFVIFNG...L....S.....D.....G....E..V....T....SVAFVEVKSG-RSNLSERERAVRDCILQQRVTYEVIR-q..
A0A1T0CPZ3_9GAMM/13-196             vltvvivgllfilikqrkehqqyriekdieisnaln-------------------------EMMRQKEEF.HAEQIKFTEefqa..........klaqKEEQIIQQKM...E...YSK...E...K...EQAI.......K.......Q...AK...KYA..LDA.....QRNKVKGQVSENFIPFM..QGF..EYQASDCHFFGNPIDYIVYNN...V....Hr..yvD.....G....E..CafddV....SIVFLEVKTG-KASLNERQKAIRDAIAQGKVRFEMVR-m..
K9RU23_SYNP3/6-169                  ................vfaigvlfgagltwsilqks----------------QRQAQRR---EVLALQQT.HQAELTDLI..................QTHEAI--LA...E...LKL...H...H...KQDI.......D.......Q...AK...QKS..LDA.....SRSVIKGQIAEQIAPYL..PNF..KYLPSDARFIGDPIDYLVINGytnL....K.....D.....GqgspE..E....L....EVVLVDIKSG-KAKLSDRQVAIENSVRAGRVRFETIR-i..
A0A385C7Q7_9GAMM/17-151             ........................lttivlsstrng----------------------------------.---------..................--KIKAEYEQ...Y...ISE...LeleH...QQAL.......A.......H...AQ...KRS..VNT.....SRAVLKGKMAEQLAPIM..PEF..RYLPSDAKFLGDPIDYVVFDG...Y....Td...fRd..gdGl..aE..D....I....EVVLIDIKSG-GARLTKGQQAIAQAIREGRVRFETIR-i..
A0A7J6ZD38_9COLE/18-149             ........................ttivlsstrngk----------------------------------.---------..................---IKAEYEQyitE...LEL...E...H...QQAL.......A.......H...AQ...KRS..VNT.....SRAVLKGKMAEQLAPIM..PEF..QYLPSDAKFLGDPIDYVIFDG...Y....TdfrdgE.....G....L..A....Ed..iEVVLIDIKSG-GARLTKGQQAIAQAIREGRVIFR----hw.
A0A1H9HXU5_9SPIR/39-144             .............................iqtirlh----------------------------------.---------..................----------...-...---...-...-...-KNH.......A.......S...LR...SDA..IKR.....SRSVLGGQLAEQVAPYL..PGF..PCNPGDARFIGKPVDFIAFPG...M....T....eD.....N....N..V....K....EVLLIEVKTG-KSALSGREREIKRAVTEGRVRYVEYR-a..
A0A0W0GHF9_9CHLR/16-144             ........................aiiylnyyvirr----------------------------------.---------..................------RFES...R...FRE...W...Q...VQEQ.......AywksevlR...AS...RQA..VTQ.....SRAVLGGKFTEQMVPFL..PEF..KYDPTEARFIGSPIDFVVFPG...L....S.....A.....G....D..P....R....EVVILEVKSGVNCQLTPSERKIRQLIEDGMVRWELV--er.
N8XJX5_9GAMM/17-151                 ...................ittiilsstrngriqae----------------------------------.---------..................----YEQYIA...E...LEL...A...H...KQAL.......V.......D...AQ...KRS..VNT.....SRAVLKGKMAEQFAPIL..PEF..QYLPSDAKFLGDPVDYVVFDG...YtdfrD....gD.....G....D..A....Ed..iEVILLDIKSG-SARLSKGQQAIAQAIREGRVRFETLR-i..
A0A2R6T6M2_9ARCH/28-162             ...............................fykks----------------------------EKLAQK.RFEERKKEL..................EESIKKEFAL...E...LKR...W...K...NDYE.......Q.......K...IR...EDA..AKR.....SDLTLSGKVAENLAPLL..DHF..NHDLKSLRHLGSPIDYIAFDN...Y....G.....E.....E....D..K....T....KIYLLEIKSG-DSRLSSNQKEIKEAIREGRVFWETVR-l..
B5Y695_COPPD/14-189                 ...................lavgivillffrlafer------------------DLERTRRELYQQYENQ.LRENQLRAEaywkaqfedwksreietlKQSIDQQYKA...A...LEQ...W...K...LEVE.......E.......E...IR...QDA..TKR.....SKSVMLGQITEHLVPFL..PDF..KYNPKDARFLGTPVDLIVFDG...L....S.....D.....G....Q..L....K....QVVFIEVKSGSSKQLTQRERQVRDIILDKHVCWEL---fyq
L0AB69_CALLD/19-151                 ............................ilylyisn------------------------------WRKSvKIDSIKSNI..................ENLANEKAKV...-...---...I...A...MESI.......E.......K...AR...KEA..VQQ.....SKAVITGKVYEQFAPYL..PNF..KHNPKEARFIGSPIDYIVFDG...I....E.....N.....N....D..V....K....AIYFVEIKSG-KSNLTNREESIKKAVEKKAVYFETI--yi.
A0A328EI90_9BACT/24-125             ..............................lvfhck----------------------------------.---------..................----------...-...---...-...-...---L.......S.......A...IK...KKS..ICH.....SRSSILGEVTEKVVPLL..PEF..PYHMKDLVFVGKGIDYIVFDG...L....S.....R.....G....K..L....R....EIVFLEVKSN-SSQLNRNEQMIKECLGAFSVRYEVVR-v..
A0A1B2M2H3_9GAMM/17-151             ...................lttimlngtrngrikae----------------------------------.---------..................----YEQYIA...E...LER...D...H...QQAL.......I.......V...AQ...KKS..VNT.....SRAVLKGKMAEQLAPLL..PEF..PYLPSDAKFMGDPVDYIVFDG...Y....Sd...fRd..gdGa..aE..D....I....EVVLIDIKSG-TARLTKGQQAIAQAVAEGRVRFETIR-i..
Q3Z792_DEHM1/20-145                 .........................favyyymrwsf----------------------------------.---------..................EKRFKRWQDA...A...VIL...W...Q...KDM-.......E.......R...VQ...KQS..VAQ.....SRATLGGRFAEQLTPYL..PEF..KYDPTEARFLGSPIDLIVFPG...L....A.....Q.....G....N..P....R....EIVIVEVKTGKHCQLTDSEKKIRQLIEDGMVRWELIQ-p..
Q9HL33_THEAC/13-166                 ....................................ILIVAIIILYLDIRSLQRKLAAKEAEIQTTLQNA.T----RTVN..................EAIAMREEAQ...K...LKE...D...L...EKRI.......E.......E...AR...RES..VQK.....SREVVAGKVSEQLAPFF..PNF..KYNPKDVRFIGTPIDLIVFNG...L....D.....S.....G....H..I....D....SIVFIEIKTG-NARMTDREKSVMDAINASRVSFEILR-i..
E7NV65_TREPH/3-109                  ...........................kltarkeiq----------------------------------.---------..................----------...-...---...-...-...-RLL.......K.......E...AR...EDA..VKR.....SRAVLGGQFSEQIAPFL..PGF..PADPTEIRFIGKPIDFIAFVG...N....S.....M.....E....D..I....S....EVLFIEVKSG-KSELSKTEKSLKRAIESGFVRWVEYR-v..
A0A288DCE4_9BACT/25-125             ................................yffi----------------------------------.---------..................----------...-...---...-...-...--KI.......K.......H...QR...QDA..VTR.....SRNVVLGNVNEKIAPLL..PGF..PYHYKDLMFLGKGIDYIVFDG...L....S.....H.....G....N..L....T....KIVFLEIKTN-SSTLNRNETMIKQCIEQKKVEYQIYR-k..
A0A0E3NY84_9EURY/10-163             .................................iif-LALFAVYILFKYIQMKGRVESRARDLFETWQTR.EM-------..................EKQVSERADN...M...FRS...W...K...IDEE.......K.......K...IR...QDA..VKK.....SEAVIRGKVTEHLIPYF..PDF..EYNPKDARFLGTPVDFIVFDG...L....S.....E.....G....D..M....N....KVVFVEVKSGKTAVLSRREKLVRDCIDKRRVTYEIIH-n..
A0A1D2RBE3_9ARCH/31-138             ............................geerakrk----------------------------------.---------..................----------...-...---...-...F...NEME.......S.......A...IR...KDA..ISR.....SRAVLCGQFSEQLAPYL..PDF..PYKPTEVRFIGKPIDFIVFKG...L....D.....E.....K....E..P....S....EVVFVEVKSG-KSRLSGVEKKLKDAVENKRVSWEEYR-i..
Q6F7K3_ACIAD/12-145                 .........................ttlilsnsrng----------------------------------.---------..................--RIKAEYEQ...Y...IAE...L...ElehQQAL.......M.......A...AQ...KRS..VNT.....SRAVLKGKMAEQLAPIL..PEF..RYLPSDAKFLGDPVDYIVFDG...YtdfrD....gE.....G....Q..A....Ed..iDVVLIDIKSG-QARLTKGQQAIAEAIRAGRVRFETLR-i..
A0A1S8CTB1_9GAMM/18-151             .............................tyfmlas----------------------------------.-------HR..................NSAVVKEYEQ...K...IQQ...L...Q...LAHQ.......E.......E...IQravKKS..LNT.....SRATIKGRVAEQFAPLL..PEF..EYLPSDAKFLGDPVDYVIFDG...Y....Td..wrDgn.lpS....E..A....I....EVILMDIKSG-QARLSKGQLAIADAIQQGRVRFETLR-i..
#=GC seq_cons                       ...............................hhhtt.....................................................................h.........ht........p....pt........p.......p...hR...ccu..lp+.....S+uVltG+luEQhAPhh..PcF...asPpDsRFlGsPlDallFcG...h....s.....c.....G....p..h....p....cllFlElKoG.supLoppp+tI+cAlcpG+Vcacpl+.l..
//