#=GF ID   Epsilon_antitox
#=GF AC   PF08998.15
#=GF DE   Bacterial epsilon antitoxin
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1gvn
#=GF GA   25.00 25.00;
#=GF TC   26.60 46.90;
#=GF NC   23.60 20.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF WK   Epsilon_antitoxin
#=GF RN   [1]
#=GF RM   12571357
#=GF RT   Crystal structure of the plasmid maintenance system
#=GF RT   epsilon/zeta: functional mechanism of toxin zeta and
#=GF RT   inactivation by epsilon 2 zeta 2 complex formation. 
#=GF RA   Meinhart A, Alonso JC, Strater N, Saenger W; 
#=GF RL   Proc Natl Acad Sci U S A 2003;100:1661-1666.
#=GF DR   INTERPRO; IPR015090;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The epsilon antitoxin, produced by various prokaryotes, forms
#=GF CC   part of a postsegregational killing system which is involved in
#=GF CC   the initiation of programmed cell death of plasmid-free cells.
#=GF CC   The protein is folded into a three-helix bundle that directly
#=GF CC   interacts with the zeta toxin, inactivating it [1].
#=GF SQ   30
#=GS A0A377MUC9_9ENTE/2-87    AC A0A377MUC9.1
#=GS K5Y7B9_9BACT/2-90        AC K5Y7B9.1
#=GS A0A1X9I6E5_9CAUD/2-34    AC A0A1X9I6E5.1
#=GS J3EPN3_9LACO/2-86        AC J3EPN3.1
#=GS S0KL36_9ENTE/4-91        AC S0KL36.1
#=GS T0U194_9ENTE/2-90        AC T0U194.1
#=GS A0A3N0I2F2_9FIRM/2-90    AC A0A3N0I2F2.1
#=GS A0A1L8RCE9_9ENTE/2-66    AC A0A1L8RCE9.1
#=GS I8WW62_9BACE/2-90        AC I8WW62.1
#=GS A0A6N8U3W2_9FIRM/2-90    AC A0A6N8U3W2.1
#=GS C8P9R2_9LACO/2-90        AC C8P9R2.1
#=GS R8W158_9CLOT/2-90        AC R8W158.1
#=GS A0A377KFR3_9ENTE/2-90    AC A0A377KFR3.1
#=GS E6LIR7_ENTI1/2-88        AC E6LIR7.1
#=GS F7UWW4_EEGSY/2-90        AC F7UWW4.1
#=GS A0A2K2UDR6_9ACTN/2-90    AC A0A2K2UDR6.1
#=GS A0A3L8GCK2_STRIN/2-90    AC A0A3L8GCK2.1
#=GS A0A7G3MJ42_9CAUD/2-34    AC A0A7G3MJ42.1
#=GS A0A430AN42_9ENTE/5-93    AC A0A430AN42.1
#=GS A0A143X1N3_9ACTN/2-90    AC A0A143X1N3.1
#=GS A0A429ZN65_9ENTE/5-93    AC A0A429ZN65.1
#=GS A0A2A7SSC8_9ENTE/2-90    AC A0A2A7SSC8.1
#=GS E8LH29_9FIRM/1-54        AC E8LH29.1
#=GS A0A429ZSI2_9ENTE/2-90    AC A0A429ZSI2.1
#=GS R2RYY6_9ENTE/1-88        AC R2RYY6.1
#=GS A0A1C0BV01_9FIRM/2-90    AC A0A1C0BV01.1
#=GS A0A430APP3_9ENTE/20-105  AC A0A430APP3.1
#=GS A0A6A0BG46_9LACT/2-90    AC A0A6A0BG46.1
#=GS A0A430AHQ4_9ENTE/5-90    AC A0A430AHQ4.1
#=GS A0A430AM49_9ENTE/2-86    AC A0A430AM49.1
A0A377MUC9_9ENTE/2-87               ..tl--DYRKTFEIEIINEFQSAIHSKMLNYVLNNELDKSDS...TNLQTNLLNQLSDMNQINLFKLSLEELEAYHEYLRSIKKYADIV-------trtk..............
K5Y7B9_9BACT/2-90                   ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDS...QLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYSKQVLNKEKVA..................
A0A1X9I6E5_9CAUD/2-34               ....AVTYEKTFEIEIINELSASVYNRVLNYCL---------...---------------------------------------------------lmii..............
J3EPN3_9LACO/2-86                   ..tl--DYRKTFEIEIINEFQSAIHSKMLNYVLNNELDKSDS...TNLQTNLLNQLSDMNQINLFKLSLEELEAYHEYLRSIKKYADSI-------trt...............
S0KL36_9ENTE/4-91                   ...k-IDYELTAKIEIINEFSYGIYNRLLNYILNNGIDKNGS...NLYS-AILSTLRRMLSIDLFSYNRGELDKMLIYWKNMNQYINEITDKVK--tq................
T0U194_9ENTE/2-90                   ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNT...RLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYSKQILNKEKVA..................
A0A3N0I2F2_9FIRM/2-90               ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDS...QLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYSKQVLNKEKVA..................
A0A1L8RCE9_9ENTE/2-66               ...e-ISYEKTFEIEIINELSASVYNRVLNYVLNHELDTDNT...QLLEVNLLNQLKLAKRVNLFEYSLDEL------------------------..................
I8WW62_9BACE/2-90                   ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDS...QLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYSKQVLNKEKVA..................
A0A6N8U3W2_9FIRM/2-90               ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDS...QLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYSKQVLNKEKVA..................
C8P9R2_9LACO/2-90                   ..kl--DYQQTYKKEILTEFASSIYAKVVNLVVDQELNIHDE...SHFLVKLMHQLGDAKLVIMDAHSLGELETIQAYWQAMNNFIDSLPTKSKVA..................
R8W158_9CLOT/2-90                   ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDS...QLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYSKQVLNKEKVA..................
A0A377KFR3_9ENTE/2-90               ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDS...QLLEVNLLNQLKLAKRVNLFEYSLEELQAVHEYWRSMNRYSKQVLNKEKVA..................
E6LIR7_ENTI1/2-88                   ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNT...RLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYSKQIVE-----msp...............
F7UWW4_EEGSY/2-90                   ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDS...QLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYSKQVLNKEKVA..................
A0A2K2UDR6_9ACTN/2-90               ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDS...QLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYSKQVLNKEKVA..................
A0A3L8GCK2_STRIN/2-90               ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDS...QLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYSKQVLNKEKVA..................
A0A7G3MJ42_9CAUD/2-34               ....AVTYEKTFEIEIINELSASVYNRVLNYCL---------...---------------------------------------------------lmii..............
A0A430AN42_9ENTE/5-93               qmes-----KIYQIELLNEFSMSVYNRLLRHVHKNKIDLTHQahqENFIVLLFHQLEETLSLNLFKKELKELEEIKHYWITMNSLTKEIC------asdv..............
A0A143X1N3_9ACTN/2-90               ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDS...QLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYSKQVLNKEKVA..................
A0A429ZN65_9ENTE/5-93               .qve----SKIYQIELLNEFSMSVYNRLLRHVHKNKIDLTHQahqENFIVLLFHQLEETLSLNLFKKELKELEEIKHYWITMNSLTKEIC------asdv..............
A0A2A7SSC8_9ENTE/2-90               ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDS...QLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYSKQVLNKEKVA..................
E8LH29_9FIRM/1-54                   ....----------------------------MNHELNKNDS...QLLEVNLLNQLKLAKRVNLFDIKLRV-------------------------vplvqyvldkakentsyc
A0A429ZSI2_9ENTE/2-90               ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDS...QLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYSKQVLNKEKVA..................
R2RYY6_9ENTE/1-88                   ...m--DYEKTFKIESLNEFSRNVYNRVLRYVVNHQIDRQNK...NDLYAELLDQLKGMLQMNLFEMSMSDLAKVESYWNAMDVYTKSITDQKA--ve................
A0A1C0BV01_9FIRM/2-90               ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDS...QLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYSKQVLNKEKVA..................
A0A430APP3_9ENTE/20-105             ...t-VNYEHTLEVEVINEFAANVRNKLINYLGQTTIDLNDA...KHPMVELLNALSEMKNRNLFEKSKEELAEVLFYWQQMNRYIETI-------tqnl..............
A0A6A0BG46_9LACT/2-90               ....AVTYEKTFEIEIINELSASVYNRVLNYVLNYELNKNDS...QLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNLYSKQVLNKEKVA..................
A0A430AHQ4_9ENTE/5-90               .qve----SKIYQIELLNEFSMSVYNRLLRHVHKNKIDLTHQ...ENFIALLFRQLEEMLSLNLFKKELEELEEIKHYWVNMNSLTKEIC------asdv..............
A0A430AM49_9ENTE/2-86               ..tl--DYRKTFEIEIINEFQSAIHSKMLNYVLNNELDKSDS...TNLQTNLLNQLSNMNQINLFKLSLEELEAYHEYLRSIKKYADSI-------trt...............
#=GC seq_cons                       ....AVTYEKTFEIEIINELSASVYNRVLNYVLNHELsKsDS...pLLEVNLLNQL+lAKcVNLF-hSLEELpAlHEYWRSMNpYoKplhsp.t....................
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