#=GF ID EspB
#=GF AC PF05802.15
#=GF DE Enterobacterial EspB protein
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE Pfam-B_8424 (release 8.0)
#=GF GA 26.50 26.50;
#=GF TC 27.30 27.30;
#=GF NC 26.40 25.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 12071694
#=GF RT Expression and purification of the recombinant enteropathogenic
#=GF RT Escherichia coli vaccine candidates BfpA and EspB.
#=GF RA Quintana Flores VM, Campos de Souza Fernandes RC, Sousa de
#=GF RA Macedo Z, Medina-Acosta E;
#=GF RL Protein Expr Purif 2002;25:16-22.
#=GF RN [2]
#=GF RM 12405637
#=GF RT Comparison of an espB gene fecal polymerase chain reaction assay
#=GF RT with bacteriologic isolation for detection of Citrobacter
#=GF RT rodentium infection in mice.
#=GF RA McKeel R, Douris N, Foley PL, Feldman SH;
#=GF RL Comp Med 2002;52:439-444.
#=GF DR INTERPRO; IPR008611;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC EspB is a type-III-secreted pore-forming protein of
#=GF CC enteropathogenic Escherichia coli (EPEC) which is essential for
#=GF CC EPEC pathogenesis [1]. EspB is also found in Citrobacter
#=GF CC rodentium [2].
#=GF SQ 72
#=GS A0A4P7KUM9_9GAMM/1-131 AC A0A4P7KUM9.1
#=GS W8WUR7_CASDE/104-308 AC W8WUR7.1
#=GS A0A4Z0QKS9_SALET/37-179 AC A0A4Z0QKS9.1
#=GS A0A2S0P952_9NEIS/32-189 AC A0A2S0P952.1
#=GS A0A366ZPH8_9ACTN/2-176 AC A0A366ZPH8.1
#=GS E0WTI6_9ENTR/41-200 AC E0WTI6.1
#=GS A0A1X0WI60_9GAMM/33-202 AC A0A1X0WI60.1
#=GS A0A1H7PD91_9ACTN/12-198 AC A0A1H7PD91.1
#=GS A0A1I5LTN1_9ACTN/16-127 AC A0A1I5LTN1.1
#=GS A0A4Y9N5X4_9ACTN/15-198 AC A0A4Y9N5X4.1
#=GS A0A516S9N7_9BURK/41-210 AC A0A516S9N7.1
#=GS A0A410UJF1_9GAMM/40-202 AC A0A410UJF1.1
#=GS A0A372J899_9ACTN/14-205 AC A0A372J899.1
#=GS H6RPQ6_BLASD/9-225 AC H6RPQ6.1
#=GS A0A1I3YVW6_9ACTN/13-201 AC A0A1I3YVW6.1
#=GS A0A098YCZ4_9ACTN/9-245 AC A0A098YCZ4.1
#=GS A0A4Q5MEQ4_9GAMM/161-330 AC A0A4Q5MEQ4.1
#=GS C5B9R0_EDWI9/34-192 AC C5B9R0.1
#=GS E3BEJ8_9VIBR/40-203 AC E3BEJ8.1
#=GS A0A6M1UNE1_9BACT/91-274 AC A0A6M1UNE1.1
#=GS A0A4V3DUS5_9NEIS/27-200 AC A0A4V3DUS5.1
#=GS W0HJ19_9GAMM/51-231 AC W0HJ19.1
#=GS A0A4P7L723_9GAMM/31-194 AC A0A4P7L723.1
#=GS Q7NUX2_CHRVO/34-198 AC Q7NUX2.1
#=GS A0A1H8RGT4_9ACTN/21-205 AC A0A1H8RGT4.1
#=GS A9MEL7_SALAR/9-167 AC A9MEL7.1
#=GS A0A285EBU4_9ACTN/3-228 AC A0A285EBU4.1
#=GS A0A366ZW33_9ACTN/30-205 AC A0A366ZW33.1
#=GS A0A2I0FUB6_9GAMM/19-177 AC A0A2I0FUB6.1
#=GS W0HX45_9GAMM/51-231 AC W0HX45.1
#=GS A0A3B0ITT1_9GAMM/36-197 AC A0A3B0ITT1.1
#=GS A0A6P0ETJ0_9ACTN/9-207 AC A0A6P0ETJ0.1
#=GS SSED_SALTY/37-195 AC Q9R803.1
#=GS A0A2Z6ETK3_9BURK/34-257 AC A0A2Z6ETK3.1
#=GS A0A238WPX7_9ACTN/22-198 AC A0A238WPX7.1
#=GS A0A367AWN1_9ACTN/29-216 AC A0A367AWN1.1
#=GS A0A1I2JY28_9ACTN/17-216 AC A0A1I2JY28.1
#=GS A0A4Y9P983_9ACTN/20-192 AC A0A4Y9P983.1
#=GS D2S4L9_GEOOG/14-198 AC D2S4L9.1
#=GS A0A261TAK7_9BORD/80-270 AC A0A261TAK7.1
#=GS A0A4Q7Y8C5_9ACTN/17-194 AC A0A4Q7Y8C5.1
#=GS A0A1H3CMK4_9ACTN/9-223 AC A0A1H3CMK4.1
#=GS A0A367B624_9ACTN/25-232 AC A0A367B624.1
#=GS G2GWP7_9ENTR/41-200 AC G2GWP7.1
#=GS I4F443_9ACTN/10-224 AC I4F443.1
#=GS A0A853CAJ8_9ACTN/17-232 AC A0A853CAJ8.1
#=GS A0A1M5MJS1_9ACTN/7-236 AC A0A1M5MJS1.1
#=GS A0A3L8PYP7_9GAMM/103-266 AC A0A3L8PYP7.1
#=GS A0A1X7EXH1_TRICW/38-196 AC A0A1X7EXH1.1
#=GS A0A323V6P9_9ACTN/1-140 AC A0A323V6P9.1
#=GS A0A0J1CL90_9BURK/32-202 AC A0A0J1CL90.1
#=GS D2TKE1_CITRI/45-319 AC D2TKE1.1
#=GS A0A7K3W8S9_9ACTN/19-201 AC A0A7K3W8S9.1
#=GS W3WJT4_PESFW/18-141 AC W3WJT4.1
#=GS V2JFG1_9BURK/30-202 AC V2JFG1.1
#=GS A0A4Y9PQP9_9ACTN/9-202 AC A0A4Y9PQP9.1
#=GS A0A562ITY7_9ACTN/9-222 AC A0A562ITY7.1
#=GS D4ZKM4_SHEVD/45-215 AC D4ZKM4.1
#=GS A0A2X4TCL2_SALER/37-195 AC A0A2X4TCL2.1
#=GS A0A2G3K3U9_9BURK/30-191 AC A0A2G3K3U9.1
#=GS D2TY37_9GAMM/36-197 AC D2TY37.1
#=GS Q8XC86_ECO57/44-310 AC Q8XC86.1
#=GS A0A509CGQ2_9ENTR/36-194 AC A0A509CGQ2.1
#=GS A0A4Y9PSZ7_9ACTN/32-213 AC A0A4Y9PSZ7.1
#=GS A0A3R9L1K1_9VIBR/35-196 AC A0A3R9L1K1.1
#=GS A0A089Q7Z2_9ENTR/45-202 AC A0A089Q7Z2.1
#=GS A0A4P7L0N2_9GAMM/31-192 AC A0A4P7L0N2.1
#=GS A0A4Y9N6I6_9BACI/9-210 AC A0A4Y9N6I6.1
#=GS A0A4S4AE25_9RHOO/85-252 AC A0A4S4AE25.1
#=GS A0A2A2HDE7_9GAMM/31-213 AC A0A2A2HDE7.1
#=GS A0A2U8I731_9GAMM/40-200 AC A0A2U8I731.1
#=GS A0A3A6TVV3_9GAMM/97-258 AC A0A3A6TVV3.1
A0A4P7KUM9_9GAMM/1-131 ................................................------------............-------MQDFNQKQ....QELEWNIQVASMDKKREG.......IDNAN........SAA.KWSV...........................................WGQIAAGVVGLAGIG..AGK.Y..LG.S...A.QIG.-------GQ.I......................................................G.NSLG..QSTQ..GITQIQ.SANDTK.....................................................................................LVELDKLT...GELQTTNAQNYAKNTNDLADKIRQVSEQMRAFT--....---.-.----------ki............................................
W8WUR7_CASDE/104-308 ............................................diys----VMALFQKC............AQEMRNQAREVRSSE....MQAQVASLKDAAKEIRKA.......AEDRL........QQA.IIQG...........................................AFQITGGAVSIGMSV..AGG.V..LN.A...KsIRK.GGEVDPDS-.Gvrvnpadnkpidlqvv.....................qdsklqgnwgsglsgtaQ.STGG..MFSSlgGMIAAG.KEQEAA.....................................................................................ERDAKKSE...LESDARVHEQSVQQANDLMQQMMDVIRDVREKLGA....---.-.---ID-----qarnetnrgia...................................
A0A4Z0QKS9_SALET/37-179 ...............................................l-FDDIWMKLMEL............AKKLRDIMRSYNVEK....QRLAWELQVNVLQTQMKT.......IDEAF........RAS.MITA...........................................GGAMLSGVLTIGLGA..VGG.E..TG.L...I.A--.---------.-......................................................G.QAVG..HTAG..GVMGLG.AGVAQR.....................................................................................QSDQDKAL...ADLQQNGAQAYNKSLTEMMEKATESMQQVSG----....---.-.----------vg............................................
A0A2S0P952_9NEIS/32-189 ...............................................l-FNEAYLAVRKL............NEDLRDVCRRYFEQQ....QVAQFDRLQAARGARREA.......IQSTF........SGE.QARG...........................................WTGIVAGVFGAGAAA..AGP.-..--.V...A.S--.--------A.S......................................................V.QGLG..RAGD..GIAGVY.AAGQQR.....................................................................................DAQGAQLL...GDMYGMVADQRTRQMNELADEAATASRRMAELQRG....LVE.A.HRNLAAAVRN..............................................
A0A366ZPH8_9ACTN/2-176 tatqtlkkagetvavrqktvllaavgagdlaverararaeqaadrtlg------------............---------------....-----------------A.......VRSAR........TS-.---Aqqvas................................avrpvtVASTVAGLVSTARTQ..TVA.T..IE.T...L.AVR.GAEVVEELR.R......................................................-.----..--QP..GVRSVV.GRA---.....................................................................................-ERAVDAV...EDAVEEVLEETAETVAEVSNEVTSITQKTAAKAEQvldsAEA.A.THEAAESAR-a.............................................
E0WTI6_9ENTR/41-200 ..............................................sv--SSFILMLNDL............MLKLRDIMRVYGAVQ....QSQGWEIVQAEYKNKAEA.......IEENK........TAA.NIEA...........................................YTMIGGGALSLFTLP.fSSI.P..AG.M...A.V--.---------.-......................................................G.MGGA..KSTE..GSGKYF.ASNDTR.....................................................................................SANLSQLA...GELQMKNAQSYADSARKLLDNATEVVSAMLNNTRS....LVD.V.MGKILASMR-l.............................................
A0A1X0WI60_9GAMM/33-202 ...............................................t-LNEVMMMLKKM............NNEIRDLQRDFVGSS....FKNAFNKEMSSLELKKEA.......IDTDY........KAA.MTNA...........................................TVKMVTGSISAAFGV..AGGfA..AG.S...K.L--.ADAVKTGSE.T......................................................F.NGVG..KAFE..SGMSMK.AAGITR.....................................................................................DARKIELR...ADMQQAQAAQIRQTISAAADKATEASRRMLEMTGE....LTR.L.QSAILDKVR-m.............................................
A0A1H7PD91_9ACTN/12-198 ..........................................efaatl------TKTNLLaaig...agdlaVERARTVVAQFRSTA....EALPGEAQVQADLAVKEA.......RTRAA........EAA.--GTarttahql...........................avaarpevLRSTVAGLVETARTQ..AIA.T..VE.T...L.AER.GAVVVEDLR.R......................................................Q.PGAR..RI--..------.---VRR.....................................................................................AEEAVDTV...EERLEDVLEEGAEAVVEASNEVTSVAQKTAAKATKaaakA--.-.----------eaevedaagaaka.................................
A0A1I5LTN1_9ACTN/16-127 ...................................tpllaavgagdla------------............LEQARTVLTSLRSRA....EALPGEAQVQVDLAAKEA.......RTRAE.......qAAD.RARGasrqlv..............................tavrpdaVASTVAELVEQARTQ..ALT.T..VE.Q...L.AER.GAEVLEELR.-......................................................-.----..----..------.------.....................................................................................--------...-----------------------------------....---.-.----------rqpgf.........................................
A0A4Y9N5X4_9ACTN/15-198 .................................nktvllaavgagdla------------............VERARAVLGTLRSRA....EALPGEAQVQADLATKEArtraeevVGRARga....vrS--.---Aqhaas................................avrpevVVSTVAGLVSTTRTQ..TVA.T..VE.T...L.AVR.GAEVVEELR.R......................................................-.----..--QP..GVRTVV.GRA---.....................................................................................-ERAVDAV...EDAVEEVLEETAETVAEASDEVTSIAQKTAAKAEKaldrAEE.A.THEVAQDAK-a.............................................
A0A516S9N7_9BURK/41-210 ...............................................l-INEVMLKLAEI............NKKNRDQNLEAKVKQ....VMESFRGQMLAYLDKLDS.......IEKAR........KAA.ITEG...........................................AGGIVGGGLGVGGAA..GHG.-..VG.A...T.IEH.TVTHEISKT.V......................................................G.ESAG..QIAS..NASKVE.GALKSA.....................................................................................EGQVAGAR...SEYTQRGTESFRQFCDEMVSRANKCSLDLKETTQA....LVD.A.IVKISSSIK-i.............................................
A0A410UJF1_9GAMM/40-202 ...............................................l-INDLAIKMAAL............FRELRDTQRQYNENQ....QKNSYEIALTSYDTKMTG.......IEKDY........EAG.MKSA...........................................NGELTAGLIGTFLSV..FGL.K..TGnT...L.WGQ.L--------.-......................................................G.NASG..EAVK..SGFDRD.AKKLSR.....................................................................................EGQELSSL...ADFQRSLADGAEKRSDQTLEMARQASSDLKQMLEM....VAQ.I.HDKLTSALH-r.............................................
A0A372J899_9ACTN/14-205 .............................vavqnktvllaavgagdla------------............VERARTVVEQLRSRA....EALPGEAQVQVDLAAKEA.......RTRAE........EAAqRARGtvqhartsvg.......................sfaaavrpdaVAGTVAGLVSTARTQ..AVA.T..IE.T...L.AVR.G--------.-......................................................G.EVVE..ELRR..QPSFR-.-TLVAR.....................................................................................AERAVDTV...EDTLEEVLEDTAEAVTEASDEVTSVAQKTAARAAKvadkAEE.K.TAEVADSAK-a.............................................
H6RPQ6_BLASD/9-225 ..................................qygetvatvtrtnl-----------Laaig...agdlaVERARTAVASFRSKA....EALPGEATVQADLAVKEA.......RTRAT.......eAAG.TARTaaqqla..............................tvvrpetLRSTVTGLVATARTQ..ATT.T..VE.T...L.AGR.GAEVVEELR.Rqpgvrriarraeqt.........................vdtvedavedaieeaA.EAVS..EASD..EVTSVA.QKTAAK.....................................................................................ADKAATTA...EETVRETADSTKATVAEVAEE--------------....---.-.----------pvaapkakpaakknsaatk...........................
A0A1I3YVW6_9ACTN/13-201 ............................tvavrnktallaavgagdla------------............VERARSVVGSLVQRA....EALPGEAQVQADLAAKEA.......RTRAG.......eAAG.RARGavqsartsaq.......................hvaaavrpdaVVGTVTGLVSVARTQ..AVA.T..IE.S...L.AVR.GAEVVEELR.R......................................................-.----..--QP..GFRTVV.S----R.....................................................................................AERAVDAV...EDRLEDILEETAETVSEASDEVTSRAQKTSAKVTK....AVD.R.VEEKTSSA--ae............................................
A0A098YCZ4_9ACTN/9-245 ................................................HHGETFVRTGLLaalg...agdvaVDRARTVVGTFRTRA....EALPGEAQVQADLAGKEAr....srIEAARa.....raAQA.AAEArvraeqarg.........................vaatvrpetVLGTVTGLVESARTQ..ALG.A..IE.E...L.AGR.GEKVVDDLR.Tqpafrkvvartera.........................vdavedtvedvleetG.ETIG..KASD..EVTSVA.QKAKSR.....................................................................................TDKAVDAV...EDTVEDVLAETGETIGKASDEVTSVAQKAKSRTDKavdaAQQ.E.TQEVAESAKR..............................................
A0A4Q5MEQ4_9GAMM/161-330 ...............................................e-INDLMYKLAKM............FQALRNIVQDAKTLF....DKLNWDIKMNALNQKMDA.......IGQTR........NAA.MLGGg........................................lsVLGAAIGSVASVCGV..VGG.A..VG.K...V.G-I.GESLSI---.G......................................................G.QMFS..KLSD..GAGSMG.SAQITY.....................................................................................GADIKRTV...AGLIDQISEQFSKDVSDAYSRANKTSVDMISLLTE....LVN.L.HRAIESAL--sk............................................
C5B9R0_EDWI9/34-192 ................................................QLNELMVQLGEL............FGKLRDVLRQYQQAQ....QSNAFKMQKTAFETRVDS.......IDKDF........QAK.QAQA...........................................VAQIVGGIAQTVGGG..-FG.E..HG.H...T.I--.---------.-......................................................S.TGLN..NMTQ..GIVGVGyANDLTR.....................................................................................QSQEEQAL...SDYQHGMADQLLKRAEETKEKALKVSGDLREILAT....LTQ.A.HEHLSSSVR-i.............................................
E3BEJ8_9VIBR/40-203 ................................................QLNDLMIKLSEV............MQKLRDVLQQYNQKQ....QELGWDIQKASMDTKKEA.......ISKAC........ESS.ILSG...........................................VLQIGAGIAGMAGAGfsKST.G..LG.E...A.TTH.L--------.-......................................................G.KGAG..DSLS..GIGTVV.SAEMTK.....................................................................................NAEIEKTE...GEFQSMNAQSYTKNIGESREKAMQISEQMRSLVKD....LVE.L.HGRISSAVKN..............................................
A0A6M1UNE1_9BACT/91-274 ............................................diys----VMALLQRC............AQEMRSQAREVRKSE....----IEAQVSSLKNAAQE.......ISKAAqd....rlTQA.IIQG...........................................SAQIIGGGVTVGMGI..AGS.V..YG.I...KsINA.GASSIQGAK.Fantaqll........................................ggtaessG.KIIG..TGGS..MIGAGM.EKA-AA.....................................................................................EHDTQRAE...LEAQARVHEQGVQQANELMQQMMDVIRDVREKLG-....---.-.----------aidqarsetnrgia................................
A0A4V3DUS5_9NEIS/27-200 ................lgsvyilleklmahflelfktnkemesllrvs------------............---------------....---QIELNGASFQQKLEA.......ADKTC........EAT.RSRA...........................................FAGMGAGVLGMGGGI..LGA.G..MS.A...G.PKS.LRNAAQQVSpT......................................................L.QSTG..EFMK..QSSAAA.TAEQDR.....................................................................................QSQQLLAQ...AEYQGKMADQSHGEMRMSEEDAKQILQALHRTQHT....LVD.L.LSQVGSAVK-l.............................................
W0HJ19_9GAMM/51-231 ...............................................r-YDEIWAKMMMM............CKKLRNMMNEYNAQR....QAQAWALDVNALTKTRDG.......IDKAF........QAA.VMSS...........................................VGGLAGGVCGMGGTV..TGF.R..AV.K...N.LKQ.NPGENLH--.Snstntf..........................................nqhqglG.HDSG..QFIN..SGCAAG.ASGMTK.....................................................................................EADTAKAE...AELLHKSAHAYEKTQDELQAQAKDIMRQMLEMGQR....YVE.Q.YSQALQ----hlvr..........................................
A0A4P7L723_9GAMM/31-194 ................................................QINELMMMLTEM............LKKLRNTLQEFNQKQ....QELGWNIQVASMDKKREG.......IDNAN........SAA.KWSA...........................................WGQIAAGVVGLAGIG..AGK.Y..LG.S...A.QIG.-------GQ.F......................................................G.NSLG..LSTQ..GITQIQ.SANDTK.....................................................................................LAELDKLT...GELQTTNAQNYAKNTNDLADKIRQVSEQMRAFTKD....LVE.L.HSRISSSIR-h.............................................
Q7NUX2_CHRVO/34-198 ...............................................t-IDNLIAMLQKM............NIDIRDMERDFHAAG....QQRAAAVQLKSIDTKLES.......IELKY........KAA.WKNA...........................................SAKVLSGFLSAGGAA..IGG.-..--.-...V.AGS.G---GDLMS.T......................................................GlSGVG..KAAE..GGINWG.TASLTR.....................................................................................DAEQKNIL...GEFQADHAAERYKALSAAAEKAAEASSRMHDLTRQ....LMS.M.QERMMSVVK-i.............................................
A0A1H8RGT4_9ACTN/21-205 ....................................pvlalvgagdla------------............VERARALVGSLVSRA....EALPGEAQVQVDLATKEA.......RTRAE.......eAAG.RARGavqtarttav.......................qfgglvkpetVRATVTGLVDTARTQ..AAG.T..LE.T...L.AER.GAGVVDELR.R......................................................Q.PTFR..R---..----VV.----AR.....................................................................................AERAVDAV...EDSLEEVLEEGAETVAEASDKVTSVAQKTAAKATKaaakVED.A.VDEAADSAK-a.............................................
A9MEL7_SALAR/9-167 ...............................................l-FDKIWETLIEL............AKKLRNIMRAYNVVK....QQLSWELQVNAFNTQLKT.......IDQTY........KAS.ILNG...........................................VGSICSGMLTIGFGV..TGG.E..AG.V...M.F--.---------.-......................................................G.QGAG..HIAA..GGFSLG.GSAAQR.....................................................................................QSDQTSTI...AELQQKGAQSYSKTLTEIMDKAADIMQQIMGMGTS....LVD.V.LAHILQSLTR..............................................
A0A285EBU4_9ACTN/3-228 ..................ttetlkkvgetvvvqnktvllaavgagdla------------............VERARAVVGTLRSRA....EALPGEAQVQADLAAKEAr....trAEEAAg.....raRDA.VQSArtsaqhv............................aaavrpesVKSTVTDLVSTARTQ..AVA.T..LE.S...L.AVR.GGEVVEELR.Rqptfrkvvfraera.........................vdvvedrledvleetA.ETVA..EASN..EVTSVA.QKAAAK.....................................................................................TAKVVDAA...EEKTAQAADTAKATIAEA-----------------....---.-.----------dvtepakpvkkssaarks............................
A0A366ZW33_9ACTN/30-205 ......................................lavvgagdla------------............LEQARTVLGQFRSKA....EALPGEAQVQADLAVREArtrateaVDNAR........TTA.HQLAvav....................................rpeaLRSTVAGYAELARTQ..ATA.T..LE.T...L.AER.GAEVVEDLR.R......................................................-.----..--QP..GFRRVV.RR----.....................................................................................AESAVDAV...EDTLDDILEETAEAVVEASNEVTSVVQKTAAKATKvaaqAEK.S.VDAAAEAA--kd............................................
A0A2I0FUB6_9GAMM/19-177 ...............................................t-INQIILEMQKM............GTKMRDLERSHAQMM....QRVAFDRQILSLETKREA.......IEQNY........QAA.LAGA...........................................ITQIVGGAISSVAAL..SGS.-..--.Q...I.ATT.G--------.-......................................................A.DGLS..KSGQ..GIAGVA.SSGMTR.....................................................................................EAQQLQLQ...GDFEQQSAEAFNKMITTAQDRASEASRQMLAIASE....LVA.L.SDRIASSVRM..............................................
W0HX45_9GAMM/51-231 ...............................................r-YDEIWAKMMMM............CKKLRNMMNEYNAQR....QAQAWTLDVNALVKTRDG.......IEKAF........QAA.VISS...........................................AGGVAGGVCSMGGTA..TGF.R..AV.K...N.LKQnPGENLH---.Snstdaf..........................................nlhqglG.RDSG..QFIN..SGCAAG.ASGMTK.....................................................................................EADTAKAE...AELLHKSAHAYDKTQDELQAQAKDIMRQMLEMGQR....YVE.Q.YSQALQ----hlvr..........................................
A0A3B0ITT1_9GAMM/36-197 ................................................QINELIIKLAEG............LKKLRNILQEFNQKQ....QELGWNIQASSLDKKRQG.......IEDAY........DAA.KLTG...........................................AFQIVSGSVGVLNGA..FAK.Q..FG.E...I.ATH.F--------.-......................................................G.QATS..KGLE..GSGQLG.SAEMTK.....................................................................................KAELEKVE...GDFQAMNAQNYAKNIKDSWDKACQLSEQVRSIVKD....LVD.L.YTRISSAV--vn............................................
A0A6P0ETJ0_9ACTN/9-207 ..............................................hy--GETLVETGRTgllaalgagdvaVDRARTVVDGLRSRA....EALPGEAQVQADLGAKEAr....arVVAAR........EQA.RRAAvharstv.............................telrpetVLGTVTGLVDGARAQ..ALE.A..IG.E...L.AGR.G--------.-......................................................E.QLVG..DLRR..Q--PVF.RKVVAR.....................................................................................TERAVDAV...EDGLEDVLDETAETVAEASDTVTSVAQKTAARTTA....AVE.SaTADVQEA---aestkatladaa..................................
SSED_SALTY/37-195 ...............................................l-FDDIWMKLMEL............AKKLRDIMRSYNVEK....QRLAWELQVNVLQTQMKT.......IDEAF........RAS.MITA...........................................GGAMLSGVLTIGLGA..VGG.E..TG.L...I.A--.---------.-......................................................G.QAVG..HTAG..GVMGLG.AGVAQR.....................................................................................QSDQDKAI...ADLQQNGAQSYNKSLTEIMEKATEIMQQIIGVGSS....LVT.V.LAEILRALTR..............................................
A0A2Z6ETK3_9BURK/34-257 ...............................................i-IDHLMTRLQKM............HLQMRDLEREFFTSQ....QSVAFEKQVHALATKREA.......IEKNF........EAA.KTGA...........................................VGQIVAGSIGLVGAS..ISA.-..VG.A...A.NKV.NNPASAA--.TttidltsasassktlnlasasastsaktanlntvsvttkaatpaanssklegigN.SMLGgkDAVA..GIAGYS.AATSKR.....................................................................................EAEQLQLD...GDFETQAAESFQKSLAKTADHALEASRQLHETTRE....LVA.L.NDRVFSAVK-f.............................................
A0A238WPX7_9ACTN/22-198 .....................................vlaaigagdla------------............VERARTVVAQFRSKA....EALPGEAQVQTDLAVKEArt...raTE---........--A.AGNArtaaqql............................atavrpemLRSTVTSLVGAARTQ..AVA.T..VE.T...L.AER.GAEVVEDLR.R......................................................Q.PAL-..----..--RRVV.----RR.....................................................................................AEAAVDAV...EDAVEDVLEETAEAVVEASNEVTSVAQKTAAKATKvaarAEE.K.VDAAAEAAK-a.............................................
A0A367AWN1_9ACTN/29-216 .....................................ilalvgagdla------------............VERARTAVAQFRSTA....EALPGEAQVQADLAVKEArt...raTEAA-........ETA.R--Araneaagsarst...................aqqlaeavrpdaLRSTVVGLVETARTQ..AVA.T..VE.T...L.AGR.GAEVVEDLR.R......................................................Q.P---..----..AFRRVV.----RR.....................................................................................AERAVDAV...EDRLEDVLEETAEAVTEASNEVTSIAQKTAAKASKvaakAEE.K.----------vedaadtaka....................................
A0A1I2JY28_9ACTN/17-216 ................................aaktqllatigagdla------------............VERAKTVLAQFRSQA....VALPGEAQVQADLAVKEA.......RTRAT........-EA.AGNArttaqql............................avatrpeaLRSTVFGLVGTARTQ..ALA.T..VG.T...L.AER.GAEVVEDLR.Qqpafrrvvrraera.........................vdtvedaledvledsA.EAVV..EASN..EVTSVA.QKTAAK.....................................................................................ATKVAEKA...EDKVEDAAETTKATA--------------------....---.-.----------edpveapkarsnaaak..............................
A0A4Y9P983_9ACTN/20-192 ...................................tlnlaaigagdla------------............VERARTAVSQLVTKA....EALPGEAQVQADLAAKEArt...raT---EvagqarsaAQQ.IATAvr......................................pevLKSTVAGLVETARTQ..AQA.T..LE.A...L.AER.GAGVVEELR.T......................................................Q.PAF-..----..--RRV-.---VRR.....................................................................................AERAVDAV...EDTLEDVLEETAEAVVEASNEVTSVAQKTASKATK....A--.-.----------aakpglaeavv...................................
D2S4L9_GEOOG/14-198 .............................vavqnkqvllaavgagdla------------............VERTRAVVGTLRSRV....EALPGEAQVQVDLAAKEAr....trAEEAVwt....arT--.--SAqqvat................................avrpdvVASTVAGLVSTARTQ..TVA.T..IE.T...L.AVR.GAEVVEELR.R......................................................Q.PV--..----..-----V.RKVVGR.....................................................................................AERAVDAV...EDALEDVLEETAETVAEASNEVTSIAQKTAAKAEKvidqAEE.A.THEAAE----qaka..........................................
A0A261TAK7_9BORD/80-270 ..........................................diyamm----------TL............FQKLAQEQRNSARAD....RAAAMDAQVQTLMSAADA.......IRDAAae....rfKGA.MVAG...........................................AFQIIGGAMQVAAGA..GAV.G..AS.L...K.SV-.------NMT.Ttsspltaaqtkfq............................tgldgfaanasglG.QGAS..GIAG..GIGSMA.QAGFDR.....................................................................................AAGAKDAEraeLEASAKVFESGVQQANDLMQQMMDVIRDVREKLSA....M--.-.----------eqsrvetnrgi...................................
A0A4Q7Y8C5_9ACTN/17-194 ....................................pllavvgagdla------------............VERARTVVASFRTKA....EALPGEAQVQADLAVKEA.......RTRAT.......eAAG.TARStvqqla..............................tvarpdvLRSTVAGLVETARTQ..AVS.T..VG.T...L.AER.GAVVVEELR.R......................................................Q.PA--..----..-VRRV-.---VRR.....................................................................................AEEAVDTV...EDTLEEALEETAEAVTEASDEVTSIVQKTAGKATKaaakAED.A.VRETAESTK-a.............................................
A0A1H3CMK4_9ACTN/9-223 ........................hytetvvesgrtgllaaigagdva------------............VDRALAAVGTVRSRA....EALPGDAQVQADLAVKEAr....arAELARg.....raAQA.AAETraraasaaeqagdaah..........sarsavstvaatvrpetVLGTVTSLVGAARAQ..AVS.T..LT.E...L.AGR.GEKVVEELR.S......................................................Q.P---..----..----VV.RRVAGR.....................................................................................TEQAVDVV...ADTVEETLAETAETVGEASDRVTSVAQKTKARADK....AVQ.E.AEQ-------dtevaadtakr...................................
A0A367B624_9ACTN/25-232 .................................artpllavvgagdla------------............VERARTAIASLRSQA....EALPGEAQVQADLAVKEArtrateaADTARt......tAQQ.LATAvr......................................peaLRSTVAGLVEVARTS..AAT.T..VE.Q...L.AER.GAEVVEELR.Rqpgvrrivrraeaa.........................vdtvedtleealedaA.EAVT..DASD..ELTSIV.QKTAGK.....................................................................................AAKAAAKA...EETVRETAESTKASVAEVAEE--------------....---.-.----------epapkakstakkssaaagk...........................
G2GWP7_9ENTR/41-200 ..............................................sv--SSFILMLNDL............MLKLRDIMRVYGAVQ....QSQGWEIVEAEYKNKAEA.......IEENK........TAA.NIEA...........................................YTMIGGGLFSLCTLP.fSSF.P..AG.M...A.I--.---------.-......................................................G.MGGA..KSIE..GSGKYF.ASNDTR.....................................................................................SANLSQLA...GDLQMKNAQSYTDSARRLLDNATEVVSAMLNNTRS....LVD.V.MGKILASMR-l.............................................
I4F443_9ACTN/10-224 ........................ygetlvdtgrtgllaaigagdvav---------DAA............VDRARAVFGTVRTRA....EALPGEAQVQADLAAKEAr....trAEQARe.....raSRA.AAEAraraalarsqaedaat..........qaraavtsaaatvrpetVLGTVTGLVESARNQ..ALA.A..IA.E...L.AGR.GEKVVDELR.T......................................................Q.PA--..----..-F----.RKVVAR.....................................................................................TERAVDAV...EDTLEDVLEETAETVGKASDEVTSVAQKTKARTDK....AVDeV.TDEVREAA--ag............................................
A0A853CAJ8_9ACTN/17-232 ................................faktpvlatigagdla------------............VQRAKLVVDQLRNRA....EALPGEAKVQADLGVKEArt...raT---Eaa....gqARA.A--Aeqfra................................svrpeaVRTTVTGLVETARTQ..AFA.T..VE.A...L.AER.GAHVVEELR.Qqpgfrrvvrraena.........................vdtvegtveeaiedgA.KAVK..DASN..EVTSVA.QKTAAK.....................................................................................ATKVADKA...ESKTAEAAESTKETVDAAAETPAKRA---------....---.-.----------prksttaarksspakasasvs.........................
A0A1M5MJS1_9ACTN/7-236 .........................lfeqvaergrtpllvavgagdla------------............VTQARTVLATLRSRA....EALPGEAQVQVDLATKEArt..raeLAADR........ARG.LAGAvr......................................peaVVGTLNTLVEQARAQ..AAG.T..VE.V...L.AER.GADVLQELR.R......................................................-.----..--QP..GFRRFA.AKAE--.....................................................................................--AAVDTV...EETVEEVIEDAAEAVTEASDEITSRVQKAASKTTKaaarAEE.A.VEEAADSAK-atieetaeaadeatakaarkpakrttaargkaagtstrvsrtrtak
A0A3L8PYP7_9GAMM/103-266 ...............................................e-INQLMIKLADL............FKKLRNILQDFNVVQ....DKLAWDITLASMAQKRDG.......IEHAM........IGM.AISG...........................................AASIAGGLFSVGFGL..GGA.A..KGsE...A.LGI.L--------.-......................................................G.QGLG..RMTD..GAGSSA.NAWQTQ.....................................................................................VSENAKLI...GSLDETNANTYMRKLGETMERARRTSTDMVSLLVE....LTQ.L.HRSLENA---lsvk..........................................
A0A1X7EXH1_TRICW/38-196 ................................................SIDDLIVLVQKF............NLEMRELDRKAAGAM....QEADFKTTVASFEERKAA.......IEKKF........NAS.VARA...........................................VGSITAGTLGMVGSV..SGN.-..--.E...M.AMG.L--------.-......................................................A.EGGG..KLDE..GLLGWA.AAGEER.....................................................................................DAEEMQMN...GELKQEFAKQFGKAADDANDKARDALRQLVQAVED....LVA.L.KGRIQEAVR-l.............................................
A0A323V6P9_9ACTN/1-140 ..................................raravqartqaega------------............---------------....------------ATQARA.......AVTT-........---.---Aastv...................................rpetVLGTVTGLVDSARNQ..ALA.A..IA.E...L.AGR.GEKVVGDLR.T......................................................Q.P---..----..----AF.RRVVAR.....................................................................................TERAVDTV...EDALEDVLEETAETVGKASDEVTSVAQKTKARTDK....AVD.R.ATE-------dgrtaarsakr...................................
A0A0J1CL90_9BURK/32-202 ................................................SISTLMIEVTKL............FQELRDQGQEFYVQS....LQRQFSIQMEELKLKQDS.......IDDTK........TSA.LLGG...........................................SFEIAAGGLGVMAGA..GSG.A..AG.L...A.LKN.GMGVEAGMQ.A......................................................G.NVLG..RMTD..GTGKVA.AAYSAA.....................................................................................DAQTSTVL...GEFAGKNAEQYKQGM----DQAMARIQDLREKALQacaaYKD.L.YDRNASAIKM..............................................
D2TKE1_CITRI/45-319 ................................................DISKLLLEVQKL............MREMVTTLQDYLQRQ....LAQSYNIQQAIFQSQNKA.......IEEKKa.....gaTAA.LIGG...........................................AISSVLGILGSFAAI..NSA.-..--.-...-.-TK.GASDVVQKA.Tsasaksvntasevs.........................tkalvkasesiadaaD.ETVG..TLQQ..GIAAATkAANRTSgiaddvttsaqkasqvaeeaadaaqdltrkanllsrft........aaagrisgstafvvvtslaegtktlpttisesvksnhdiNEQRAKSV...ENLQASNLETYKQDVRRSQDDIASRLRDMTATARD....LND.L.INRMGQSAR-l.............................................
A0A7K3W8S9_9ACTN/19-201 ...................................rtgllaaigagdv-----------V............LDKARTVVEQLRSRA....EALPGELQVQADLAAKEA.......RQRAE........QAA.AAAAqartaatq..........................aassvrpeaLADTMAGLVESARKQ..ALV.T..IE.Q...L.AER.G--------.-......................................................E.KLVG..ELRR..QPGF--.RAVVSR.....................................................................................TERAVDAV...EDALEDVLEETSEAVDKASAEVTSVAQKTAARADK....AID.E.VEGEARSA--aaaaka........................................
W3WJT4_PESFW/18-141 .....ngsvqqltdidrrnlepesveivdllplvqhpddvakrfdipg------------............---------------....------------------.......-----........---.----...........................................---------------..---.-..--.-...-.---.---VDLDSV.A......................................................D.EVWG..KVKS..EVADAV.DAAKKT.....................................................................................FDDAVSTA...KETLDKAVAMAKEAIEKIKDEVEKIWEEVKKKVAE....LED.K.----------vfsaih........................................
V2JFG1_9BURK/30-202 ............................................saqa----MILEFQAL............MRKLYNTYVECHAAL....EKNVADLQKLAYQRAIEA.......KDQRK........SAE.VGSG...........................................ITGIVTGGFSLLCGI..GGG.V..YG.ArnpA.MGF.GMGADMGSH.L......................................................G.TPAG..NIGN..MVGQIV.TAGTRG.....................................................................................KAEEAQIH...ADLARNVSDSAARDSGKARDNADQHHDQYLREAGQ....LT-.-.-QEMI-----aaikatv.......................................
A0A4Y9PQP9_9ACTN/9-202 ........................qygetavstyktlnlavigagdla------------............VERARTALGQFRSKAassvLALPGEAQVQADLAVKEA.......RTRAT........-EA.AGNArttaqql............................avavrpetLKSTVAGLVETARTQ..AVA.T..VG.T...L.AER.GAEVVEDLR.R......................................................Q.----..---P..AFRKV-.---VRR.....................................................................................AERAVDAV...EDTLEDVLEDTAEAVVEASNEVTSIAQKTAAKATK...vAAK.A.ENKIED----aaettka.......................................
A0A562ITY7_9ACTN/9-222 ...............................................k-HGENVVRTGLLaalg...agdvaVDRARTVVGQFRSRA....EALPGEAQVQADLAGKEAr....trAEDAR........TRA.AHAAaeararagqareqaaaaaqqarvaaaqartaavdaaatvrpetVFGTVTGLVGTARTQ..ALT.T..IG.E...L.ADR.G--------.-......................................................A.TLVG..----..---PTF.QRFAGR.....................................................................................AEQAVDTV...EDAVADAADTVQETVDAASNEVTSVAQKTAARADD...aLDT.V.TDETAEAA--aatkr.........................................
D4ZKM4_SHEVD/45-215 ................................................QINELMVQLAEM............FKKLRNVMQEHNIKQ....QSLGWDVQVSAMKDKRES.......IDKAY........KSS.MMTG...........................................GMQLGAGLVGLVGSG..AAG.H..YG.L...N.KLN.SEKSALASG.L......................................................G.SGFG..KSMG..GIGTMA.SAGLTK.....................................................................................DAELAKAR...GNFKEQSAQNYIKVANELNDKAKQISEQMRSMIKD....LVD.L.HGRISSAVH-n.............................................
A0A2X4TCL2_SALER/37-195 ...............................................l-FDDIWRKLIEL............AKKLRNIMRAYNEVK....QQLSWELAVNAFNTQMKT.......IDQTY........KAS.TLNG...........................................VGSILSGMLTIGFGV..TGG.E..AG.V...M.F--.---------.-......................................................G.QGAG..HIAA..GGFSLG.GSAAQR.....................................................................................QSDQTSAI...AELQQKGAQSYNKTLTEIMDKAADIMQKIMSMGAS....LVE.V.LAQILQSLA-r.............................................
A0A2G3K3U9_9BURK/30-191 ...............................................v-INDLMVKLGSL............LGKMRDLMREYNQLL....NSNTFKMQQTSFNTRMEG.......IQKNF........EAQ.QHAA...........................................IGQILGGMVEMGGGM..LAG.G..MQ.N...-.---.----QAVSS.I......................................................S.SGMS..NISQ..SSFKLD.AAALSR.....................................................................................DGEVDQAK...AEFQHGLADAMLKRSDEILAKVTDIQTQMREMVKM....VVE.A.YERLASSVR-..............................................
D2TY37_9GAMM/36-197 ................................................QINELIIKLAEV............LKKLRNILQEFNQKQ....QELGWNIQTASLDKKRQG.......IEDAC........SAA.ISTG...........................................ACQILSGVVGLLSAP..LSK.Q..FD.E...I.ATH.L--------.-......................................................G.QASG..KSLE..GIGQLS.SAEKTK.....................................................................................KAELEKVE...GDFQATNAQSYAKNIKDSWDKACQLSEQMRSIVKD....LVD.L.YTRISSAV--vn............................................
Q8XC86_ECO57/44-310 ...............................................d-ICKLMLEIQKL............LGKMVTLLQDYQQKQ....LAQSYQIQQAVFESQNKA.......IEEKKa.....aaTAA.LVGG...........................................IISSALGILGSFAAM..NNA.AkgAG.E...I.AEK.AS-SASSKA.Agaaseva........................................nkalvkaT.ESVA..DVAE..EASS--.-----AmqkamatttkaasrasgvaddvakasdfaedladaaektsrinkllnsvdkltnttafvavtslaegtktlpttisesvksthevNEQRAKSL...ENFQQGNLELYKQDVRRTQDDITTRLRDITSAVRD....LLE.V.QNRMGQSG--rl............................................
A0A509CGQ2_9ENTR/36-194 ...............................................l-FDKIWMKLLEL............AKKLRDILRSYNEVR....QKLSWELQKNALQTQMEA.......INKTC........EAA.IFTG...........................................VGSCLSGVLTMGFGF..AGG.E..SG.V...I.F--.---------.-......................................................G.QGVG..HTAM..GGFGLA.AGIVQR.....................................................................................QGDQEGAI...AGLQQNGAQSYSKNMMDIMEKALEIMQQIMGMGMS....LVQ.V.LAQMLQSLA-r.............................................
A0A4Y9PSZ7_9ACTN/32-213 ........................................vvgagdla------------............VERAKTAIATFRSKAtssvLALPGEAQVQADLAVKEA.......RTRATeaa..gtaR--.---Staqqfa..............................gavhpeaLRSTVVGFVETARTQ..AVA.T..IE.K...L.AEH.GAEVVEELR.Q......................................................Q.PTFR..R---..----V-.---VRR.....................................................................................AERAVDTV...EDALEDVLEDTAETVVDVSNKATSVAQKTAARATK...vAAK.A.EDKVEDAAK-ttkasaek......................................
A0A3R9L1K1_9VIBR/35-196 ................................................QLNELIVKLAEI............FKKLRNILQEYNQKQ....QLLGWDVQKASMDSKRDS.......IESAF........ESA.AWAG...........................................GLQILSGVIGMAGVG..ATG.K..FG.E...G.ATH.L--------.-......................................................G.QAFG..KGVD..GVGSTV.SASMTK.....................................................................................NAEMEKMD...GEFKAMNSQNYAKNVNELSDKARQISDQMRALVKE....LVE.L.HGRITSAVRN..............................................
A0A089Q7Z2_9ENTR/45-202 ...............................................m-FDEIWSKLLML............AKQLRDTMQFYNQKK....QELSWGLEINTLQQSVKA.......IDDSY........GAA.KAGA...........................................IGGMFAGVLTVGGAF..-FG.E..AG.M...T.V--.---------.-......................................................G.NAMG..QVAN..GIGSWA.SGSETR.....................................................................................KADAEKAI...AELQNKGAQSYAKTLDDTLMKAREIMQQMMEMGRN....LVE.V.FSQVLRAIS-r.............................................
A0A4P7L0N2_9GAMM/31-192 ................................................QINELMMMLTEM............LKKLRNTLQEFNQKQ....QELGWNIQVASMDKKREG.......IDNAN........SAA.KWSV...........................................WGQIAAGVVGLAGIG..AGK.Y..LG.S...A.QIG.-------GQ.I......................................................G.NSLG..QSTQ..GITQIQ.SANDTK.....................................................................................LVELDKLT...GELQTTNAQNYAKNTNDLADKIRQVSEQMRAFTKD....LVE.L.HSRISS----wl............................................
A0A4Y9N6I6_9BACI/9-210 ........................qygetvatvakpavlaaigagdla------------............VERAKNVVAQFRSRA....EALPGEAQVQADLAVKEA.......RTRAT.......eAAG.TARTtaqqla..............................vavrpeaLRSTVAGLVETARTQ..AIA.T..VE.S...L.AAH.GAEVVEELR.Q......................................................-.----..--QP..GFRRVV.R----R.....................................................................................AERAVDTV...EDALEDVLEDTAEAVVEASNEVTSVAQKTAAKATKvaakAED.K.VE--------daadkakataeeaveapkaa..........................
A0A4S4AE25_9RHOO/85-252 ............................................nlst----DMQAVMLL............FAKMAQSMREVSRNQ....RQAELGAQVEAMGDAAQK.......IRDAAek....rfAAA.MVQG...........................................ACQIGSGVASIGGAA..---.-..-G.G...M.IKG.GDAAMISAR.Tq....................................................iG.SGTG..NIIS..GIGTMA.SGSLER.....................................................................................DAGLIDAE...K-AELDKLATTHEKARESDNDMMQNMQDI---IRD....IKD.K.LAAIAQS---qie...........................................
A0A2A2HDE7_9GAMM/31-213 ................................................QINELMMMLTEM............LKKLRNTLQEFNQKQ....QELGWNIQVASMDKKREG.......IDNAN........SAA.KWAA...........................................WGQIAAGGIGLAGTG..AGA.L..YG.R...S.AAV.AANTVDKAN.Qamqtsl..........................................tvggqiG.SGLG..HGTQ..GITQIQ.SANDTK.....................................................................................LAELDKLT...GELQTTNAQNYAKNTNDLADKIRQVSEQMRAFTKD....LVE.L.HSRINSAIR-h.............................................
A0A2U8I731_9GAMM/40-200 ...............................................n-MDQLMIEVKKL............FNKLAQTASETLTAN....VLAEFKMMVKNFETKLEA.......AEKQR........KAG.NVEA...........................................IIGIVMGVIGVAAAG..SSF.K..LT.E...L.VNS.L--------.-......................................................A.QMAD..KLVT..SVGKIP.VNSINN.....................................................................................QVNIDRAN...ADMQEKMAQQIQKLVQESINKIRDYLKQLQDTCET....---.-.----------imrantgamtkam.................................
A0A3A6TVV3_9GAMM/97-258 ...............................................e-INDLMTKLATL............FQELRNIIQDFDVKQ....EKLAWAVQVSGYDQKEQG.......IGQQS........IAG.ALSA...........................................GFTIAGGIAGVAGGA..LGS.G..FG.E...A.IAI.G--------.-......................................................G.QGLG..KALE..GAGGVA.NATMTK.....................................................................................TAEEEKLI...GGFDESNANTFIKKLVEMLERARKTSADMVSLLTE....LTQ.L.HRSLENA---lmk...........................................
#=GC seq_cons ...............................................h...........h............hc+hRshhppapspt....ptLsh-hQVpu..st+EA.......lccst........puu.hhpu...........................................ltuhluGllssutst..usu.s..hs.p...h.stp.s................................................................s.pshu..ph.p..uhtphs.ttshs+.....................................................................................tsctscsh...t-h.pcstcphscsls-st-cspplspphtshspp....h.p.h.htph.pu...h.............................................
//
