#=GF ID EspB_PE
#=GF AC PF18625.5
#=GF DE ESX-1 secreted protein B PE domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF08042
#=GF GA 29.00 29.00;
#=GF TC 35.60 39.50;
#=GF NC 28.60 28.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0352
#=GF RN [1]
#=GF RM 26051906
#=GF RT Structure of EspB, a secreted substrate of the ESX-1 secretion
#=GF RT system of Mycobacterium tuberculosis.
#=GF RA Korotkova N, Piton J, Wagner JM, Boy-Rottger S, Japaridze A,
#=GF RA Evans TJ, Cole ST, Pojer F, Korotkov KV;
#=GF RL J Struct Biol. 2015;191:236-244.
#=GF DR INTERPRO; IPR041275;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The ESX-1 secretion system is an important virulence determinant
#=GF CC in Mycobacterium tuberculosis. ESX-1 secreted protein B (EspB)
#=GF CC contains putative PE (Pro-Glu) and PPE (Pro-Pro-Glu) domains,
#=GF CC and a C-terminal domain, which is processed by MycP1 protease
#=GF CC during secretion. This domain represents the PE domain located
#=GF CC at the N-terminal region of EspB which carries the conserved
#=GF CC YxxxD/E secretion motif [1].
#=GF SQ 58
#=GS A0A1X1T8G9_9MYCO/11-86 AC A0A1X1T8G9.1
#=GS B2HKG6_MYCMM/12-87 AC B2HKG6.1
#=GS A0A1E8PYB0_9MYCO/10-85 AC A0A1E8PYB0.1
#=GS A0A5S9QWP3_MYCVN/11-89 AC A0A5S9QWP3.1
#=GS A0A7I7Z0I9_9MYCO/12-88 AC A0A7I7Z0I9.1
#=GS A0A1Q4H4V0_9MYCO/10-84 AC A0A1Q4H4V0.1
#=GS A0A124E003_9MYCO/13-91 AC A0A124E003.1
#=GS A0A4Y9MQR1_9MYCO/10-86 AC A0A4Y9MQR1.1
#=GS A0A1A3MY57_MYCAS/12-88 AC A0A1A3MY57.1
#=GS A0A6N4V5E6_9MYCO/11-89 AC A0A6N4V5E6.1
#=GS A0A1A3C7Z8_9MYCO/10-87 AC A0A1A3C7Z8.1
#=GS A0A1X1XNP4_9MYCO/12-88 AC A0A1X1XNP4.1
#=GS A0A498R1I8_9MYCO/12-88 AC A0A498R1I8.1
#=GS A0A124E006_9MYCO/14-93 AC A0A124E006.1
#=GS K5BDH4_MYCHD/12-89 AC K5BDH4.1
#=GS A0A0J6VBI3_MYCCU/11-89 AC A0A0J6VBI3.1
#=GS B2HKG7_MYCMM/12-87 AC B2HKG7.1
#=GS B2HMS3_MYCMM/12-88 AC B2HMS3.1
#=GS A0A7G1INV1_MYCKA/1-33 AC A0A7G1INV1.1
#=GS A0A7I7MU06_9MYCO/12-88 AC A0A7I7MU06.1
#=GS A0A1X2CEE0_9MYCO/10-86 AC A0A1X2CEE0.1
#=GS A0A1X2LU03_9MYCO/12-88 AC A0A1X2LU03.1
#=GS A0A7I7K775_9MYCO/11-89 AC A0A7I7K775.1
#=GS A0A1E3S2Y8_9MYCO/11-86 AC A0A1E3S2Y8.1
#=GS A1T191_MYCVP/10-88 AC A1T191.1
#=GS A0A0T1WD85_9MYCO/10-89 AC A0A0T1WD85.1
#=GS A0A7I7S0D1_9MYCO/10-85 AC A0A7I7S0D1.1
#=GS A0A7I7NQQ1_9MYCO/4-79 AC A0A7I7NQQ1.1
#=GS X7Y9R1_MYCKA/1-57 AC X7Y9R1.1
#=GS A0A0I9U374_9MYCO/12-88 AC A0A0I9U374.1
#=GS A0A5A7WPT4_9MYCO/10-89 AC A0A5A7WPT4.1
#=GS B2HMQ6_MYCMM/12-88 AC B2HMQ6.1
#=GS W9BKS0_MYCCO/11-87 AC W9BKS0.1
#=GS B2HT33_MYCMM/12-88 AC B2HT33.1
#=GS A0A1X0HC88_9MYCO/1-69 AC A0A1X0HC88.1
#=GS A0A132PM82_9MYCO/10-88 AC A0A132PM82.1
#=GS A0A1X2BDZ0_9MYCO/12-88 AC A0A1X2BDZ0.1
#=GS V5X4N0_MYCNE/9-85 AC V5X4N0.1
#=GS ESPB_MYCTU/12-88 AC P9WJD9.1
#=GS I4BCA0_MYCCN/11-89 AC I4BCA0.1
#=GS A0A1X2LRH5_9MYCO/12-88 AC A0A1X2LRH5.1
#=GS B2HET1_MYCMM/12-88 AC B2HET1.1
#=GS X8F6L1_MYCUL/4-79 AC X8F6L1.1
#=GS A0QNK4_MYCS2/10-85 AC A0QNK4.1
#=GS A0A7I7YZG3_9MYCO/11-87 AC A0A7I7YZG3.1
#=GS A0A1Z4EGF0_9MYCO/11-87 AC A0A1Z4EGF0.1
#=GS A0A0N9XY14_MYCFO/99-174 AC A0A0N9XY14.1
#=GS A0A0Q2XGF5_MYCGO/12-88 AC A0A0Q2XGF5.1
#=GS A0A7G1I9Y7_MYCKA/12-88 AC A0A7G1I9Y7.1
#=GS ESPB_MYCMM/12-88 AC B2HNQ9.1
#=GS A0A498QX66_9MYCO/12-88 AC A0A498QX66.1
#=GS A0A1Z4EPW2_9MYCO/10-86 AC A0A1Z4EPW2.1
#=GS X7Y4P0_MYCKA/1-39 AC X7Y4P0.1
#=GS A0A1A0TGV6_9MYCO/9-84 AC A0A1A0TGV6.1
#=GS A0A7I7MSE0_9MYCO/12-88 AC A0A7I7MSE0.1
#=GS A0A5N5UY01_MYCPH/11-88 AC A0A5N5UY01.1
#=GS A0A7I7XPV7_9MYCO/10-89 AC A0A7I7XPV7.1
#=GS X8FB26_MYCUL/1-33 AC X8FB26.1
A0A1X1T8G9_9MYCO/11-86 ................a-DLRARATSLDEEVL-...DESQRPT..APCGLPFVTASAAGIAAGSDTLRSHLVSGNREAERLAAVLSEAADVYQQIDDR-a...
B2HKG6_MYCMM/12-87 .................EELMGRASELESLIA-...APTASLE..ALCALPMVVNATADLVFSANAMLTYIDAGNKARQQLADALREAAKSYVGTDEQV....
A0A1E8PYB0_9MYCO/10-85 ................a-ELDAKAAQISEPPPA...APGQPL-..PPCALQVAVDAVAELNKSAAMLVGYAASGQAEATRLAETFRSAAVAYRQIDEQA....
A0A5S9QWP3_MYCVN/11-89 .................DDLDRKAEIVDSIP-Wg.pDPGEVPL.sRPDTLQSSYAAVTNLSKNAAALADYQKYGIAESQRLADTLRLVGGAYRRVDDA-a...
A0A7I7Z0I9_9MYCO/12-88 .................DELMARAAELEEPIPG...MPTGNPA..APCNLGFVRRAAQQIGLSADNMRTYLGVGERERSRLAQSLRNAAKAYEEADEG-a...
A0A1Q4H4V0_9MYCO/10-84 ................a-DLRNKAAQLDIPLPA...TPTPPN-..PPCGLDLAGVAVRQVIAEGDGMKSFIEAGQEEAKLLSRAFQGAAATYEATDA--a...
A0A124E003_9MYCO/13-91 ................e-TLEAKASDLEADLPT...VPEMPSLgdTPCELQMARKAVAIISASLENLRSTVEAGNAEAKRLAACLRATADVYRLVDEA-k...
A0A4Y9MQR1_9MYCO/10-86 ...............ea--LNARAGVLEGKQWP...PAPENVM..PPDGLPFAPAVAENINTNARALAEYNEYARAEAQRFAGVLREAATAYGTVDSEY....
A0A1A3MY57_MYCAS/12-88 .................QEILSRATEVEAPMAT...PPTDVPV..APSGITTAINATEQIKLNAENMQMFLEVGARERTRLATSLRNAARAYGDVDEE-g...
A0A6N4V5E6_9MYCO/11-89 ................r-DLHGKAAQIDALAWP..sQAAQPPL.iSADALVIASVAVTNLRVNADGLWARQAYGQKEGERLAQTLRNVGDAYAQIDQ--ms..
A0A1A3C7Z8_9MYCO/10-87 ................s-ELRKRSAEMTAQRWH...NPAAEAV.vPPDALPSSSAAVANLNDNARSLLDFQRWAEAENQRIAEMLQIAADAYTEVDENY....
A0A1X1XNP4_9MYCO/12-88 .................QEILNRANEVEAPMAV...APTDVPA..APCALTAAENAAQQLTVSADNMRLYLQAGARERSRLATSLRNAAKAYGDVDEQS....
A0A498R1I8_9MYCO/12-88 .................DEILKRATEVEAPMAV...APNDAPA..APCDLTAATNAARQLAVSADNMRLYLQAGARERQRLATSLRNAAKAYGEVDEES....
A0A124E006_9MYCO/14-93 ................e-TLRTKASQLTDDFPQapqDPGDLSG..SPCELEIAQEAVSVIRASVTNLRNAAEAGESEGRRLAACLSAAADAYQLVEDA-a...
K5BDH4_MYCHD/12-89 .................EDLRNKANMMKNSPWK...NPFTEPV.aPPDQLPSTLAAIENLNTNARTLADFQEWGQAEKNRLADMLIGAADEYERVDRE-f...
A0A0J6VBI3_MYCCU/11-89 ................a-DLTGKAAQIRGLSWS...SQTAQPAliSPDALVISSVAITNLAANAESLWAYQEFGRLEGERLAQTLDNVAAAYAQVDQQ-s...
B2HKG7_MYCMM/12-87 .................EELMGRASELESLIA-...APTASLE..ALCALPMVVNATADLVFSANAMLTYIDAGNKARQQLADALREAAKSYVGTDEQV....
B2HMS3_MYCMM/12-88 ................s-EIVARATEVEAPIAD...PPGGAVL..AACALDPAVAGATQLALSAESMRAYLQSGAQARQRLAKFMRDAAKAYEQIDEG-a...
A0A7G1INV1_MYCKA/1-33 .................----------------...-------..---------------------MREFLAAGAKERQKLATSLRNAAKAYGEVDSE-s...
A0A7I7MU06_9MYCO/12-88 .................QEILSRANEVESPMAE...PPTDVPQ..PPCGLTAANNAAQQLVLSADNMRTYLAAGHRERQRLATSLRNAAKAYGEVDEEA....
A0A1X2CEE0_9MYCO/10-86 .................QELMARADEIEQPLPV..iPPINPP-..APCLLSFVKDAATQLALNADSLRLYLKACEREWKTLAQSLRNAAKAYEEVDEG-s...
A0A1X2LU03_9MYCO/12-88 .................EELMARVAELEAPLPN...PPSGNPV..PPSQLAMVIRATAQIGLSADNMRLYLDAGSRERGRLAVSLRNAAKAYEETDEQA....
A0A7I7K775_9MYCO/11-89 .................EDLRRKATQIESLSWG...TASAQPEvvPPDALPGSGVAVQNLVVNAKALWAHQEFGKVEGHRLAQTLRNVANAYAQVDQA-s...
A0A1E3S2Y8_9MYCO/11-86 ................v--LKAQAAAMRQLTWS...PPAVQPI..PPDALGLAKDAVDNLNEIARVLGDYQTWAEAENQRIAEMLDNAAAAYERVDEAY....
A1T191_MYCVP/10-88 .................DDLDTKAGTVEAIP-Wg.eDPSAVAV.aDPDKLTPTTASVRNLIKNAEALGAEQRWGIAESRRLAETLRLVAQAYRAVDEA-s...
A0A0T1WD85_9MYCO/10-89 ................g-DLRTKARQVSNVEFAdaeGLSSGLQ..APDSLPHTKRTIEHLQANADYLAKNQAFAKTEQQRLADTLNSVAKAYDDFDEAA....
A0A7I7S0D1_9MYCO/10-85 ................a-ELEAKAAQIGQPMPT...APGQPL-..PPCALQVAVSAVGELNKSAEALRGYAASGQAEAMRLAETFRSAAAAYRQLDEQA....
A0A7I7NQQ1_9MYCO/4-79 .................EELLARAQELEITIT-...PPAENPQ..APCNLAMAINAAQQLGFSADNMRAYVAAGQREWAKLAKSLRNAARAYKKVDEG-a...
X7Y9R1_MYCKA/1-57 ...............mp----------------...------N..PPCALTAAKNAAQQLALSAENMREFLAAGAKERQKLATSLRNAAKAYGEVDSE-s...
A0A0I9U374_9MYCO/12-88 ................t-EILARAAEVESAMTA...APTDVVA..DACALQVAVNAAQQLNLNADNMRTYLAAGYQEWKKLAQSMRNAAKAYGEVDEES....
A0A5A7WPT4_9MYCO/10-89 ................v-DLVSKAVQIESLHWS..nPLTDNPLviPPDQLHLSKTAVENLQKNATFLYQNQNYGHLEGTRLAESLRSVAKAYDDIDAAW....
B2HMQ6_MYCMM/12-88 ................s-EIVARATEVEAPIAD...PPGGAVL..AACALDPAVAGAMQLALSAESMRAYLQSGTQARQRLAQFMRDAAKAYEQIDEG-a...
W9BKS0_MYCCO/11-87 ................a-DLRGLAGAMRAVFWY...QPDAQAM..PPDQLPLAITATANLNDNAAELAQYQKLAEAQGHRLAEMLDSAAKAYDEVDEKY....
B2HT33_MYCMM/12-88 .................NEILARADELDTPIAN...PPSDPVK..AACGLETAVTGAKQIKLSADNLRTRLAVGAQERHRIAEFMRSAAKAYEDVDEQA....
A0A1X0HC88_9MYCO/1-69 ............mkgqn--------------WH...APSEITV.tPPDALPATKDAVANLNDNARSLTEFERWAEIENRRIAEMLEIAAAAYQKIDDD-y...
A0A132PM82_9MYCO/10-88 .................EELTKRATWISEQAGR..wPTEAPKA.sPPDDLSSTKTAVDNLNAYGESLQKFTDVSKEESLRLARTLEKVAKAYSDVDENW....
A0A1X2BDZ0_9MYCO/12-88 .................QEILARANEVEAPMAE...PPTNVPA..APCTLTAAQNAAEQLDLSAENMRTFLAAGHRERQRLATSLRNAAKAYGEVDDE-s...
V5X4N0_MYCNE/9-85 .................DELDATANARSG--AQ..wPPVETKA.qAPDGLQSSAAAVEKLNANAAALAKYQTIADQQNMTLTHMLHSTASAYRKVDKEY....
ESPB_MYCTU/12-88 .................QEILNRANEVEAPMAD...PPTDVPI..TPCELTAAKNAAQQLVLSADNMREYLAAGAKERQRLATSLRNAAKAYGEVDEEA....
I4BCA0_MYCCN/11-89 .................DDLNRKAGQIEAISWG..dNPVEMPT.vPADGLGTARTAVENLNQNAKTLTDFQEYGKKQGQRLAETLRSVAAAYRTVDQNA....
A0A1X2LRH5_9MYCO/12-88 .................QEILNRANEVEAPMAD...PPSDVPM..TPCDLTAAKNAAQQLVLSAENMREYLVAGAKERQRLATSLRNAAKAYGDVDEEA....
B2HET1_MYCMM/12-88 .................EELLARAVRLEAPIPG...LPTEDPQ..PPCDFAPAKEAAAELARSAGEMRKYLGYFDTERARLAQSLRNAAKAYEEVDEHA....
X8F6L1_MYCUL/4-79 .................EELMGRASELESLIA-...APTASLK..ALCALPMVVNATADLVFSANAMLTYIDAGNKARQQLSDALREAAKSYVGTDEQV....
A0QNK4_MYCS2/10-85 ................p-GLERKAHECESTRPE...GPGDAT-..KPDELATTASVYSKLMASAAKLKATFAAGDREGERIAAAIRAAAGAYQKIEEQ-k...
A0A7I7YZG3_9MYCO/11-87 .................DELWDRAEGLEYPMPA...APSADPH..APCALDMSVEASRTLRASAERIRTYLDRGAKEWGKLAQSLRNAAQAYEEVD---fga.
A0A1Z4EGF0_9MYCO/11-87 ................a-ELTARARDIEAQLAG...VPLDNAD..AACTLQLVRTATEQLALSADNMRIYLAAGDRERGRLAQSLRDAADAYRETDER-a...
A0A0N9XY14_MYCFO/99-174 ................s-DMKASAQKCSTPSPK...GPKSPP-..APDGLEITAAAIEQLKTSAERLVETLDAGDQEGRRIAFALNAAANAFDKV----vqeq
A0A0Q2XGF5_MYCGO/12-88 .................QEILSRADEVEAPMAT...PPNDAAA..APCGLTAAKNAAQQLALSAENMRDFLTAGHRERARLATSLRNAAKAYGDVDEE-g...
A0A7G1I9Y7_MYCKA/12-88 ................s-EILARADEVESPIAD...PPSNVVV..GACALDAATTAARQIMLSAENMRTYLAAGATERQRLAQFMRNVANAYDDVDQE-s...
ESPB_MYCMM/12-88 .................QEILNRADEVEAPMAT...PPTDVPQ..APSGLTAANNAAEQLAVSADNVRLYLQAGERERQRLATSLRNAAAAYGEVEDE-s...
A0A498QX66_9MYCO/12-88 .................KELLERADELDAPRPG...RPSGGPQ..PTCHLEAAYKANLELALAVKSMQIYLDAGEQERRRLAQALRSAARAYEGVDTN-a...
A0A1Z4EPW2_9MYCO/10-86 .................QELMARADEIDAPLPK...LPVGNPQ..APCSLAFVRDAAVQIAINADSLRLYIQACQREWSALAKSLRTAAKAYEEVDEG-a...
X7Y4P0_MYCKA/1-39 .................----------------...-------..---------------MLSAENMRTYLAAGATERQRLAQFMRNVANAYDDVDQE-s...
A0A1A0TGV6_9MYCO/9-84 ...............qt--LRTQADAMTFPFV-...KLQSEAQ..RPDRLTATIAAVENLNKNAAALSQYWSYAETENANIMGSLRSAADAYQNVDEEY....
A0A7I7MSE0_9MYCO/12-88 .................QELVARAAELEAPAPG...RPHGGPK..ATCHVAAAYKANLALTLNIKAVQTYLDAGEGERRRLAQALRNAAKAYGHVDDNA....
A0A5N5UY01_MYCPH/11-88 adlramaaalggngwit----------------...QMRVDVQ..APDGLKCSQAAVQNLSANAKAMLGFQRWIEAENDYLAQLFANTATAYEAVDA--ac..
A0A7I7XPV7_9MYCO/10-89 .................EDLRTRASEVANVELGdaeTLVPDLR..PPDALASTHAAVALLRLDADYLVANQAYGQVEAFRLAETLRSVADAYDRVDEG-a...
X8FB26_MYCUL/1-33 .................----------------...-------..---------------------MRKYLGYFDTERARLAQSLRNAAKAYEEVDEHA....
#=GC seq_cons ..................-Lhs+Aspl-ushst...sPssssh..sPssLshutsAsppLshsAcshppalssGppEppRLApsLRsAAcAYpcVD-p.....
//
