#=GF ID Evf
#=GF AC PF18270.5
#=GF DE Virulence factor Evf
#=GF AU Smart A;0000-0002-6965-5633
#=GF SE ECOD:EUF04896
#=GF GA 25.00 25.00;
#=GF TC 25.00 25.00;
#=GF NC 19.60 19.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 18978353
#=GF RT Evf, a virulence factor produced by the Drosophila pathogen
#=GF RT Erwinia carotovora, is an S-palmitoylated protein with a new
#=GF RT fold that binds to lipid vesicles.
#=GF RA Quevillon-Cheruel S, Leulliot N, Muniz CA, Vincent M, Gallay J,
#=GF RA Argentini M, Cornu D, Boccard F, Lemaitre B, van Tilbeurgh H;
#=GF RL J Biol Chem. 2009;284:3552-3562.
#=GF DR INTERPRO; IPR041576;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is found in Erwinia virulence factor (Evf) present
#=GF CC in the Drosophila Pathogen, Erwinia carotovora. Evf is able to
#=GF CC bind to model membranes containing negatively charged
#=GF CC phospholipids and to promote their aggregation. Palmitoic acid
#=GF CC covalently binds to the completely conserved Cys209. The
#=GF CC structure of Evf is unlike any virulence factors known to date
#=GF CC [1].
#=GF SQ 24
#=GS W1IM22_9GAMM/37-271 AC W1IM22.1
#=GS A0A2D0KBL1_9GAMM/37-271 AC A0A2D0KBL1.1
#=GS A0A4R1SBY4_9HYPH/47-281 AC A0A4R1SBY4.1
#=GS A0A068QSD7_9GAMM/37-271 AC A0A068QSD7.1
#=GS D3VGN9_XENNA/37-271 AC D3VGN9.1
#=GS B4EW12_PROMH/43-276 AC B4EW12.1
#=GS A0A1H0G4U6_9PSEU/254-439 AC A0A1H0G4U6.1
#=GS A0A2T0S5G0_9PSEU/166-415 AC A0A2T0S5G0.1
#=GS A0A0T5P5P5_9RHOB/34-267 AC A0A0T5P5P5.1
#=GS A0A5M6CLP9_9BACT/45-269 AC A0A5M6CLP9.1
#=GS A0A5D0V8T1_9RHOB/70-289 AC A0A5D0V8T1.1
#=GS A0A4S5IX59_9HYPH/47-281 AC A0A4S5IX59.1
#=GS V7FCI3_9HYPH/41-275 AC V7FCI3.1
#=GS C0B3Y8_9GAMM/40-253 AC C0B3Y8.1
#=GS A0A4V2G1E3_9BACT/48-281 AC A0A4V2G1E3.1
#=GS D3V267_XENBS/37-271 AC D3V267.1
#=GS A0A549T090_9HYPH/46-280 AC A0A549T090.1
#=GS A0A2S1QZ49_9FLAO/44-277 AC A0A2S1QZ49.1
#=GS W1ITS9_9GAMM/37-271 AC W1ITS9.1
#=GS T0NXG2_PHOTE/1-176 AC T0NXG2.1
#=GS Q7N4B6_PHOLL/38-272 AC Q7N4B6.1
#=GS A0A0N0Z7Q0_9GAMM/53-287 AC A0A0N0Z7Q0.1
#=GS D9SU84_CLOC7/29-275 AC D9SU84.1
#=GS A0A4R1UHN3_9SPHN/65-297 AC A0A4R1UHN3.1
W1IM22_9GAMM/37-271 .......................................................................................RFSDTDGLVQFVITSQLSDKSAVMKKLNEIKKIQIALSSIATDYI.IKYSN.TR.GRQYRTDVQFWGDIMGKLP..LMSIRNIEEQTYHHVMKGFSIATNLLQLIMDIVVNTQ.SPSMKSFSQFLQKQGDAIRLGLKKNSDHYSTLTLASV..IEAVGNED.Q....V..M..Y.IPKM.KLYKLDFDRNNSEITSNCASNETINVEFIYSSCVSLFDYQAL.ED..P...E.IK.TAFERFILKNKQSSIERSDNFFNGEF..........
A0A2D0KBL1_9GAMM/37-271 .......................................................................................RFSDADGLVQFVIASQLNDKSHVMKKMDDIKKTQIALSSIATDYI.IRYSD.TR.GRQYRTDVQFWGDIMGKLP..LMSVRNIEKQTYQHVMKGFSIATNLLQLIMDIVVNTN.SPGMKSFSQFLQKQGDAIRLGLKKNDDRYSTITLASI..IEAVGNDN.Q....V..I..Y.IPKI.KLFKLDFDRTNSEVTSNCASNETINVEFNYSSCVSLFDYQAL.ED..P...E.IK.SAFENFLLKNKRASIEKSDNFFSGEF..........
A0A4R1SBY4_9HYPH/47-281 ....................................................................................tia---NSEGTVQFHLIGQKTTDPAYSDIMNENQDNLLGIGGLVHDYM.HTHYP.TI.-DSTKLDINTWTNVVGNIP..DLAVGGQKQKSYSNKIVGTSVSGTFLSLIAKAIITDG.ASLLTDFQSFLNEMGN-LTFSANSKAETYKALTCTYQ..SYLVENGA.G....G..Y..YdYGAI.VLRQIQFKQYFLEMKSSCASAQYVNIDMDYTEVTNLIQTRRI.RK..G...G.TDyTAFQSLLNKNSTQQFANAKNFFNG--gs........
A0A068QSD7_9GAMM/37-271 ......................................................................................r-LSDTDGLVQFIITSNIVDKASVIQKMNEIKKIQIALSSIAAGYI.SQYTH.IH.GQEYKTDIQFWGDIMAKLP..LMSVMNIESQTYQHEMKGISIATNLLQLIMDIILNAN.SPSLKNFSDFLQKQGDAIRLGLKRNGNHYSTLTLASV..IEAVGIED.H....V..M..Y.VPKM.KLYKIDFDRTNSEVTSNCASNENINVGFTYSSCVSLFHYQAL.ED..Q...D.VK.TAFDNFMLKNQKTSIEDSDSFFNGEF..........
D3VGN9_XENNA/37-271 .......................................................................................RFSDTDGLVQFVITSQITDKTQVIQKLNDINKTQIALSSIATDYI.TQYAD.VH.GKQYKTDIEFWSNVIAKLP..LMSVRNIEKQTYCHEMKGISIATNLLQLIMDIVLSAD.SPNIKNFANFLQKQGDAIRLGLKQNNDHYSTLTLASV..IEAVGVED.Q....V..I..Y.IPKM.KFYKIDFNRTNSEVASNCASNANVNVEFTYSSFISLFDYQAL.DD..P...E.VK.TAFNNFILKHKKSSIENSDSFFSGQF..........
B4EW12_PROMH/43-276 .....................................................................................ni--KDTEGLVQFIIASPKRFNESEKMIMTQLKDIQIALISIMSNHL.SVLKK.ED.SEAYYQ-PEHWLETLNHLP..LLSRNKVESKRLDKQTFDFSIAQAFVQLLLGAAINAA.SPSLAEFIDFLRNQGQQIELGIRQSFDSYKTITIAGV..TEILNHNN.Q....L..I..F.VPKL.KIMSLRFSHRTAKMLLASCSGRKFTISVEYTTITSIFDIGAL.ND..P...L.IN.RQFYAFLNKFRQLSITQSDSFFSGDF..........
A0A1H0G4U6_9PSEU/254-439 .............................................................patqwdasvthvmqhllqesggltdy---------------------------------------------.-----.--.-------------------..-----SITQETYSDTQVLAEFSTSFIKLFFDAVT-VP.SSIISGISTFISGVGKSLQLGWDNRQRDYQVALLGQC..HEAVQENS.Dg..aP..VyrY.FPKL.KYYFLRVSSSQTEFTSDCATVRKITFNFQYEYYVTAVAAAVL.DT..T...T.ADyKSFTDFLNTAQTA-------------nytdakdkln
A0A2T0S5G0_9PSEU/166-415 afqdsdglisfvnlssdlvnhsaeyktgtevfdkianffstlrvkvftamqngkitplkgdpkpatqwdltvthymqyllqetgglt---------------------------------------------.-----.--.-------------------..---DYAITEETYSETQVVAEFSADFVKLLFDAVTV-P.SSVIGGVTAFISGVGTTLRTSWDDRVRTYSVDLLGQC..HEAVQQNS.DgapdY..R..Y.FPKL.KYYHLTVDSQQSEFTSDCATVRKITFNFRYEAYVTAVAAAVL.DK..T...T.AEyKSFTAFLDKAQAANYKD---------aqnqldt...
A0A0T5P5P5_9RHOB/34-267 ..................................................................................iatdk------GMVQYHVIAETPTGSQYAAMMQENADNLMGMGGLIHGYM.TANYP.TV.DSQL-LDINLWNTVVGHLP..DLAVGPTVRKQYSNTVAGTDLAGTFLQMLAKAKVAPG.AKIGTDFGTWLEAMGQLV-FAAHGAGQTYKAITCSYL..CYLVDNGA.G....G..F..YdYGAI.VLREVDITQDFMTYKGACQASPGVQVELQFTEITSPVQLSRI.RKggP...D.FQ.-LFQQLVNANATTAFSKAPNFFDG--rn........
A0A5M6CLP9_9BACT/45-269 .....................................................................seesmavfivvtpknssd-----------------------AQREEEIKSYLKSFVSIMAEYI.NRYYE.VK.GPQFITDLDSWLRPLNALP..LMSRANIEKHEFKRNEPGTEIASQLISLF----YKPN.SIASEEFKNFLRDRSRRIKDLINRNGSF-KMIFVVSS..IEIVGNGS.E....Q..K..H.SAKI.KLFKTELNKNNSGWIDNCNNSAKIDINVEYSLVISELNIAEL.RN..N...D.TK.KALDRFIQSTRKFDDYNDGNFYEGA-y.........
A0A5D0V8T1_9RHOB/70-289 ...............................................ekqafaklltdqqfylqsglglvtawmtnnyqrqpdkwan---------------------------------------------.-----.--.-------PDNWQKPLSALPseFYTPTDITSYKYQEHVKGVEVATKFLENL---VTWAAaEAIAPAFGSFITSLGNQISAGIKSKYKEMNTYHLSFN..YQPVLNSA.N....S..W..E.LMSIaEYYFISFTEKEKTVYSSCASAETFDFDFKYQKGSLLLNWATL.SA..PanaE.NK.KAWDAAITGATKDDVTKAQNFFG---ska.......
A0A4S5IX59_9HYPH/47-281 ....................................................................................tia---NDKGSVQFHLIGQKTNDPIYSGIMNENQDNLLAIGGLIHDYM.HTHYS.II.DSQ-KLDINTWTDVVASIP..DVSIGRHKQKSYSNRFAGTSVAATFLSLLANAIITDG.ASLLTDFQFFLTGMGNLT-FAANGRAQQYKALTCTYQ..SYLLDNGA.G....G..Y..YdYGAI.VLRQIEFKEDFLELKSSCSSAQYVHVNIDYTEVTNLVQTRRI.RK..G...GpDH.ENFRGLVNENSTDQFKKAKNFFNG--gs........
V7FCI3_9HYPH/41-275 ....................................................................................tia---NAQGTVQFHLIGQKTEDPTYSGTLNENQDNLLAIGGIINDYMhTHYAN.I-.D-AQKLDINTWTDVVGNIP..DLSMGGQKLKSFSKKVAGTSVSATFLSLIAKAIITDG.ASLLLDFQSFLTEMGNL-TFSANGKAQRYKALTCTYQ..SYLLDNGA.G....G..Y..YdYGAI.VLRQIEFKEHFLELKSSCSSTHYVRVDMDYAEVTNLVQTRRI.RK..G...GpDH.ENFQELVNKNSTDQFKKAKNFFNG--gs........
C0B3Y8_9GAMM/40-253 .....................................................................................ni--KDSEGLVQFIIASPKPFEPSEIEKMSQLKNIQIGLISIMANHL.AALKK.ED.NEAYYR-PEHWLDTLNHLP..LLGHNKVETKKLHKQTFDFSVAQAFIQLLLGAAINAT.SPALGEFIDFLRTQGQKIEIGLQKSLDSYQTITIAGI..TEILNHNN.H....L..I..F.VPKL.KILSLRFSYQSAKMLLASCIGSKFTLSLEYTTITSIFDTSAL.DD..P...L.IN.QQFYDF--------------------..........
A0A4V2G1E3_9BACT/48-281 ...................................................................................istd-----TGLVSCICADVKDIDPKVQATLDVQKQYMISLTGLASSYV.RTQAN.TKqNTALMFDSGLWLSVYNHLP..LMAPPQLVVKHQDTTIQGVEIATKFIEMILGVAVT-G.GEALAPFTIWLSGLGSQIRAGIKSTNSSFNFTTLAIA..LTTQKLGN.Q....T..R..A.FPYL.KYYSINFTQSQFETYSYCGSRSSYRMVFDMKTISTLWNYEVLaDR..P...D.VK.EKLDRLIKVSQLDDIESSANFFA---vt........
D3V267_XENBS/37-271 .......................................................................................QFSDIDGLVQFVITSQINDKSGVIQRLNEIKRTQISLSSIATDYI.IKYAN.TH.GQQYRTDVQFWGDIIEKLP..LMSVRNIESQTYSHVMKGFSIATNLLQLIMDIVLNTN.SSSMKSFSQFLQKQGDTIRLGLKKNNDHYSTLTLASV..IEAIGVED.Q....V..I..Y.IPKM.KLYKVNFDRSNSEIASNCASNDNINVEFTYSSCVSLFDYQAL.ED..P...E.IK.ASFDLFIHNNKKSSIENSDNFFNGEF..........
A0A549T090_9HYPH/46-280 .....................................................................................qi--ANDKGTVQFHLIGQSTTDPAYSSIMNQNQDNLLAIGGLIHDYM.HTKFP.TI.DAQ-KLDINTWSKVLGYIP..DLSIGKSNRKVFTNRIAGVSVSGTFLQLIAQAIITDG.ASLLTDFSKFLEQMGNV-TFSAESKSQKYKAITCTYQsyLVDNGAGG.Y....F..D..Y.-GAI.VLREIDFTQNFSELRSSCSSANYINISMEYNEIVNLVQTRRI.RK..G...G.ADyDNFQELVNANSTEQFKKAKNFFNG--gs........
A0A2S1QZ49_9FLAO/44-277 ......................................................................................p-YADKDGLIQFICGVELLQDPIVTAKLAELKSLLISLTSVVTAYI.NRYAA.AK.GAQYKTDADLWEMALSKLP..LMGPSKIDTQTYSRRTRGVEIAGDFINLVLDIAT-GE.GQALQSFKSFLEKQGGALRAGIEANKDSYKTITVGVC..VEVLKIGS.E....I..M..Y.IPKI.KQYKVLFTRENTKWSSSCASYEEVDMHFEYMYASNVFDYEAL.NN..P...D.IK.RDFEKFVTGAQKAQIEDASTFFNDDF..........
W1ITS9_9GAMM/37-271 .......................................................................................QFTDTDGLVQFVITSQIDDKVSVMKKLHEIKRAQIALSSIAAGYI.SRYAN.NF.GPQYKTDIQFWSEIITKLP..LMSVKSIESQSYNQEMNGVSIATNLLQLIMDIMLETC.TPCLQSFANFLQRQGDAIRMGLKRNHDHYSTLTLASV..IEATGLGD.Q....V..V..Y.IPKI.KLFKIDFDTTNSEVTSNCASNQKVNVKFSYSSCIALFNYQAL.ET..P...E.VN.TAFHDFIIKNEKYSIENSDNFFSGEF..........
T0NXG2_PHOTE/1-176 .......................................................................................---------------------------------------------.-----.--.-------MAFWTQVVNKLP..LMGTTKVESKNYTDSLTGLSISKSFLHFIMNVVVFEN.TDMLANFADFLTKQGETIRLGIRKNKGFYSTMTLTVA..IDTLVVGE.K....T..V..Y.IPKL.KLYRINFDSNNSNFLSSCASNENVNIDFEYSSLISVLDYEAL.EH..P...D.LK.ASFDNFINKHRKISIEDSDDFFSGEF..........
Q7N4B6_PHOLL/38-272 .......................................................................................KYNEKDGLVQFIIAKQLSDKPEVIDKTNSLSQTLIALSSIATNYV.NKYAE.KY.GEQYKTDMDFWTKVVNKLP..LMGTSKVESKNYTDSLNGLSISKSFLNFIMNVVVFEN.TDMLPDFAKFLTKQGETIRLGIRKNKGFYSTVTLTIA..IDTLIVGE.K....T..V..Y.IPKL.KLYRVNFDSTNSNFLSSCASNENINIDFEYSSLISVLDYEAL.EN..P...E.IK.ASFDNFINKQRKTSIEESDDFFSGEF..........
A0A0N0Z7Q0_9GAMM/53-287 ......................................................................................r-NSDNDGIIQYIIDRSLYKKPGIHEKLTKLKKYLISLISIVTHYI.NTNHPiDT.LSSHQPGLKNWLDATQQLP..LITCSAIQKKEISHQVKGITVAKGVLALIMETILNVQ.NEGLDAFLLFLQEQEQAMQLRLKKNINQFSTTLIFCV..IEAHNIMQ.N....S..V..F.YPKI.CFYHLHFNRKNAQLMLNCNSSDSFEINFEYTSFSAFFNDDAL.KD..E...L.VS.HQFEQFIQRHLLSSIQKSDNFFG---rh........
D9SU84_CLOC7/29-275 ..nfqdsdglisflnlsssfinncnqykvgrqlcdnvcsfyatlrnktyryltknpakvlpgdaypstqwdrsvthymeemlvdagg---------------------------------------------.-----.--.-------------------..-FSGFKITSETYSNTQNIKSFSVDVFKQIFDAAEIPN.-SITNDATKFIQGVGQTLKNCWDQTSKNYQLALMAQC..HEGVPIDEsN....F..I..Y.IPKV.KYYYISINTSQTEFTSDCSKVRQLTFNFNFETYVSMLKASVL.EE..K...N.QDyLKFKAFLDKAQQVQYTE---------cnnnlde...
A0A4R1UHN3_9SPHN/65-297 ....................................................................................vat----DQGSVQFHLIGQKPDDPKYSDIMQENADNLLAMGGLIYGYM.KKSYP.SI.NLQ-TMDIGTWVNVVKNLP..DLAIGQQVEKTYTNRLVGASVSGDFLSMIAKAIITDG.ASLLTDFTSYLNSIGNVV-FSASNTKESYNVVTCTY-..-QNYLVSD.Q....MggY..YdYSAI.VLRQINFLEYFTQLKSSCASAEYVNIDMKYSEVTTLVQSRRI.RQggP...D.Y-.NLFQGLVNADATAQFANANNFFNG--g.........
#=GC seq_cons ..........................................................................................ptpGhVQFhlhsphspcsth.thhsp.pp..lulsulhtsYh.pphh...h.stphhhDhphWtpllspLP..hhussplcpcsYscphtGhSlAssFLpLIhcsllsss.ushlssFssFLpp.GsslchulcpstppYpslTlu.s..h-sls.ss.p....s..h..Y.hPKl.KlaplsFspspochtSsCuSscplslsFcYophsolhshpsL.cc..s...p.hc.psFpsFlppsppsshppussFFsG............
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