#=GF ID FIN1
#=GF AC PF17300.6
#=GF DE Filaments in between nuclei protein-1
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE PRODOM:PD127795
#=GF GA 25.00 25.00;
#=GF TC 29.00 28.90;
#=GF NC 22.30 22.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 11929974
#=GF RT The Saccharomyces cerevisiae Fin1 protein forms cell
#=GF RT cycle-specific filaments between spindle pole bodies.
#=GF RA van Hemert MJ, Lamers GE, Klein DC, Oosterkamp TH, Steensma HY,
#=GF RA van Heusden GP;
#=GF RL Proc Natl Acad Sci U S A. 2002;99:5390-5393.
#=GF RN [2]
#=GF RM 26832405
#=GF RT Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1
#=GF RT from Kinetochores in Anaphase.
#=GF RA Bokros M, Gravenmier C, Jin F, Richmond D, Wang Y;
#=GF RL Cell Rep. 2016;14:1074-1085.
#=GF DR INTERPRO; IPR035260;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Fin1 is a kinetochore protein, predicted to contain two putative
#=GF CC coiled-coil regions at its C terminus. It is present in a
#=GF CC filamentous structure associated with the spindle and spindle
#=GF CC pole in dividing cells during anaphase [1]. Fin1 is a substrate
#=GF CC of S-phase cyclin-dependent kinase (CDK). It binds to PP1
#=GF CC creating the Fin1- PPI complex which is recruited onto
#=GF CC kinetochores promoting spindle assembly checkpoint (SAC)
#=GF CC dis-assembly during anaphase [2]. This is an important step in
#=GF CC cell division since the kinetochore is the docking site for the
#=GF CC spindle assembly checkpoint that monitors the defects in
#=GF CC chromosome attachment and blocks anaphase onset [1]. Fin1 has
#=GF CC two RXXS/T sequences: S377 (RVTS), S526 (RKVS) that can be
#=GF CC phosphorylated. Upon phosphorylation, interactions with other
#=GF CC proteins such as Bmh1 and Bmh2 is promoted. However,
#=GF CC de-phosphorylation during anaphase promotes the kinetochore
#=GF CC recruitment of Fin1-PP1 [2].
#=GF SQ 28
#=GS A0A376B2W4_9ASCO/36-318 AC A0A376B2W4.1
#=GS C5DMZ2_LACTC/14-262 AC C5DMZ2.1
#=GS G8JTI2_ERECY/17-247 AC G8JTI2.1
#=GS H2AR55_KAZAF/2-110 AC H2AR55.1
#=GS Q6CJB4_KLULA/24-230 AC Q6CJB4.1
#=GS FIN1_YEAST/15-283 AC Q03898.1
#=GS J8PJT9_SACAR/15-285 AC J8PJT9.1
#=GS A0A1X7R617_9SACH/1-78 AC A0A1X7R617.1
#=GS G8ZX91_TORDC/12-250 AC G8ZX91.1
#=GS A0A4C2E034_9SACH/15-254 AC A0A4C2E034.1
#=GS A0A7H9I0N7_9SACH/11-251 AC A0A7H9I0N7.1
#=GS A0A1G4JIE6_9SACH/4-256 AC A0A1G4JIE6.1
#=GS A0A7H9B839_ZYGMR/20-256 AC A0A7H9B839.1
#=GS I2H7S1_TETBL/72-227 AC I2H7S1.1
#=GS J4TT80_SACK1/15-282 AC J4TT80.1
#=GS A0A1S7HK91_9SACH/15-255 AC A0A1S7HK91.1
#=GS G0WGS5_NAUDC/22-283 AC G0WGS5.1
#=GS A0A1S7HGQ8_9SACH/15-260 AC A0A1S7HGQ8.1
#=GS G8BR78_TETPH/10-257 AC G8BR78.1
#=GS Q6FXC3_CANGA/6-256 AC Q6FXC3.1
#=GS A0A0C7MTG6_9SACH/4-252 AC A0A0C7MTG6.1
#=GS A7TJ22_VANPO/10-269 AC A7TJ22.1
#=GS G0VBX4_NAUCC/1-227 AC G0VBX4.1
#=GS H2AR55_KAZAF/85-204 AC H2AR55.1
#=GS A0A1X7R617_9SACH/79-184 AC A0A1X7R617.1
#=GS A0A1G4KIZ7_9SACH/26-259 AC A0A1G4KIZ7.1
#=GS A0A1G4MK74_LACFM/15-258 AC A0A1G4MK74.1
#=GS Q750A6_ASHGO/6-227 AC Q750A6.1
A0A376B2W4_9ASCO/36-318 .............................nnltn---STTENNN.....NSSNVFKR..LSpvfNKPAIRISPD...----KNKRIA....IKRTNTSsiyesvalTTTPLLTPkkKRLVS.PTKY.NNLISrgngikSR.IYSV...GNSTT..NKIDKPKN...VHk........pVSKEILNYEFPTSPLK--...LSPT.RTIGGDGSLNRIRSRFSQlKKNSPEKKDIMETey.......................dkLDTTPFHSKRNLLTKLLEEEV..........QNTPIKSALKPEVFAKD....eKSDHKM....dDPISVTKKKVTFNLPDTSmss..ndpSLIEQE-QEI------------------------hhnslldtgdkkdeilsillqvlkrqdaiehkldiiink....
C5DMZ2_LACTC/14-262 ...........................hddqaah------LQGS.....PSKNIMKR..LS...TSPVRKM--P...VISRSSARLS....PVRPSHSr.....elPMYLQTTP..KRLKS.PPSL.QSYRP.....vSG.TVSV...DRAQF..KNNL----...--..........-ADKSVQLSFPTSPIRST...YSNS.TTTGGDGSLSRIRARFGS.GLRSPQKPTNKDYalpgpp...............knllpqLEEESEDPERNSSAKLNENAL..........ESDNEVSKSIMKRHGSQ.....NGSQVT.....KPKLQARKSVKFELSSREg......nDQIMKKLSQMTQMLAKVMERQDQLEAKLDAMQ--ha.........................................
G8JTI2_ERECY/17-247 ..................................NDISNKDTSN.....RGSNVFKR..LS...TSPMRKPGLS...VIDKPAVRLS....PT-----........KSSYQTSP..KRLIP.PEHL.S----......NV.TRSV...DRHHFikRPEHTSSL...IQ..........SLHGGADIVIPISPIKMEsekFGSV.TTVGGDGSLSRIKNRF--.---SPSKDRKSIMt.........................vNEETLSPTRQNLLNKLQRDED..........--LSKVTKKNTKLNSELi..snFKVGKS.....-QITTRSKNVKFELPED-........RMIAIELQNLKQLLQMLLERQDRLELKIAELESK...........................................
H2AR55_KAZAF/2-110 .............................vhtem--------NE.....TSSNVFKR..LQ...ISPSKNS---...RIKKPAMRLS....PKKITT-........SAVPQYTP..MKISS.PECL.K----......RY.TRSL...DRTGT..INVA-PKT...VHlspv..rthaSLR-SSHGVTIVSPIRAN...LQD-.------------------.-------------...........................---------------------..........-----------------.....------.....------------------........----------------------------------qys........................................
Q6CJB4_KLULA/24-230 ..............................qels----SNASPPs...sASGEIFKR..LS...VSPNRNR--K...LLEKPAARLS....PQQ----........---RVQTP..KRLPS.PDIL.-----......GP.NLSL...DRYER..----QKS-...--..........SVVKINEIVFPNSPTKASg.aLRNV.PVLGGDGSLSRIRNRFKI.NNASPV-------...........................--------KANLLDKLNKEET..........ETDTAKRKRKTDTPNAMk...gSRVEKN.....-ERRTRSKSVMFKLPED-........RIISIELNEMRKLNEALIARIEELEQRMARLEDR...........................................
FIN1_YEAST/15-283 ................................nt--IGRNNIPS.....DKDNVFVR..LS...MSPLRTTSQK...EFLKPPMRIS....PNKTDGM........KHSIQVTP..RRIMS.PECL.KGYVS......KE.TQSL...DRPQF..KNSNKNVK...IQ..........NSDHITNIIFPTSPTKLT...FSNE.NKIGGDGSLTRIRARFKN.GLMSPERIQQQQQqhilpsdaksntdlcsntelkdapfenDLPRAKLKGKNLLVELKKEEEd.......vgNGIESLTKSNTKLNSML.....ANEGKI.....-HKASFQKSVKFKLPDNI.......vTEETVELKEIKDLLLQMLRRQREIESRLSNIEL-q..........................................
J8PJT9_SACAR/15-285 ................................nt--IGRNNLPS.....NKNNVFVR..LS...MSPSKTIGQR...EFLKPPMRLS....PKKTDAS........KHSIQVTP..RRILS.PECL.KGYIP......KV.TQSL...DRPQF..KNTSKDAK...IE..........NSDHMTNIIFPTSPTKLT...FSNE.NKIGGDGSLTRIRARFKN.GLMSPERIQQQHQqqifqpqatnstdiddndefkvnpfegELPQDKLRGKNLLSELKKEDEg.......vgNGVESLTKSNTKLNSML.....AKEGKV....qKQKAGFQKSVKFKLPDNV.......vNEETVELRDIKDLLLQMLRRQREIESRLTNIEHQ...........................................
A0A1X7R617_9SACH/1-78 .................................m-------SES.....QSSDVFRR..LQ...ISPSKNNA--...-IKKPALRLS....PRKVSR-........TRDLQYTP..SKYES.--HL.NPD--......MF.TKSL...DRSS-..--------...--..........------------------...----.------------------.-------------...........................---------------------..........-----------------.....------.....------------------........----------------------------------klligkipshdng..............................
G8ZX91_TORDC/12-250 ..........................dinnlmep--------PSte.rlHQSNVFKR..LS...TSPSKAYAND...-LSKPPVRMS....PVKRSPS........KSGNQLTP..KRLAS.PDCL.KNDVS......KI.TQSM...DRPYF..EKHGGNPK...IE..........DSGSVTNLVFPASPTRVT...FSNE.RKIGGDGSLSKLRSRFTN.GLLSPQRGA----...........................NMPKTELQGKNLFSKLENDEQ..........--INDFTTSPKRRLENL.....EEEAIS....sNKRKQIKKTVKFELPASDe......nENLRKQVQDLKHTLSKVIEHQNEMEVRLKLVESQ...........................................
A0A4C2E034_9SACH/15-254 ..................................NTRTSSHSPS.....TQGNVFKR..LG...TSPSMRCPNG...-LSKPPARMS....PARKSPI........KPPLQLTP..KRIPS.PECL.REYKS......NL.VRSG...RSPSV..NDNITSK-...VE..........NKGPTTSIVFPTSPTRTI...FANE.RKIGGDGSLGRIRSRFTN.GLLSPQRRLAPTPiknrlep............gtessdnhDNSDKEIQAKNLFEKLKETEE..........--------IETETNQEN.....-----S.....-RSQPHKKSVKFNLPRNNs......kESLKKELQELKVLLEKVTRKQSELETRLSKLEE-g..........................................
A0A7H9I0N7_9SACH/11-251 ...........................qditnvm-------EQStd.lsHQSNVFKR..LS...TSPTKAYPDD...-ISKPAMRLS....PVKRSPN........KIRTQMTP..KRLVS.PECL.KNYIP......RI.TQSM...DRPHF..NREERVQK...YE..........EDGSVTNLVFPSSPTKMA...FRSD.KKIGGDGSLSKLRSRFSN.GLLSPQRFANGTS...........................----SRFQGTNLFSKLEEEAE.........eAEKDSERMLNFKRELAH.....TQDHSK.....ISKKRLQKTVKFQIPATDg......eSDMTARVNYLELTLSQVLKRQKELEDRLMMMEQR...........................................
A0A1G4JIE6_9SACH/4-256 ...........................ddgdsrl-------RGS.....PSKNVFKR..LS...TSPVKKMSTN...-LNKSGIRAS....PLRRKPNw.....dhTIGFQTTP..KRLKS.PPYL.QSFER.....sAG.TVSV...DRVHF..---SND--...--..........PNDESIKLSFPTSPVRTT...YGNS.VAPGGDGSLSRIRSRFSG.GQRSPSKALDSARs........................tkSLQALSKSTRNLLPELQEHDSeinh.itaveDNSPNITRQNTLLNSALp...pNRDRPNfkikkPHSPHRHKTVKFEPITNE........KEIKEQLTNISALLAKVMERQDQLEAKLNSI---gh.........................................
A0A7H9B839_ZYGMR/20-256 .......................sdlsvtsknqv---------F....cTNSTAVKR..LG...DSSSKVHISD...-LSKPPGRLS....PVRKGP-........--ARQLTP..KRLAS.PTCL.KDQ--......ST.TDFR...DRSLP..PNSNRSE-...-E..........EDKHATSLIFTTSPTKLL...FSSD.KKIGGDGSLSKLRSRFSN.GLLSPQRLSTVPG...........................--SSKEVKGKNLLSKLQDQEY..........KSPKNETSTHTQNNETKs...lSQEGRV....tKSQQQRKKTVKFKVPDAEk......dTLIETELADLKSLLLQVLKHQKVLESKLINLEN-n..........................................
I2H7S1_TETBL/72-227 aksddtlklgiqrqrqkqkqnsnksslnvypikn----------.....--------..--...----------...----------....-------........--------..--SLS.PSSL.S--IP......SL.TSSS...SNPII..--------...--..........SNGT---TTLQLSPIQSYkrnNSQG.KKVGGDGSMSKLRAQLPH.GLLSPNRDKLNKErs.......................llS--------------------..........-----------------.....------.....------------------........----------------------------------skegevsllssresikdkhlitaisggnvnkkrgtsiatntnh
J4TT80_SACK1/15-282 ..................................NKIGRNNIPS.....DKDNVFVR..LS...MSPSKTAGQK...GFLKPPMRLS....PKRTDVT........KHSIQVTP..RRIVS.PECL.KGYIP......KV.TQSL...DRPQF..KNTSGDMK...VQ..........SSDHITNLIFPTSPTKLT...FSNE.NKIGGDGSLTRIRARFKN.GLMSPERIQQQHQvpqilpsqakngt.gvtdepnensydnELSQDKLKAKNLLSELKKEEEd.......lgNGIESVTKSNTKLNSML.....AKEGKV.....-QKASFQKSVKFKLPDNIv......tTEI-AELRDIKDLLLQMLRRQREIESRLTNIEL-q..........................................
A0A1S7HK91_9SACH/15-255 .................................n-VRTTSHSPS.....NYNHGLKR..FA...TSPASRHLND...-LSKPPARIS....PSRKTPM........KHSIQLTP..KRLPS.PECL.KEYKT......KR.LKNT...ESPLM..HPEVTDV-...-E..........QRGSSTTVVFQTSPTRAI...FSNE.RKIGGDGSLGRIRSRFGN.GLLSPQRRIVPAPrq......................kalNPEEKELEAKNLFEKLEEAEK..........-----LERTHSDLTSDDd...rAKDAKA....pKSVQCSKKSVKFELPLEDt......rEKILEELHEVGKLLEEAFKRHRELELRLAKFEHQ...........................................
G0WGS5_NAUDC/22-283 .............................mstnn----NHRSNSk..lhPTKDVFKR..LS...LSPSRNDKTSkpqSHYKNEKRISlslsPIRIQET........ARHLGSPP..KRLVSfPHHLeKTYRD......SI.SDSLlsnTREHL..PNHDDDDD...DD..........DDDDNELLYFPTSPTK--...FNID.KTVGGDGSRSRIRSRFKN.GLMSPERIQSERDps......................slsPLRASPSKNKNLLQKLEREND..........--LDTLTEMNTLHNSRK.....DTHGDS.....--SMIPKKRVKFHVPSSRtpeedgknEAVLQQLEEAKDMLIKIIKKQDDLEIRMSRIEH-s..........................................
A0A1S7HGQ8_9SACH/15-260 .................................n-VRTTSHSPS.....NYIHGLKR..FA...TSPASRHPND...-LSKPPARIS....PSRKTPM........KHPIQLTP..KRLPS.PECL.KEIKT......KR.LKNT...ESPLM..HPEVAEV-...-D..........QGGSSTTMVFQTSPTRAI...FSNE.RKIGGDGSLGRIRSRFSN.GLLSPQRRIVPAPkq......................kalNPEEKELEAKNLFEKLEEAEKl........eKSHSDLTCDNPKRNDDG.....GKDAKA....aKSVQCSKKSVKFELPPEDt......rIKILEELHEVGKLLEEAFKRHRELELRLAKFENQ...........................................
G8BR78_TETPH/10-257 .................................n-SSTSKRSESlnhagKGITDFKKnsLQ...KDPVRSILKS..sRLFKSPEKLN....NCKVSK-........KSTLHITP..KKLAS.PECL.RDYIP......KV.TRSV...DYSDF..RKMHEPI-...IE..........TNGTVTNVLFPTSPLKIR...FSDSiKPIGGDGSLNRIRAKFKN.GLMSPEKLIQRKG...........................TSIITSKARRNLFEEIQRESTs.......ttIDTNKIKTIQKSLNNGI.....LKKEIQ.....-KGESPHKSVKFHIPDNE........SDIRQQLNDINNLLNAILTRQDVLEKEISEIKR-n..........................................
Q6FXC3_CANGA/6-256 .................................s-DIGNVVQGR.....DTRNVFDR..LS...ISPQKRSSNKrdsVVWKPASRIS....PKKSNNAp......lTTAIHETP..KRLQS.PSFL.KDR--......SF.TQSL...DRPQFdpKDIVSATP...VNkvkpgiprsvGNPTTSTFMIPISPTKIT...FSNE.KRTGGDGSSSRILSRMRN.IRASPVRSVPSTA...........................----TTIKKRNLTERLRQEEE.........gENKNNEKRVRFQVPSQP.....-RPGSS....qSSSRTPSRDSNESMTNAN........KHISRERKAPMPVKTSPDARIDQLENTVRLLEER...........................................
A0A0C7MTG6_9SACH/4-252 ...........................htierql-------RGS.....PTKNVFKR..LS...TSPNKKLLPN...TNRKSSSKLS....PERGQNAw.....erPVVYQATP..KRLKS.PPYL.LDLKP.....pGG.TLSV...DRVHF..KNDPE---...--..........--DNSIQLSFPTSPVRTT...YSNS.TASGGDGSLSRIRTRFGG.GQRSPGKVSNATL..........................sAVTTTVNSARNLLPELQEQDEvalenksssgNDYDNY-KHRSSLPKIS.....ANDGFKi..rkPRSLNPKKSVKFESDMAE........NDVQEQLSKIVSMLLEIMERQDRLEAKVSSMD--rv.........................................
A7TJ22_VANPO/10-269 ..................................NKVGNEKDGSfp.shRDNNVFKR..LT...LSPPKKYLSK...PSSNSPSRLP....VSTSGNVk......gKYGIQVTP..KRIAS.PDCL.KDFNV......K-.---I...DQPLM..MTDSGSKKrsvLV..........DTDSVTKVTFPTSPIKIK...FAET.KPLGGDGSLNRIRAKFKN.GLMSPERHNAGSTsilh..................sepinEIRPSLRAGRNLFKELQREDSig......seEDYNSVTKRNTSYNASM.....KKSGSI.....TKSSPMKKSVKFAVPSDDq.....eySELKSELSDIKNLLLSLVNKQTSIESRLSQLEEQ...........................................
G0VBX4_NAUCC/1-227 ................................mk-------EYS.....TKKDVFRR..LS...NSPTKNKVAK..lSVSSSKVQNF....PITSRTS........PIRNIKTH..ARLTS.PKCL.KDYQP.....tML.VQSV...DRHHF..--------...--..........-NEGRGDLNFLTSPTK--...FNLE.KTVGGDGSRTRIRSRFKN.GLLSPERLQNERE..........................qLSPSKHIQGSNLFTKLKREDE.........eWDMDKLTEINTSHNKKS.....-EDSPT....yIPLSPNKKNVKFELPITTr......dQEINDSLKDIKSMLINVIKKQDEMNSRISQLED-t..........................................
H2AR55_KAZAF/85-204 ..............................thas----------.....--------..--...----------...----------....-------........--------..-----.----.-----......--.----...-----..--------...--..........------------------...----.-----------LRSSHGV.TIVSPIRANLQDQy........................skDELKEEVKGSNLLTKLKDEFS.........gEPHGNEATYHAPLPQNS.....DSNTRS.....-SASQPKKAVKFALSNE-........---NSTEEDLRSLIEQMKDNQLTLEKKLDSLT--sef........................................
A0A1X7R617_9SACH/79-184 ..............ppqndhsrsnppsilkqgpp----------.....--------..--...----------...----------....-------........--------..-----.----.-----......--.----...-----..--------...--..........------------------...----.------------------.-------------...........................-TSSSRLGGNNLLNKLREEES..........--------ISSRVDKIM.....NENKKR.....YKSKMEEKNVKFYLPTD-........DNIREEVDSLKSMLEHIISRQDTLEKSIEEIKS-l..........................................
A0A1G4KIZ7_9SACH/26-259 ...........................hgdhlst---------S.....PARNVYRS..LS...TSPAKKMQAR...DLTQPARRLS....PKKRSREg.....dfEAGFQTTP..KRLQS.PTSL.QDHLK......NLgTVSV...DRVKF..E-------...-K..........DNSAVKKLKFPVSPAKTQ...FSSS.QTLGGDGSLSRIRTRFGG.GLKSPQRALSGKE..........................dHQRPVDATQRILTSKLDAEAD..........--KPSIKSMGFDVIHQKa..phLRFGSP.....-EPAPNRKRVKFELSNDP........MELKKEVSELRSLLEELNKRQDELEARLSRLEER...........................................
A0A1G4MK74_LACFM/15-258 .................................s-DIGNKVRCS.....PSKNVYKR..LG...TSPMKKYSND...-LSKPPMRIS....PAKRQPPh.....egSNFFQTTP..KRLRS.PQSL.KAYPR......EG.TSSV...DRINF..-KGSESV-...--..........-NSTGTDFVFHTSPVRPK...FSNI.INVGGDGSLSRIRTRFSN.GVKSPQKEKEIHS...........................--AYPDKVQKNLFVQLQQQESlh.....nslSDFNDTTRINTTINSMKirpqdDKKTIK....kPKSLAKKKTVKFELNEE-........KNLKSELSEIRALLMNLTERQDQLEQRLFS----rees.......................................
Q750A6_ASHGO/6-227 ..................................NDISNREAAT.....RGSDVFKR..LA...GSPMRRDGAA...-MDKPAMRLS....PG-----........KHAYQTSP..KRLLA.PEHL.R----......SL.TQSV...DRHFF..-NTARAT-...--..........GRPGSRDAAFTASPTKGDg.gFSNM.TVAGGDGSLSRIRNRF--.---SPVKERKPILa.........................sEQEDGAATRQNLLAKLQREED..........--VTQVTRRNTRQNSEAs...rYKVGKS.....-QIVTRSRNVKFELPED-........RMIAIELQNLKQLIHTLIERQDQLEDRLTRLEEQ...........................................
#=GC seq_cons .........................................psS.....sppsVFKR..Lu...hSPs+ph.tp....lpKPshRlS....Pt+tss.........phshQhTP..KRLhS.PpsL.+sh........ph.TpSl...DRsph...p..ts.................ssspssplhFPoSPs+ht...Fusp.pplGGDGSLoRIRuRFps.GlhSPp+htt.p...............................tpphpt+NLhs+Lpc--p............hsphpphpsphspth.....tppsps......ptts.cKsVKFcLPss.........pplppcLp-lcplL.plhcRQcpLEt+lsplEp............................................
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