#=GF ID   FIT1_2
#=GF AC   PF17357.6
#=GF DE   Facilitor Of iron transport 1 and 2
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   PRODOM:PD082765
#=GF GA   26.10 26.10;
#=GF TC   28.70 26.10;
#=GF NC   25.50 25.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   26721269
#=GF RT   Cell Surface Interference with Plasma Membrane and Transport
#=GF RT   Processes in Yeasts.
#=GF RA   Francois JM;
#=GF RL   Adv Exp Med Biol. 2016;892:11-31.
#=GF DR   INTERPRO; IPR035323;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Fit proteins (facilitor of iron transport) found on
#=GF CC   Saccharomyces cerevisiae cell wall are mannoproteins implicated
#=GF CC   in the siderophore-iron bound transport. This domain family can
#=GF CC   be found in FIT1 and FIT2 proteins in Saccharomycetaceae. The
#=GF CC   FIT1-3 cell wall mannoproteins are attached to the beta-glucan
#=GF CC   layer through a GPI (glycosylphosphatidylinoisitol) anchor. They
#=GF CC   are very rich in serine and threonine residues (40-50 % serine
#=GF CC   and threonine) and bear several short repeat of 6-7 amino acids
#=GF CC   sequence. The exact domain function is unknown.
#=GF SQ   22
#=GS J5S5Z1_SACK1/25-112      AC J5S5Z1.1
#=GS A0A1S7HAJ3_9SACH/40-125  AC A0A1S7HAJ3.1
#=GS Q6CUG6_KLULA/50-141      AC Q6CUG6.1
#=GS Q6CUG6_KLULA/201-255     AC Q6CUG6.1
#=GS J8LHN3_SACAR/25-112      AC J8LHN3.1
#=GS A0A1S7HDG6_9SACH/83-170  AC A0A1S7HDG6.1
#=GS A0A1S7HDH0_9SACH/25-110  AC A0A1S7HDH0.1
#=GS A0A1S7HTS8_9SACH/25-110  AC A0A1S7HTS8.1
#=GS Q6CUG6_KLULA/309-370     AC Q6CUG6.1
#=GS Q6CY00_KLULA/50-139      AC Q6CY00.1
#=GS FIT1_YEAST/169-259       AC Q04433.1
#=GS A0A1G4MJA8_LACFM/28-111  AC A0A1G4MJA8.1
#=GS Q6CXZ9_KLULA/50-131      AC Q6CXZ9.1
#=GS Q6CXZ8_KLULA/25-110      AC Q6CXZ8.1
#=GS FIT2_YEAST/25-112        AC Q08906.1
#=GS C5DJ06_LACTC/25-108      AC C5DJ06.1
#=GS J5PX14_SACK1/20-106      AC J5PX14.1
#=GS Q6CUG5_KLULA/23-108      AC Q6CUG5.1
#=GS J5PX14_SACK1/81-166      AC J5PX14.1
#=GS A0A1S7HLT6_9SACH/25-110  AC A0A1S7HLT6.1
#=GS A0A1S7I0R4_9SACH/25-110  AC A0A1S7I0R4.1
#=GS J5PX14_SACK1/141-226     AC J5PX14.1
J5S5Z1_SACK1/25-112                 ................MTTKTITVTNGNNVYTKVVTDTADPIITYSTT....RT.VVVSNSAGTYTKVV.TEGP.DST.SE.K...STT..KTLTLTNGSGSSTnlYTKTVTQPIESS....
A0A1S7HAJ3_9SACH/40-125             ................KTTKVITATNGDNVYTKTVTDDADPVLSHSTT....RT.VTVSNSAATYTKVI.TEGP.NV-.-E.S...STT..KTLTLTNSVGSSTdlYTKTIAEAVESS....
Q6CUG6_KLULA/50-141                 ...............y-YLSTIIVTRGDVVYTKVITEQSAVATSETTS...sEE.TTASILTAVDEEAI.SSAV.EET.SS.AeeaSTTeyETITLTLYKNDHW..FTKTVTQPVGYV....
Q6CUG6_KLULA/201-255                tgeattytgvapwass--------------------------------....--.-------------S.AEEA.STT.LD.A...DEL..ETVTLTLSKNGHW..FTKTVTQT----kgfv
J8LHN3_SACAR/25-112                 ................MTTKTITATNGNVVYTKVVTDTADPVISYSTT....RT.VVVSNSAGTYTKVV.TEGP.DTT.SL.K...STT..KTVTLTNGSGSSTnlYTKTVTQAIESS....
A0A1S7HDG6_9SACH/83-170             ..............ns-ITTTITATKNGHVYTKTITQDATFVWQGEGS....NA.KSTSSSESSSEPGS.TKAP.SSTrNG.S...GKS..TTKTITATKNGHV..NTKTVTQD----atfi
A0A1S7HDH0_9SACH/25-110             ................KTTKVITATNGDNVYTKTVTDDADPVLSHSTT....RT.VTVSNSAATYTKVI.TEGP.NV-.-E.S...STT..KTLILTNSVGSSTdlYTKTVAEAIESS....
A0A1S7HTS8_9SACH/25-110             ................KTTKVITATNGDNVYTKTVTDDADPVLSHSTT....RT.VTVSNSAATYTKVI.TEGP.NV-.-E.S...STT..KTLTLTNSVGSSTdlYTKTVAEAIESS....
Q6CUG6_KLULA/309-370                .............wtg----------------------------EATT....YTgVAPWASSSAEEASS.TEEA.STT.LD.A...DEL..ETVTLTLSKNGHW..FTKTVTQT----kgfv
Q6CY00_KLULA/50-139                 ................EYLTSIVVTRGDTVYTKVITESSAAATEETTAa.aeET.TAAAETTSAAAETT.TAAPaEET.SS.A...QES..ETITLTLSKNGHW..FTKTVTQAVGYV....
FIT1_YEAST/169-259                  ...............s-ITTTITATKNGHVYTKTVTQDATFVWTGEGErapvST.VATVETAASPVTSV.AEPS.AST.DEgS...GSS..ITTTITATKNGHV..YTKTVTQD----atfv
A0A1G4MJA8_LACFM/28-111             ...............a-TTKTITATNGSVVYTKVVTDTADPVVTYSTT....RT.TTYTTGDATYVKTY.TEGP.DST.SE.S...STV..KTITATNGSNT--..YEKTVTEAVTSS....
Q6CXZ9_KLULA/50-131                 ................EYLTSIVVTRGDTVYTKVITESSAAATEETT-....--.-AAAEETTAAAETT.AAAA.EEE.AS.T...TEY..ETVTLTLSKNGHW..FTKTVTQAVGF-v...
Q6CXZ8_KLULA/25-110                 ................STIKTIVATNGDHVYTKVVTDSAAPVYTESTT....VT.TTITNNGASYVKTL.TIAP.QTT.IG.S...STT..SKITITNSDNGAT..YTKTNVVAISSS....
FIT2_YEAST/25-112                   ................MTTKTITATNGNNVYTKVVTDTADPIISYSTT....RT.VVVSNSDATYTKVV.TEGP.DTT.SE.K...STT..KTLTLTNGSGSSTnlYTKTVTQAVESS....
C5DJ06_LACTC/25-108                 ................MTTKTITATNGSNVYTKVVTDTADPIISQSTT....RT.VTVKNSDATYTKVV.TEGP.DTT.SL.S...STT..KTITATNQSGS--..YTKTVTAAVTSS....
J5PX14_SACK1/20-106                 ...............s-VTTTITATKNGHVYTKTVTQDATFVWTGEGDy..gAA.ATSAPVEASAAPVAeTASA.DEG.SG.S...SIT..KVITATK--NGNV..YTKTVTQD----atfv
Q6CUG5_KLULA/23-108                 ................STVKTITATNGGHVYTKVVTDTADPIITASTT....RT.TTYTENGASYVKTY.TEGP.DTT.SV.K...STT..SKVTITNSDNGAT..YTKTNVVAIS--td..
J5PX14_SACK1/81-166                 ...............s-ITKVITATKNGNVYTKTVTQDATFVWTGEGEy..aVA.TSAPAEASAALVAE.TSSA.DEG.SG.S...SIT..KVITAT--KNGHA..YTKTVTQD----atfv
A0A1S7HLT6_9SACH/25-110             ................KTTKVITATNGDNVYTKTVTDNADPVLSHSTT....RT.VTVSNSAATYTKVI.TEGP.NV-.-E.S...STT..KTMTLTNSVGSSTglYTKTIAEALGSS....
A0A1S7I0R4_9SACH/25-110             ................KTTKVITATNGDNVYTKTVTDDADPVLSHSTT....RT.VTVSNSAATYTKVI.TEGP.NV-.-E.S...STT..KTLTLTNSVGSSTglYTKTVAEAVESS....
J5PX14_SACK1/141-226                ...............s-ITKVITATKNGHAYTKTVTQDATFVWTGEGEy..aVA.TSAPAEASAALVAE.TSSA.DEG.SG.S...SIT..KVITAT--KNGHA..YTKTVTQD----atfv
#=GC seq_cons                       .................hTKsITATpGssVYTKsVT-sAsslhotoTo....pT.sosssssuohscsh.TEuP.sss.sp.o...SoT..cTlTlTsupsups..YTKTVTpslt......
//