#=GF ID   Fib-H_N
#=GF AC   PF20820.1
#=GF DE   Fibroin heavy chain, N-terminal domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF SE   ECOD:3408.1.1
#=GF GA   27.00 27.00;
#=GF TC   27.20 40.90;
#=GF NC   26.20 26.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF RC   Paper describing PDB structure 3ua0
#=GF RN   [1]
#=GF RM   22387468
#=GF RT   N-Terminal domain of Bombyx mori fibroin mediates the assembly
#=GF RT   of silk in response to pH decrease.
#=GF RA   He YX, Zhang NN, Li WF, Jia N, Chen BY, Zhou K, Zhang J, Chen Y,
#=GF RA   Zhou CZ;
#=GF RL   J Mol Biol. 2012;418:197-207.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found at the N-terminal end of Fibroin heavy
#=GF CC   chain (Fib-H) from Bombyx mori and similar proteins mainly from
#=GF CC   arthropods and bacteria. This hydrophilic region plays an
#=GF CC   important role in the assembly of silk by changing its
#=GF CC   conformation in response to pH decreases: it transitions from
#=GF CC   random coil to beta sheets and form micelle-like oligomers at
#=GF CC   around pH 6.0 [1].
#=GF SQ   11
#=GS A0A821P926_9NEOP/34-106  AC A0A821P926.1
#=GS A0A6J1X4G6_GALME/33-104  AC A0A6J1X4G6.1
#=GS FIBH_BOMMA/35-107        AC Q99050.2
#=GS A0A6J2JYR4_BOMMA/35-107  AC A0A6J2JYR4.1
#=GS A0A5E4Q010_9NEOP/6-83    AC A0A5E4Q010.1
#=GS A0A3S2N8V1_CHISP/32-106  AC A0A3S2N8V1.1
#=GS A0A4C1Z4W5_EUMVA/34-107  AC A0A4C1Z4W5.1
#=GS A0A8B8IS05_VANTA/35-107  AC A0A8B8IS05.1
#=GS A0A0N1IQP8_PAPMA/39-109  AC A0A0N1IQP8.1
#=GS FIBH_BOMMO/35-107        AC P05790.4
#=GS A0A8J2VS67_9NEOP/38-110  AC A0A8J2VS67.1
A0A821P926_9NEOP/34-106             ....let---KKVNETDELDYDATGNVYEKSTTTKEYEAYGDVDKDV...TGDDVKVKTIVIKTDSTGHETIWEEDVLIHKKS..
A0A6J1X4G6_GALME/33-104             .......FIEIGESTTAEVDVE-NGTLVERETTRKKYERDGDITPNI...SGEDKIVRTFVIETDASGHETVYEEDVVIKRKP..
FIBH_BOMMA/35-107                   .......VTVQSSNTTDEIIRDASGAVIEEEITTKKMQRKNKNHGIL...GKNEKMIKTFVITTDSDGNESIVEEDVLMKTLS..
A0A6J2JYR4_BOMMA/35-107             .......VTVQSSNTTDEIIRDASGAVIEEQITTKKMQRKNKNHGIL...GKNEKMIKTFVITTDSEGNETIVEKDVLMKTLS..
A0A5E4Q010_9NEOP/6-83               fvifcca--LQKVNETDEIDVDQKGDLYEKSTTTKEYEAYGDFDEDV...TGDDVKVKTLVIRTDAKGHESIWEKDVLIKKKG..
A0A3S2N8V1_CHISP/32-106             .......LIETDETKTDEFELSKNGTVLEKSITRKKFESENDFQPQFlpkAGE-KTVTTLVIETDAEGHQTIYEEDVVIKEVA..
A0A4C1Z4W5_EUMVA/34-107             .......FRETDLADTDEYQTDSNGTMFEKKTTRKKFEKDGSTMVNS..dSGEDKIVRTFVVETDASGHEVIYEEDVVIKKVP..
A0A8B8IS05_VANTA/35-107             .....yq--ETNLTTSDEFDVDQTGNVIERSTIRKEFEQDGDTSGDI...VGDDVNVKTIVIKTDAFGHKRIYEEDVSIHKVP..
A0A0N1IQP8_PAPMA/39-109             .......FQETTETKSDEVIKK-NGTLVERQIIKKKYVDRSRHKHNK...SGE-RITKTFTIESGPNGEETIYETDVVETT--vp
FIBH_BOMMO/35-107                   .......VTVQSSNTTDEIIRDASGAVIEEQITTKKMQRKNKNHGIL...GKNEKMIKTFVITTDSDGNESIVEEDVLMKTLS..
A0A8J2VS67_9NEOP/38-110             ....lqt---KNVSTSDEFDVDQTGGVWEKSTTRTNFERQGHASSDV...TGDDVKVRTIRIEVDASGRERIFEEDVIIKKVP..
#=GC seq_cons                       .......h..ps.ssTDElphDtsGsVlE+phTpKKaEccucspssl...uG--+hVKThVIcTDusG+EoIaEEDVlIKcls..
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