#=GF ID FkbO_Hyg5-like_N
#=GF AC PF21168.1
#=GF DE Chorismatase FkbO/Hyg5-like, N-terminal
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF SE ECOD:EF20912
#=GF GA 27.00 27.00;
#=GF TC 27.20 27.60;
#=GF NC 26.80 26.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RC Paper describing PDB structure 4bps
#=GF RN [1]
#=GF RM 24036425
#=GF RT Mechanistic implications for the chorismatase FkbO based on the
#=GF RT crystal structure.
#=GF RA Juneja P, Hubrich F, Diederichs K, Welte W, Andexer JN;
#=GF RL J Mol Biol. 2014;426:105-115.
#=GF RC Paper describing PDB structure 5a3k
#=GF RN [2]
#=GF RM 26247872
#=GF RT Chorismatase Mechanisms Reveal Fundamentally Different Types of
#=GF RT Reaction in a Single Conserved Protein Fold.
#=GF RA Hubrich F, Juneja P, Muller M, Diederichs K, Welte W, Andexer
#=GF RA JN;
#=GF RL J Am Chem Soc. 2015;137:11032-11037.
#=GF RN [3]
#=GF RM 21383123
#=GF RT Biosynthesis of the immunosuppressants FK506, FK520, and
#=GF RT rapamycin involves a previously undescribed family of enzymes
#=GF RT acting on chorismate.
#=GF RA Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA,
#=GF RA Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE,
#=GF RA Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay
#=GF RA PF, Wilkinson B;
#=GF RL Proc Natl Acad Sci U S A. 2011;108:4776-4781.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is found in the N-terminal region of Chorismatase
#=GF CC from (FkbO) and 3-hydroxybenzoate synthase (Hyg5) from
#=GF CC Streptomyces hygroscopicus and in similar bacterial proteins.
#=GF CC These enzymes catalyse the hydrolysis of chorismate into
#=GF CC pyruvate and (dihydro)benzoic acid derivatives and are involved
#=GF CC in the biosynthetic pathways forming polyketidic
#=GF CC immunosuppressants such as ascomycin (FK520) and tacrolimus
#=GF CC (FK506), which prevent T-cell proliferation through initial
#=GF CC binding to the immunophilin FKBP12. FkbO is organised into three
#=GF CC domains: N-terminal, central and C-terminal. This entry
#=GF CC represents the N-terminal and central domains of FkbO, which
#=GF CC show two beta-sheets and three alpha-helices. This fold is also
#=GF CC found in Hyg5, which employ a fundamentally different reaction
#=GF CC mechanism than the typical hydrolysis seen in FkbO [1-3].
#=GF SQ 418
#=GS F3PPM9_9BACE/90-218 AC F3PPM9.1
#=GS A0A0K0Y0E4_9GAMM/58-180 AC A0A0K0Y0E4.1
#=GS A0A2S9PZQ8_9ACTN/71-192 AC A0A2S9PZQ8.1
#=GS A0A7X5ZH04_9GAMM/64-186 AC A0A7X5ZH04.1
#=GS M5UMJ4_9BACT/181-305 AC M5UMJ4.1
#=GS C5BQ16_TERTT/32-157 AC C5BQ16.1
#=GS A0A1T4S3T5_9GAMM/88-210 AC A0A1T4S3T5.1
#=GS A0A2U3IFA8_9BURK/56-177 AC A0A2U3IFA8.1
#=GS A0A5R9PHM4_9GAMM/67-188 AC A0A5R9PHM4.1
#=GS A0A4Q2Y434_9BACT/62-183 AC A0A4Q2Y434.1
#=GS A0A7W8JPN0_9GAMM/50-172 AC A0A7W8JPN0.1
#=GS A0A4R6JMM3_9ACTN/83-203 AC A0A4R6JMM3.1
#=GS A0A3N5Y9Q1_9ALTE/52-174 AC A0A3N5Y9Q1.1
#=GS A0A1M6DJG0_9BACT/98-219 AC A0A1M6DJG0.1
#=GS A0A1C9VN18_9BURK/13-142 AC A0A1C9VN18.1
#=GS R4LAH9_9ACTN/62-183 AC R4LAH9.1
#=GS A0A7G3UNW8_STRT9/62-183 AC A0A7G3UNW8.1
#=GS A0A244EBL3_9BURK/63-187 AC A0A244EBL3.1
#=GS A0A101SPX9_9ACTN/71-192 AC A0A101SPX9.1
#=GS A0A4R7P4R2_9GAMM/46-167 AC A0A4R7P4R2.1
#=GS A0A5Q0BBQ4_9GAMM/59-179 AC A0A5Q0BBQ4.1
#=GS G2J0T4_PSEUL/55-181 AC G2J0T4.1
#=GS A0A8G2F3Y9_9BACT/115-218 AC A0A8G2F3Y9.1
#=GS A0A147H8A9_9BURK/65-187 AC A0A147H8A9.1
#=GS B8GUQ7_THISH/56-178 AC B8GUQ7.1
#=GS A0A1Y6CZX1_9GAMM/58-178 AC A0A1Y6CZX1.1
#=GS A0A399T8F4_9BACT/98-219 AC A0A399T8F4.1
#=GS A0A3N4VBB3_9GAMM/63-187 AC A0A3N4VBB3.1
#=GS A0A8J2UMI2_9BURK/56-184 AC A0A8J2UMI2.1
#=GS A0A415E2Q6_9BACT/92-220 AC A0A415E2Q6.1
#=GS K5ZTW8_9BACT/89-219 AC K5ZTW8.1
#=GS A0A2Z5ZH55_9PROT/57-180 AC A0A2Z5ZH55.1
#=GS A0A1H1G7J8_9GAMM/68-189 AC A0A1H1G7J8.1
#=GS A0A3N8LKB1_9BURK/34-175 AC A0A3N8LKB1.1
#=GS I4VLD7_9GAMM/45-167 AC I4VLD7.1
#=GS A0A238DM48_9BURK/114-223 AC A0A238DM48.1
#=GS A4G900_HERAR/58-190 AC A4G900.2
#=GS B4VDU3_9ACTN/71-192 AC B4VDU3.1
#=GS A0A6P2ET96_9BURK/63-187 AC A0A6P2ET96.1
#=GS A0A290QB20_9BACT/55-170 AC A0A290QB20.1
#=GS A0A519ZJ58_9BURK/61-187 AC A0A519ZJ58.1
#=GS I9S2Z9_9BACE/101-222 AC I9S2Z9.1
#=GS A0A4R2R1Z1_9PSEU/60-179 AC A0A4R2R1Z1.1
#=GS A0A7Y7DLF1_9ALTE/52-174 AC A0A7Y7DLF1.1
#=GS A0A7L6AXU1_9GAMM/66-188 AC A0A7L6AXU1.1
#=GS A0A1Y0EKU3_9BURK/102-223 AC A0A1Y0EKU3.1
#=GS A0A6C2D2T6_9RHOO/57-186 AC A0A6C2D2T6.1
#=GS A0A4R0YS76_9GAMM/40-162 AC A0A4R0YS76.1
#=GS A0A2T6E1M5_9BACT/52-166 AC A0A2T6E1M5.1
#=GS A0A1N6U6P0_9RHOO/66-196 AC A0A1N6U6P0.1
#=GS A0A2S5SZY6_9BURK/10-132 AC A0A2S5SZY6.1
#=GS B7J6K5_ACIF2/72-205 AC B7J6K5.1
#=GS A0A4R4EV38_9GAMM/33-154 AC A0A4R4EV38.1
#=GS A0A4Z0LZG6_9GAMM/70-193 AC A0A4Z0LZG6.1
#=GS A0A1Y2QTP2_9BURK/49-179 AC A0A1Y2QTP2.1
#=GS A0A1X4I8V0_9ACTN/69-190 AC A0A1X4I8V0.1
#=GS A0A1T5KI05_9GAMM/68-189 AC A0A1T5KI05.1
#=GS A0A6C2UKE0_9BACT/128-246 AC A0A6C2UKE0.1
#=GS A0A330L618_9BACT/77-200 AC A0A330L618.1
#=GS A0A091BGZ0_9GAMM/53-174 AC A0A091BGZ0.1
#=GS A2SFF4_METPP/62-188 AC A2SFF4.1
#=GS A0A3B7AGK9_9RHOO/55-184 AC A0A3B7AGK9.1
#=GS A0A5B7ZTK2_9GAMM/31-152 AC A0A5B7ZTK2.1
#=GS A0A399CZT3_9BACT/98-219 AC A0A399CZT3.1
#=GS A0A1R1IE43_9RHOO/53-181 AC A0A1R1IE43.1
#=GS A0A2K8U3B6_9GAMM/65-195 AC A0A2K8U3B6.1
#=GS Q5GUP7_XANOR/95-216 AC Q5GUP7.1
#=GS A0A427CA75_9GAMM/53-174 AC A0A427CA75.1
#=GS A0A6C2U7R1_9BACT/129-246 AC A0A6C2U7R1.1
#=GS A0A0G3BM51_9BURK/63-187 AC A0A0G3BM51.1
#=GS A0A2R5FCR2_9PROT/53-179 AC A0A2R5FCR2.1
#=GS Q8P3Q5_XANCP/33-154 AC Q8P3Q5.1
#=GS A0A7G9SSM4_9GAMM/66-189 AC A0A7G9SSM4.1
#=GS A0A8J7VVI4_9GAMM/64-188 AC A0A8J7VVI4.1
#=GS A0A6N1XHZ5_9RHOO/55-184 AC A0A6N1XHZ5.1
#=GS D6CVB5_THIA3/59-190 AC D6CVB5.1
#=GS A0A0A0EUL7_9GAMM/30-155 AC A0A0A0EUL7.1
#=GS A0A1P8XRH5_9ACTN/56-177 AC A0A1P8XRH5.1
#=GS A0A5C4RP88_9GAMM/48-169 AC A0A5C4RP88.1
#=GS H0PSE4_9RHOO/12-144 AC H0PSE4.1
#=GS A0A840VQR7_9PROT/9-130 AC A0A840VQR7.1
#=GS A0A5B9W8P1_9BACT/113-246 AC A0A5B9W8P1.1
#=GS A0A346NQ23_9ALTE/29-151 AC A0A346NQ23.1
#=GS A0A4R4ZRK2_9ACTN/45-163 AC A0A4R4ZRK2.1
#=GS Q89ZE8_BACTN/104-226 AC Q89ZE8.1
#=GS A0A317MY94_9GAMM/52-175 AC A0A317MY94.1
#=GS A0A2C6J2Y5_9PROT/1-113 AC A0A2C6J2Y5.1
#=GS A0A423PJY3_9GAMM/48-173 AC A0A423PJY3.1
#=GS A0A3D8VC37_9GAMM/58-189 AC A0A3D8VC37.1
#=GS A6L9N6_PARD8/111-218 AC A6L9N6.1
#=GS A0A0F5IRU3_9BACT/98-218 AC A0A0F5IRU3.1
#=GS L0DS45_THIND/51-170 AC L0DS45.1
#=GS A0A087MHH2_9GAMM/43-150 AC A0A087MHH2.1
#=GS A0A4S3KM53_9GAMM/69-191 AC A0A4S3KM53.1
#=GS A0A4U5JRA7_9GAMM/30-157 AC A0A4U5JRA7.1
#=GS A0A1C6QFW6_9BURK/102-226 AC A0A1C6QFW6.1
#=GS A0A848FI46_9BURK/55-179 AC A0A848FI46.1
#=GS K9WEI8_9CYAN/52-169 AC K9WEI8.1
#=GS A0A379MTS2_9BACT/111-227 AC A0A379MTS2.1
#=GS A0A2W1JYC9_9CYAN/61-175 AC A0A2W1JYC9.1
#=GS A0A653JYE9_9BURK/63-187 AC A0A653JYE9.1
#=GS A0A1I6RL47_9PSEU/61-182 AC A0A1I6RL47.1
#=GS A0A4R1ENP9_9GAMM/55-178 AC A0A4R1ENP9.1
#=GS I3YB26_THIV6/55-177 AC I3YB26.1
#=GS A0A1V3ZYA4_9ACTN/48-169 AC A0A1V3ZYA4.1
#=GS Q3SF99_THIDA/59-186 AC Q3SF99.1
#=GS Q3J9A9_NITOC/68-190 AC Q3J9A9.1
#=GS A0A3M2I5I6_9GAMM/66-187 AC A0A3M2I5I6.1
#=GS A0A286RIW1_9BACT/113-244 AC A0A286RIW1.1
#=GS A0A1P8UE11_9GAMM/65-184 AC A0A1P8UE11.1
#=GS A0A5D8YZN9_9GAMM/31-153 AC A0A5D8YZN9.1
#=GS A0A2W7N9T6_9BACT/113-224 AC A0A2W7N9T6.1
#=GS A0A290XHP5_9GAMM/30-159 AC A0A290XHP5.1
#=GS A0A1I5AYC2_9GAMM/167-294 AC A0A1I5AYC2.1
#=GS A0A0A0EXF2_9GAMM/60-186 AC A0A0A0EXF2.1
#=GS A0A809RMX0_9PROT/63-192 AC A0A809RMX0.1
#=GS G7US74_PSEUP/69-190 AC G7US74.1
#=GS A0A1H5NGD7_9ACTN/69-190 AC A0A1H5NGD7.1
#=GS A0A368NS44_9GAMM/81-201 AC A0A368NS44.1
#=GS A0A4Q7LC00_9BURK/61-193 AC A0A4Q7LC00.1
#=GS A0A0L6T9V9_9BURK/55-179 AC A0A0L6T9V9.1
#=GS A0A0Q9EW65_9GAMM/54-183 AC A0A0Q9EW65.1
#=GS A0A286D8E4_9GAMM/69-190 AC A0A286D8E4.1
#=GS A0A4R5M3I7_9BURK/137-281 AC A0A4R5M3I7.1
#=GS G4E4Z5_9GAMM/64-187 AC G4E4Z5.1
#=GS X5DK32_9BACT/98-219 AC X5DK32.1
#=GS A0A3N0VHJ4_9GAMM/36-156 AC A0A3N0VHJ4.1
#=GS A0A6M8HSC7_9PROT/57-177 AC A0A6M8HSC7.1
#=GS A0A410UJM5_9GAMM/69-191 AC A0A410UJM5.1
#=GS A0A7W7QC17_9PSEU/62-182 AC A0A7W7QC17.1
#=GS A0A7W8Z8L8_9ACTN/66-187 AC A0A7W8Z8L8.1
#=GS A0A0T2ZM00_9BURK/55-183 AC A0A0T2ZM00.1
#=GS A0A423PSG8_9GAMM/47-173 AC A0A423PSG8.1
#=GS A0A5C1EAH5_9RHOO/76-205 AC A0A5C1EAH5.1
#=GS A0A6M4MDN5_9ALTE/52-174 AC A0A6M4MDN5.1
#=GS A0A2S0MFG6_9BURK/91-213 AC A0A2S0MFG6.1
#=GS A0A1V3ND50_9GAMM/57-179 AC A0A1V3ND50.1
#=GS A0A0N1L1N2_9PROT/74-200 AC A0A0N1L1N2.1
#=GS B3PFI8_CELJU/60-181 AC B3PFI8.1
#=GS A0A6I6JYT6_9BACT/100-219 AC A0A6I6JYT6.1
#=GS A0A2R3QGU3_9BURK/30-152 AC A0A2R3QGU3.1
#=GS W8KMR4_9GAMM/58-181 AC W8KMR4.1
#=GS A0A1Z3HS80_9CYAN/59-174 AC A0A1Z3HS80.1
#=GS A0A1Q4X5H0_9PSEU/54-175 AC A0A1Q4X5H0.1
#=GS A0A7X0DIK2_9GAMM/69-191 AC A0A7X0DIK2.1
#=GS A0A1M4TLQ5_9GAMM/65-186 AC A0A1M4TLQ5.1
#=GS A0A8A8D0P8_9BURK/105-244 AC A0A8A8D0P8.1
#=GS A0A178IKC9_9BACT/14-135 AC A0A178IKC9.1
#=GS A0A2M9E190_9GAMM/63-184 AC A0A2M9E190.1
#=GS A0A839HNQ0_9BURK/73-206 AC A0A839HNQ0.1
#=GS A0A369URK1_9GAMM/69-191 AC A0A369URK1.1
#=GS A0A7W7T2T0_9PSEU/60-181 AC A0A7W7T2T0.1
#=GS A0A4R7B262_9NEIS/63-190 AC A0A4R7B262.1
#=GS A0A1M5FXN7_9BACE/79-200 AC A0A1M5FXN7.1
#=GS A0A1A9NN07_9PROT/40-165 AC A0A1A9NN07.1
#=GS D2U928_XANAP/69-192 AC D2U928.1
#=GS A0A250KSX1_9GAMM/84-207 AC A0A250KSX1.1
#=GS A0A2K1Q0M0_9GAMM/65-186 AC A0A2K1Q0M0.1
#=GS A0A4R7W5R4_9PSEU/62-181 AC A0A4R7W5R4.1
#=GS A0A2T5MFM1_9GAMM/62-184 AC A0A2T5MFM1.1
#=GS A0A4Q6C6L3_9GAMM/68-189 AC A0A4Q6C6L3.1
#=GS A0A2P1PY60_9GAMM/68-190 AC A0A2P1PY60.1
#=GS A0A0H2LY81_VARPD/62-187 AC A0A0H2LY81.1
#=GS A0A3A5J5H3_9GAMM/47-174 AC A0A3A5J5H3.1
#=GS A0A4R8IYP3_9GAMM/62-182 AC A0A4R8IYP3.1
#=GS A0A2T6DE26_9BACT/44-161 AC A0A2T6DE26.1
#=GS A0A0F3K8L1_9NEIS/40-168 AC A0A0F3K8L1.1
#=GS A0A559QR05_9ALTE/55-179 AC A0A559QR05.1
#=GS A0A1I5FZB9_9BURK/64-189 AC A0A1I5FZB9.1
#=GS A1KCI0_AZOSB/55-184 AC A1KCI0.1
#=GS E5C4U2_9BACE/97-221 AC E5C4U2.2
#=GS A0A368VG40_9BACT/109-235 AC A0A368VG40.1
#=GS A0A840QK51_9PSEU/33-154 AC A0A840QK51.1
#=GS A0A0R0BR17_9GAMM/63-185 AC A0A0R0BR17.1
#=GS U2ERZ5_9GAMM/53-179 AC U2ERZ5.1
#=GS A0A0R0EB44_9GAMM/52-175 AC A0A0R0EB44.1
#=GS A0A853JEZ8_9GAMM/65-186 AC A0A853JEZ8.1
#=GS A0A2T0SQW5_9PSEU/6-126 AC A0A2T0SQW5.1
#=GS D5BXE9_NITHN/68-190 AC D5BXE9.1
#=GS A0A1N6RPH4_9GAMM/66-187 AC A0A1N6RPH4.1
#=GS A0A1I6KRX5_9GAMM/69-191 AC A0A1I6KRX5.1
#=GS A0A318E7H1_9GAMM/95-220 AC A0A318E7H1.1
#=GS A0A7W5VHB9_9ACTN/61-182 AC A0A7W5VHB9.1
#=GS A0A160N2N4_9GAMM/57-179 AC A0A160N2N4.1
#=GS A0A4R6DQ58_9RHOO/68-202 AC A0A4R6DQ58.1
#=GS A0A212RT46_9PROT/13-131 AC A0A212RT46.1
#=GS A0A848G3M5_9RHOO/35-164 AC A0A848G3M5.1
#=GS A0A3D8JV73_9BURK/20-163 AC A0A3D8JV73.1
#=GS A0A845UVR9_9GAMM/58-178 AC A0A845UVR9.1
#=GS R6N0R2_9BACE/112-219 AC R6N0R2.1
#=GS A0A6G8IH94_9BURK/51-178 AC A0A6G8IH94.1
#=GS A0A8J7X1T2_9GAMM/37-159 AC A0A8J7X1T2.1
#=GS A0A127F7R4_STEDE/90-223 AC A0A127F7R4.1
#=GS A0A2Z6GCT6_9PROT/59-183 AC A0A2Z6GCT6.1
#=GS A0A2M9EB96_9GAMM/62-183 AC A0A2M9EB96.1
#=GS A0A1M5LQ92_9GAMM/54-173 AC A0A1M5LQ92.1
#=GS A0A1Q5JRJ3_9ACTN/70-191 AC A0A1Q5JRJ3.1
#=GS A0A1I4RCA5_ECTMO/63-186 AC A0A1I4RCA5.1
#=GS R7DGK0_9BACT/110-219 AC R7DGK0.1
#=GS Q608J5_METCA/66-187 AC Q608J5.1
#=GS Q0BTN8_GRABC/125-250 AC Q0BTN8.1
#=GS I4WB29_9GAMM/69-191 AC I4WB29.1
#=GS A0A3S0H4N6_9BURK/63-189 AC A0A3S0H4N6.1
#=GS J1H812_9ACTO/16-136 AC J1H812.1
#=GS A0A1H8FLM8_9BURK/73-204 AC A0A1H8FLM8.1
#=GS A0A519F8R6_9BURK/62-186 AC A0A519F8R6.1
#=GS Q9PFA9_XYLFA/40-161 AC Q9PFA9.1
#=GS A0A1M4W551_9BACT/98-219 AC A0A1M4W551.1
#=GS A0A323UVH5_9RHOO/59-188 AC A0A323UVH5.1
#=GS A0A563EVB6_9PSEU/51-166 AC A0A563EVB6.1
#=GS A0A1X7CEX4_TRICW/90-232 AC A0A1X7CEX4.1
#=GS A0A7X0UYW0_9GAMM/65-186 AC A0A7X0UYW0.1
#=GS A0A059KQ45_9BURK/31-163 AC A0A059KQ45.1
#=GS A0A7V8K6V8_9GAMM/58-179 AC A0A7V8K6V8.1
#=GS A0A173MMF7_9BACT/32-161 AC A0A173MMF7.1
#=GS F8XPD8_9PROT/49-182 AC F8XPD8.1
#=GS A0A429X0D0_9BURK/55-179 AC A0A429X0D0.1
#=GS A0A562C0F3_9GAMM/66-195 AC A0A562C0F3.1
#=GS A0A5C5UA81_9GAMM/30-166 AC A0A5C5UA81.1
#=GS S6B7Z5_SULDS/40-169 AC S6B7Z5.1
#=GS A0A0K8QJK0_9GAMM/60-181 AC A0A0K8QJK0.1
#=GS A0A1I2H7K3_9GAMM/45-167 AC A0A1I2H7K3.1
#=GS A0A2T4DU81_9BACT/31-158 AC A0A2T4DU81.1
#=GS A0A7X1AWD1_9BACT/54-164 AC A0A7X1AWD1.1
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