#=GF ID   Flu_PB2_1st
#=GF AC   PF20947.1
#=GF DE   Influenza RNA polymerase PB2 N-terminal region
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Bateman A
#=GF GA   27.00 27.00;
#=GF TC   27.50 37.30;
#=GF NC   22.30 20.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   8806170
#=GF RT   Recombinant-baculovirus-expressed PB2 subunit of the influenza A
#=GF RT   virus RNA polymerase binds cap groups as an isolated subunit. 
#=GF RA   Shi L, Galarza JM, Summers DF; 
#=GF RL   Virus Res 1996;42:1-9.
#=GF RN   [2]
#=GF RM   26503046
#=GF RT   Crystal structure of the RNA-dependent RNA polymerase from
#=GF RT   influenza C virus.
#=GF RA   Hengrung N, El Omari K, Serna Martin I, Vreede FT, Cusack S,
#=GF RA   Rambo RP, Vonrhein C, Bricogne G, Stuart DI, Grimes JM, Fodor E;
#=GF RL   Nature. 2015;527:114-117.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Influenza virus encodes a large, multidomain RNA-dependent RNA
#=GF CC   polymerase that can both transcribe and replicate the viral RNA
#=GF CC   genome. In influenza virus, the polymerase is composed of three
#=GF CC   polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase
#=GF CC   active site, whereas PB2 and PA/P3 contain, respectively,
#=GF CC   cap-binding [1] and endonuclease domains required for
#=GF CC   transcription initiation by cap-snatching [2]. This entry
#=GF CC   represents the N-terminal extended region of Flu PB2 protein,
#=GF CC   which is the N-terminal PB1 interaction domain.
#=GF SQ   29
#=GS PB2_INCAA/5-40          AC Q6I7C4.1
#=GS Q6VE63_9INFA/10-45      AC Q6VE63.1
#=GS PB2_I96A0/1-36          AC Q9Q0V1.1
#=GS F2P1F0_I66A1/1-36       AC F2P1F0.1
#=GS PB2_I66A1/1-36          AC Q0A449.1
#=GS A0A097F2S1_9ORTO/5-40   AC A0A097F2S1.1
#=GS E4UF22_9INFA/1-36       AC E4UF22.1
#=GS Q71FS4_9INFA/1-34       AC Q71FS4.1
#=GS A2V6J9_9INFA/1-36       AC A2V6J9.1
#=GS PB2S1_I34A1/1-36        AC P0DOG6.1
#=GS A0A2S3ZRU2_ARTGL/13-48  AC A0A2S3ZRU2.1
#=GS A0A0B4UWZ1_9INFA/1-36   AC A0A0B4UWZ1.1
#=GS D1LNU3_I63A3/1-36       AC D1LNU3.1
#=GS A0A2V5LCG3_9MICC/12-47  AC A0A2V5LCG3.1
#=GS PB2_I34A1/1-36          AC P03428.2
#=GS PB2_INCJH/5-40          AC Q9IMP3.2
#=GS A0A0E4C2S8_9ORTO/5-40   AC A0A0E4C2S8.1
#=GS Q0QGM5_9INFA/1-36       AC Q0QGM5.1
#=GS A3DRU4_9INFA/1-36       AC A3DRU4.1
#=GS A0T1J1_9INFA/1-36       AC A0T1J1.1
#=GS Q6DNN3_9INFA/1-36       AC Q6DNN3.1
#=GS V5SN71_9INFA/1-36       AC V5SN71.1
#=GS PB2_INBLE/3-38          AC Q9QLL6.1
#=GS A0S741_9INFA/10-45      AC A0S741.1
#=GS PB2S1_I96A0/1-36        AC P0DOG5.1
#=GS A0A172SNP0_9INFB/3-38   AC A0A172SNP0.1
#=GS Q07FS4_9INFA/1-36       AC Q07FS4.1
#=GS E6XY50_9INFA/1-36       AC E6XY50.1
#=GS PB2_I68A5/1-36          AC P26108.1
PB2_INCAA/5-40                     LTIAKEYKRLCQDAKAAQMMTVGTVSNYTTFKKWTT
Q6VE63_9INFA/10-45                 MERIKELRYLMSQSRTREILTKTTVDHMAIIKKYTS
PB2_I96A0/1-36                     MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS
F2P1F0_I66A1/1-36                  MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS
PB2_I66A1/1-36                     MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS
A0A097F2S1_9ORTO/5-40              LTIAKEYKRLCQDAKAAQMMTVGTVSNYTTFKKWTT
E4UF22_9INFA/1-36                  MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS
Q71FS4_9INFA/1-34                  --RIKELRELMSQSRTREILTKTTVDHMAIIKKYTS
A2V6J9_9INFA/1-36                  MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS
PB2S1_I34A1/1-36                   MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTS
A0A2S3ZRU2_ARTGL/13-48             MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS
A0A0B4UWZ1_9INFA/1-36              MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS
D1LNU3_I63A3/1-36                  MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS
A0A2V5LCG3_9MICC/12-47             MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS
PB2_I34A1/1-36                     MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTS
PB2_INCJH/5-40                     LTIAKEYKRLCQDAKAAQMMTVGTVSNYTTFKKWTT
A0A0E4C2S8_9ORTO/5-40              LTLAKEYANLTKDKKSCKLLSQGTVSSYTTFKKWTT
Q0QGM5_9INFA/1-36                  MERIKELRDLMLQSRTREILTKTTVDHMAIIKKYTS
A3DRU4_9INFA/1-36                  MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTS
A0T1J1_9INFA/1-36                  MERIKELRELMSQSRTREILTKTTVDHMAIIKKYTS
Q6DNN3_9INFA/1-36                  MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS
V5SN71_9INFA/1-36                  MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS
PB2_INBLE/3-38                     LAKIELLKQLLRDNEAKTVLRQTTVDQYNIIRKFNT
A0S741_9INFA/10-45                 MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS
PB2S1_I96A0/1-36                   MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS
A0A172SNP0_9INFB/3-38              LAKIELLKQLLRDNEAKTVLKQTTVDQYNIIRKFNT
Q07FS4_9INFA/1-36                  MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS
E6XY50_9INFA/1-36                  MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTS
PB2_I68A5/1-36                     MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTS
#=GC seq_cons                      MERIKELR-LMSQSRTREILTKTTVDHMAIIKKYTS
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