#=GF ID Flu_PB2_2nd
#=GF AC PF20948.1
#=GF DE Influenza RNA polymerase PB2 second domain
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Bateman A
#=GF GA 25.00 25.00;
#=GF TC 100.00 98.00;
#=GF NC 24.00 17.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 8806170
#=GF RT Recombinant-baculovirus-expressed PB2 subunit of the influenza A
#=GF RT virus RNA polymerase binds cap groups as an isolated subunit.
#=GF RA Shi L, Galarza JM, Summers DF;
#=GF RL Virus Res 1996;42:1-9.
#=GF RN [2]
#=GF RM 26503046
#=GF RT Crystal structure of the RNA-dependent RNA polymerase from
#=GF RT influenza C virus.
#=GF RA Hengrung N, El Omari K, Serna Martin I, Vreede FT, Cusack S,
#=GF RA Rambo RP, Vonrhein C, Bricogne G, Stuart DI, Grimes JM, Fodor E;
#=GF RL Nature. 2015;527:114-117.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Influenza virus encodes a large, multidomain RNA-dependent RNA
#=GF CC polymerase that can both transcribe and replicate the viral RNA
#=GF CC genome. In influenza virus, the polymerase is composed of three
#=GF CC polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase
#=GF CC active site, whereas PB2 and PA/P3 contain, respectively,
#=GF CC cap-binding [1] and endonuclease domains required for
#=GF CC transcription initiation by cap-snatching [2]. This entry
#=GF CC represents the domain of the Flu PB protein that follows the
#=GF CC N-terminal extended region.
#=GF SQ 29
#=GS PB2_INCJH/41-112 AC Q9IMP3.2
#=GS A2V6J9_9INFA/37-105 AC A2V6J9.1
#=GS V5SN71_9INFA/37-105 AC V5SN71.1
#=GS PB2_I96A0/37-105 AC Q9Q0V1.1
#=GS Q6VE63_9INFA/46-114 AC Q6VE63.1
#=GS A3DRU4_9INFA/37-105 AC A3DRU4.1
#=GS Q6DNN3_9INFA/37-105 AC Q6DNN3.1
#=GS PB2S1_I96A0/37-105 AC P0DOG5.1
#=GS Q71FS4_9INFA/35-103 AC Q71FS4.1
#=GS A0A172SNP0_9INFB/39-107 AC A0A172SNP0.1
#=GS D1LNU3_I63A3/37-105 AC D1LNU3.1
#=GS E4UF22_9INFA/37-105 AC E4UF22.1
#=GS PB2_INCAA/41-112 AC Q6I7C4.1
#=GS F2P1F0_I66A1/37-105 AC F2P1F0.1
#=GS PB2_I34A1/37-105 AC P03428.2
#=GS A0S741_9INFA/46-114 AC A0S741.1
#=GS Q0QGM5_9INFA/37-105 AC Q0QGM5.1
#=GS PB2_INBLE/39-107 AC Q9QLL6.1
#=GS A0T1J1_9INFA/37-105 AC A0T1J1.1
#=GS A0A2S3ZRU2_ARTGL/49-117 AC A0A2S3ZRU2.1
#=GS A0A097F2S1_9ORTO/41-112 AC A0A097F2S1.1
#=GS A0A2V5LCG3_9MICC/48-116 AC A0A2V5LCG3.1
#=GS Q07FS4_9INFA/37-105 AC Q07FS4.1
#=GS PB2_I68A5/37-105 AC P26108.1
#=GS E6XY50_9INFA/37-105 AC E6XY50.1
#=GS A0A0E4C2S8_9ORTO/41-112 AC A0A0E4C2S8.1
#=GS PB2_I66A1/37-105 AC Q0A449.1
#=GS PB2S1_I34A1/37-105 AC P0DOG6.1
#=GS A0A0B4UWZ1_9INFA/37-105 AC A0A0B4UWZ1.1
PB2_INCJH/41-112 SRKEKNPSLRMRWAMSSKFPIIANK.RMLEeaQIP.KEHNNVALWEDTEDVSKrDHVLASASCINYWNFCGP-cv
A2V6J9_9INFA/37-105 GRQEKNPALRMKWMMAMKYPITADK.RIMD..MIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRSGP-t.
V5SN71_9INFA/37-105 GRQEKNPALRMKWMMAMKYPITADK.RIMD..MIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRSGP-t.
PB2_I96A0/37-105 GRQEKNPALRMKWMMAMKYPITADK.RIME..MIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRNGP-t.
Q6VE63_9INFA/46-114 GRQEKNPALRMKWMMAMKYPITADK.RIME..MIPeRNEQGQTLWIKTNDAGS.DRVMVSPLAVTWWNRNGP-t.
A3DRU4_9INFA/37-105 GRQEKNPSLRMKWMMAMKYPITADK.RIIE..MVPeRNEQGQTLWSKMSDAGS.DRVMVSPLAVTWWNRNGPV..
Q6DNN3_9INFA/37-105 GRQEKNPALRMKWMMAMKYPITADK.RIIE..MIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRNGP-a.
PB2S1_I96A0/37-105 GRQEKNPALRMKWMMAMKYPITADK.RIME..MIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRNGP-t.
Q71FS4_9INFA/35-103 GRQEKNPALRMKWMMAMKYPITADK.RIME..MIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRNGPI..
A0A172SNP0_9INFB/39-107 SRIEKNPSLRMKWAMCSNFPLALTKgDMAN..RIP.LEYKGIQLKTNAEDIGT.KGQMCSIAAVTWWNTYGPI..
D1LNU3_I63A3/37-105 GRQEKNPALRMKWMMAMKYPITADK.RIME..VIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRNGP-t.
E4UF22_9INFA/37-105 GRQEKNPALRMKWMMAMKYPITADK.RIME..MIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRNGP-t.
PB2_INCAA/41-112 SRKEKNPSLRMRWAMSSKFPIIANK.RMLEeaQIP.KEHNNVALWEDTEDVSKrDHVLASASCINYWNFCGP-cv
F2P1F0_I66A1/37-105 GRQEKNPALRMKWMMAMKYPITADK.RIME..MIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRNGP-t.
PB2_I34A1/37-105 GRQEKNPALRMKWMMAMKYPITADK.RITE..MIPeRNEQGQTLWSKMNDAGS.DRVMVSPLAVTWWNRNGPI..
A0S741_9INFA/46-114 GRQEKNPALRMKWMMAMKYPITADR.RIME..MIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAITWWNRNGP-t.
Q0QGM5_9INFA/37-105 GRQEKNPALRMKWMMAMKYPITADK.RIME..MIPeRNEQGQTLWSKTSDAGS.DRVMVSPLAVTWWNRNGP-t.
PB2_INBLE/39-107 SRIEKNPSLRMKWAMCSNFPLALTKgDMAN..RIP.LEYKGIQLKTNAEDIGT.KGQMCSIAAVTWWNTYGPI..
A0T1J1_9INFA/37-105 GRQERNPSLRMKWMMAMKYPITADK.RIME..MIPeRNEQGQILWSKTNDAGS.NRVMVSPLAVTWWNRNGP-t.
A0A2S3ZRU2_ARTGL/49-117 GRQEKNPALRMKWMMAMKYPITADK.RIME..MIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRNGP-t.
A0A097F2S1_9ORTO/41-112 SRKEKNPSLRMRWAMSSKFPIIANK.RMLEeaQIP.KEHNNVALWEDTEDVSKrDHVLASASCINYWNFCGP-cv
A0A2V5LCG3_9MICC/48-116 GRQEKNPALRMKWMMAMKYPITADK.RIME..MIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRNGP-t.
Q07FS4_9INFA/37-105 GRQEKNPALRMKWMMAMKYPITADK.RIME..MIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRNGP-t.
PB2_I68A5/37-105 GRQEKNPSLRMKWMMAMKYPITADK.RITE..MVPeRNEQGQTLWSKMSDAGS.DRVMVSPLAVTWWNRNGPM..
E6XY50_9INFA/37-105 GRQEKNPALRMKWMMAMKYPITADK.RIME..MIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRNGP-t.
A0A0E4C2S8_9ORTO/41-112 SRKEKNPSLRMRWAMGSKFPIMANR.EILEeaGIP.EQWEGIDLWSKKDDVSKlGMVLASPAAITYWNFCGP-gv
PB2_I66A1/37-105 GRQEKNPALRMKWMMAMKYPITADK.RIME..MIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRNGP-t.
PB2S1_I34A1/37-105 GRQEKNPALRMKWMMAMKYPITADK.RITE..MIPeRNEQGQTLWSKMNDAGS.DRVMVSPLAVTWWNRNGPI..
A0A0B4UWZ1_9INFA/37-105 GRQEKNPALRMKWMMAMKYPITADK.RIME..MIPeRNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRNGP-t.
#=GC seq_cons GRQEKNPALRMKWMMAMKYPITADK.RIME..MIPERNEQGQTLWSKTNDAGS.DRVMVSPLAVTWWNRNGP.s.
//
