#=GF ID   Flu_PB2_7th
#=GF AC   PF20952.1
#=GF DE   Influenza RNA polymerase PB2 C-terminal domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Bateman A
#=GF GA   25.00 25.00;
#=GF TC   25.10 72.20;
#=GF NC   24.00 18.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   8806170
#=GF RT   Recombinant-baculovirus-expressed PB2 subunit of the influenza A
#=GF RT   virus RNA polymerase binds cap groups as an isolated subunit. 
#=GF RA   Shi L, Galarza JM, Summers DF; 
#=GF RL   Virus Res 1996;42:1-9.
#=GF RN   [2]
#=GF RM   26503046
#=GF RT   Crystal structure of the RNA-dependent RNA polymerase from
#=GF RT   influenza C virus.
#=GF RA   Hengrung N, El Omari K, Serna Martin I, Vreede FT, Cusack S,
#=GF RA   Rambo RP, Vonrhein C, Bricogne G, Stuart DI, Grimes JM, Fodor E;
#=GF RL   Nature. 2015;527:114-117.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Influenza virus encodes a large, multidomain RNA-dependent RNA
#=GF CC   polymerase that can both transcribe and replicate the viral RNA
#=GF CC   genome. In influenza virus, the polymerase is composed of three
#=GF CC   polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase
#=GF CC   active site, whereas PB2 and PA/P3 contain, respectively,
#=GF CC   cap-binding [1] and endonuclease domains required for
#=GF CC   transcription initiation by cap-snatching [2]. This entry
#=GF CC   represents the C-terminal domain of Flu PB2 protein.
#=GF SQ   26
#=GS Q71FS4_9INFA/680-755      AC Q71FS4.1
#=GS PB2_I96A0/682-757         AC Q9Q0V1.1
#=GS Q0QGM5_9INFA/682-757      AC Q0QGM5.1
#=GS A0A2S3ZRU2_ARTGL/694-769  AC A0A2S3ZRU2.1
#=GS Q07FS4_9INFA/682-757      AC Q07FS4.1
#=GS A2V6J9_9INFA/682-757      AC A2V6J9.1
#=GS A0T1J1_9INFA/682-757      AC A0T1J1.1
#=GS Q6DNN3_9INFA/682-757      AC Q6DNN3.1
#=GS F2P1F0_I66A1/682-757      AC F2P1F0.1
#=GS A0A0B4UWZ1_9INFA/682-757  AC A0A0B4UWZ1.1
#=GS E6XY50_9INFA/682-757      AC E6XY50.1
#=GS A0A2V5LCG3_9MICC/693-768  AC A0A2V5LCG3.1
#=GS PB2_INCJH/702-773         AC Q9IMP3.2
#=GS PB2_INCAA/702-773         AC Q6I7C4.1
#=GS PB2_I68A5/682-757         AC P26108.1
#=GS A0A097F2S1_9ORTO/702-773  AC A0A097F2S1.1
#=GS A0A172SNP0_9INFB/686-761  AC A0A172SNP0.1
#=GS V5SN71_9INFA/682-757      AC V5SN71.1
#=GS PB2_I66A1/682-757         AC Q0A449.1
#=GS A3DRU4_9INFA/682-757      AC A3DRU4.1
#=GS Q6VE63_9INFA/691-766      AC Q6VE63.1
#=GS PB2_INBLE/686-761         AC Q9QLL6.1
#=GS A0A0E4C2S8_9ORTO/700-771  AC A0A0E4C2S8.1
#=GS E4UF22_9INFA/682-757      AC E4UF22.1
#=GS PB2_I34A1/682-757         AC P03428.2
#=GS A0A2V5ISC9_9MICC/519-594  AC A0A2V5ISC9.1
Q71FS4_9INFA/680-755                 .g-TAGVESAVLRGFLILGKEDRRYGPALSISELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILNDSQTATKRIRMA.
PB2_I96A0/682-757                    .g-TAGVESAVLRGFLILGREDKRYGPALSINELSNLAKGEKANVLIMQGDVVLVMKRKRDFSILTDSQTATKRIRMA.
Q0QGM5_9INFA/682-757                 gi--AGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
A0A2S3ZRU2_ARTGL/694-769             .g-TAGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
Q07FS4_9INFA/682-757                 .g-TAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
A2V6J9_9INFA/682-757                 .g-TAGVESAVLRGFLILGKEDRRYGPALSIDELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
A0T1J1_9INFA/682-757                 .g-TAGVESAVLRGFLILGKEDRRYGPALSISELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
Q6DNN3_9INFA/682-757                 .g-TAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
F2P1F0_I66A1/682-757                 .g-TAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
A0A0B4UWZ1_9INFA/682-757             .g-TAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
E6XY50_9INFA/682-757                 .g-KAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
A0A2V5LCG3_9MICC/693-768             .g-TAGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
PB2_INCJH/702-773                    ..MDTSL--ALLEGFSVC-ENDPR-APMVTRQDLIDVGFGQKVRLFVGQGSVRTFKRTASQRAASSDVNKNVKKIKMS.
PB2_INCAA/702-773                    ..MDTSL--ALLEGFSVC-ENDPR-APMVTRQDLIDVGFGQKVRLFVGQGSVRTFKRTASQRAASSDVNKNVKKIKMS.
PB2_I68A5/682-757                    .g-TSGVESAVLRGFLILGKEDRRYGPALSINELSTLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
A0A097F2S1_9ORTO/702-773             ..MDTSL--ALLEGFSVC-ENDPR-APMVTRQDLIDVGFGQKVRLFVGQGSVRTFKRTASQRAASSDVNKNVKKIKMS.
A0A172SNP0_9INFB/686-761             ..RNRSMGNAVLAGFLVSGKYDPDLGDFKTIEELEKLKPGEKANILLYQGKPVKVVKRKRYSALSNDISQGIKRQRMT.
V5SN71_9INFA/682-757                 .g-TAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDIVLVMKRKRDSSILTDSQTATKRIRMA.
PB2_I66A1/682-757                    .g-TAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
A3DRU4_9INFA/682-757                 sa--SGVESAVLRGFLIIGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
Q6VE63_9INFA/691-766                 .g-TAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
PB2_INBLE/686-761                    ..RNRSMGNAVLAGFLVSGKYDPDLGDFKTIEELERLKPGEKANILLYQGKPVKVVKRKRYSALSNDISQGIKRQRMT.
A0A0E4C2S8_9ORTO/700-771             ..MDTSL--AFVEGFQVC-EYDPR-APLIPRRDLRLIGFGKKVRVFVGQGQEKTLVRTSSKRAASHDVSKNIRRMRL-e
E4UF22_9INFA/682-757                 .g-TAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
PB2_I34A1/682-757                    .g-TAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
A0A2V5ISC9_9MICC/519-594             .g-TAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
#=GC seq_cons                        .G.TAGVESAVLRGFLILGKED+RYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA.
//