#=GF ID Fve
#=GF AC PF09259.15
#=GF DE Fungal immunomodulatory protein Fve
#=GF AU Sammut SJ;0000-0003-4472-904X
#=GF SE pdb_1osy
#=GF GA 25.00 25.00;
#=GF TC 25.30 25.20;
#=GF NC 22.50 18.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 12948495
#=GF RT A 1.7A structure of Fve, a member of the new fungal
#=GF RT immunomodulatory protein family.
#=GF RA Paaventhan P, Joseph JS, Seow SV, Vaday S, Robinson H, Chua KY,
#=GF RA Kolatkar PR;
#=GF RL J Mol Biol. 2003;332:461-470.
#=GF DR INTERPRO; IPR015339;
#=GF DR SCOP; 1osy; fa;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Fve is a major fruiting body protein from Flammulina velutipes,
#=GF CC a mushroom possessing immunomodulatory activity. It stimulates
#=GF CC lymphocyte mitogenesis, suppresses systemic anaphylaxis
#=GF CC reactions and oedema, enhances transcription of IL-2, IFN-gamma
#=GF CC and TNF-alpha, and haemagglutinates red blood cells. It appears
#=GF CC to be a lectin with specificity for complex cell-surface
#=GF CC carbohydrates. Fve adopts a tertiary structure consisting of an
#=GF CC immunoglobulin-like beta-sandwich, with seven strands arranged
#=GF CC in two beta sheets, in a Greek-key topology. It forms a
#=GF CC non-covalently linked homodimer containing no Cys, His or Met
#=GF CC residues; dimerisation occurs by 3-D domain swapping of the
#=GF CC N-terminal helices and is stabilised predominantly by
#=GF CC hydrophobic interactions [1].
#=GF SQ 38
#=GS A0A4Q9MD29_9APHY/2-110 AC A0A4Q9MD29.1
#=GS A0A067MEZ4_9AGAM/4-111 AC A0A067MEZ4.1
#=GS A0A1Y2IY48_PYCCO/131-240 AC A0A1Y2IY48.1
#=GS A0A8E2AVM2_9APHY/562-660 AC A0A8E2AVM2.1
#=GS A0A0H2SFW9_9AGAM/561-660 AC A0A0H2SFW9.1
#=GS A0A5C3P6D3_9APHY/2-111 AC A0A5C3P6D3.1
#=GS A0A371D6G4_9APHY/3-111 AC A0A371D6G4.1
#=GS A0A0C2WQ98_AMAMK/6-113 AC A0A0C2WQ98.1
#=GS A0A4Y7Q2V5_9AGAM/3-103 AC A0A4Y7Q2V5.1
#=GS A0A5C3PJM5_9APHY/3-111 AC A0A5C3PJM5.1
#=GS A0A8E2AGQ5_9APHY/517-614 AC A0A8E2AGQ5.1
#=GS A0A1M2V762_TRAPU/3-111 AC A0A1M2V762.1
#=GS M2QVQ0_CERS8/4-101 AC M2QVQ0.1
#=GS A0A084QD05_STAC4/3-111 AC A0A084QD05.1
#=GS K5W7W1_PHACS/41-71 AC K5W7W1.1
#=GS A0A1M2V769_TRAPU/10-118 AC A0A1M2V769.1
#=GS A0A2G8RV27_9APHY/2-110 AC A0A2G8RV27.1
#=GS A0A3M2SLJ9_9HYPO/5-113 AC A0A3M2SLJ9.1
#=GS A0A428TVZ6_9HYPO/30-138 AC A0A428TVZ6.1
#=GS K5W7W1_PHACS/4-44 AC K5W7W1.1
#=GS A0A1X6MNP6_9APHY/1-98 AC A0A1X6MNP6.1
#=GS A0A0C2WMX8_AMAMK/6-113 AC A0A0C2WMX8.1
#=GS A0A4Q9Q1W7_9APHY/6-114 AC A0A4Q9Q1W7.1
#=GS A0A5C2SJP9_9APHY/3-111 AC A0A5C2SJP9.1
#=GS A0A4Q9MVQ6_9APHY/5-111 AC A0A4Q9MVQ6.1
#=GS A0A5C2SS06_9APHY/3-111 AC A0A5C2SS06.1
#=GS A0A8H4P4P6_9HYPO/5-117 AC A0A8H4P4P6.1
#=GS A0A0C2WK68_AMAMK/6-113 AC A0A0C2WK68.1
#=GS A0A8E2AVM2_9APHY/669-770 AC A0A8E2AVM2.1
#=GS C7ZE17_FUSV7/5-113 AC C7ZE17.1
#=GS A0A4R0RG39_9APHY/527-621 AC A0A4R0RG39.1
#=GS M2PWI3_CERS8/37-130 AC M2PWI3.1
#=GS A0A428P1G9_9HYPO/5-113 AC A0A428P1G9.1
#=GS A0A4S4N9A7_9APHY/442-538 AC A0A4S4N9A7.1
#=GS A0A0D2Q4N7_HYPSF/462-551 AC A0A0D2Q4N7.1
#=GS A0A428QTC5_9HYPO/408-516 AC A0A428QTC5.1
#=GS M2R9U0_CERS8/4-78 AC M2R9U0.1
#=GS A0A0D2Q4N7_HYPSF/347-442 AC A0A0D2Q4N7.1
A0A4Q9MD29_9APHY/2-110 ............v-DTSVLLALAAQHQRVHFDYTPAWGR...GSPAS.YVDNVTFPHVLDDKAYQYRVIVG....DKDLGLRKSYSIQPDGSQKVNFLEYNGGYGIA.DSNRIRVYVVDPESGN.--QYLIAQW..............
A0A067MEZ4_9AGAM/4-111 ............d-TTAQIFHLVASLPKLSYDYTPNWVK...D--RQ.YINSVTFAKVLADKAYTYRVMAG....DKDLGVKPSYAVGSDGSQKINFLEYNGGYGIDgNANTVYVYVVDPETGN.--QYKIAQ-s.............
A0A1Y2IY48_PYCCO/131-240 ..........sds--SSMMLYLTSTMHTINIDYNPKWAR...GSPSS.FIDNVTFPRVLADKAYTYRVYKD....DTDLGVRKSYAIQGDGSQKVNFLEYNKGHGIP.DSSTIRVYVIHPDTEN.--QYLVAKW..............
A0A8E2AVM2_9APHY/562-660 .....sdwmslvq------------------AYPPKWTR...GTPNT.YIDSLRFPRVLTDRPYAYRVIVG....ETDLGTQLTNPLGPDGSQVINLLNYNAGRGVA.DTMPISILVVD--LTN.EQETLLAKW..............
A0A0H2SFW9_9AGAM/561-660 .....waqslhla--------------------EPTWKR...GNPSI.YIDELTIPLLPSDKQYQYRVVKG....DTDLGIKETYPREIGGSQRINLLEYNEGYGIQ.DTVPIKVYAVDPEEEEgNRETLVASW..............
A0A5C3P6D3_9APHY/2-111 ..........sdq--SALIFALIPQTKKESWDYTANYGR...GSPSS.YIDNITFPKVLADKKYQYRVVAA....GKDLGVRAGYTVQSDGSQKVNFLDYNAGGGIP.DSQTIKVYAVDPDSGN.--QYLVSQW..............
A0A371D6G4_9APHY/3-111 ............d-QTGYIFALIEPVPVLSWDYTPNWGH...GNPSS.YIDNVTFKKVITLKDFEYRVVAG....GKDLGVRAAYGVQSDGSQKVNFLEYNNGYGIA.DSQTIKVYTVDPDNGN.--QYLVAQW..............
A0A0C2WQ98_AMAMK/6-113 ...........tn--EALAFLLVSQIKKIHFDYTPNYYR...PMP-G.FTDAVTFPKVLADKAYEYQVIVD....GVSKGIRRDYSVAPDGSQKVNFLGYNEGHGIL.NSSNTQVYVVDPETNI.-AYYI----ltv...........
A0A4Y7Q2V5_9AGAM/3-103 ...........qp--------------HIDFDYTPKWTSvpwGRPGDfYINDVTFPKVLRDKPYKYHVFKG....DEDLGVREPYEIRSDGSQTVNILEYHRGYGIL.ETNPIVIYLLDPDTEV.--EYKLTEW..............
A0A5C3PJM5_9APHY/3-111 ..........dqt---DSIFAVIAKNPALCFDYNPRWGR...GNPRS.YIDNVTFPKVMTTKNFKYRVVAD....ESDFGVRDAYGVQSDGSQKLNFLDWNAQHGIA.DSKTIKVYSVDPDSGN.--QYLVARW..............
A0A8E2AGQ5_9APHY/517-614 rtyppqwtsreal----------------------NPTK...GEIIT.YVDSVTLLHVLADKPYQYRVVER....NNDLGVRESSPLKTDGSQTINLHEYNGGRGIQ.H-HPIKVFVVDPVD--.---------rsetllae......
A0A1M2V762_TRAPU/3-111 ...........sp--SSILLHLVATLRKVHFDYTPQWKR...DASQK.NIIAVTFPRVLVDKRYSYRVVCE....DNDLGIRRGTGPFAGGAETVNFLEYSHGSGIP.QTHRLRVYVVDPDTGN.--QYLVAQ-r.............
M2QVQ0_CERS8/4-101 ....ewvklvrtn--------------------SATWKR...GNPKV.YFDHVTLPGVPTDKAYQYRVVKG....DLDLGTRPTYELNKDGSQTINLLEYNKGYGIH.EETPINVFVVDPEDGM.--ETLVAEW..............
A0A084QD05_STAC4/3-111 .........apty----LLVPFVTAVGKINVDYTPNWGR...GSPSS.YIDNVKFPRVLTDRQYKYRVVKG....STDLGVRDAYAIESDGSQKINFLEYNSGRGIE.DSTAIKIYIVEPDTGN.--QSLLVQW..............
K5W7W1_PHACS/41-71 ...........lp--------------------------...-----.-----------------------....--------------------------KGYGVE.QGSTIQIYAVDPDDGN.--QYLIARW..............
A0A1M2V769_TRAPU/10-118 ...........tt--ISLLLHLTSTLGKVHFDYTPHWGH...GHPNT.YIDNVTFPHVLTDKPYIYRVCMD....DTDLGMQPALAVQSDGSQKLNFLQWNGGHGIP.QTHRIRVYVVDP--GN.AIQYLVALW..............
A0A2G8RV27_9APHY/2-110 .............SDTALIFRLAWDVKKLSFDYTPTWGR...GNPSR.FVDNVTFPQVLADKAYTYRVVVS....GRDLGVRPSYAVGSDGSQKVNFLEYNQGYGIA.DTNTIQVFVIDPDTDA.--DFIIAQW..............
A0A3M2SLJ9_9HYPO/5-113 ............n-DSAILFYLVASHKKLNFDYTPNWGR...GSPNS.YIDNLTFPRVLTNKPYKYRVVKA....GQDLGVRDSYSVQSDGSQKVNFLEYNAGRGIA.DTQTIQVYVVDPDNGN.--QYLVAQW..............
A0A428TVZ6_9HYPO/30-138 ............n-DSAILFYLVASHKKLNFDYTPNWGR...GSPNS.YIDNLTFPRVLTNKPYKYRVVKA....GQDLGVRDSYSVQSDGSQKVNFLEYNAGRGIA.DTQTIQVYVVDPDNGN.--QYLVAQW..............
K5W7W1_PHACS/4-44 ............s-SSAALFYLVQIMSRVCFDYTPDWQR...GNPNS.YIDMVKLPK--------------....--------------------------------.----------------.---------g.............
A0A1X6MNP6_9APHY/1-98 .............---------------VDFDYTPKWKRvewGAPGQfYLDEVTFPKVLKDKRYKYRVVSG....STDLGIREPYDVQADGSQRINFLEYNQGYGIR.DTNTVTVYLVDPETAT.--EY-----kltqs.........
A0A0C2WMX8_AMAMK/6-113 ..........ane---GLAFLLVSQVKKIDFDYTPNYYR...PT-SG.YTDAVTFPKVLTDKAYEYKVVVD....GVDKGTRRDFSVAPDGSQKVNFLAYNAGLGIP.TGSSIQVYAVDPNTGI.-AYYI----ltv...........
A0A4Q9Q1W7_9APHY/6-114 ............n-NTAITFALVWAEKKLTFDYTPNWVR...GHPSS.YVDNVVFPKVLTDKKYSYRVLVS....GKDLGVRDGYSVQSDGSQKVNFLEYNAGRGIA.DSNTIQVYAVDPDDGN.--NYLVAQ-c.............
A0A5C2SJP9_9APHY/3-111 ...........dl--TGFIFSLIEQVPVLDLDYTPRWGR...GNPSQ.YIDNVTFKKVLTTKKWMYRIVKG....GDDLGVQAGYTVESDGAHRVNFLAYNAGHGIM.DTLSILVYVVDPDNGN.--QFLVAKW..............
A0A4Q9MVQ6_9APHY/5-111 ...........lt--TATIFALVWTQTKICFDYTPDWID...GGP-R.YINGVVFPKVLTDKNYSYRVE-S....DRDYGVRAGYQVQADGSQKVNFLDYNYGLGIE.PYRGIKVYVVDPDDGK.--NYLVAE-l.............
A0A5C2SS06_9APHY/3-111 ............d-STGIIFALIAQYKALCWDYTANWGR...GNPSS.YIDNITFKKVITTKNFKYRVVSA....GNDLGVRDAYSVQSDGSQKVNFLDYNAGRGIE.DTKRIQVYVVDPDNGN.--QYLVAQW..............
A0A8H4P4P6_9HYPO/5-117 ............n-DSTLIFHLIANLKKVNVDYTPQWGR...GNPRS.YVDNVTFPHVLTDKAYKYRVVKGgwggGQDMGVRNSYAVQSDGSQKINFLEYNSGHGIE.DTHTIQVYVVDPDNGN.--QYLIAQW..............
A0A0C2WK68_AMAMK/6-113 ..........vne---GLVFLLVSQVKKIDFDYTPHYYR...PT-SG.YTDAVTFPKVLANKAYKYQVVVD....GVSKGIRRDHAVAPDGSQKINFLDYNAGYGIP.NKSSTQVYAVDPDTGI.-AYYI----ltv...........
A0A8E2AVM2_9APHY/669-770 .kfesewrrvvea-------------------HRPIWVR...GNPST.YIDSVKLPRVLTTKTYDYRVVKD....TTDLGIRPTYPRNADGSQDINLLEYHSGYGIA.DRVSIKVVVVDPVDNK.--EFLVAEW..............
C7ZE17_FUSV7/5-113 ............n-DSAVLFYIVASQKKLSFDYTPNWGR...GSPNS.YIDNLTFPRVLTNKPYKYRVVKA....GQDLGVRDSYSVQSDGSQKVNFLEYNAGRGIA.DTQTIQVYVVDPDNGN.--QYLVAQW..............
A0A4R0RG39_9APHY/527-621 .......stvsah--------------------RPEWTR...GNPPV.FVDSVTFPQVLTDKPYTYRVVKG....GEDLGVKPSYEVQQDGSQTVNLLEYNQGYGVH.ETTPVEVYAVDPDDER.--ETLVAEW..............
M2PWI3_CERS8/37-130 ......lnartpt----------------------IWKR...GNPTD.YVDHVTLPRVPADKIYQCRVMKS....NLDLGIQPTHPLNEDGSQTINLTEYNKRYGIH.DTQNIKVYVIDPADNT.--EKPVAKW..............
A0A428P1G9_9HYPO/5-113 ............n-DSAILFYLVASHKKLNFDYTPNWGR...GSPNS.YIDNLTFPCVLTNKPYKYRVVKA....GQDLGVRDSYSVQSDGSQKVNFLEYNAGRGIA.DTQTIQVYVVDPDNGN.--QYLVAQW..............
A0A4S4N9A7_9APHY/442-538 ......wrsmvet-------------------HKPRWTR...GNPPN.YIDAVKFPRVLKDKPYQYRVVRG....EDDLGIKPSYEIQTDDSQTVNLLEYNSGYGVS.DRIPIQVFAVDPEDKG.--ETLVAQW..............
A0A0D2Q4N7_HYPSF/462-551 ......aggirwt--------------------------...-TDSS.LVLSVSINHVLNNKDYMLRIMRD....GADLGVHPAGPLTADKTLNIDLTKYNDGQGLP.VQSLIKVLVVDPDAR-.---------glgtlvsgw.....
A0A428QTC5_9HYPO/408-516 ............n-DSAILFYLVASHKKLNFDYTPNWGR...GSPNS.YIDNLTFPRVLTNKPYKYRVVKA....GQDLGVRDSYSVQSDGSQKVNFLEYNAGRGIA.DTQTIQVYVVDPDNGN.--QYLVAQW..............
M2R9U0_CERS8/4-78 .........rasp---------------------PVWRR...GNPTI.YVDYVTIPHAPADKVCQYRVIKS....GTDLGVRPTQPLNEDGSQTVKLRQ--------.----------------.---------cpalrnqnssfvqk
A0A0D2Q4N7_HYPSF/347-442 sivqafppqwkyv----------------------NWG-...--ARN.YVDEVTLPFVLIDKPYRYRVRSG....ISDLGIRETYELSADGSQRINFLEYNKGYGII.DSMHIKIFVVDPEGNE.---AL----vayw..........
#=GC seq_cons ............s...s.hh.lh....tlphDYTPpWsR...GsPss.YlDsVTFP+VLsDKsYpYRVVpu....spDLGlRsuYslpuDGSQ+lNFLEYNsGhGIt.DopsIpVYVVDP-sus...pYLlApW..............
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