#=GF ID   GBR_NSP5
#=GF AC   PF17580.6
#=GF DE   Group B Rotavirus Non-structural protein 5
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   PRODOM:PD035122
#=GF GA   25.00 25.00;
#=GF TC   32.70 27.80;
#=GF NC   23.90 23.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   NSP5_(rotavirus)
#=GF RN   [1]
#=GF RM   20200192
#=GF RT   Analysis of genetic diversity and molecular evolution of human
#=GF RT   group B rotaviruses based on whole genome segments.
#=GF RA   Yamamoto D, Ghosh S, Ganesh B, Krishnan T, Chawla-Sarkar M, Alam
#=GF RA   MM, Aung TS, Kobayashi N;
#=GF RL   J Gen Virol. 2010;91:1772-1781.
#=GF DR   INTERPRO; IPR020244;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Family members such as non-structural protein 5 (NSP5), are
#=GF CC   found in Group B rotaviruses (GBR). Group B rotavirus (GBR) is
#=GF CC   genetically and antigenically distinct from Group A rotavirus
#=GF CC   (GAR). Hence phylogneetic studies have been carried out and show
#=GF CC   that the C-terminal region of NSP5, which is conserved among GAR
#=GF CC   and critical for its function for viroplasm-like structure
#=GF CC   formation in cells, was also conserved in GBR NSP5 [1].
#=GF SQ   8
#=GS A0A1L6BXL0_9VIRU/1-165  AC A0A1L6BXL0.1
#=GS U3R085_9VIRU/1-189      AC U3R085.1
#=GS A0A0E3JVA7_9VIRU/1-87   AC A0A0E3JVA7.1
#=GS NSP5_ROTJ1/1-176        AC Q45UF0.1
#=GS Q6JPH2_9VIRU/13-166     AC Q6JPH2.1
#=GS A0A0F6T6W8_9VIRU/1-174  AC A0A0F6T6W8.1
#=GS A0A024CES9_9VIRU/1-181  AC A0A024CES9.1
#=GS Q6XD85_ROTGA/1-170      AC Q6XD85.1
A0A1L6BXL0_9VIRU/1-165             ..........................................MSEELAFTF...KSKK..SK-..KLSPKLI...LPEN...D..AASTVIV..E..EDVKSLASESESSEH.SY.ERYAKAYDDFSRELA.A.-.---S..ESKSVDF--AEDFED..V----ETVEEKRKA.PKVLSKVQKPIVQSG.ND.G..LEY.KLAQLQLRLEKVESENKAKTLESAMNMVIANVDNLTTPQKKTLLHAIISTMK......
U3R085_9VIRU/1-189                 ..........................................MAEVSEFDFnikKTKK..KIDttTRQKKNFkmnFNDT...A..TEITNDN..L..IETKSNYSEESFHTN.-T.SSYSDAYNRLKKELE.S.DeSNDI.kCKKTIENWAEEMDREdiEDLCDMQDTEEISQ.KISVKITDNMKANGD.YTtE..MLLnEISRLRVEIDVVKEVSKINSIDAAFNTILRNIDNLSTKQKHALVNAIVTTMK......
A0A0E3JVA7_9VIRU/1-87              ...................maddssftltrkktnkkekeknv---------...----..---..------T...RGQR...MnfEEEDVSVagE..TDTKSIATESESSTH.SY.EDYERAYRELTKDSS.S.E.QISL..TS-------------..--------------.---------------.--.-..---.----------------------------------------------------ttaeqk
NSP5_ROTJ1/1-176                   ..........................................MSEVPRFEL...RSKR..KIG..KKQKVDI...FGDK...D..DESMLQI..D..CETDSLISESVSSTH.SY.EDYSKAYKELTLETP.A.D.VNDS..ASTIVDSVCEESWYD..KTIKDEQTKEDKKT.DKKLKRIEKVKENNQ.ND.S..MSL.QIAQLSLRIQRIESETKLKTLDSAYNTIITQADNLTTPQKKSLISAILATMR......
Q6JPH2_9VIRU/13-166                ..........................nrkrdkvskthtkrmp---------...----..---..-------...----...-..-------..-..--SDSMSTKSESKSS.SC.DDAASVYSAETINSE.Y.E.EA-Y..NKLRREPVIEESNDS..CCLDESFTTSELQR.KTKSKRVTEIRYEHTdNS.D..VLE.KLSELTLELEKLKTATQPIGVDAAFNQILRNVDNLNTKQKQALVNAIVNSM-n.....
A0A0F6T6W8_9VIRU/1-174             maeasefnfntrrkrrtvnekretkeivkpkmpveeksdnye---------...----..---..-------...----...-..-------..-..----EIESASVYSQEsSR.SNYSDAYEKLKREPVvE.D.SNDE..RYKTLEYSEDEEIFK..ST-----SK---RG.DKPARNNSRTQREDS.ND.SsiVME.KISELSLEIERLKQEHQPLTVDSAFNMTLRNVDNLTTRQKQALITAIVNSM-n.....
A0A024CES9_9VIRU/1-181             ..........................................MAEVSEFDF...KIKKdkKKQ..EKTKPKK...MVVK...D..NETVVTH..EekSERGSVYSEE-SSNH.SS.SNYAEAYERLQRELN.TnE.SNDNkcKRTIRNWADEVERQE..SESESEYDIPDTESiPKKTNIIDMG-SET-.KE.Q..IMN.EISKIRMEMDVIKEAMKPQGVDAAFNLILKNVDNLSTKQKHALVNAIVMSMK......
Q6XD85_ROTGA/1-170                 ...................................maeasef-------NF...TTKR..---..---KQRI...MSDRrtrE..DTKQKKI..EekSDVDLVDSASVYSQE.SArSNYSDAYDKLKREPI.V.EeSNDA..KYRNFEFSE-----D..EEVYRPSSKASDKS.YREMKR--KYDGTST.SD.S..ILE.KLSELNLEIEKIKQMNQPVTIDAAFNMILRNVDNLTIRQKQALINAIINSM-n.....
#=GC seq_cons                      .................................................ph...p.K+.............h...hspp...t..spp.hph..-..p-scSltSES.SSsc.St.ssYucAYccLp+Ess.s.-.sNDt..pppph-.st-Ep..-..pp..p..sptchcs..+ph+phpchptpss.s-.s..lh..clScLpLEl-+lKptspsholDuAFNhIL+NVDNLoT+QKpALlsAIlsoM.......
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