#=GF ID GEP5
#=GF AC PF17053.9
#=GF DE Genetic interactor of prohibitin 5
#=GF AU Llagostera M;0000-0001-8177-8321
#=GF SE PHMMER:C5DSN0
#=GF GA 36.00 36.00;
#=GF TC 36.20 37.70;
#=GF NC 34.40 22.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 19221197
#=GF RT The genetic interactome of prohibitins: coordinated control of
#=GF RT cardiolipin and phosphatidylethanolamine by conserved regulators
#=GF RT in mitochondria.
#=GF RA Osman C, Haag M, Potting C, Rodenfels J, Dip PV, Wieland FT,
#=GF RA Brugger B, Westermann B, Langer T;
#=GF RL J Cell Biol. 2009;184:583-596.
#=GF RN [2]
#=GF RM 19751518
#=GF RT Genome-wide deletion mutant analysis reveals genes required for
#=GF RT respiratory growth, mitochondrial genome maintenance and
#=GF RT mitochondrial protein synthesis in Saccharomyces cerevisiae.
#=GF RA Merz S, Westermann B;
#=GF RL Genome Biol. 2009;10:R95.
#=GF DR INTERPRO; IPR031455;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Genetic interactor of prohibitin 5 (GEP5), also known as
#=GF CC required for respiratory growth protein5 (RRG5), has been shown
#=GF CC to interact with prohibitin ring complexes in the mitochondrial
#=GF CC inner membrane that regulate cell proliferation as well as the
#=GF CC dynamics and function of mitochondria [1]. It is required for
#=GF CC mitochondrial genome maintenance and is essential for
#=GF CC respiratory growth [2].
#=GF SQ 53
#=GS A0A8H7GV98_9ASCO/9-146 AC A0A8H7GV98.1
#=GS GEP5_ASHGO/5-228 AC Q74ZX6.1
#=GS C4XXQ3_CLAL4/27-262 AC C4XXQ3.1
#=GS A3LZH8_PICST/15-251 AC A3LZH8.1
#=GS A0A1G4JIN2_9SACH/7-222 AC A0A1G4JIN2.1
#=GS A0A2H0ZY82_CANAR/12-245 AC A0A2H0ZY82.1
#=GS A0A1G4KIS6_9SACH/6-221 AC A0A1G4KIS6.1
#=GS GEP5_VANPO/15-241 AC A7TRR5.1
#=GS A5E304_LODEL/8-230 AC A5E304.1
#=GS A0A2V1AR00_9ASCO/11-245 AC A0A2V1AR00.1
#=GS B5RT13_DEBHA/12-250 AC B5RT13.1
#=GS A0A1E4U0X6_PACTA/21-295 AC A0A1E4U0X6.1
#=GS K0KMI0_WICCF/109-253 AC K0KMI0.1
#=GS A0A1E5RVN1_9ASCO/20-314 AC A0A1E5RVN1.1
#=GS A0A1D8PMU0_CANAL/6-206 AC A0A1D8PMU0.1
#=GS A0A2P7YZW2_9ASCO/11-223 AC A0A2P7YZW2.1
#=GS G0W625_NAUDC/12-235 AC G0W625.1
#=GS G0V9H2_NAUCC/9-228 AC G0V9H2.1
#=GS A0A1S7H9K8_9SACH/12-229 AC A0A1S7H9K8.1
#=GS G8JTL4_ERECY/8-252 AC G8JTL4.1
#=GS A0A1E3P8R3_WICAA/15-295 AC A0A1E3P8R3.1
#=GS A0A1E4RJ95_9ASCO/10-216 AC A0A1E4RJ95.1
#=GS A0A1L0BJ26_9ASCO/10-244 AC A0A1L0BJ26.1
#=GS G8BGL9_CANPC/8-222 AC G8BGL9.1
#=GS A0A1G4MKG5_LACFM/4-222 AC A0A1G4MKG5.1
#=GS A0A4P6XJ74_9ASCO/9-246 AC A0A4P6XJ74.1
#=GS G8YH15_PICSO/12-248 AC G8YH15.1
#=GS A0A1A0H8I0_9ASCO/9-246 AC A0A1A0H8I0.1
#=GS A0A642UY70_DIURU/9-230 AC A0A642UY70.1
#=GS G3B290_CANTC/10-255 AC G3B290.1
#=GS A0A4C2E847_9SACH/13-230 AC A0A4C2E847.1
#=GS A0A512ULC2_9ASCO/9-247 AC A0A512ULC2.1
#=GS A0A367YGU7_9ASCO/6-216 AC A0A367YGU7.1
#=GS A0A7H9HZS3_9SACH/12-235 AC A0A7H9HZS3.1
#=GS GEP5_YEAST/9-250 AC Q12393.1
#=GS J7RNT4_KAZNA/8-232 AC J7RNT4.1
#=GS A0A1E4SQ67_9ASCO/15-247 AC A0A1E4SQ67.1
#=GS A0A0C7NCB9_9SACH/5-227 AC A0A0C7NCB9.1
#=GS GEP5_KLULA/9-247 AC Q6CJE6.1
#=GS A0A7H9B7H4_ZYGMR/18-270 AC A0A7H9B7H4.1
#=GS A0A8J5QU07_9ASCO/11-244 AC A0A8J5QU07.1
#=GS A0A1X7R7K3_9SACH/3-218 AC A0A1X7R7K3.1
#=GS A0A1D2VQX1_9ASCO/114-222 AC A0A1D2VQX1.1
#=GS A0A376BA30_9ASCO/19-313 AC A0A376BA30.1
#=GS G8ZX60_TORDC/9-233 AC G8ZX60.1
#=GS A0A1S7HTP0_9SACH/12-228 AC A0A1S7HTP0.1
#=GS A0A4P9ZIQ5_9ASCO/2-187 AC A0A4P9ZIQ5.1
#=GS G8BYF7_TETPH/21-246 AC G8BYF7.1
#=GS A0A1E4S6D2_CYBJN/13-246 AC A0A1E4S6D2.1
#=GS A0A1V2L614_CYBFA/9-244 AC A0A1V2L614.1
#=GS A0A1E3QZQ9_9ASCO/11-270 AC A0A1E3QZQ9.1
#=GS GEP5_LACTC/4-219 AC C5DN25.1
#=GS H2AQC1_KAZAF/20-216 AC H2AQC1.1
A0A8H7GV98_9ASCO/9-146 ...........................................................LYRRVTRLPLDHRSL....GIAKQKLRLHftqekv........vptfsvvNRKLYDRVVSVFDSILVDE.----.................KYKDFELLLSLIY............RDL.-EPR..PQ.WVDQL....RhTR.....YSAFKKT..WP-QVHLIDEFA........DQKNSKE.YH....V--.---.-......----..------------..-.......................................................................-----------........................................-----------------...----...-...-----.--.-----..----------------------------------.------------alakmqpvteflfvkalgiprte
GEP5_ASHGO/5-228 ...........................................................IQRIVSRLPLHRATS....EVILAYLSKQ.....................QAQYPTERIELVEPLNDFLrKGGH.................--QGLQRLVFHVH............FQL.MLRA..PE.HLRLL....R.RH.....REELQRF..WPYERHHSLLAL........SDVRSQS.LR....RLW.EDG.Q......EEVL..QQMQYCRHHWLR..Egd...................................................................vpERYALTQAQRE........................................EVLHRVFAQYMFLKQRP...ALWS...V...RRLPI.PV.VEIGM..TPLGFDIPDVRVDGLFKDKTKSVLRLLYREHPAL.TPAAEEDMLRII.......................
C4XXQ3_CLAL4/27-262 ...........................................................LYRKIGRLPLDVKSI....SLFKQSLRYEfsskrs........fhkyagvDPKKYTSMVSLLDDILIYR.----.................KYKRIPELLDEIY............KRK.IPSP..SW.ATEFF....S.TK.....YSAWKPF..WP-HVHLIYEFGne....ksISVYRKE.LS....RME.PEN.S......FSLM..KELALSLPK---..N.......................................................................DIPLTPLPRRTsss.................................rpmaELLKKVQEFHAFISKHA...NI--...L...SDVKI.YP.LEIHFepSRLGLPLSIAVREKKLRDKVSYAKHLLRTYKPL-.DKEDLDHLICI-a......................
A3LZH8_PICST/15-251 ...........................................................LCRRVYKLPLSRAMI....SRLMDLSKHKfttin..........pysprfSSTKFHNYMTLLDDILVEE.----.................KYSRVHDLLDLIY............KLP.ASSQ..SW.KDKFL....T.ID.....YKELENH..WP-QVHAIDEITsd...pkyLEAYREK.Q-....RAE.KNE.E......VSVV..KHFGLKSKRDN-..-.......................................................................QSPALTMIRKYsdvdq..............................ddsipQVLKNVQELHKFLFKNQ...AV--...-...FDVKI.PP.LEVFYptNKVALPIHPRERNKLLKKKVASIRNVFKSLRPI-.AEDDLRQLYE--fa.....................
A0A1G4JIN2_9SACH/7-222 .........................................................ct--RYLKSLPLDARTV....DLLSRKV---.....................TEGAILGLPELLHRYQVYE.----.................DSKTLETIIHKTY............FQW.TNDL..PS.HIVEF....R.KN.....YGELRDH..WPREFHRSLLSM........ESPKVGS.LR....HLW.NNC.N......PKVL..ERMEFSKHRWAR.eP.......................................................................GSATLTDGQRN........................................AHFRDIFLHYMFLKQSP...HLCK...N..rKAVAA.PV.VEIPM..KPLGHDIAETRIRNLLKRKVAYVWKVLAVDNPPL.SLGNEKLLQQII.......................
A0A2H0ZY82_CANAR/12-245 ...........................................................IYRCINRLPIDLKSL....KVAKDKVKNAfktkhs.........snsalaDPKQYKDSI----------.---Rlmts.........llngDYKSFPETLDLIY............KKG.EPFD..DW.ARDFL....H.TK.....YSSFKSS..WP-QVHLLEEFGmk....yhIDHYNKE.LQ....KSKpEDM.E......FSLM..KEMKLSLLSHEK.pIq.....................................................................pLRHHHHK---Ss.....................................vqSLVKEAEKFYKFILANS..nAL--...-...LNGRS.KP.FEVIYepTRFGLPKSVAAREHDLRTKVTHVKNIIRQLRPL-.SREQLTHLAEV-a......................
A0A1G4KIS6_9SACH/6-221 ...........................................................LSRAIEKLPLDIRTN....ELLMRVA---.....................SAQKPLRLEHMIAQFESTR.----.................EPKQLENIIHELY............FRW.NNEL..PE.HLKRF....R.RF.....YAELRDH..WPYERHRALLAM........SNPRETS.VR....YLW.VNK.S......SVAL..ENLQLERHGWAL.qA.......................................................................QPYCLSNLGRS........................................LVMHEIFHHCLFLKRSP...RLCK...N..rKEVPI.PI.VEIPL..NPLGHDIPDVRIRNLFRRKVAETFRLLAEENPPL.SDECEKALRKII.......................
GEP5_VANPO/15-241 ...........................................................LLESLERLPLHKPTL....DILERRI---.....................HVADLPFMEEYVGILNEYEiSKINsk............venESRALEKIVKKTH............IVWnNDKF..PN.HLEKF....K.NH.....YMELLHH..WPYEFHSDVLNM........ARPGTGS.LI....YLC.LNN.D......DRFF..NFYKSQINNKWF..Ns.....................................................................vDQYKLTDEQRV........................................SIYNDIFKQIFFLKRHT...TISE...V..nKNM-V.PI.VEVPL..KPIGCDIPACRIKNLFNKKVDYIWKLLSLSSPAI.SLSHEKIIMNIL.......................
A5E304_LODEL/8-230 ...........................................................LQRLFKRLPLPRAVL....KYSSRKLKKDf...................rAGNATHLYQTLLYEILHKE.----.................QYKKLPHLLDTLY............-KW.--DR..PD.WCRQF...aR.AH.....YMTLKPH..WP-TVHLIYELT........KDADALK.VY....NDK.LKK.P......FSLV..EFVKEDVGNQNEsiS.......................................................................TNETLPLLKKFsdqr...............................rnyvpGMLNEVENWYNFIQKQP...TF--...-...-DLAK.RP.FEMIYypSKLGTPQDPVTIDGQFKKHVEYMKQLAKEHQPIL.KAN-L-------qllmaq.................
A0A2V1AR00_9ASCO/11-245 ...........................................................LYKNLNRLPLDVGSL....NLAKSKARDAfrngrs........ipnapveDPKWYHKVMKTTDEVLKGD.----.................-NFSIHKVLDLLY............KDS.EPQQ..PW.VKEFI....N.TK.....YSAFKPV..WP-TVHLLHEFGqk....khISRYDKE.LA....N--.---.SspelkgFSLM..NEMKLSLPRGET..-.......................................................................PIKPLRKIHSKss....................................ieEVLEKVKPFYSFVLKHS..eTL--...-...LDVKL.KP.LEVLHepTSYGLPKSVASRERDIRTKVSSVKDIIQRIRPL-.TKKHMFHLGEV-a......................
B5RT13_DEBHA/12-250 ...........................................................ICRRIHRLPLDCKTI....ERFQLYCKSKfvtplkk......gqyqhssiDKRSYDKGIKILDDVLVSE.----.................NYESLNVILDFIY............KET.-SPQ..PSwISGFM....K.YK.....YTAFKPY..WP-QVHLLNELT........TTPKQSK.LYeeslQRD.KDA.D......LSLS..DYFGIKPDSVDI..G......................................................................lRPLKSTTGDKTsp....................................vsTIMSEFKKLHSFLYKNQ..eKL--...-...THLKM.QS.LEVTYptNRFALPIHVTQRDNLLRSKINYAKNLTTEFRPI-.CEDSLNHLIK--fa.....................
A0A1E4U0X6_PACTA/21-295 ...........................................................LTKHINNLPFDVRTI....NLLQNYKKKTfrs..............rkntN---EIYHYKLIHYYLNLT.SSISek.............vnNFQAIEELLDFAYl.........qgVQL.NKRA..PN.WFKSFlalkK.DD.....YDLIISHgiWP-HEHAIYSFI.......kNKNYNKE.V-....--D.DNE.A......IKFL..SK--YDNYLSNQ.kNvkngdiritdlipvt........................................igtpddiklnisygvgDNSKSIDDQKKlqd..................................kiiQMKRLIENLQKFVSTTE..kKMSS...K..kDMVTL.KD.FKVEYlpNSLGLPLSKKRSKNLILRKIKYFKTALLQDFNPL.SFEDFNYLEK--mv.....................
K0KMI0_WICCF/109-253 kndklvskltfprpsralpsvssiisqydmkfgqqrtkennvnvdvepceslssppkkh---------------....----------.....................-------------------.----.................-------------............---.----..--.-----....-.--.....-------..------------........-------.--....---.---.-......----..------------..-.......................................................................----------Veky.................................efydQLVRHVFRLINFLSGNT...VI-H...N...KNVKL.PM.VYIPP..NFLGGEIPLVRKKNLIKRHITYLRNIIQQIPPL-.QKQDLEFLL---nyt....................
A0A1E5RVN1_9ASCO/20-314 ..........................................................y----------HQKTL....DRLERIVRGKekyctrnraikdytknnqavlR------------------.---AslenkvyggteqlnqvkVSKNHISLLWELYy.........lgSQP.RSVL..PL.HLQNL....L.KH.....PLDLTTH..WPYERDHDIVFGe......kAHDLRTS.LR....YLW.KES.KkksdliEEAI..NNFQS--QKWLL.qKhpgnvkhtny..................................................qddfldnetvdY---------NpdtsnehsntllsflkesvqqerqqlifpvheelnedirnNTIKDVMRHYLFLKNHP...NIFQlfaA..gAYYAT.PI.VNIPM..TILGHDVGIKRMRNIFYRKVALMRSTLIEEMPPL.CDPLHDELQSII.......................
A0A1D8PMU0_CANAL/6-206 ...................................iqrqfrrlplpppividgsrvlkr---------------....----------.....................---DYKAGKSAVADLLALP.----.................HSQSIPKLLDYIY............KSQ.---P..AW.WNKFM....K.CS.....YYNLKDK..WP-IVHLIDELK........--VDTKD.Y-....--H.NHQ.Q......FSLV..EGTPTRPTLPL-..I.......................................................................KSYANQKDTTT........................................AMIKEVEKLYKFILSKR...GLFN...-...--VTN.HP.MEVIYtpSKLGKIHHQVVLDKELRDKVKLIKRVFREIQPI-.DKKTLDKLRAI-d......................
A0A2P7YZW2_9ASCO/11-223 ...........................................................LYKKINCLPIDLRSL....RTAKCIARDAfragrv........vpnspieDPKRYRKVSQLADSVLNGD.----.................-FYLLSQLLDLIY............KDP.LPQK..PW.ISQFL....Q.TK.....YSAFKPV..WP-VVHLLHQFGkd....khKNLYDRElLK....STP.ESQ.E......FLVM..KEMNLSLSPDDIpiK.......................................................................PIQKVHHNQSI.......................................vNLVKQMQGFYKFVCRHP..dVL--...-...LDHKA.KS.FEIVLepTRFGLPKSVAARERDYRTK---------------.------------fdpc...................
G0W625_NAUDC/12-235 ...........................................................LLSSLQNLPLHSNTL....AQLERKCLTR....................nIKATKSFKIPLLTLINSYEkAQASgq............sklSNKTLESIIYHTY............FEW.TNDL..AS.HLKPF....Q.RQ.....YSTLLTF..WPHIYHSKI---........-DSKKNS.II....LTW.NKS.SnsknmlRELL..SHLNYTQS----..-.......................................................................---LVPQKKDF.......................................qVIFKKIYQHYIFLSLNP...SLCS...N..gKRLPS.PI.VEIPM..NAMGYDIPKKRINNLLRSKIARTWNYLAITNPIL.NLENEAQLDEII.......................
G0V9H2_NAUCC/9-228 ...........................................................LLRSLPNVPLHRKTL....DLLERKIQTAn...................dKSTRHSFKVPLLQLLCKYErYNIQed............krgIEKVLESIAYNTY............FIW.NNPV..PS.HLQVF....Q.KN.....NEMLRRY..WPCVYHRGM---........-DTKRDS.II....VQW.AKS.Nn....gDALL..KG---TMNH---..-.......................................................................-IQPGASAEEL........................................LMFKKIFQHYIFLTLNA...RITS...N..aKRLQP.PL.VGVPM..NSMGETIPQVRVKNLFRKKVSWTANALCALNPVL.NVENHGFLDEII.......................
A0A1S7H9K8_9SACH/12-229 ..........................................................l-HSRIAALPLHKETI....RVLAKYSE--.....................--RNSERALSVAQEVCNYE.-RGD.................SSKALEMLICRAH............MLW.NNPL..PP.HLKNF....Q.AN.....YAELRNH..WPYEHHRSLLYM........ENPRKES.LA....YLW.RDC.N......SSVL..RRMCYDKHRWAD.dS.......................................................................ALETLTPTQRQ........................................QLLDMIFHHYLFLKNNV...RLCQ...N..sRKLPV.PI.VEIPM..RPLGNDAADSRIRNIFKHKIAMAWNLLAWDNRPL.SRENELLLSDII.......................
G8JTL4_ERECY/8-252 ...........................................................VLEIVSRLPLHAHTK....KVIADNVGS-.....................VGKGEFKRVDVIEPINRYLlSGEV.................--SYLRRVIFDVY............FRI.LNPK..AE.HVRQF....E.RY.....LKELQLF..WPYERHSCLLSG........ERPYKDS.AR....YLW.SRN.N......AKVL..DIMRYDRHLWLR.dRepkfsldsifge..............................................pftqqlqylrhekDKNTLGETERI........................................ALLKLIFSHYLFVKSRP...TLCG...H...KNLPI.PI.VEVGM..SPLGEDMPDVRIDNLFRKRSKATLKTLLHDFPPL.SREVESLLHSII.......................
A0A1E3P8R3_WICAA/15-295 ........................................................fwn---KIQHLEIDTRTK....DRLIKDAV-K.....................IGTKNPEDEKLLQLETMVDnVKNH.................QKKSLHPILARYY............LDK.GYSE..NR.HINYF...mK.NHidrwlLESLVTR..YTNEKDSLYVQA.......kSNTRLNS.LK....LPR.EER.Q.....lPSVM..ELLTGNLQKNNE..Ekkfaiksselktkggi.......................................vinsrlsknpkvvgkrT---------Tndaveeaeekeeilp.........lefelpdneqkleqmdIMVRQVIKHMNFLSSHK...YF-H...T...RKLAS.PI.VQTPA..TLLGEDIPEFRKKNLTQKKLTYIRGIFQLYPPI-.RIDDSNYL----tsmv...................
A0A1E4RJ95_9ASCO/10-216 .........................................................fs--RRVRRLPFDKRTL....DLLQAKTKNEftnlndg.......lfsyssiDINKYNKYAKIFDKFLVDE.----.................NYDALHDILDLAYk.........nePLW.----..--.VQQFQ....Q.IN.....YLSFKNS..WP-QVHLVHEFGsk....qsINKYDEQ.LA....YFQ.SKKpQ......LDLF..GYFNIDRKSLAK.dR.......................................................................IRPFSRTIENEss....................................veELISKARKLFKFVEQNK...HILC...H...YV--L.RD.FEVVYepTKFGLPGNDIKRDK--------------------.------------el.....................
A0A1L0BJ26_9ASCO/10-244 ..........................................................i-TRRICRLPLDVKSI....EILQLSVRQSfrsaks........vssysivHRKQYDRLSTIVDEILERN.----.................KYRELGTLLDFIY............KDK.GNLE..PW.KARFA....N.IR.....YNRWKSI..WP-QIHLLREFGkp....khISAYDKE.LS....RMD.GVG.E......FSIL..KELNLAVPPDLA.pLe.....................................................................pLKKHSSGSDLN........................................ALFEQVQDFHKFLKKNS..kAL--...-...MTVTL.KP.LEVTYepSRIGLPLSVAAREKKLRSKITYIKSLCQEFRPL-.KDGSLQHLI---lva....................
G8BGL9_CANPC/8-222 ...........................................................LQRQLRRLPLPRGMI....LDGSRVLKQQ....................yLLGKAKRFEHLLHQILDQE.----.................QYKKISEVLDAIYkv........dkPQW.----..--.YKEFE....N.IP.....YMKVKGH..WP-TVHLIDSLT........DNEDPKK.TY....YNK.LPQ.P......FSVT..QALNINTES---..-.......................................................................LREPLPLIKRYaeqi................................npvvDIIKEVRKVYAFIMSQR...IF--...-...-DVTK.HP.FEVFYypSKLGIPEHPVGLDSLLRKKVSQVKRVLETFQPI-.QKSQLEKLMN--a......................
A0A1G4MKG5_LACFM/4-222 ...........................................................LLNAIRELPLDSRTV....NLLQGITGSL.....................SVNSLFQLRSLVRHFQLHE.----.................DSKSLDAIIYNTY............FHW.SNYQ..LP.HLKSF....R.VH.....YSELRDH..WPYERHRMLFTM........ASPKKTS.LR....YMW.NDC.K......PKVL..AAMQYNQHRWPT.sK.......................................................................IPYCLPEIQRT........................................LLFNEIFQHYLFLKKHP...HLCK...N..kRQLPV.PI.VEIPM..KPLGQDIADVRIANLFKRKVAETWTFLAEDNPAL.SLENEELLLNI-l......................
A0A4P6XJ74_9ASCO/9-246 ...........................................................LYRRVARLPLDHRSL....GIAKQKLRFHftqekv........vptfsvvNRKLYDRVVSVFDSILVDE.----.................KYKDFDQLLSLIY............RDL.-EPR..PQ.WVDQL....RhTR.....YSAFKRT..WP-QVHLIDEFAdr....knSKAYHVA.LA....KMQ.PVT.E......FLFV..KALGIPRTDFLG..Tl.....................................................................kPLSRLGFENQEts....................................esQLLEEVQRFHKFLSTNA..kHL--...-...LDTQI.SM.LEVCYkpNRYGLPPSIATMEAELKAKVNYAKYLVDAFRPL-.SKDNLLYLI---dfv....................
G8YH15_PICSO/12-248 ...........................................................IYRHIVRLPVDVTTL....EQIKTISRNEfrtplkk......aefryssiDDRKYNEHFTLLRKILVNE.----.................EYDTLNDVYNLVYkr........ekISW.----..--.MEELR....R.TR.....YIAFRPF..WP-VVHLFLQLQis....dkHKKKYQN.LL....EKD.KDK.D......FSLM..SFFNIAPDEVQC..-.......................................................................DIDRLGGSDGSsvn..................................eaeSLVKQIRKFHDFLKKNQ..eKL--...-...THLKI.HP.FELELpsNSFGLPLHASRRDRLLKEKINYCKQLCENFIPI-.DQKGLAHLIKV-a......................
A0A1A0H8I0_9ASCO/9-246 ...........................................................LCRRVARLPLDHHSL....EVARRTLKAQftqsks........vptysvvDRKLYDRVISVLDDILIYE.----.................KYKDFDKLLNLVY............RDL.-KPR..PL.WVEKF...hH.TR.....YGAFKKV..WP-QVHLMDEFGds....nrCKEYHDA.LA....KMQ.PAT.E......FLFL..EAMQIPVNADLG..Slsl.................................................................lgrATSTDKVPQES........................................ELLKKLIVFHQFLKTHA..nAL--...-...LDTQI.HM.LDVCYkpNRYGLPPSVAAMEAELKKKVNYAKHLLDSFKPI-.EKEDLLYLI---eft....................
A0A642UY70_DIURU/9-230 .........................................................vt---AIRRLPVDTVTL....NRIVASVKSQvkqa............rnpqdLPRLYRSWISLQRQLVEDE.----.................RWSSLSDVLDRCYk.........rpPQW.----..--.YHQFR....S.VS.....PVQLKPF..WP-QVHLIDEFGte....paLRKYHEA.Q-....ALI.GAS.N......TSWL..RQGPGESPFTM-..L.......................................................................RKYGSGVSLYE........................................QLTDKAVKLTRFVSHNQ..sRLAA...K...RNIK-.P-.-EVSYptDQYALPLSAKRQNNIFVKKIREVKQLVTQFVPL-.AKYDLDWLI---tva....................
G3B290_CANTC/10-255 ...........................................................VLQRIRRLPFDSYTQ....QCLQKHARQQfstplkys.....yshsgkpvDAKKYNRFIKICDEILIYE.----.................DWNKLTMLFDYIFkdv......mgsESY.PEQY..GA.LKKFE....S.YN.....YDQVRDI..YP-QVHLFKRLDvp...ekyHQEFDKE.L-....-KQ.EKD.D......FSLV..NYFKFDAN----..-.......................................................................TIPDIPLISRNqlndeh............................ekeemkKVLNHVKQMYNFIASKE...NI--...-...THLKL.RP.MEVTYpsNKYGLPLHIIQRDKLLKDKLIYVKSVVNRYKPI-.PASILDQLGQIT.......................
A0A4C2E847_9SACH/13-230 ...........................................................LSRSIRQLPLHLETQ....KVLETHC---.....................-QKSSFKFLQVAQSIRDFE.-KNN.................DHKSLDLLIYRAH............FLW.DNPL..PL.YLKRF....Q.YH.....YRELRNY..WPHEYQRALIGM........SNPRRES.LS....YLW.KDC.N......ELAL..SKLWFEKHRWAD.dN.......................................................................VIDRLSVEQGT........................................NLLQSIFVHYFFLKSHP...RLCY...N..nRKLPV.PI.VEIPL..RPLGHNAADCRIRNLFRRKTAIVWNALAWENRPL.STRNEQLLGELI.......................
A0A512ULC2_9ASCO/9-247 ...........................................................LYRRVARLPLDHRSL....EITRQKLRSHftnskn........vptysvvNRKLYDRVVSVLDGILIDE.----.................QYKKFDKLLDLIY............LDL.EPRA..EW.VDQFY....H.TR.....YGAFKTS..WP-QVHLIDEFGda....ksRRNYHEV.LA....RMQ.PTT.D......FSFV..KAMKIPRDAEFG..N.......................................................................LKPLQHSPKSEpgv.................................fspsELFGQVRIFHSFLNSQA..kVL--...-...SDTQI.HM.LDVCYkpNRYGLPPSIATMEAELKLKVNYAKLLLEKFRPI-.GKENLMYLIE--fv.....................
A0A367YGU7_9ASCO/6-216 ...........................................................LQRQFRRLPLPQPIIidggPVLKRHY---.....................LASGARQFAQLLNAILVDE.----.................KYQQLPKVLDFIY............KDD.---K..PR.WLKEF...kQ.IP.....YKQLKGK..WP-VVHMIDKLN........---VDKS.V-....YNA.YDR.P......PVVV..ADMIPGEPGTPL..Pl.....................................................................lRHYANQYNNVA........................................DIVKNVEQMYHFLLSNR...GV--...-...FDVTR.DP.MEVVHfpSKFGTVHHPATLDRVLRNRITKMRHVFQEYQPI-.PKQALDKLVAI-y......................
A0A7H9HZS3_9SACH/12-235 ...........................................................LVESLERLPLHRKTL....ELLETKLK--.....................SQPSKQFTLSLAGLISDYEkSCGRp..............alERRQLESLVYHTH............FVW.NSPQ..PE.HLKLF....C.KH.....YTEMVAF..WPYEHHRAILSM........KKPKSTS.LR....YRW.DDN.S......ATVL..SMMRYTKNPWSE..P.......................................................................PNPGLTSLQRE........................................LLFNTIFTHYLFLKQNP...RLCK...N..gRKLPI.PI.VEIPM..RPLGNDIAAVRIKNLFKRKVSNIYHILAIDNPIL.SRESEALLHSII.......................
GEP5_YEAST/9-250 .........................................................ll--PVIESTPLHQITK....VALTTTLTSKq...................sDYKFKEIAVPLTKSLQLYEkAQ-Rrqd...........lraSLKALESIIYQTH............FQW.NNPL..PR.HAHLF....Q.KH.....YHFLLTH..WPFENHRDLVDS........IAVNNGK.LN....STS.SRS.Vw...lkADWI..TLFNVKNP-WVQ..Tppsl..............................................................mrlsgTDLDTFTPERI........................................FLINSLGNHYKFLIANS...HLSY...N..hKKYPS.PG.VQIPV.rNALGEVSPAKQIAQLFARQLSHIYKSLFIENPPL.SPENELALTA--vf.....................
J7RNT4_KAZNA/8-232 ...........................................................LLRELRSLPLHSLTL....ARLSRHVA--.....................ATKSIPRLKHVAETLQNFH.DVPStk............khtQYKILTTLLLQLYcqw......dnsFSR.LSHL..PP.HLAPF....E.QD.....FPGLVRI..WPRESHLSLKQS........-TKGHAT.LK....HAW.VTN.N......KHAL..QM-SFDAAA---..-.......................................................................ANPTSGNIELR........................................GSLRQILSHYQLLYNNM...RMFG...K...IKLQV.PV.AEIPL..NVFGEEIPACRTANLLQRKVGYVKRVLIEELPALyNTECIAELTAII.......................
A0A1E4SQ67_9ASCO/15-247 ...........................................................LCRQANRLPLDRGTI....SRFLALVKLEfrtgspl.......kssqipvSRKKYNLLSQQLDSILIEE.----.................KYDEVQDLLDVIY............KRE.--PP..PS.WLREF...nE.LN.....YTQMKGI..WP-QVHLIRELTkd...aevISKYNKS.L-....ELE.KNE.D......FSMM..RHFSLTSAKEGL..S......................................................................lVRSYSQSPDLK........................................PMMKSVSSLYNLLLDNQ..sKL--...-...SRSKI.QS.LEVVYptNRFALPISPHKRDRMLRDKIASVRNLLHQYKPI-.PKHDLQRLID--vs.....................
A0A0C7NCB9_9SACH/5-227 ..........................................................c-LEVLESLPIDVRTI....GLLAGKLR--.....................---SSTRSQELTSLLQRYElTK--.................ETKTLENIIHFTY............FRCeNNPL..PP.HLCLF....R.KH.....YVELRNH..WPHERHRSILSM........ENPKSQS.LR....FLW.TND.N......PRAL..TAMRYELHRWGS.sQta..................................................................eeqHESSLPELQRS........................................VLFHEIFQHYMFLKKNP...NLCK...N..rKSVAI.PI.VEIPM..KPLGQTIPDSRIRNMFKRRVAHVWNVLALENPAL.SPSQEALLTEIV.......................
GEP5_KLULA/9-247 ................................................sklykglhsit--------------K....DAISKV----.....................DTFPKNKQHETLHRLNSFN.ENP-.................TRKTLEKLVYSVH............FHL.LNDP..PK.HVDIL....R.QY.....PNELAKF..WPYEMQHSILEM........DDPNLTS.QT....ILW.SRN.N......KDAL..DFLSFNRHKWLR.pKnwqtpneel....................................................ikditgidglQSTQITE---Vlrlp...............................aekikETLRQIFEHYYFLKTNP...KLCA...T...KKLQA.PI.VEIGM..KPDGFDIADIRIDNLFKKKVKLISDLLYSQNPVL.TSDAESILTSIV.......................
A0A7H9B7H4_ZYGMR/18-270 ...........................................................LINSLDRLPLHRETL....SLLESRLKD-.....................DKTNRDMLVSMSDLVLQYE.RAAHrsi...........gseKKKALESLIHHVY............FIW.NNPL..PD.HLQKF....R.KN.....YRDMIMF..WPYERHRSLLNM........ENPKKLS.LR....YRW.SDN.N......ENVL..AMMRYEKNPWMT.yCkqdaqpegadlt..............................................qafaeserdpvnvPNKNGPVIDRD........................................NLFFSIFTHYLFLKSNA...RLCK...N..gKNLPI.PI.VEIPL..RPLGQDVAVSRIQNIFKRKVAQIWKILAVENPVL.SVTNEHALYRIV.......................
A0A8J5QU07_9ASCO/11-244 ...........................................................VVKQIRRLPLPSPII....QDTRKFVKKRyrka............lrsssSTANVHTLKILLDDILIEE.SY--.................-TIKIPELLDTIYkg........rdNSW.----..--.IYQFH....K.IP.....YIKFKPF..WP-QIEMINEIGksgdadadVKQYNNQ.L-....KSY.INA.D......FSVT..EFLGYEGLDSKV..Kpl..................................................................elyKHYGIRENPVE........................................NIFKRVDQLYKFILNHK..dRL--...-...-EVKP.PI.FEILYppTNYGLPIGSHFRDRLVKTRISQVRQILTSCKPML.KKDIID------iaqmv..................
A0A1X7R7K3_9SACH/3-218 ...........................................................LLRALRNIPLHASTT....RLIEQRVLLN.....................PHANQDEKLQLYELIKNFNvARKTt...............qKNKAIEQLIYTTY............FKW.KNTV..PN.YLKVF....E.TR.....YTDLHND..WP--IDKDSEHV........NDKKVPL.LR....DLW.LRN.D......HKAI..QY---TLEHML-..R.......................................................................QNPNCP----T........................................DMFEPIFEQFHFIMSKP...QLQR...RklgKTARV.PI.LLLPM..NVLGSDIPDCRAENLLKNQINEIKSILTVDNPIL.SPDVAQELLN--l......................
A0A1D2VQX1_9ASCO/114-222 ........................................esilktskdnkpfvlsaei---------------....----------.....................-------------------.----.................-------------............---.----..--.-----....-.--.....-------..------------........-------.--....---.---.-......----..------------..-.......................................................................DPAKTEDYSRE........................................EIVKYSLDLLKFLKSAK...GMIH...S...RNLEP.AA.AVIPL..TPLGLPIAECRHKNLIRKKIRYVKQLFMTFVPM-.------------hpfwfnhvedii...........
A0A376BA30_9ASCO/19-313 ..........................................................q---------FHYKTL....DHLENFIIN-.....................STTKRLSIANAINQILNCGiTTAQ.................GTKLKSRLLWLIY............YQW.LNKSrnLP.HIAIL...rS.EN.....IHDLVTH..WPYERDHDFLIHn......sQHMETKN.EK....YKH.NNN.S......SHIFlrDMWKSPSNLSKR..NleklqnwiqtysskpwlleyfiprkdnknvkkvkksrtsnvstgldtitfddlkvfqnesdmalitekqypAINTLNEIHRD........................................DTIRNILQHFLFLRMNSlvfNMGS...E...KSLDLsPI.VYIPM..NPLGLDIPGVRIKNIFRRKINELYEILAYKFPAI.TAEIELELQEIL.......................
G8ZX60_TORDC/9-233 ...........................................................LLKALEKLPLHSKTL....DLLACKLK--.....................GDELKTVIIPLAKLVSNLEsSRAEt...............qRIKALESIIYHTH............FVW.GSPL..PV.HLKMF....Q.SH.....YTDMLMH..WPYERHRSILNM........EKPRSTS.LR....YRW.EDS.S......KTVL..SMAEYSKNPWIE.dN......................................................................iLSKKLTIIQRD........................................LLFHSVFSHYLFLKANP...RLCN...N..gRNLPI.PI.VEIPM..RPLGNDIAVSRIKNLFKSKVAHTYRILAIENPVL.SRGSENILSEII.......................
A0A1S7HTP0_9SACH/12-228 .......................................................lrsc----IAALPLHKETI....RMLTKCS---.....................-ERNSERALSVAQEVYNYE.-RGD.................SSKALEMLICRAH............MLW.NNPL..PP.HLKNF....Q.AN.....YAELRNH..WPYEHHRSLLYI........ENPRKES.LA....YLW.RDC.N......SSVL..RKMCYDKHRWAD..D.......................................................................SAEALAPTQRQ........................................QLLDMIFHHYLFLKNNV...RLCQ...N..sRKLPV.PI.VEIPM..RPLGNDAADSRIRNIFKRKIAMAWNLLAWDNRPL.SGENELLLSDII.......................
A0A4P9ZIQ5_9ASCO/2-187 .................................................dallehrkfl---------------....----------.....................-------------------.----.................---AFPALLDLVY............KYD.EPTE..PW.VEQFR....H.TK.....YTAFKRL..WP-HVHLIDEFG........-ATAHVR.LY....YAE.LAK.Qep.vpgFLLM..AELNLADP----..D.......................................................................CAPLVPLGRTEpgt.................................lavdALLREFGVFYAFLARNY..pAL--...L...LGLKL.SP.LEVTYepNRFGYPQSVAAREIALRRKVNAMKALLHAHVPL-.QKTSLDSIIR--fi.....................
G8BYF7_TETPH/21-246 ..........................................................i-LDGLNRLPLHPNTL....DLLQKQVHT-.....................KLTKNSELIELLFDYNNAFiNKQKp...............gQLKCLQRIIFKTHl..........iFNN.SYKN..YD.HLKAF....K.LK.....YNYLTHN..WPYERHDILFAAn......kNVPETKA.LE....YLW.NNC.N......SDNL..AFMGSKFMKEIT.rQiqnkyitegdy.................................................vhvflkerynsEIHTLSEIIDEke...................................ieiNLFGELFKQLHYIN---...TI--...-...NKLQI.PI.VILPL..NALGLKIPKSRLYNKFKKKLQ-------------.------------vf.....................
A0A1E4S6D2_CYBJN/13-246 ..................................................lirqtrssf---------LDARTQ....RLMIAELKKRir.................rdQPKLFDEVRHLISKVSDGD.----.................-VYSIPTVLERYY............LQG.N--Y..-R.DHKDV....Q.YF.....LKGHLDS..WP---HESIRRI........LNNEKNT.LE....QKC.RH-.-......MNQL..KSIKFPQRDERQ.iPsissimgish...................................................vsrdidilpvE---------Strlytd............................kdqrfnLMLTKVLAIYRFLLGNT...YV-H...S...RNLQS.PI.ARIPL..KVSGEDVAQCRKVNIIRKKIRYLRHVLKSIPPL-.ELDDHNYLTN--ll.....................
A0A1V2L614_CYBFA/9-244 ...........................................................LMEKVRSCFLDKHTQ....GLLLREINKRtr.................rsQPKLLQEVKGLVDRIHDND.----.................-THAIQPVLERCY............LQG.---L..YR.DHKLI....R.YF.....LKAKIDS..WPSESIRVI---........LEQQNNT.LD....YMS.--N.N......SKMI..PSITFPSPAER-..-.......................................................................EIPSITSILASdldsssakeldplp............ingalytdrdqehnTMLTQVLTLYKFLRSNS...FL-H...S...RNLGS.PI.AQIPL..TALGDDVSEARKKNVVKKKIAHIRTAFTTLPPL-.EVADSEILTKV-v......................
A0A1E3QZQ9_9ASCO/11-270 ..........................................................i-VRKTSQLPLDHKAV....SYLRKYAKHSfk.................qpLTKRNF---EAIDTHTTLL.DRALr...............lDVSPLETLIELAYkqgakpdnyrdrPPW.LKHF..T-.STRVG....S.TD.....VDDLVYR..WP-QIHLAERHS.......kSQEYQKT.YR....TSL.EAQ.K......RDFQ..QRYAFSIHNIEA..Lvlsesfni......................................................ssdtacpppT---------Tiplteps.........................vvesplvrLDISQIEALYKLVCHTT...SLIT...H..yKKALL.PFqAEVPP..HQLGHPVANVRIKNITARKIEALQAFFNNDFMNM.SLENLRHLEA--lv.....................
GEP5_LACTC/4-219 ..........................................................a-VRALEKLPLDIRTL....ELLERKL---.....................LKKSLPGFQELAQQYTADG.----.................SSKSLESIVHLTY............FHW.CNED..AP.HIKKF....R.EH.....YAELRDH..WPYEFHRSILSM........DTPKTQS.IR....FLW.SSN.S......PKVL..SKMSYEKYAHDT.eE.......................................................................RPSRLTELQRT........................................VQFHEVFQHFLFLKSRP...HLCK...T..rKGLAV.PI.VEIPM..KPLGQNIPEVRVRNLFKRKIAYVWKVLALDSPAL.SRQNELSLAKII.......................
H2AQC1_KAZAF/20-216 .........................................................it--NAIEGLPLHQKTL....LQLQDTLK--.....................--RNDALAIPLLRDVVSYE.-TTG.................KSKFLESIIYRLY............FQW.LNEV..PS.HLKPL....L.NQ.....YEHLKSN..WPIERHIKFKNA........-EPEAIS.LR....NAW.MRN.K......ATAV..DL---ST-----..-.......................................................................---------SD........................................GVIKPILNHFRYLRVNE..dRLCK...-...KKVGL.PI.LEVPL..NVFGTEIPECRVNNLLKKRIAHVKKSLLEDNPML.SPKLEDTLHSII.......................
#=GC seq_cons ...........................................................lhctlppLPLctpTl....phlppphp.......................p.pphpphhplhpplh.h-......................ph+sLppllphhY............hph.......s..ahchh....p.pp.....Ypph+sh..WP.phHhhh.hh........tpstpps.Lt....hhh.tss.s......hphl..phhphstpt.............................................................................t..ths..ppp........................................tllcplhpaatFLppss...pL.........ppltl.Ph.lElsh..s.hGhslsssRhcslh++KlshhtplLtt.pPh..stps.phLhp.........................
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