#=GF ID GPR15L
#=GF AC PF15854.9
#=GF DE G-protein coupled receptor ligand 15
#=GF PI DUF4725;
#=GF AU Coggill P;0000-0001-5731-1588
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE Jackhmmer:Q6UWK7
#=GF GA 27.00 27.00;
#=GF TC 29.20 27.80;
#=GF NC 26.90 26.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 28900043
#=GF RT A natural ligand for the orphan receptor GPR15 modulates
#=GF RT lymphocyte recruitment to epithelia.
#=GF RA Suply T, Hannedouche S, Carte N, Li J, Grosshans B, Schaefer M,
#=GF RA Raad L, Beck V, Vidal S, Hiou-Feige A, Beluch N, Barbieri S,
#=GF RA Wirsching J, Lageyre N, Hillger F, Debon C, Dawson J, Smith P,
#=GF RA Lannoy V, Detheux M, Bitsch F, Falchetto R, Bouwmeester T,
#=GF RA Porter J, Baumgarten B, Mansfield K, Carballido JM, Seuwen K,
#=GF RA Bassilana F;
#=GF RL Sci Signal. 2017; [Epub ahead of print]
#=GF RN [2]
#=GF RM 28936214
#=GF RT A Mucosal and Cutaneous Chemokine Ligand for the Lymphocyte
#=GF RT Chemoattractant Receptor GPR15.
#=GF RA Ocon B, Pan J, Dinh TT, Chen W, Ballet R, Bscheider M, Habtezion
#=GF RA A, Tu H, Zabel BA, Butcher EC;
#=GF RL Front Immunol. 2017;8:1111.
#=GF DR INTERPRO; IPR031713;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC GPR15 is an orphan G protein-coupled receptor (GPCR) that is
#=GF CC found in lymphocytes. It functions as a co-receptor of simian
#=GF CC immunodeficiency virus and HIV-2 and plays a role in the
#=GF CC trafficking of T cells to the lamina propria in the colon and to
#=GF CC the skin [1]. An activating ligand named GPR15L is shown to bind
#=GF CC GPR15 and attract GPR15-expressing T cells including lymphocytes
#=GF CC in colon-draining lymph nodes and thymic precursors of dermal
#=GF CC epithelial T cell. This 9kDa CC-motif containing cationic
#=GF CC polypeptide has been previously described as the 57 amino acid
#=GF CC antimicrobial peptide AP-57, and as a Sushi Containing Domain-2
#=GF CC (SUSD2)-binding factor (CSBF), capable of inhibiting the growth
#=GF CC of intestinal epithelial cancer cell lines. The chemokine is
#=GF CC expressed by epithelial cells in gastrointestinal and
#=GF CC genitourinary mucosae and in the skin [2]. In humans GPR15L, is
#=GF CC encoded by the gene C10ORF99 and has some features similar to
#=GF CC the CC family of chemokines [1]. However, it lacks significant
#=GF CC homology to classic CC and CXC chemokines, yet shares many
#=GF CC features with them, including a cationic domain predicted to
#=GF CC comprise two disulfide bonds and a highly conserved
#=GF CC GPCR-activating terminal peptide. Furthermore, the activating
#=GF CC peptides of CC chemokines are typically located at the
#=GF CC N-terminus, while that of GPR15L is C-terminal, a feature that
#=GF CC it shares with some other GPCR ligands like chemerin and apela
#=GF CC [2].
#=GF SQ 101
#=GS A0A0D9RAY8_CHLSB/1-80 AC A0A0D9RAY8.1
#=GS A0A6P5BIL3_BOSIN/1-80 AC A0A6P5BIL3.1
#=GS A0A2K6JVV5_RHIBE/1-80 AC A0A2K6JVV5.1
#=GS A0A8C3X1W8_9CETA/1-80 AC A0A8C3X1W8.1
#=GS A0A2Y9G1M8_TRIMA/1-74 AC A0A2Y9G1M8.1
#=GS A0A667IUM6_LYNCA/1-59 AC A0A667IUM6.1
#=GS A0A7J8B8L0_MOLMO/1-78 AC A0A7J8B8L0.1
#=GS U3AQY5_CALJA/1-79 AC U3AQY5.1
#=GS A0A287CXV5_ICTTR/1-75 AC A0A287CXV5.1
#=GS A0A8C0E4P8_BALMU/1-80 AC A0A8C0E4P8.1
#=GS A0A1S3GFC4_DIPOR/1-65 AC A0A1S3GFC4.1
#=GS A0A6J0XI58_ODOVR/1-80 AC A0A6J0XI58.1
#=GS A0A7J8G4B2_ROUAE/1-75 AC A0A7J8G4B2.1
#=GS A0A667IUZ6_LYNCA/1-80 AC A0A667IUZ6.1
#=GS A0A6I9ZJI4_ACIJB/1-80 AC A0A6I9ZJI4.1
#=GS A0A8C2UHC5_CHILA/23-51 AC A0A8C2UHC5.1
#=GS A0A8J4J288_EUDMI/1-76 AC A0A8J4J288.1
#=GS A0A212CPU5_CEREH/1-80 AC A0A212CPU5.1
#=GS A0A2K5KRW4_CERAT/1-80 AC A0A2K5KRW4.1
#=GS A0A8D2H7Z6_UROPR/1-75 AC A0A8D2H7Z6.1
#=GS A0A8C9EFS3_PHOSS/1-80 AC A0A8C9EFS3.1
#=GS A0A673V462_SURSU/1-79 AC A0A673V462.1
#=GS A0A1U7UH62_CARSF/1-77 AC A0A1U7UH62.1
#=GS A0A8C9GA88_9PRIM/1-80 AC A0A8C9GA88.1
#=GS A0A2K5HFS8_COLAP/1-80 AC A0A2K5HFS8.1
#=GS A0A8C9Q1A8_SPEDA/1-75 AC A0A8C9Q1A8.1
#=GS A0A8C0KMW2_CANLU/1-87 AC A0A8C0KMW2.1
#=GS GP15L_HUMAN/1-80 AC Q6UWK7.1
#=GS A0A384CIV7_URSMA/1-80 AC A0A384CIV7.1
#=GS S7N110_MYOBR/1-31 AC S7N110.1
#=GS A0A6J3GCN0_SAPAP/1-80 AC A0A6J3GCN0.1
#=GS G7PEW8_MACFA/1-80 AC G7PEW8.2
#=GS A0A6I9LCE6_PERMB/1-75 AC A0A6I9LCE6.1
#=GS M7B9A3_CHEMY/1-46 AC M7B9A3.1
#=GS W5PL54_SHEEP/1-77 AC W5PL54.1
#=GS A0A8C8YSQ8_PROSS/1-77 AC A0A8C8YSQ8.1
#=GS A0A337S931_FELCA/1-80 AC A0A337S931.1
#=GS A0A8C9KHD3_PANTA/1-80 AC A0A8C9KHD3.1
#=GS A0A667HQS5_LYNCA/1-59 AC A0A667HQS5.1
#=GS A0A2K5RT01_CEBIM/1-80 AC A0A2K5RT01.1
#=GS L9KU06_TUPCH/1-29 AC L9KU06.1
#=GS A0A6A1QCD0_BALPH/10-77 AC A0A6A1QCD0.1
#=GS G5BDQ1_HETGA/1-74 AC G5BDQ1.1
#=GS A0A4W2EPN5_BOBOX/46-125 AC A0A4W2EPN5.1
#=GS A0A811YMH9_NYCPR/1-80 AC A0A811YMH9.1
#=GS A0A2Y9EKT0_PHYMC/1-80 AC A0A2Y9EKT0.1
#=GS A0A484GQ76_SOUCH/1-80 AC A0A484GQ76.1
#=GS A0A2K6DUQ4_MACNE/1-80 AC A0A2K6DUQ4.1
#=GS A0A667HQJ1_LYNCA/1-70 AC A0A667HQJ1.1
#=GS A0A1U7QF70_MESAU/1-77 AC A0A1U7QF70.1
#=GS A0A383ZHL3_BALAS/1-80 AC A0A383ZHL3.1
#=GS A0A8C6QQ86_NANGA/1-75 AC A0A8C6QQ86.1
#=GS A0A6G1AAV4_CROCR/1-57 AC A0A6G1AAV4.1
#=GS A0A7N5P4P7_AILME/1-80 AC A0A7N5P4P7.1
#=GS A0A8C7ADS5_NEOVI/1-79 AC A0A8C7ADS5.1
#=GS GP15L_MOUSE/1-77 AC A0A0B4J1N3.1
#=GS A0A671FX96_RHIFE/1-80 AC A0A671FX96.1
#=GS H2Q266_PANTR/1-80 AC H2Q266.1
#=GS A0A1S3GFC4_DIPOR/70-123 AC A0A1S3GFC4.1
#=GS A0A8J4LLM4_APTPA/1-76 AC A0A8J4LLM4.1
#=GS A0A2R9CNJ5_PANPA/1-80 AC A0A2R9CNJ5.1
#=GS A0A6P5L7K3_PHACI/1-78 AC A0A6P5L7K3.1
#=GS A0A8C6EC04_MOSMO/1-80 AC A0A8C6EC04.1
#=GS A0A7J7T091_PIPKU/1-80 AC A0A7J7T091.1
#=GS G3R9V7_GORGO/1-80 AC G3R9V7.1
#=GS GL15L_PIG/1-80 AC I3LGZ3.1
#=GS A0A3Q1MJW9_BOVIN/1-80 AC A0A3Q1MJW9.1
#=GS A0A8D2K367_THEGE/1-80 AC A0A8D2K367.1
#=GS GP15L_RAT/1-76 AC D3ZKM3.2
#=GS A0A286XXC9_CAVPO/1-28 AC A0A286XXC9.1
#=GS V8P3Y2_OPHHA/1-77 AC V8P3Y2.1
#=GS A0A8C4MUQ0_EQUAS/75-132 AC A0A8C4MUQ0.1
#=GS A0A8C8X290_PANLE/1-80 AC A0A8C8X290.1
#=GS A0A6P6HEM2_PUMCO/1-80 AC A0A6P6HEM2.1
#=GS A0A3Q7PQW3_CALUR/1-98 AC A0A3Q7PQW3.1
#=GS A0A2K6EGF0_PROCO/1-77 AC A0A2K6EGF0.1
#=GS A0A8D2CLS0_SCIVU/1-77 AC A0A8D2CLS0.1
#=GS A0A2K6S3X8_SAIBB/1-80 AC A0A2K6S3X8.1
#=GS A0A8C5ZBD3_MARMA/1-75 AC A0A8C5ZBD3.1
#=GS A0A8B7AWV7_ORYAF/1-24 AC A0A8B7AWV7.1
#=GS A0A2K6NCD9_RHIRO/1-80 AC A0A2K6NCD9.1
#=GS H2NAE6_PONAB/1-80 AC H2NAE6.1
#=GS A0A340WGA1_LIPVE/1-80 AC A0A340WGA1.1
#=GS A0A7J7RMS1_MYOMY/1-80 AC A0A7J7RMS1.1
#=GS A0A5F9DI79_RABIT/1-74 AC A0A5F9DI79.1
#=GS A0A6P6DBR4_OCTDE/1-74 AC A0A6P6DBR4.1
#=GS A0A2Y9M8R5_DELLE/1-80 AC A0A2Y9M8R5.1
#=GS A0A2K5EA12_AOTNA/1-80 AC A0A2K5EA12.1
#=GS A0A2R8M4X9_CALJA/1-80 AC A0A2R8M4X9.1
#=GS A0A6P3INM3_BISBI/1-80 AC A0A6P3INM3.1
#=GS A0A8C2UHC5_CHILA/1-29 AC A0A8C2UHC5.1
#=GS A0A8C6H490_MUSSI/29-89 AC A0A8C6H490.1
#=GS A0A8I3MQM0_CANLF/1-77 AC A0A8I3MQM0.1
#=GS A0A8I5NC73_PAPAN/1-80 AC A0A8I5NC73.1
#=GS A0A6I9IKY9_VICPA/1-80 AC A0A6I9IKY9.1
#=GS A0A286XXC9_CAVPO/23-51 AC A0A286XXC9.1
#=GS A0A8C5Y9Z6_MICMU/1-80 AC A0A8C5Y9Z6.1
#=GS A0A8B9YUD9_BOSMU/67-146 AC A0A8B9YUD9.1
#=GS A0A1S3WQD0_ERIEU/1-81 AC A0A1S3WQD0.1
#=GS G1RJ21_NOMLE/1-80 AC G1RJ21.1
#=GS A0A2K5Y3M4_MANLE/1-80 AC A0A2K5Y3M4.1
A0A0D9RAY8_CHLSB/1-80 .......................MRLLILSSLLCILLLCFSVFS.TEGK...RR...PAKPw.psRRA...RLC.CHRVPSPSLTNPK..................GHH..VR.LC...KPCKLELD.P.RPWVVPGALPQ.............
A0A6P5BIL3_BOSIN/1-80 .......................MRLLILTSLLCILLLCLSVFS.AEGR...SH...SKHHa.kpGKG...KPC.CLRIPGPDLMTQK..................GHR..TR.NC...RPCKLKSK.H.RXWVVPGALPQ.............
A0A2K6JVV5_RHIBE/1-80 .......................MRLLVLFSMLCILLLCFSIFS.TEGK...RR...PAKPw.pgKRA...RLC.CHRVPSPNLTNAK..................GHH..VR.LC...KPCKLEPQ.P.RPWVVPGALPQ.............
A0A8C3X1W8_9CETA/1-80 .......................MRFLALTGLLSILFLCLSFFS.AEGR...RH...PRHPa.kpGKG...RPC.CPRLPDPDLMPQK..................GHR..MR.IC...RPCKFKPK.P.RFWIVPGALPQ.............
A0A2Y9G1M8_TRIMA/1-74 .......................MRLSILTSVLCILLLCFSIFL.AEGR...RH...HAKP....RRG...RPC.CPRGTG---LVLR..................GHH..VR.PC...RPCKLRTG.L.PNWVVPGALPQ.............
A0A667IUM6_LYNCA/1-59 .......................MRFLALSRLLCILLLCFSIFS.VEGR...RH...SRHLa.kpRKG...KLC.CSRVPSPVPTAQK..................AQ-..--.--...--------.-.-----------anfa.........
A0A7J8B8L0_MOLMO/1-78 .......................MRLLVLCSLLCTVLLGLCLFS.AEGK...RH...PKHPa.kpWKG...KPC.CPPVPDPVRRTQK..................GDR..VR.TC...RECK--PK.L.PFWVVPGALPQ.............
U3AQY5_CALJA/1-79 .......................MRLLVLSSLLCILLLCFSVFS.MEGR...RH...PDKVw.pgRRP...RLC.CHRVLRPNPTNLK..................R-H..VR.LC...KPCKLEPK.A.HPWVVPGALPQ.............
A0A287CXV5_ICTTR/1-75 .......................MRLLILSSLFCILLLCFSIFS.SEGK...RH...PAK-....-SW...KLC.CHRVPALNLTTQK..................GNR..MR.LC...RVCKLKPM.S.QSWVVPGALPQ.............
A0A8C0E4P8_BALMU/1-80 .......................MRFLALARLLCILLLCLSVFS.AEGR...RH...PRHPa.kpGKG...KPC.CPRVPGPDLMTRK..................GHH..VR.SC...RPCKFKPK.P.RSWVVPGALPQ.............
A0A1S3GFC4_DIPOR/1-65 .......................MRLLVLSSLLFVLLLCFSVFS.LEGR...RH...FAKP....GKL...RFC.CRLAPSRNQTTQK..................GY-..--.--...--------.-.-----------rehavdsqdsvlk
A0A6J0XI58_ODOVR/1-80 .......................MRFLVLTSLLCILLLCLSVFS.AEGR...RH...PRHHa.kpGKG...KPC.CPRIPGPDLMTQK..................GHH..MR.NC...RPCKLKPK.P.RFWVVPGALPQ.............
A0A7J8G4B2_ROUAE/1-75 .......................MRFLVYFSLLCVLLLCFSVFS.IEGK...KR...PAKP....WKD...KPC.CPQAST--LRGQK..................GRH..IK.NC...RRCKSKPE.L.RFWIVPGALPQ.............
A0A667IUZ6_LYNCA/1-80 .......................MRFLALSRLLCILLLCFSIFS.VEGR...RH...SRHLa.kpRKG...KLC.CSRVPSPVPTAQK..................GRH..VR.IC...RQCKVKPG.S.RTWVVPGALPQ.............
A0A6I9ZJI4_ACIJB/1-80 .......................MRFLALSRLLCILLLCFSIFS.VEGR...RH...SRHLa.kpRKG...KLC.CSRVPSPVPTAQK..................GRH..VR.IC...RQCKVKPG.S.RTWVVPGALPQ.............
A0A8C2UHC5_CHILA/23-51 ......................e---------------------.----...--...----....---...---.-------------..................GNR..IR.LC...RPCRPKPV.PtRSWVVPGALPQ.............
A0A8J4J288_EUDMI/1-76 .......................MKLLALCGFLFVLLLCLNAFT.AEGR...KV...KK--....---...-VC.CSKLPKLNKKAHKgi.............nfkMTP..ME.IR...KYCKPCPQ.P.APPVVPGPLPQ.............
A0A212CPU5_CEREH/1-80 .......................MRFLVLTSLLCILLLCLSVFS.AEGR...RH...PRHHa.kpGKG...KPC.CPRIPGPDLMTQK..................GHH..MR.NC...RPCKLKPK.P.RIWVVPGALPQ.............
A0A2K5KRW4_CERAT/1-80 .......................MRLLILSSLLCILLLCFSVFS.TEGK...RR...PAKPw.pgKRA...RLC.CHRVPSPNLTNPK..................GHH..VR.LC...KPCKLEPE.P.RPWVVPGALPQ.............
A0A8D2H7Z6_UROPR/1-75 .......................MRLLILSSLFCILLLCFSIFS.SEGK...RH...PAK-....-SW...KLC.CHRVPALNLTTQK..................GNR..MR.LC...RVCKLKPM.S.QSWVVPGALPQ.............
A0A8C9EFS3_PHOSS/1-80 .......................MRFLALASLLCILLLCLSVFS.AEGR...RHlshPAKP....GKG...KPC.CPRVPGPDLMTRK..................GHH..VR.SC...RPCKFKPK.P.HSWVVPGALPQ.............
A0A673V462_SURSU/1-79 .......................MRLAVLSRLFCILLLCFSIFS.VEGM...AV...PPGGw..pRKS...KLC.CSRVPSPGLTTQK..................VRH..VR.IC...RQCSVKSG.S.RTWVVPGALPQ.............
A0A1U7UH62_CARSF/1-77 .......................MRLLIISSLLCILLFCFSVFS.AEGR...RH...PAKS....WRV...RPC.CHGVSSPNTTALK..................GHR..VR.YC...KPCKLKLA.S.KTWVVPGPLPQ.............
A0A8C9GA88_9PRIM/1-80 .......................MRLLVLSSMLCILLLCFSVFS.TEGK...RR...LAKPw.pgRRA...RLC.CHRVPNPNLTNLK..................GHH..VR.LC...KPCKLEPQ.P.RPWVVPGALPQ.............
A0A2K5HFS8_COLAP/1-80 .......................MRLLVLSSMLCILLLCFSVFS.TEGK...RH...PAKPw.pgRRA...RLC.CHRVPNPNLTNPK..................GHH..VR.LC...KPCKLEPQ.P.RPWVVPGALPQ.............
A0A8C9Q1A8_SPEDA/1-75 .......................MRLLILSSLFCILLLCFSIFS.SEGK...RH...PAK-....-SW...KLC.CHRVPALNLTTQK..................GNR..MR.LC...RVCKLKPM.S.QSWVVPGALPQ.............
A0A8C0KMW2_CANLU/1-87 .......................MRLLVVSRLLCIILLCFSTFA.AEGR...AA...PQGAepsaVFS...RLR.ARRLPASLALAWPaps............lfpGRP..VR.IC...RPCKFKPE.P.HKWVVPGALPQ.............
GP15L_HUMAN/1-80 .......................MRLLVLSSLLCILLLCFSIFS.TEGK...RR...PAKAw.sgRRT...RLC.CHRVPSPNSTNLK..................GHH..VR.LC...KPCKLEPE.P.RLWVVPGALPQ.............
A0A384CIV7_URSMA/1-80 .......................MRLLVISSLLCILLLCFSVFS.VEGR...KN...SSHLi.kpSKR...RLC.CSRVPSPALTTQK..................GRP..VR.LC...RPCKFKPE.S.RIWVVPGALPQ.............
S7N110_MYOBR/1-31 .......................MRALVLCSLLCTLLLCFSVFS.MEGS...H-...----....---...---.-------------..................---..--.--...--------.-.-----------vytln........
A0A6J3GCN0_SAPAP/1-80 .......................MRLLVLSSLLCILLLCFTVFS.TEGR...RH...PNKVw.pgKRA...RLC.CHRVLRPNPTNLK..................RQH..VR.LC...KPCKLEPE.A.RPWVVPGALPQ.............
G7PEW8_MACFA/1-80 .......................MRLLILSSLLCILLLCFSVFS.TEGK...RR...HAKPw.pgRRA...RLC.CHRVPSPNLTNPK..................GHH..VR.LC...KPCKLEPE.P.LPWVVPGALPQ.............
A0A6I9LCE6_PERMB/1-75 .......................MRLLALSSLLCVLLLCFSILS.SEGK...RH...PAKI....SK-...-SC.CNLVPRSRLTTQK..................GNH..LR.HC...KPCKSKPP.F.KSWVVPGALPQ.............
M7B9A3_CHEMY/1-46 .......................MKLFTLFGLLSVLILCLSVFS.AEGR...YS...RK--....---...-HC.CRRSPKIRK----..................---..--.--...--------.-.-----------aqanya.......
W5PL54_SHEEP/1-77 .......................MRLLVLTSLLCTLLLCLSLFS.AEGR...TL...PC--....--P...CPG.CRSLSRCLFLSARcs..............flGHH..TR.NC...RPCKLKPR.P.RFWVVPGALPQ.............
A0A8C8YSQ8_PROSS/1-77 .......................MRLLVLSSLLCILLLCFSVFS.AEGR...RR...PAKP....WRV...RPC.CQRVPSHHLTAQK..................GHR..AR.LC...RLCKLNPG.T.SSWVVPGALPQ.............
A0A337S931_FELCA/1-80 .......................MRFLALSRLLCILLLCFSIFS.VEGR...RH...SRQLa.kpRKG...KLC.CSRVPSPVPTAQK..................GRH..VR.IC...RQCKVKPG.S.RTWVVPGALPQ.............
A0A8C9KHD3_PANTA/1-80 .......................MRFLVLSRLLCILLLCFSIFS.VEGR...RH...SRHLa.kpRKG...KLC.CSRVPSPVPTAQK..................GRH..AR.IC...RQCKVKPG.S.RTWVVPGALPQ.............
A0A667HQS5_LYNCA/1-59 .......................MRFLALSRLLCILLLCFSIFS.VEGR...RH...SRHLa.kpRKG...KLC.CSRVPSPVPTAQK..................AQ-..--.--...--------.-.-----------anfa.........
A0A2K5RT01_CEBIM/1-80 .......................MRLLVLSSLLCILLLCFTVFS.TEGR...RH...PNKVw.pgKRA...RLC.CHRVLRPNPTNLK..................RQH..AR.LC...KPCKLEPE.A.RPWVVPGALPQ.............
L9KU06_TUPCH/1-29 .......................MRLLVLSSLLCTLLLCSSVFS.VEG-...--...----....---...---.-------------..................---..--.--...--------.-.-----------lpdsg........
A0A6A1QCD0_BALPH/10-77 .......krgslslcppserrhp---------------------.----...RH...PAKP....GKG...KPC.CPRVPGPDLMTRK..................GHH..VR.SC...RPCKFKPK.P.RSWVVPGALPQ.............
G5BDQ1_HETGA/1-74 .......................MRFLVLSSLICILLFCVSIFS.GEGK...RL...RIKI....RKP...RPC.CRQAPG---FNLK..................GNH..TR.LC...RPCRPKPT.P.HPWVVPGALP-l............
A0A4W2EPN5_BOBOX/46-125 .......................MRLLILTSLLCILLLCLSVFS.AEGRshlRH...HAKP....GKG...KPC.CPRIPGPDLMTQK..................GHR..TR.NC...RPCKLKSK.H.RFWVVPGALPQ.............
A0A811YMH9_NYCPR/1-80 .......................MRLLVISRLLCIILLCFSTFA.AEGR...RP...SQHV....GKPwsgRFC.CTRAPRLVLTTQT..................GRP..VR.IC...RPCKFKPE.P.HKWVVPGALPQ.............
A0A2Y9EKT0_PHYMC/1-80 .......................MRFLALASLLCILLLCLSVFS.AEGR...MH...PRHPa.kpGKG...KPC.CPRVPGPDLMTRK..................GHH..VR.SC...RPCKFKPK.P.RSWVVPGALPQ.............
A0A484GQ76_SOUCH/1-80 .......................MRFLALTSLLCILLLCLSVVS.AEGR...KHlshPAKP....GKG...KPC.CPRVPGPDVMTRK..................GHH..VR.SC...RPCKFKPK.P.HSWVVPGALPQ.............
A0A2K6DUQ4_MACNE/1-80 .......................MRLLILSSLLCILLLCFSVFS.TEGK...RR...HAKPw.pgKRA...RLC.CHRVPSPNLTNPK..................GHH..VR.LC...KPCKLEPE.P.RPWVVPGALPQ.............
A0A667HQJ1_LYNCA/1-70 .......................MRFLALSRLLCILLLCFSIFS.VEGR...RH...SRHLa.kpRKG...KLC.CSRVPSPVPTAQK..................GSH..VY.--...--------.-.-----------tlngtdpegdpi.
A0A1U7QF70_MESAU/1-77 .......................MRLLVLCSLLCVLLLCFCTLS.SEGR...KH...HVKL....SKF...RPC.CNLIHRFKLATQK..................GQH..TR.PC...RSCRIKPP.S.KPWVVPGALPQ.............
A0A383ZHL3_BALAS/1-80 .......................MRFLALARLLCILLLCLSVFS.AEGR...RH...PRHSa.kpGKG...KPC.CPRVPGPDLMTRK..................GHH..VR.SC...RPCKFKPK.P.RSWVVPGALPQ.............
A0A8C6QQ86_NANGA/1-75 .......................MRLLTLSSLLCLLLLCFCILS.SEGR...RR...PARP....WRL...RPC.CHVAPRLKPTTQK..................GIR..PR.PC...RLCRI--K.S.SSWIVPGALPQ.............
A0A6G1AAV4_CROCR/1-57 ..................gtrhs---------------------.----...RH...LTKP....WKG...KLC.CSRVPSPVLKAQK..................GHH..AR.IC...RQCKVKPA.S.RTWVVPGALPQ.............
A0A7N5P4P7_AILME/1-80 .......................MRLLVISSLLCILLLCLSVFS.VEGR...KN...SSHLi.kpSKR...RLC.CSRVPSPALMTQK..................GRL..VR.IC...RPCKFKPE.S.RIWVVPGALPQ.............
A0A8C7ADS5_NEOVI/1-79 .......................MRLLVVSRLLCILLLCFSIFS.TEGR...KN...SVISa..gRKR...RPC.CSRVPNPALTTRK..................GRR..VR.IC...RLCNFKPE.S.RLWVVPGALPQ.............
GP15L_MOUSE/1-77 .......................MRLLALSGLLCMLLLCFCIFS.SEGR...RH...PAKS....LKL...RRC.CHLSPRSKLTTWK..................GNH..TR.PC...RLCRNKLP.V.KSWVVPGALPQ.............
A0A671FX96_RHIFE/1-80 .......................MRFLVLSSLLCILLLCFSISS.VEGK...RH...RRHPa.kpFKG...KLC.CSQHPSPVLKTQN..................GRL..RK.TC...RPCKTKSE.S.HFWVVPGALPQ.............
H2Q266_PANTR/1-80 .......................MRLLVLSSLLCILLLCFSIFS.TEGK...RR...PAKAw.sgRRT...RLC.CHRVPSPNSTNLK..................GHH..VR.LC...KPCKLEPE.P.RLWVVPGALPQ.............
A0A1S3GFC4_DIPOR/70-123 slkfkvqkhllsfiicldshllg---------------------.----...--...----....---...---.-----------SKe................eRNR..MK.VC...RVCKVKAV.A.QPWVVPGALPQ.............
A0A8J4LLM4_APTPA/1-76 .......................MKLLALCGFLFVLLLCLNAFT.AEGR...KV...KK--....---...-VC.CSKLPKLNKKAHKgi.............nfkMTP..ME.IR...KYCKPCPQ.P.APPVVPGPLPQ.............
A0A2R9CNJ5_PANPA/1-80 .......................MRLLVLSSLLCILLLCFSIFS.TEGK...RR...PAKAw.sgRRT...RLC.CHRVPSPNSTNLK..................GHH..VR.LC...KPCKLEPE.P.RLWVVPGALPQ.............
A0A6P5L7K3_PHACI/1-78 .......................MKFPTLSSLLYILFLCLLAFS.TEGV...RR...VS--....HQK...VLC.CQNAPHYALKSLK..................GRN..PK.MGprhKFCKGRVS.R.LCKRIPGALPQ.............
A0A8C6EC04_MOSMO/1-80 .......................MRFLVLTSLLCIVFLCLSVFS.AEGR...RH...PRHHa.kpGKG...KPC.CPRVPGPDLMTQK..................GHH..MR.NC...RPCKLKPK.P.RFWVVPGALPQ.............
A0A7J7T091_PIPKU/1-80 .......................MRALVLSGLLCMLLLCNSVFS.AEGR...RHlrpPVKP....WKG...KPC.CSQVPDPALRTQK..................GHR..VR.IC...KPCKFKPE.S.PFWVVPGALPQ.............
G3R9V7_GORGO/1-80 .......................MRLLVLSSLLCILLLCFSIFS.TEGK...RH...PAKAw.sgRRT...RLC.CHRVPSPNSTNLK..................GHH..VR.LC...KPCKLGPE.P.RLWVVPGALPQ.............
GL15L_PIG/1-80 .......................MRFLALTSLLCILLLCLSFFS.AEGR...RH...PRNPa.kpGKI...RIC.CPRLPGPDLMPQK..................GHH..MR.IC...RPCKFKQK.P.QLWVVPGALPQ.............
A0A3Q1MJW9_BOVIN/1-80 .......................MRLLILTSLLCILLLCLSVFS.AEGRshlRH...HAKP....GKG...KPC.CPRIPGPDLMTQK..................GHR..TR.NC...RPCKLKSK.H.RFWVVPGALPQ.............
A0A8D2K367_THEGE/1-80 .......................MRLLILSSLLCILLLCFSVFP.TEGK...RR...PAKPw.pgKRA...RLC.CHRVPSPNLTNPK..................GHH..VR.LC...KPCKLEPE.P.RPWVVPGALPQ.............
GP15L_RAT/1-76 .......................MRLLTLSGLFFMLFLCLCVLS.SEGR...KR...PAKF....PKL...RPC.CHLSPRSKPITWK..................GNH..TR.PC...RPCR-KLE.S.NSWVVPGALPQ.............
A0A286XXC9_CAVPO/1-28 .......................MRLLPLSSLLCILLLCVSVFF.GEGN...RT...----....---...---.-------------..................---..--.--...--------.-.-----------r............
V8P3Y2_OPHHA/1-77 .......................MRIQKVFALLLILILCLGTFS.ADGA...GS...RM--....--R...RKClCKTKKHLPVMDRKi................vGQH..KKcLC...QPYKERKL.S.HHVFVPGPLP-l............
A0A8C4MUQ0_EQUAS/75-132 ................ggtcsea---------------------.----...--...-IKK....REA...KMC.MHTRAHTCAHAVH..................RKHslVN.SC..aRPCKFKPE.A.-PWVVPGALPQ.............
A0A8C8X290_PANLE/1-80 .......................MRFLVLSRLLCILLLCFSIFS.VEGR...RH...SRHLa.kpRKG...KLC.CSRVPSPVPTAQK..................GRH..VR.IC...RQCKVKPG.S.RTWVVPGALPQ.............
A0A6P6HEM2_PUMCO/1-80 .......................MRFLALSRLLCILLLCFSIFS.VEGR...RH...SRHLa.kpRKG...KLC.CSRVPSPVPTAQK..................GRH..VR.IC...RQCKVKPG.S.RTWVVPGALPQ.............
A0A3Q7PQW3_CALUR/1-98 .......................MRFLVVSRLLCIWLLCFSIFF.VEGR...KN...SSHLs.kpRKR...RLC.CSRVPSPALTTQKdeepkhrevkslveghpaGRH..VK.IC...RLCKFKPE.S.RIWVVPGALPQ.............
A0A2K6EGF0_PROCO/1-77 .......................MRLLVLSSLLCILLLCFSVFS.AEGR...RR...PAKT....WRV...RPC.CQRVPGHNLRALK..................GHR..AR.LC...RLCKLNPG.T.SSWVVPGALPQ.............
A0A8D2CLS0_SCIVU/1-77 .......................MRLLILSSLFCILLLSFSISS.SEGK...RY...PAKS....WKH...RHC.CHRVPGLSLTTQK..................GNS..SR.PC...RMCKLKPP.S.QAWVVPGALPQ.............
A0A2K6S3X8_SAIBB/1-80 .......................MRLLVLSSLLCFLLLCFTVFS.TEGR...RH...PNKVw.pgTKA...RLC.CHRVLRPNPTNLK..................RQH..VR.LC...KPCKIEAE.V.RPWVVPGALPQ.............
A0A8C5ZBD3_MARMA/1-75 .......................MRLLILSSLFCILLLCFSIFS.SEGK...RH...PAK-....-SW...KLC.CHRVPALNLTTQK..................GNR..MR.LC...RVCKLKPM.S.QSWVVPGALPQ.............
A0A8B7AWV7_ORYAF/1-24 .......................MRLPILTSLLCILLLCFSFFS.AE--...--...----....---...---.-------------..................---..--.--...--------.-.-----------e............
A0A2K6NCD9_RHIRO/1-80 .......................MRLLVLSSMLCILLLCFSVFS.TEGK...RR...PAKPw.pgKRA...RLC.CHKVPSPNLTNAK..................GHH..VR.LC...KPCKLEPQ.P.RPWVVPGALPQ.............
H2NAE6_PONAB/1-80 .......................MRLLVLSSLLCILLLCFSIFS.TEGK...RR...PAKPw.sgRRT...RLC.CHRVPSPNSTNLK..................GHH..VR.LC...KPCKLEPQ.P.RPWVVPGALPQ.............
A0A340WGA1_LIPVE/1-80 .......................MRFPALASLLCILLLCLSVFS.AEGR...RHvshPAKP....GKG...KPC.CLRVPGPDLMTRK..................GHH..VR.SC...RPCKLKPK.P.RSWVVPGALPQ.............
A0A7J7RMS1_MYOMY/1-80 .......................MRALVLGGLLCTLLLCSSVFS.VEGR...RH...PRPPa.kpWKG...KPC.CSQVPDPALRTQK..................GHR..VR.IC...KPCKFKPA.S.PFWVVPGALPQ.............
A0A5F9DI79_RABIT/1-74 .......................MRLLVLSSLLCILLL---FFP.VEGR...RH...PIRS....QRV...WRC.CP-VARPLRTILK..................GRY..AG.PC...RLCKIKPSlI.HQWVVPGALPQ.............
A0A6P6DBR4_OCTDE/1-74 .......................MRLQVLSSLLCILLLCASLFS.GEAK...SP...RTKI....RKP...RPC.CRQAPG---SNLH..................RNR..IR.RC...RPCRPKPV.L.PTWVVPGALPQ.............
A0A2Y9M8R5_DELLE/1-80 .......................MRFLALASLLCILLLCLSVFS.AKGR...RHlshPAKP....GKG...KPC.CPRVPGPDMMTRK..................GHH..VR.SC...RPCKSKPK.P.HSWVVPGALPQ.............
A0A2K5EA12_AOTNA/1-80 .......................MRLLVLSGLFCILLLCFSVFS.TEGR...RH...PEKVw.pgRRA...RLC.CHRVLRHNLTNLK..................RQH..VR.RC...KPCKLEPE.T.HPWVVPGALPQ.............
A0A2R8M4X9_CALJA/1-80 .......................MRLLVLSSLLCILLLCFSVFS.MEGR...RH...PDKVw.pgRRP...RLC.CHRVLRPNPTNLK..................RQH..VR.LC...KPCKLEPE.A.HPWVVPGALPQ.............
A0A6P3INM3_BISBI/1-80 .......................MRLLILTSLLCILLLCLSVFS.AEGRshlRH...HAKP....GKG...KPC.CPRIPGPDLMTQK..................GHR..TR.NC...RPCKLKSK.L.RFWVVPGALPQ.............
A0A8C2UHC5_CHILA/1-29 .......................MRLLVLSGLICILLLCVSILS.GEGN...RI...R---....---...---.-------------..................---..--.--...--------.-.-----------l............
A0A8C6H490_MUSSI/29-89 ..................siflf---------------------.FSGR...RH...PAKS....LKL...RRC.CHLSPRSKLTTWK..................GNH..TR.PC...RLCRNKLP.V.KSWVVPGALPQ.............
A0A8I3MQM0_CANLF/1-77 .......................MRLLVVSRLLCIILLCFSTFA.AEGR...RR...PGKP....WSG...RLC.CTRAPRPVLTTQT..................GRP..VR.IC...RPCKFKPE.P.HKWVVPGALPQ.............
A0A8I5NC73_PAPAN/1-80 .......................MRLLILSSLLCILLLCFSIFS.TEGK...RR...PAKPw.pgKRA...RLC.CHRVPSPNLTNPK..................GHH..VR.LC...KPCKLEPE.P.RPWVVPGALPQ.............
A0A6I9IKY9_VICPA/1-80 .......................MRLPALTSLLCILLLCLSVFS.VEGR...RH...PRHPa.kpGRG...RPC.CPRGPSPDLMAQK..................EHH..VR.NC...RSCKLKKK.P.HYWVVPGALPQ.............
A0A286XXC9_CAVPO/23-51 ......................e---------------------.----...--...----....---...---.-------------..................GNR..TR.LC...EPCKYKLKtA.GRWVVPGALPQ.............
A0A8C5Y9Z6_MICMU/1-80 .......................MRLLVLSSLLCILLLC-SVFS.AEGR...RR...PAKP....SRL...RPC.CQRVPSHNPTALRgy..............lpRHR..AR.LC...RLCKLNPG.T.SSWVVPGALPQ.............
A0A8B9YUD9_BOSMU/67-146 .......................MRLLILTSLLCILLLCLSVFS.AEGRshlRH...HAKP....GKG...KPC.CPRIPGPDLMTQK..................GHR..TR.NC...RPCKLKSK.L.RFWVVPGALPQ.............
A0A1S3WQD0_ERIEU/1-81 .......................MRFLVLSSLLCILLLGFSIFSaAEGR...RL...PRQPa.kaWKG...RPC.CSRTPGPILPAQR..................GRH..VK.KC...RPCKLKPK.S.QFWVVPGALPQ.............
G1RJ21_NOMLE/1-80 .......................MRLLVLSSLLCILLLCFSIFS.TEGK...RR...PAKPw.pgRRT...RLC.CHRVPSPNSTNLK..................GHH..VR.LC...KPCKLEPE.P.RTWVVPGALPQ.............
A0A2K5Y3M4_MANLE/1-80 .......................MRLLILSSLLCILLLCFSVFS.TEGK...RR...PAKPw.pgRRA...RVC.CHRVPSPNLTNPK..................GHH..VR.LC...KPCKLEPE.P.RPWVVPGALPQ.............
#=GC seq_cons .......................MRLLlLSSLLCILLLChSlFS.sEG+...R+...st+s....t+s...+.C.CpRVPuPshps.K..................G++..sR.hC...+PCKh+Pp.s.+.WVVPGALPQ.............
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