#=GF ID GluRS_N
#=GF AC PF18466.5
#=GF DE Glutamate--tRNA ligase N-terminal domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF06597
#=GF GA 26.70 26.70;
#=GF TC 26.70 26.70;
#=GF NC 26.60 26.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 17139087
#=GF RT Structures of the interacting domains from yeast glutamyl-tRNA
#=GF RT synthetase and tRNA-aminoacylation and nuclear-export cofactor
#=GF RT Arc1p reveal a novel function for an old fold.
#=GF RA Simader H, Hothorn M, Suck D;
#=GF RL Acta Crystallogr D Biol Crystallogr. 2006;62:1510-1519.
#=GF RN [2]
#=GF RM 16914447
#=GF RT Structural basis of yeast aminoacyl-tRNA synthetase complex
#=GF RT formation revealed by crystal structures of two binary
#=GF RT sub-complexes.
#=GF RA Simader H, Hothorn M, Kohler C, Basquin J, Simos G, Suck D;
#=GF RL Nucleic Acids Res. 2006;34:3968-3979.
#=GF DR INTERPRO; IPR041103;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is an N-terminal domain of Glutamate--tRNA ligase (GluRS,
#=GF CC EC:6.1.1.17). The domain adopts a classical glutathione
#=GF CC S-transferase (GST)-like fold and it interacts with
#=GF CC tRNA-aminoacylation cofactor ARC1 (Arc1p) N-terminal domain for
#=GF CC the formation of aminoacyl-tRNA synthetase (aaRS) complex in
#=GF CC yeast [1, 2].
#=GF SQ 81
#=GS A0A0B7N2G1_9FUNG/24-76 AC A0A0B7N2G1.1
#=GS A0A1E4RK63_9ASCO/23-78 AC A0A1E4RK63.1
#=GS A0A8H6BYI4_CANAX/23-75 AC A0A8H6BYI4.1
#=GS A0A4T0WWH3_9ASCO/23-76 AC A0A4T0WWH3.1
#=GS A0A8J5QBL4_9ASCO/23-79 AC A0A8J5QBL4.1
#=GS G8Y3K2_PICSO/23-78 AC G8Y3K2.1
#=GS A0A8H7V7W9_9FUNG/24-76 AC A0A8H7V7W9.1
#=GS A0A421JNG3_9ASCO/23-71 AC A0A421JNG3.1
#=GS A0A4P6XSW2_9ASCO/22-74 AC A0A4P6XSW2.1
#=GS A5E7A7_LODEL/23-77 AC A5E7A7.1
#=GS A0A3N4HL97_ASCIM/26-81 AC A0A3N4HL97.1
#=GS A0A1S7HHT3_9SACH/22-73 AC A0A1S7HHT3.1
#=GS A0A4C2E7U5_9SACH/22-63 AC A0A4C2E7U5.1
#=GS J8Q5E4_SACAR/23-64 AC J8Q5E4.1
#=GS H2B153_KAZAF/23-64 AC H2B153.1
#=GS A0A875S367_EENNA/23-75 AC A0A875S367.1
#=GS G3B199_CANTC/24-74 AC G3B199.1
#=GS G0VF30_NAUCC/23-64 AC G0VF30.1
#=GS J7RPX7_KAZNA/24-65 AC J7RPX7.1
#=GS A0A8H7GZB7_9ASCO/22-74 AC A0A8H7GZB7.1
#=GS A0A061AV07_CYBFA/23-71 AC A0A061AV07.1
#=GS S2JA54_MUCC1/24-76 AC S2JA54.1
#=GS A0A1G4JX08_9SACH/22-63 AC A0A1G4JX08.1
#=GS A0A367KUX8_RHIST/24-76 AC A0A367KUX8.1
#=GS C4QYY3_KOMPG/22-73 AC C4QYY3.1
#=GS G8Y0L5_PICSO/23-78 AC G8Y0L5.1
#=GS A0A2U9R109_PICKU/23-76 AC A0A2U9R109.1
#=GS A0A1G4MGI7_LACFM/23-64 AC A0A1G4MGI7.1
#=GS C5DLH1_LACTC/22-63 AC C5DLH1.1
#=GS A0A0H5C639_CYBJN/23-71 AC A0A0H5C639.1
#=GS A0A167DZB5_9ASCO/24-80 AC A0A167DZB5.1
#=GS A0A1E4T2A3_9ASCO/23-76 AC A0A1E4T2A3.1
#=GS A0A8H7T091_9FUNG/24-76 AC A0A8H7T091.1
#=GS A0A1E3QYC9_9ASCO/22-76 AC A0A1E3QYC9.1
#=GS Q6CYG1_KLULA/23-65 AC Q6CYG1.1
#=GS A0A8H6BZF1_CANAX/23-75 AC A0A8H6BZF1.1
#=GS A0A642UDV0_DIURU/21-73 AC A0A642UDV0.1
#=GS A0A2H0ZZX3_CANAR/22-74 AC A0A2H0ZZX3.1
#=GS A0A1E4SHV0_9ASCO/23-78 AC A0A1E4SHV0.1
#=GS S9X8H4_SCHCR/21-75 AC S9X8H4.1
#=GS A0A2P7YRC9_9ASCO/22-72 AC A0A2P7YRC9.1
#=GS A0A7H9HRW2_9SACH/22-63 AC A0A7H9HRW2.1
#=GS A0A1Q2YFZ3_9ASCO/23-76 AC A0A1Q2YFZ3.1
#=GS A0A421J8X9_9ASCO/21-74 AC A0A421J8X9.1
#=GS M3J5K8_CANMX/23-76 AC M3J5K8.1
#=GS A0A7H9B9C9_ZYGMR/20-61 AC A0A7H9B9C9.1
#=GS A0A0E9NHL4_SAICN/27-82 AC A0A0E9NHL4.1
#=GS G8ZUC7_TORDC/22-63 AC G8ZUC7.1
#=GS A0A2G4SR57_RHIZD/24-76 AC A0A2G4SR57.1
#=GS A0A162RFV8_MUCCL/24-76 AC A0A162RFV8.1
#=GS A0A0C9MXA5_9FUNG/24-76 AC A0A0C9MXA5.1
#=GS Q753P8_ASHGO/23-64 AC Q753P8.2
#=GS A0A367J4K1_RHIST/24-76 AC A0A367J4K1.1
#=GS A0A8H7RNR6_9FUNG/24-76 AC A0A8H7RNR6.1
#=GS C4Y8S5_CLAL4/29-81 AC C4Y8S5.1
#=GS Q6BKC8_DEBHA/23-76 AC Q6BKC8.1
#=GS A0A367K9B4_RHIAZ/24-76 AC A0A367K9B4.1
#=GS A0A1X7QXH7_9SACH/23-64 AC A0A1X7QXH7.1
#=GS G0WGI2_NAUDC/24-65 AC G0WGI2.1
#=GS A0A1C7NQR4_9FUNG/24-76 AC A0A1C7NQR4.1
#=GS A0A1E3NYC6_WICAA/23-71 AC A0A1E3NYC6.1
#=GS A0A2V1B1F9_9ASCO/22-74 AC A0A2V1B1F9.1
#=GS G8BP48_TETPH/23-62 AC G8BP48.1
#=GS A0A1L0C518_9ASCO/23-70 AC A0A1L0C518.1
#=GS A0A512U820_9ASCO/22-74 AC A0A512U820.1
#=GS A0A1E4TRA3_PACTA/23-69 AC A0A1E4TRA3.1
#=GS A7TPG0_VANPO/23-62 AC A7TPG0.1
#=GS W1QK21_OGAPD/23-75 AC W1QK21.1
#=GS G8B923_CANPC/23-77 AC G8B923.1
#=GS Q6FWY4_CANGA/23-65 AC Q6FWY4.1
#=GS K0KQB3_WICCF/23-71 AC K0KQB3.1
#=GS A0A1A0GZ72_9ASCO/22-74 AC A0A1A0GZ72.1
#=GS A0A1D8PQL8_CANAL/23-75 AC A0A1D8PQL8.1
#=GS A0A1X0SCP0_RHIZD/24-76 AC A0A1X0SCP0.1
#=GS I1C819_RHIO9/24-76 AC I1C819.1
#=GS A0A376B4F3_9ASCO/22-64 AC A0A376B4F3.1
#=GS I1BTT8_RHIO9/24-76 AC I1BTT8.1
#=GS A3LWB3_PICST/23-75 AC A3LWB3.1
#=GS A0A1E3PDH5_9ASCO/23-75 AC A0A1E3PDH5.1
#=GS I2H3Y0_TETBL/23-64 AC I2H3Y0.1
#=GS A0A1E3NJV1_9ASCO/23-76 AC A0A1E3NJV1.1
A0A0B7N2G1_9FUNG/24-76 ..aq--INA.VK.NG-AVNVEFCDAKNLEGASKPTASI-..SYNGETY.ETTNAIARLVARLHP..........
A0A1E4RK63_9ASCO/23-78 ...g-FVNS.SD.NDVSIPVEFIDEKSVDSSNPNAIVKL.vTPEGKTY.FDQVEVLNYLAEKFP..........
A0A8H6BYI4_CANAX/23-75 ....NFINS.SD.VDVSIPIEFVDDKTVDS---KDSIKL.vTPGGETF.IDQLDALDYLSQTLP..........
A0A4T0WWH3_9ASCO/23-76 ....AFVNT.-S.SEGDIKLNFIDGKTVSNEVKTS-AQL.lKGDESVA.TDSIDILNYIATEF-a.........
A0A8J5QBL4_9ASCO/23-79 ...s-FINSnSS.TDISIPIEFIDEKSVDSSDANATIKL.vTPEGKTF.TNQLDALTYLSSKFP..........
G8Y3K2_PICSO/23-78 ....EFVNR.SN.GDGKIDLQVVDQKSVDSADANSASKL.tTTDGKEI.KGEAEVLKELGKLFP..........
A0A8H7V7W9_9FUNG/24-76 ..aq--INA.VK.KD-AVEVEFRDVKNLEG-DSKAAASV..NYNGETY.ETTNSIARLLARLNP..........
A0A421JNG3_9ASCO/23-71 ...g-LIND.-S.ND-SIPIEVLDVKQIN----DVSFKL..VTPTETF.IEQDRALEFLSQQFP..........
A0A4P6XSW2_9ASCO/22-74 ....EFVKA.DS.GA-EITLDIVDEKSAA-AGADVSAAF..TVDGKTT.AGETEVLQVLASLAP..........
A5E7A7_LODEL/23-77 ...f-FINS.SK.KDISIPVEFVDEKLATK-EGSASIKM.vTPGGETF.VDQLDALDYLAQTIP..........
A0A3N4HL97_ASCIM/26-81 ....EIVNE.TV.PEKSIAFGYKDVDLIEKGNTNSAVGL.eVDGGEFI.YGAQPIIKKLLESFP..........
A0A1S7HHT3_9SACH/22-73 ....RIVNE.NC.KD-AITIEFVDQKGAAPAVFNGSSE-..DTFTAII.SENP-----------evfgkltegv
A0A4C2E7U5_9SACH/22-63 ....RIVNA.AH.KD-AITVEFVDEKNAAPAVFNG----..-------.-SSDDTFTKIIGTYP..........
J8Q5E4_SACAR/23-64 ....RIVNA.LA.PN-SITIEFVDDKKAPAAKLDD----..-------.-VTEDVFSKITGKF-a.........
H2B153_KAZAF/23-64 ....RLVNA.AR.PD-AIKIEFVDDKKSAPATFNG----..-------.-SSEGSFNKIVAAFP..........
A0A875S367_EENNA/23-75 ....AFINE.SD.AD-TIKVEYINEKTIA--DTKLSAQL.lKGDEVVA.SSSDEILNAVASTFP..........
G3B199_CANTC/24-74 ....NLVNA.SS.SDESINFEFIDEKDIE----GDSVKL..TNDGKIL.VGQLAILNGLADKFP..........
G0VF30_NAUCC/23-64 ....RIVNE.TK.PN-SISIEFVDDKKAAPATFNG----..-------.-DNKDAFLKIVAQF-s.........
J7RPX7_KAZNA/24-65 ....RIANS.AK.SS-SVAIEFVDDKNAAPAVFNG----..-------.-DSEDVLSKIAAQFP..........
A0A8H7GZB7_9ASCO/22-74 ....EFVKA.DS.GA-EISLDIVDEKSAA-AGADVSAAF..TVDGKTT.AGETEVLQVLASLAP..........
A0A061AV07_CYBFA/23-71 ....AFVNS.AK.AD-TIAVKFVDDKQVD----GASVTL..VKGDSTF.KNA-DVLSKLVSDFP..........
S2JA54_MUCC1/24-76 ..aq--INS.VK.KD-AVQVEFRDAKNLEGASKPAASV-..SYNGETY.ETTNAIARLLARLNP..........
A0A1G4JX08_9SACH/22-63 ..rr--VNT.-A.TESSVDIEFVEDKKAAPATFDG----..-------.-ASEAVFERLVKAYP..........
A0A367KUX8_RHIST/24-76 ..dh--INK.AK.KG-SITVELRDVKNLEGASKPAASV-..SYNGETY.DTTNAIVRLLTRLHP..........
C4QYY3_KOMPG/22-73 ....AFVNT.-G.TDNQITLDFQDVKELEK-DITVSVS-..KDEKVVA.SNIDNVLNFFAEEYP..........
G8Y0L5_PICSO/23-78 ....EFVNR.SN.GDGKIDLQVVDQKSVDSADANSASKL.tTSDGKEI.KGEADVLKELGKLFP..........
A0A2U9R109_PICKU/23-76 ....AFVNT.-S.TDASVKLEFLDSKTISK-DVNASAQL.lKDGESVA.TDSAEILNYLATEYP..........
A0A1G4MGI7_LACFM/23-64 ....RIVND.SK.PG-SIDVEFVDEKKASSATFDG----..-------.-SSEEVFTKVIGAFP..........
C5DLH1_LACTC/22-63 ....RLVNS.AK.TD-AIEIEFVEDKKSSPATFED----..-------.-SCDDVLKRIVQTYP..........
A0A0H5C639_CYBJN/23-71 ....AFVNS.-E.TDSSITVDFVDEKAVD----GASVVL..KAGTETV.KDG-AVVEKLASEFP..........
A0A167DZB5_9ASCO/24-80 ...f-IINH.EE.PTSPIDLSFVDAAVVDSSVPESNTVLthGTEGKSV.YGTVEVLNALAEAFP..........
A0A1E4T2A3_9ASCO/23-76 ....AFINS.AD.DSTAIKVDFIDDKIISK-DSPSTFKL..TTKDQSY.TSNVDALNALASDFP..........
A0A8H7T091_9FUNG/24-76 ..aq--VNA.VK.KG-SVEIELREGKSLEGSSKPAASI-..TYNGETY.ESNNAIARLIARLNP..........
A0A1E3QYC9_9ASCO/22-76 ...a-VVNS.AS.TDAPIKVDFVDDKVAAADQKSAPIKL..VTGGTTV.YETTEALNVLADTYP..........
Q6CYG1_KLULA/23-65 ..rk--VNA.SK.GDNTIEISFVEDKKAAAASFNG----..-------.-ETEDVLTKLSAAYP..........
A0A8H6BZF1_CANAX/23-75 ....NFINS.SD.VDVSIPIEFVDDKTVDS---KDSIKL.vTPGGETF.IDQLDALDYLSQTLP..........
A0A642UDV0_DIURU/21-73 ....NYVNS.TKdIDGNVEVDIVDDKEVGE--AKESVQL..EDGTTVI.AGQKNVITYLAEKF-..........
A0A2H0ZZX3_CANAR/22-74 ....EFVNS.-T.TDKAITVEFVDDKSVE-AGKDATVKY..AAHDKAV.YGDIEVLNELTSLSP..........
A0A1E4SHV0_9ASCO/23-78 ...g-FVNA.SD.ADVSIPIEFVDEKSTDSSDANASIKL.vTPEGQTF.LNQLDALNYLSEKFP..........
S9X8H4_SCHCR/21-75 ....EFVNA.-S.GLAHIATKFEDVNLLDNADKESNVAV.dLDGNKKE.YGSEKVVAAFLEKFP..........
A0A2P7YRC9_9ASCO/22-72 eivi-----.SD.SDKAVTVEFVDDKNVEK---DATVKY..TDGGNSV.TGDVEVLSQLTSAAP..........
A0A7H9HRW2_9SACH/22-63 ....RIVNG.VK.AN-SIEIEFVDDKKAAPAVLNG----..-------.-ESNDVLSKIVSGFP..........
A0A1Q2YFZ3_9ASCO/23-76 ....AFVNT.-S.SEGDIKLNFVDGKTVSKEVATS-AQL..LKGEETVsTDSIEILNYFATEFP..........
A0A421J8X9_9ASCO/21-74 ....NLINN.SD.NSASIEVEYVDDKAAS--DKDAPINL.iTENGSEI.VRQELALAHLGTKFP..........
M3J5K8_CANMX/23-76 ....NFINS.SD.IDVSIPIDFADDKTVD--DTKSSIKL.vTPGGETF.VDQLDALDYLAQTFP..........
A0A7H9B9C9_ZYGMR/20-61 ....RIVNG.VN.AG-AIKIEFVDDKKASPAVFND----..-------.-DSSEVFNKIIKDFP..........
A0A0E9NHL4_SAICN/27-82 ....SFINA.DN.VLPPVSIRYKEAALIVESDKSSNVSL.qGKEGDVI.YGVENVAKALAKGCP..........
G8ZUC7_TORDC/22-63 ....RVVNT.VN.PE-SINVEFVDDKKAAPAVLDG----..-------.-ESEGVFMKIIEAFP..........
A0A2G4SR57_RHIZD/24-76 ...s-YINS.VK.EG-SVNVELRDVKNLEGASKPAASI-..SYNGETY.DTTNAIIRLLTRLHP..........
A0A162RFV8_MUCCL/24-76 ..aq--INA.VK.KD-AVQVEFRDAKNLDGASKPAASV-..SYNGETY.ETTNAIARLLARLNP..........
A0A0C9MXA5_9FUNG/24-76 ..aq--INA.VK.KD-AIQVEFRDAKNLDGDSKPA-ASV..SYNGETY.ETTNAIARLLARLNP..........
Q753P8_ASHGO/23-64 ....RAVNE.AK.QD-AVAIQFTEGKEAAAASFDG----..-------.-ESQNALERMVEKYP..........
A0A367J4K1_RHIST/24-76 ..aq--INA.VK.KG-SVEVVVRDGKNLEGASKPTAS-V..NYNGEVY.ESTNAIARLLARLHP..........
A0A8H7RNR6_9FUNG/24-76 ..aq--VNA.VK.KG-SVEIELREGKSLEGASKPSASV-..TYNGETY.ETTNAIARLLARLNP..........
C4Y8S5_CLAL4/29-81 ....EFVKA.-E.TDVSLTVEFVDEKSVES-GSDATAKL..VVGEKTY.SGELESLKGLAALIP..........
Q6BKC8_DEBHA/23-76 ...g-FIDA.SD.SEISIPIEFVDEKTVD--STDAGVKL.vTPEGKTY.SNQLDILNYLAEKFP..........
A0A367K9B4_RHIAZ/24-76 ...s-YINS.VK.EG-SVNVELRDVKNLEGASKPAASI-..SHNGETY.ETTNAIIRLLTRLHP..........
A0A1X7QXH7_9SACH/23-64 ....RIANN.TK.PE-SVKIEFVDDKKAAPSTFNG----..-------.-STENTFQAIVDAFP..........
G0WGI2_NAUDC/24-65 ....RIIND.AK.PT-SIDIQFVDDKKSAPSVFNG----..-------.-SSDSTFLKIIEGFP..........
A0A1C7NQR4_9FUNG/24-76 ..aq--INS.VK.KN-AIEVEIREGKNLEGASKPV--AL.vNYNGEVY.ETTNSIVRLLARLHP..........
A0A1E3NYC6_WICAA/23-71 ....AFVNS.-Q.TETAIKIDFVDEKAVD----KAAVKL..TKGDETF.VDN-QALEKLAADFP..........
A0A2V1B1F9_9ASCO/22-74 ....EIVNS.-D.SDKAITVEFVDEKTAES-GKDVTVKY..VENGNTV.TGDKEVLSQLSALAP..........
G8BP48_TETPH/23-62 ....RIVNS.VK.PD-SITIEFVEDKKAAAASLNG----..-------.-ETDDVLSKIVS---a.........
A0A1L0C518_9ASCO/23-70 .esa-----.-E.SS-PITVDFVDDKAVEK---DATAKL..VVGDKTY.VGESEVLKAFGSLVP..........
A0A512U820_9ASCO/22-74 ....EFVKA.-E.SDASLAVEFVDEKTAH-ASSDVSVAF..TIDDKVT.AGEPDVLQVLASLAP..........
A0A1E4TRA3_PACTA/23-69 ....AFINT.EK.SDTSINVSFVDEKAPE-------VKL..SQGDKVIaTDNNSVFNHLV----gl........
A7TPG0_VANPO/23-62 ....RIVNS.SK.PD-SIKIEFVEDKKASPATLNG----..-------.-DSVDVLSKIV----ta........
W1QK21_OGAPD/23-75 ....AFVNK.-G.SNESIEIDVVDDKVVSK-EANSPLRL..TQGDKII.TSGPEALNFLADEYP..........
G8B923_CANPC/23-77 ...f-FVNS.SD.TDVSIPVEFVDDKSVDK-KTPSAIKL.vTPSGETF.IDQLDALDYLAQTFP..........
Q6FWY4_CANGA/23-65 ....RLVND.SK.SDASVTVEFVDDKKSAAATFDG----..-------.-KSDNALEAIVAKFP..........
K0KQB3_WICCF/23-71 ....QFVNA.QS.QD-AVKIEFVDEKAVD----KASAKL..TKGDETV.VDG-EILTKLASAFP..........
A0A1A0GZ72_9ASCO/22-74 ...g-FVRA.-E.SDVAVALEYVDDKSAS-ASTDVSAVL..TVDGQTT.AGEPEILHVLASLVP..........
A0A1D8PQL8_CANAL/23-75 ....NFINS.SD.VDVSIPIEFVDDKTVDS---KDSIKL.vTPGGETF.IDQLDALDYLSQTLP..........
A0A1X0SCP0_RHIZD/24-76 ...s-YINS.VK.EG-SVNVELRDVKNLEGASKPAASI-..SHNGETY.ETTNAIIRLLTRLHP..........
I1C819_RHIO9/24-76 ...s-YINN.VK.KD-SINIELRDVKNLEGASKSTASI-..NYNGETY.DTVNAIARLLTRLHP..........
A0A376B4F3_9ASCO/22-64 ....RYVNA.TL.GKTAITIEIVDDKKAAPAVFNG----..-------.-KSENVLKEIALQFP..........
I1BTT8_RHIO9/24-76 ...d-YINS.VK.KD-SVVVELRDVKNLEGDSKPSASI-..SYNGETY.ATTNAIVRLLTRLHP..........
A3LWB3_PICST/23-75 ....NFVNT.SD.VDSSILIEFIDEKSVE--GSDSSVKL..VSAGKTV.TDQVEILSILAEQFP..........
A0A1E3PDH5_9ASCO/23-75 ...t-IING.--.ADSTITISYVDAPLVDKDNKESTAVL..KADGEAI.VGVEAVLKVLGEKFP..........
I2H3Y0_TETBL/23-64 ....RIVNN.SS.AN-AVDISFVEDKKAAPATLDG----..-------.-SSDDVLAKIVALSP..........
A0A1E3NJV1_9ASCO/23-76 ....AFINT.-S.SDGDIKLNFVDGKTVSKDVATS-AQL..LKGDETVsTDSIEILNYFGTEFP..........
#=GC seq_cons ....thlNu.sc.s-.uIslEFVD-Kslsssshsus.....s.sspsh..sspslLphLuptaP..........
//
