#=GF ID   Glyc_hyd_38C_2
#=GF AC   PF18230.5
#=GF DE   Glycosyl hydrolases family 38 C-terminal sub-domain
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF01469
#=GF GA   26.20 26.20;
#=GF TC   26.20 29.50;
#=GF NC   25.70 26.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0369
#=GF RN   [1]
#=GF RM   12960159
#=GF RT   Insights into the mechanism of Drosophila melanogaster Golgi
#=GF RT   alpha-mannosidase II through the structural analysis of covalent
#=GF RT   reaction intermediates.
#=GF RA   Numao S, Kuntz DA, Withers SG, Rose DR;
#=GF RL   J Biol Chem. 2003;278:48074-48083.
#=GF DR   INTERPRO; IPR041566;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a subdomain found in the C-terminal region of golgi
#=GF CC   alpha-mannosidase II present in Drosophila melanogaster. These
#=GF CC   proteins are important in glycoprotein processing and are
#=GF CC   thought to cleave mannosidic bonds through a double displacement
#=GF CC   mechanism involving a reaction intermediate.This subdomain is
#=GF CC   found at the C-terminal of Glycosyl hydrolases family 38
#=GF CC   C-terminal domain [1].
#=GF SQ   33
#=GS B4GP61_DROPE/1000-1088      AC B4GP61.1
#=GS A0A7R8URP5_HERIL/530-609    AC A0A7R8URP5.1
#=GS A0A6J2TL60_DROLE/1020-1111  AC A0A6J2TL60.1
#=GS A0A6I9UPU3_BACDO/391-478    AC A0A6I9UPU3.1
#=GS B4LW20_DROVI/1018-1111      AC B4LW20.1
#=GS A0A3B0K5A5_DROGU/1012-1100  AC A0A3B0K5A5.1
#=GS A0A0Q9WQX2_DROVI/1018-1112  AC A0A0Q9WQX2.1
#=GS MAN2_DROME/1019-1107        AC Q24451.2
#=GS A0A6P4HY50_DROKI/1018-1106  AC A0A6P4HY50.1
#=GS Q7PMM6_ANOGA/1047-1139      AC Q7PMM6.4
#=GS A0A084VTM1_ANOSI/1024-1116  AC A0A084VTM1.1
#=GS B4QWM5_DROSI/1019-1107      AC B4QWM5.1
#=GS A0A0Q9WPC2_DROVI/1018-1114  AC A0A0Q9WPC2.1
#=GS A0A6P4EYX1_DRORH/1019-1107  AC A0A6P4EYX1.1
#=GS B3M057_DROAN/1015-1103      AC B3M057.1
#=GS A0A6I8TLI4_AEDAE/1049-1140  AC A0A6I8TLI4.1
#=GS A0A6I8UMC4_DROPS/1012-1100  AC A0A6I8UMC4.1
#=GS Q16NG2_AEDAE/1048-1139      AC Q16NG2.1
#=GS B0WS34_CULQU/1040-1131      AC B0WS34.1
#=GS A0A0M4ERB8_DROBS/1015-1107  AC A0A0M4ERB8.1
#=GS B4K4Z8_DROMO/1019-1112      AC B4K4Z8.1
#=GS A0A182GXK5_AEDAL/1049-1140  AC A0A182GXK5.1
#=GS B4HKD8_DROSE/1019-1107      AC B4HKD8.1
#=GS B4JEK9_DROGR/1017-1109      AC B4JEK9.1
#=GS A0A6I9UXC6_BACDO/1042-1126  AC A0A6I9UXC6.1
#=GS A0A182YG16_ANOST/1050-1143  AC A0A182YG16.1
#=GS A0A6P8XMP2_DROAB/1019-1110  AC A0A6P8XMP2.1
#=GS A0A0L0C6C3_LUCCU/1040-1144  AC A0A0L0C6C3.1
#=GS A0A6J2THU7_DROLE/1009-1100  AC A0A6J2THU7.1
#=GS B4N8V8_DROWI/1015-1102      AC B4N8V8.1
#=GS A0A484B642_DRONA/1019-1112  AC A0A484B642.1
#=GS A0A6J0RL53_BACDO/1041-1125  AC A0A6J0RL53.1
#=GS A0A0B4KFG0_DROME/1020-1108  AC A0A0B4KFG0.1
B4GP61_DROPE/1000-1088                 .....................DLDVTVMRRLTK...N....T...A........K...TQRVGFVLHRTNLMQCGG.EEQQTEK...FDVCHLM..PHAD......RCE..RTTLTFLQVLEHFEPPTAPPLCAMETEAYVTSHT...
A0A7R8URP5_HERIL/530-609               ...............qvgdkr------------...-....-...-........T...QDRVGLIMHRTQIDECDI.SDNYSGK...INIRNLLglQNNA......EIF..SSPLTFVETNEKITTDH-VDFCPMEIKSFVI---qr.
A0A6J2TL60_DROLE/1020-1111             .....................DLDVVVMRRLSK...A....T...A........K...SQRIGFVLHRTQVQQCG-.VEPKAKK...FDVCSLL..ETGDqr..iiSCD..RSTLTFLQKLQQYEPKKAPALCPMETAAYVVTY-p..
A0A6I9UPU3_BACDO/391-478               ......kipvardrttkeplm------------...-....-...-........-...--NTGIVVHRTLLLQCHA.ADQQTGI...VNLSKLL..MLDTi....tGVY..NTSLTFLQSSQKLDSVESINLCPLDTQAYILQH-r..
B4LW20_DROVI/1018-1111                 .....................DLDVVVLRRLTN...S....T...A........K...KQRVGCVLHRTQLLQCN-.DESPVEK...FNVCNIL..QNEEeptltdRCQ..RTTLTFLQDLEQFEPKLAPLLCPMETAAYIISHN...
A0A3B0K5A5_DROGU/1012-1100             .....................DLDVTVMRRLTK...N....T...A........K...TQRVGYVLHRTNLMQCGG.EEQQTEK...FDVCHLM..PNAA......RCE..RTTLTFLQILEHFDPLIAPPLCPMETEAYVTSHS...
A0A0Q9WQX2_DROVI/1018-1112             .....................DLDVVVLRRLTN...S....T...A........K...KQRVGCVLHRTQLLQCND.ESPVEKQ...FNVCNIL..QNEEeptltdRCQ..RTTLTFLQDLEQFEPKLAPLLCPMETAAYIISHN...
MAN2_DROME/1019-1107                   .....................DLDVSVMRRLTK...S....S...A........K...TQRVGYVLHRTNLMQCGT.PEEHTQK...LDVCHLL..PNVA......RCE..RTTLTFLQNLEHLDGMVAPEVCPMETAAYVSSHS...
A0A6P4HY50_DROKI/1018-1106             .....................DLDVSVMRRLTK...S....T...A........K...TQRVGYVLHRTNLMQCGA.TENHSQK...LDVCHLL..PHTA......RCE..RTTLTFLQNLERFETMVAPEVCPMETAAYVSSHT...
Q7PMM6_ANOGA/1047-1139                 ....................g-LEVVAIRQLSH...VhfgrT...S........G...ASPVGLIVHRTNFEDCGS.EANMEGM...LNIKKLL..NLDDe....hDIY..SARLTLLKPLELVPSD-DISLCPMDAKAYIV---kr.
A0A084VTM1_ANOSI/1024-1116             ...................gm--EVVAMRELPH...V....RfgrA.......tS...GHPIGLVIHRTNFEDCGS.EANTEGL...LNIKKLL..NLDD......EHDifTAPLTLLKPQEMVQSDD-LTLCPMDAKAYIV---kr.
B4QWM5_DROSI/1019-1107                 .....................DLDVSVMRRLTK...S....S...A........K...TQRVGYVLHRTNLMQCGT.PEENAQK...LDVCHLL..PNVA......RCE..RTTLTFLQNLEHLDGMVAPEVCPMETAAYVSSHS...
A0A0Q9WPC2_DROVI/1018-1114             .....................DLDVVVLRRLTN...S....T...A........K...KQRVGCVLHRTQLLQCN-.DESPVEKvspFNVCNIL..QNEEeptltdRCQ..RTTLTFLQDLEQFEPKLAPLLCPMETAAYIISHN...
A0A6P4EYX1_DRORH/1019-1107             .....................DLDVPVMRRLTK...S....S...A........K...TQRVGFVVHRTNLMQCGA.AEEHAKK...LDVCHLL..PNTA......RCE..RTTLTFLQNLEQFESMVAPEVCPMETVAYVSSHT...
B3M057_DROAN/1015-1103                 .....................DLDVTVMRRLTK...S....S...A........K...TQRIGYVLHRTNLMQCGA.DNQLPQK...IDVCHLL..PNTA......KCE..RTTLTFLQTLEQLEPIVAPDVCPMETVAFVSSHT...
A0A6I8TLI4_AEDAE/1049-1140             ....................g-MEVVAMRSLPHvriG....K...D........K...RPCLGLVVHRTNFEDCGS.EASGEGN...LNIKKLL..DLDDg....hEIY..GSALTLLRKQEPVASDD-VSFCPMDTKAFII---qr.
A0A6I8UMC4_DROPS/1012-1100             .....................DLDVTVMRRLTK...N....T...A........K...TQRVGFVLHRTNLMQCGG.EEQQTEK...FDVCHLM..PHAD......HCE..RTTLTFLQVLEHFEPPTAPPLCAMETEAYVTSHT...
Q16NG2_AEDAE/1048-1139                 ....................g-MEVVAMRSLPHvriG....K...D........K...RPCLGLVVHRTNFEDCGS.EASGEGN...LNIKKLL..DLDDg....hEIY..GSALTLLRKQEPVASDD-VSFCPMDTKAFII---qr.
B0WS34_CULQU/1040-1131                 .....................DLELVAMRSLPHvklG....K...D........R...RPTIGLVVHRTNLEDCGS.EASGEGN...LSIKKLL..NLDDg....hEVY..ASPLTLLRRQEPVSAD-DLNLCPMDTKAFII---qr.
A0A0M4ERB8_DROBS/1015-1107             .....................DLDVVTVRRLSK...Y....T...S........K...TQRVGCVLHRTQLLQCG-.NELPADK...FNACNLL..PEAAaq.sdvSCH..RTTLTFLQQLEEFRQQKAAPLCPMDTAAYVISYS...
B4K4Z8_DROMO/1019-1112                 .....................DLDVVVMRRLTK...S....T...A........K...RQRVGCVLHRTQLLQCNE.EEAPVDT...FNICNVL..QSGTqr.qrqRCQ..RTSLTFLQNLEQFESQAAPPLCPMETGAYVISYS...
A0A182GXK5_AEDAL/1049-1140             ....................g-MEVVAMRSLPHvrvG....K...D........K...RPGIGLVVHRTNFEDCGS.EASGEGN...LNVKKLL..DLDDg....hEIY..SSALTLLRKQEPVPSD-DISLCPMDTKAFII---qr.
B4HKD8_DROSE/1019-1107                 .....................DLDVSVMRRLTK...S....S...A........K...TQRVGYVLHRTNLMQCGT.PEENAQK...LDVCHLL..PNVA......RCE..RTTLTFLQNLEHLDGMVAPEVCPMETAAYVSSHS...
B4JEK9_DROGR/1017-1109                 .....................DLDVVVMRRLTK...G....T...A........K...KQSIGCVLHRTQLLQCN-.EETPPDK...FNVCNVL..QADDqt.snhRCQ..RSTLTFLQILEQIEPKVAPQLCPMESAAYIISYS...
A0A6I9UXC6_BACDO/1042-1126             .........vardrtikeplm------------...-....-...-........-...--NTGIVVHRTLLLQCHA.ADQQTGI...VNLSKLL..MLDTi....tGVY..NTSLTFLQSSQKLDSVESINLCPLDTQAYILQH-r..
A0A182YG16_ANOST/1050-1143             ielvamrelphvhfgrtsaga------------...-....-...-........-...SPPVGLIVHRTNFEDCGS.EANMEGM...LNIKKLL..NLDDg....hDIY..SARLTLLNALELVQSDD-ISLCPMDAKAYIV---kr.
A0A6P8XMP2_DROAB/1019-1110             ...................at--DVVVMRRLSK...N....T...A........N...IQRIGCVLHRTQLMECS-.DARLEDK...FNACNLL..QNSDdp..svSCH..RSTLTFLQILENLEHKVAPVPCPMETNAYIISFS...
A0A0L0C6C3_LUCCU/1040-1144             .....................DMEIVVMRNLPA...S....S...AipaiardrKphmQQNTGLIIHRTNLMQCSGlQAQNTGE...LNLHHLL..QWGSqn..vsAVY..KTNLTFLKRLSSQKIDEDITLCPMDSLAFIL---qrh
A0A6J2THU7_DROLE/1009-1100             .....................DLDVVVMRRLSK...A....T...A........K...SQRIGFVLHRTQVQQCG-.VEPKAKK...FDVCSLL..ETGDqr..iiSCD..RSTLTFLQKLQQYEPKKAPALCPMETAAYVVTY-p..
B4N8V8_DROWI/1015-1102                 .....................DLDVVVMRRLSK...S....K...A........K...AQRVGFVLHRTSLVQCS-.SESQAEK...FNVCLVL..AHTA......RCE..RSTITFLDTLGLIESKMAPALCPMDTEAYVATT-n..
A0A484B642_DRONA/1019-1112             .....................ELDVVVMRRLTK...S....T...A........K...RQRVGCVLHRTQLLQCNE.EEAPVDN...FNICAVL..QTRAqr.qrqRCQ..RTSLTFLQDLEQFESQAAPPLCPMETGAYVISYS...
A0A6J0RL53_BACDO/1041-1125             .........vardrtikeplm------------...-....-...-........-...--NTGIVVHRTLLLQCHA.ADQQTGI...VNLSKLL..MLDTi....tGVY..NTSLTFLQSSQKLDSVESINLCPLDTQAYILQH-r..
A0A0B4KFG0_DROME/1020-1108             .....................DLDVSVMRRLTK...S....S...A........K...TQRVGYVLHRTNLMQCGT.PEEHTQK...LDVCHLL..PNVA......RCE..RTTLTFLQNLEHLDGMVAPEVCPMETAAYVSSHS...
#=GC seq_cons                          .....................DLDVsVMRRLo+...u....o...A........K...pQRlGhVLHRTpLhQCGs.p-ptspc...hNlC+LL...pss......cCp..RToLTFLQsLEph-sphAPsLCPMETtAYlloa....
//