#=GF ID Glyco_hydro_59_C
#=GF AC PF21708.1
#=GF DE Galactocerebrosidase, C-terminal lectin domain
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF SE ECOD:EF18094
#=GF GA 27.00 27.00;
#=GF TC 27.00 27.00;
#=GF NC 26.90 26.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0004
#=GF RC Paper describing PDB structure 3zr5
#=GF RN [1]
#=GF RM 21876145
#=GF RT Insights into Krabbe disease from structures of
#=GF RT galactocerebrosidase.
#=GF RA Deane JE, Graham SC, Kim NN, Stein PE, McNair R, Cachon-Gonzalez
#=GF RA MB, Cox TM, Read RJ;
#=GF RL Proc Natl Acad Sci U S A. 2011;108:15169-15173.
#=GF RC Paper describing PDB structure 4ccc
#=GF RN [2]
#=GF RM 24297913
#=GF RT Structural snapshots illustrate the catalytic cycle of
#=GF RT beta-galactocerebrosidase, the defective enzyme in Krabbe
#=GF RT disease.
#=GF RA Hill CH, Graham SC, Read RJ, Deane JE;
#=GF RL Proc Natl Acad Sci U S A. 2013;110:20479-20484.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is found at the C-terminal end of
#=GF CC Galactocerebrosidase from Mus musculus (GALCERase) and similar
#=GF CC proteins predominantly found in animals and bacteria. GALCERase
#=GF CC hydrolyses the galactose ester bonds of glycolipids such as
#=GF CC galactosylceramide and galactosylsphingosine. It is responsible
#=GF CC for the lysosomal catabolism of galactosylceramide, a major
#=GF CC lipid in myelin, kidney and epithelial cells of small intestine
#=GF CC and colon. This protein is organised into three domains, all of
#=GF CC them contributing residues to the substrate- binding pocket.
#=GF CC This entry represents the lectin domain, which is not present in
#=GF CC other lysosomal enzymes, is likely to be be involved in
#=GF CC processes that are not found in related enzymes. Mutations in
#=GF CC this domain lead to Krabbe disease [1].
#=GF SQ 1479
#=GS A0A8C7XC64_9TELE/292-403 AC A0A8C7XC64.1
#=GS A0A815K431_ADIRI/489-659 AC A0A815K431.1
#=GS F7C8M7_MONDO/516-670 AC F7C8M7.2
#=GS A0A6J3IM21_SAPAP/482-657 AC A0A6J3IM21.1
#=GS A0A8D2HGK6_UROPR/506-681 AC A0A8D2HGK6.1
#=GS A0A671MKZ7_9TELE/462-637 AC A0A671MKZ7.1
#=GS A0A8J7GP10_9ACTN/496-670 AC A0A8J7GP10.1
#=GS A0A6J0Z0Q6_ODOVR/496-671 AC A0A6J0Z0Q6.1
#=GS A0A8W8IWH6_CRAGI/140-312 AC A0A8W8IWH6.1
#=GS A0A671QH19_9TELE/486-650 AC A0A671QH19.1
#=GS A0A561WBP7_ACTTI/508-682 AC A0A561WBP7.1
#=GS A0A8V5FXT2_MELUD/500-675 AC A0A8V5FXT2.1
#=GS A0A091SU51_NESNO/443-617 AC A0A091SU51.1
#=GS A0A4W2EPF2_BOBOX/514-689 AC A0A4W2EPF2.1
#=GS A0A7W5AZ90_9BACL/870-1057 AC A0A7W5AZ90.1
#=GS A0A8B6FE20_MYTGA/393-571 AC A0A8B6FE20.1
#=GS A0A8B9G4K9_9PSIT/623-761 AC A0A8B9G4K9.1
#=GS A0A3P8WJC9_CYNSE/490-665 AC A0A3P8WJC9.1
#=GS A0A667GNF1_LYNCA/536-711 AC A0A667GNF1.1
#=GS A0A8V0ZAV9_CHICK/486-661 AC A0A8V0ZAV9.1
#=GS A0A7K8DWP3_LEURO/443-616 AC A0A7K8DWP3.1
#=GS A0A4W4G808_ELEEL/501-667 AC A0A4W4G808.1
#=GS A0A7F8QY42_LEPWE/509-556 AC A0A7F8QY42.1
#=GS H3CL19_TETNG/493-668 AC H3CL19.1
#=GS H2T8L4_TAKRU/563-738 AC H2T8L4.3
#=GS A0A8D2DAV3_SCIVU/298-444 AC A0A8D2DAV3.1
#=GS A0A1G6ZMS1_9SPHI/482-642 AC A0A1G6ZMS1.1
#=GS A0A8C9HEP1_9PRIM/486-661 AC A0A8C9HEP1.1
#=GS A0A226P748_COLVI/483-658 AC A0A226P748.1
#=GS A0A1C4S2U4_9ACTN/208-378 AC A0A1C4S2U4.1
#=GS A0A852CWN9_PASAF/496-669 AC A0A852CWN9.1
#=GS A0A7L1V8Z5_SITEU/443-616 AC A0A7L1V8Z5.1
#=GS A0A267E2J8_9PLAT/501-689 AC A0A267E2J8.1
#=GS A0A6P6R8X9_CARAU/488-663 AC A0A6P6R8X9.1
#=GS A0A671MDK5_9TELE/491-666 AC A0A671MDK5.1
#=GS A0A543C077_9ACTN/491-665 AC A0A543C077.1
#=GS A0A8C5BC55_GADMO/497-672 AC A0A8C5BC55.1
#=GS A0A3P9CKK1_9CICH/490-665 AC A0A3P9CKK1.1
#=GS T1FBT6_HELRO/27-95 AC T1FBT6.1
#=GS A0A8C1GYV8_CYPCA/300-351 AC A0A8C1GYV8.1
#=GS A0A8C0GP44_CHEAB/275-411 AC A0A8C0GP44.1
#=GS A0A452F6F4_CAPHI/514-689 AC A0A452F6F4.1
#=GS A0A7J5Y4J7_DISMA/501-674 AC A0A7J5Y4J7.1
#=GS A0A7J6AM73_AMEME/464-639 AC A0A7J6AM73.1
#=GS A0A852G024_PEUTA/257-430 AC A0A852G024.1
#=GS A0A452J2J4_9SAUR/520-695 AC A0A452J2J4.1
#=GS A0A8J1LJR8_XENLA/392-567 AC A0A8J1LJR8.1
#=GS A0A7L2VXY9_9AVES/412-585 AC A0A7L2VXY9.1
#=GS A0A8J3YHE1_9ACTN/452-621 AC A0A8J3YHE1.1
#=GS A0A8C5APE6_GADMO/475-637 AC A0A8C5APE6.1
#=GS A0A1H0GAU4_9BACI/599-788 AC A0A1H0GAU4.1
#=GS A0A8D0BZB4_SALMN/487-661 AC A0A8D0BZB4.1
#=GS A0A4W5JCQ5_9TELE/489-664 AC A0A4W5JCQ5.1
#=GS A0A124HH83_9ACTN/504-675 AC A0A124HH83.1
#=GS A0A8B7IBQ9_9AVES/453-628 AC A0A8B7IBQ9.1
#=GS A0A8W8IWI1_CRAGI/17-125 AC A0A8W8IWI1.1
#=GS A0A7L4DR85_9AVES/443-616 AC A0A7L4DR85.1
#=GS A0A851Z3I6_9AVES/399-574 AC A0A851Z3I6.1
#=GS A0A7K4J9W7_GEOCA/361-534 AC A0A7K4J9W7.1
#=GS L5MF48_MYODS/444-619 AC L5MF48.1
#=GS W2ETR3_9ACTN/482-654 AC W2ETR3.1
#=GS A0A1C4IKA2_9ACTN/496-669 AC A0A1C4IKA2.1
#=GS A0A6J3AKY8_VICPA/508-683 AC A0A6J3AKY8.1
#=GS A0A8D2QTH8_ZOSLA/391-566 AC A0A8D2QTH8.1
#=GS A0A3P8WM32_CYNSE/491-666 AC A0A3P8WM32.1
#=GS A0A4Y3V9I2_9ACTN/611-775 AC A0A4Y3V9I2.1
#=GS A0A6J3AMY7_VICPA/392-567 AC A0A6J3AMY7.1
#=GS A0A0M0JSS7_9EUKA/513-698 AC A0A0M0JSS7.1
#=GS A0A1M7QFL7_9ACTN/487-657 AC A0A1M7QFL7.1
#=GS A0A7K8T748_9AVES/514-687 AC A0A7K8T748.1
#=GS A0A7L2C0K1_9PASS/421-594 AC A0A7L2C0K1.1
#=GS A0A7K9IG12_9CORV/443-616 AC A0A7K9IG12.1
#=GS A0A8B8EEX8_CRAVI/495-671 AC A0A8B8EEX8.1
#=GS A0A672JXE8_SINGR/485-660 AC A0A672JXE8.1
#=GS A0A553RA47_9TELE/428-603 AC A0A553RA47.1
#=GS GALC_MOUSE/509-683 AC P54818.2
#=GS A0A6P6RNV9_CARAU/485-658 AC A0A6P6RNV9.1
#=GS A0A1H5L4I1_9MICO/897-1071 AC A0A1H5L4I1.1
#=GS A0A8J4DVG0_9ACTN/485-659 AC A0A8J4DVG0.1
#=GS A9UXR4_MONBE/517-624 AC A9UXR4.1
#=GS A0A0Q5B6F5_9MICO/667-844 AC A0A0Q5B6F5.1
#=GS A0A7L0SFZ5_PODPO/420-593 AC A0A7L0SFZ5.1
#=GS A0A812ISV7_9DINO/495-674 AC A0A812ISV7.1
#=GS A0A671XEJ8_SPAAU/499-671 AC A0A671XEJ8.1
#=GS A0A8C0FI01_BUBBB/484-659 AC A0A8C0FI01.1
#=GS A0A7L3AN26_9AVES/302-475 AC A0A7L3AN26.1
#=GS A0A5B8VIL5_9BACT/367-431 AC A0A5B8VIL5.1
#=GS A0A8C2XKZ1_CYCLU/509-684 AC A0A8C2XKZ1.1
#=GS A0A851WWV7_CORMO/399-572 AC A0A851WWV7.1
#=GS A0A7J8B025_PIPKU/480-655 AC A0A7J8B025.1
#=GS A0A091HBB8_BUCRH/432-606 AC A0A091HBB8.1
#=GS A0A8D2D9N4_SCIVU/448-582 AC A0A8D2D9N4.1
#=GS A0A0D0W050_9ACTN/498-670 AC A0A0D0W050.1
#=GS A0A4R5DH90_9ACTN/502-675 AC A0A4R5DH90.1
#=GS A0A1C0ZT62_9BACL/472-640 AC A0A1C0ZT62.1
#=GS A0A3Q7ULW0_VULVU/473-648 AC A0A3Q7ULW0.1
#=GS A0A8C4Z445_GADMO/483-658 AC A0A8C4Z445.1
#=GS A0A1S3HJ33_LINUN/497-677 AC A0A1S3HJ33.1
#=GS A0A6P5CHV9_BOSIN/470-645 AC A0A6P5CHV9.1
#=GS A0A8V0Z505_CHICK/500-675 AC A0A8V0Z505.1
#=GS A0A1H9ISV2_9FLAO/659-820 AC A0A1H9ISV2.1
#=GS A0A7I8V9S0_9ANNE/488-641 AC A0A7I8V9S0.1
#=GS A0A7K4XTC0_REGSA/205-378 AC A0A7K4XTC0.1
#=GS A0A7W7ZEF0_9BACT/487-660 AC A0A7W7ZEF0.1
#=GS A0A6P8TQZ4_GYMAC/335-510 AC A0A6P8TQZ4.1
#=GS A0A5N5N500_PANHP/491-666 AC A0A5N5N500.1
#=GS A0A268E7N3_9BACI/607-790 AC A0A268E7N3.1
#=GS A0A673VDP8_SURSU/486-661 AC A0A673VDP8.1
#=GS A0A7L0QE27_SETKR/459-632 AC A0A7L0QE27.1
#=GS A0A5F8GE17_MONDO/514-690 AC A0A5F8GE17.1
#=GS G1NJZ8_MELGA/500-675 AC G1NJZ8.2
#=GS A0A1S3WG58_ERIEU/486-661 AC A0A1S3WG58.1
#=GS A0A8B9G4S0_9PSIT/636-774 AC A0A8B9G4S0.1
#=GS A0A2S5X1T6_9MICO/735-912 AC A0A2S5X1T6.1
#=GS W5NYK8_SHEEP/514-689 AC W5NYK8.1
#=GS A0A8B9Q1T9_APTOW/458-633 AC A0A8B9Q1T9.1
#=GS A0A7K8M0C4_9CORV/507-680 AC A0A7K8M0C4.1
#=GS G0MGD2_CAEBE/196-367 AC G0MGD2.1
#=GS A0A3R8TG75_9ACTN/618-782 AC A0A3R8TG75.1
#=GS A0A261G584_9BIFI/611-801 AC A0A261G584.1
#=GS A0A7L0PHA7_9AVES/398-571 AC A0A7L0PHA7.1
#=GS A0A267DRE3_9PLAT/122-303 AC A0A267DRE3.1
#=GS A0A329LLS2_9BACL/884-1071 AC A0A329LLS2.1
#=GS A0A7K8W1B2_9FURN/496-669 AC A0A7K8W1B2.1
#=GS A0A0P7V3A0_SCLFO/435-470 AC A0A0P7V3A0.1
#=GS A0A428N015_9BACI/579-783 AC A0A428N015.1
#=GS A0A4W3H0C3_CALMI/479-651 AC A0A4W3H0C3.1
#=GS A0A4W4HDX9_ELEEL/435-609 AC A0A4W4HDX9.1
#=GS A0A7K8LG75_9GRUI/496-669 AC A0A7K8LG75.1
#=GS A0A6J1ZYC7_ACIJB/509-644 AC A0A6J1ZYC7.1
#=GS A0A8C8M8W0_ONCTS/489-664 AC A0A8C8M8W0.1
#=GS A0A430FL39_9BIFI/602-786 AC A0A430FL39.1
#=GS A0A8C3LZC7_CHRPC/500-675 AC A0A8C3LZC7.1
#=GS GALC_XENLA/499-674 AC Q498K0.2
#=GS GALC_CANLF/493-668 AC P54804.1
#=GS A0A669E2B0_ORENI/490-665 AC A0A669E2B0.1
#=GS A0A8C4FKG3_9TELE/460-627 AC A0A8C4FKG3.1
#=GS A0A484C5P7_PERFV/530-705 AC A0A484C5P7.1
#=GS A0A8B7WBQ5_CASCN/502-677 AC A0A8B7WBQ5.1
#=GS A0A2R9AN43_PANPA/486-661 AC A0A2R9AN43.1
#=GS A0A6J2S1Z9_COTGO/489-664 AC A0A6J2S1Z9.1
#=GS A0A498CA15_9MICO/881-1052 AC A0A498CA15.1
#=GS D9T230_MICAI/501-674 AC D9T230.1
#=GS A0A2I4AKI9_9TELE/1-122 AC A0A2I4AKI9.1
#=GS A0A5F9C272_RABIT/486-661 AC A0A5F9C272.1
#=GS A0A8D0DAR0_SANLU/603-653 AC A0A8D0DAR0.1
#=GS A0A8C9HJT2_9PRIM/509-684 AC A0A8C9HJT2.1
#=GS H3BG35_LATCH/392-567 AC H3BG35.1
#=GS A0A2C1KH60_9BACI/565-769 AC A0A2C1KH60.1
#=GS A0A2K6D8N8_MACNE/453-586 AC A0A2K6D8N8.1
#=GS A0A1H1RRP9_9BACL/518-707 AC A0A1H1RRP9.1
#=GS A0A2R9AG83_PANPA/483-658 AC A0A2R9AG83.1
#=GS A0A669CYQ2_ORENI/489-664 AC A0A669CYQ2.1
#=GS A0A7M7NZ15_STRPU/492-665 AC A0A7M7NZ15.1
#=GS A0A8C7H5T4_ONCKI/459-634 AC A0A8C7H5T4.1
#=GS A0A663M7Y8_ATHCN/497-672 AC A0A663M7Y8.1
#=GS A0A7J6C028_9TELE/485-660 AC A0A7J6C028.1
#=GS A0A4U1FNN9_MONMO/502-677 AC A0A4U1FNN9.1
#=GS A0A8W8J061_CRAGI/1-93 AC A0A8W8J061.1
#=GS A0A674F5L0_SALTR/499-674 AC A0A674F5L0.1
#=GS A0A6P7T7L8_OCTVU/501-679 AC A0A6P7T7L8.1
#=GS A0A091P7V6_LEPDC/247-421 AC A0A091P7V6.1
#=GS A0A7J6C4W2_9TELE/497-672 AC A0A7J6C4W2.1
#=GS A0A6I9JAD1_CHRAS/509-684 AC A0A6I9JAD1.1
#=GS A0A329QHI5_9ACTN/495-668 AC A0A329QHI5.1
#=GS F6ZPN8_MONDO/516-690 AC F6ZPN8.2
#=GS A0A543BZX2_9ACTN/602-676 AC A0A543BZX2.1
#=GS G8X446_STREN/477-649 AC G8X446.1
#=GS A0A8I3N237_CANLF/509-684 AC A0A8I3N237.1
#=GS A0A671N629_9TELE/491-666 AC A0A671N629.1
#=GS G3SWK6_LOXAF/509-683 AC G3SWK6.1
#=GS A0A673JWZ8_9TELE/455-630 AC A0A673JWZ8.1
#=GS A0A7N6AA10_ANATE/505-680 AC A0A7N6AA10.1
#=GS A0A8C8I1X6_ONCTS/450-615 AC A0A8C8I1X6.1
#=GS A0A812E8S5_SEPPH/449-627 AC A0A812E8S5.1
#=GS A0A7Y0ENR9_9BIFI/571-757 AC A0A7Y0ENR9.1
#=GS A0A6J3IM16_SAPAP/554-729 AC A0A6J3IM16.1
#=GS A0A8C2XJW0_CYCLU/508-683 AC A0A8C2XJW0.1
#=GS A0A4V2FYM5_9ACTN/478-650 AC A0A4V2FYM5.1
#=GS A0A3E0GWG1_9PSEU/499-671 AC A0A3E0GWG1.1
#=GS A0A665TAM2_ECHNA/489-664 AC A0A665TAM2.1
#=GS R6QYY4_9FIRM/519-690 AC R6QYY4.1
#=GS W6S3I8_9CLOT/62-203 AC W6S3I8.1
#=GS A0A673KG89_9TELE/455-630 AC A0A673KG89.1
#=GS R6VI63_9FIRM/617-792 AC R6VI63.1
#=GS A0A8B6E3B3_MYTGA/491-667 AC A0A8B6E3B3.1
#=GS A0A671XEQ6_SPAAU/481-657 AC A0A671XEQ6.1
#=GS A0A369B2P1_9FIRM/588-775 AC A0A369B2P1.1
#=GS A0A7L3LCB9_9CHAR/497-670 AC A0A7L3LCB9.1
#=GS A0A8C8M8W2_ONCTS/466-641 AC A0A8C8M8W2.1
#=GS A0A0P7V3A0_SCLFO/514-563 AC A0A0P7V3A0.1
#=GS A0A7K4S6N3_COLPI/511-684 AC A0A7K4S6N3.1
#=GS A0A7K7T978_9TYRA/404-577 AC A0A7K7T978.1
#=GS A0A6Q2ZF59_ESOLU/473-648 AC A0A6Q2ZF59.1
#=GS A0A7K4K5U5_9AVES/420-593 AC A0A7K4K5U5.1
#=GS A0A2L0N9G4_9ACTN/503-675 AC A0A2L0N9G4.1
#=GS F0RXK4_SPHGB/74-211 AC F0RXK4.1
#=GS A0A6G1ADT7_CROCR/401-576 AC A0A6G1ADT7.1
#=GS A0A7K5X2Q6_9SYLV/496-669 AC A0A7K5X2Q6.1
#=GS A0A433SSY3_ELYCH/497-672 AC A0A433SSY3.1
#=GS A0A5Q2W049_9CELL/585-755 AC A0A5Q2W049.1
#=GS A0A4Q2L8W1_9MICO/611-797 AC A0A4Q2L8W1.1
#=GS A0A8C6FKU4_MOSMO/486-661 AC A0A8C6FKU4.1
#=GS A0A665TM28_ECHNA/502-677 AC A0A665TM28.1
#=GS A0A8C9N353_SERCA/498-673 AC A0A8C9N353.1
#=GS A0A561EI18_9ACTN/494-667 AC A0A561EI18.1
#=GS A0A6J8ALV8_MYTCO/47-229 AC A0A6J8ALV8.1
#=GS A0A8C5FTW1_GADMO/468-643 AC A0A8C5FTW1.1
#=GS A0A850X022_PIACA/304-477 AC A0A850X022.1
#=GS A0A668V9T6_OREAU/487-621 AC A0A668V9T6.1
#=GS A0A430FWN8_9BIFI/584-768 AC A0A430FWN8.1
#=GS A0A668VCQ4_OREAU/465-635 AC A0A668VCQ4.1
#=GS A0A7F8QW41_LEPWE/457-590 AC A0A7F8QW41.1
#=GS A0A8C4THD5_ERPCA/505-680 AC A0A8C4THD5.1
#=GS A0A3P9P7G2_POERE/493-668 AC A0A3P9P7G2.1
#=GS A0A2K5XQK5_MANLE/486-661 AC A0A2K5XQK5.1
#=GS A0A7N6A6L6_ANATE/499-674 AC A0A7N6A6L6.1
#=GS A0A1S3IXV0_LINUN/498-681 AC A0A1S3IXV0.1
#=GS R0JZ07_ANAPL/399-574 AC R0JZ07.1
#=GS A0A6Q2YD54_ESOLU/429-604 AC A0A6Q2YD54.1
#=GS A0A1H3VYR8_9SPHI/487-588 AC A0A1H3VYR8.1
#=GS A0A7K5RWT4_LANLU/443-616 AC A0A7K5RWT4.1
#=GS A0A2I3M510_PAPAN/453-587 AC A0A2I3M510.1
#=GS A0A8B9NL08_9AVES/498-642 AC A0A8B9NL08.1
#=GS A0A7I8EKU5_9CHLR/502-674 AC A0A7I8EKU5.1
#=GS A0A852L3U6_UROIN/399-572 AC A0A852L3U6.1
#=GS A0A337S656_FELCA/486-661 AC A0A337S656.1
#=GS A0A3B5PS37_XIPMA/492-614 AC A0A3B5PS37.1
#=GS I3JW33_ORENI/482-657 AC I3JW33.2
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