#=GF ID Glyco_hydro_84_hel
#=GF AC PF21809.1
#=GF DE Bacterial GH84, post-catalytic domain
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF SE ECOD:EF17133
#=GF GA 27.00 27.00;
#=GF TC 27.00 27.10;
#=GF NC 26.90 26.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0770
#=GF RC Paper describing PDB structure 2chn
#=GF RN [1]
#=GF RM 16565725
#=GF RT Structure and mechanism of a bacterial beta-glucosaminidase
#=GF RT having O-GlcNAcase activity.
#=GF RA Dennis RJ, Taylor EJ, Macauley MS, Stubbs KA, Turkenburg JP,
#=GF RA Hart SJ, Black GN, Vocadlo DJ, Davies GJ;
#=GF RL Nat Struct Mol Biol. 2006;13:365-371.
#=GF RC Paper describing PDB structure 2j47
#=GF RN [2]
#=GF RM 17057847
#=GF RT Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a
#=GF RT PUGNAc-imidazole hybrid inhibitor.
#=GF RA Shanmugasundaram B, Debowski AW, Dennis RJ, Davies GJ, Vocadlo
#=GF RA DJ, Vasella A;
#=GF RL Chem Commun (Camb). 2006;42:4372-4374.
#=GF RC Paper describing PDB structure 2j4g
#=GF RN [3]
#=GF RM 17227027
#=GF RT Analysis of PUGNAc and NAG-thiazoline as transition state
#=GF RT analogues for human O-GlcNAcase: mechanistic and structural
#=GF RT insights into inhibitor selectivity and transition state poise.
#=GF RA Whitworth GE, Macauley MS, Stubbs KA, Dennis RJ, Taylor EJ,
#=GF RA Davies GJ, Greig IR, Vocadlo DJ;
#=GF RL J Am Chem Soc. 2007;129:635-644.
#=GF RC Paper describing PDB structure 2jiw
#=GF RN [4]
#=GF RM 17728868
#=GF RT A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a
#=GF RT diverse group of beta-N-acetylglucosaminidases.
#=GF RA Scaffidi A, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Vocadlo
#=GF RA DJ, Stick RV;
#=GF RL Org Biomol Chem. 2007;5:3013-3019.
#=GF RC Paper describing PDB structure 2vvn
#=GF RN [5]
#=GF RM 18587388
#=GF RT A potent mechanism-inspired O-GlcNAcase inhibitor that blocks
#=GF RT phosphorylation of tau in vivo.
#=GF RA Yuzwa SA, Macauley MS, Heinonen JE, Shan X, Dennis RJ, He Y,
#=GF RA Whitworth GE, Stubbs KA, McEachern EJ, Davies GJ, Vocadlo DJ;
#=GF RL Nat Chem Biol. 2008;4:483-490.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is a helical domain found after the catalytic domain of
#=GF CC enzymes from the Glycoside hydrolase family 84 from Bacteroides
#=GF CC spp. and certain pathogenic Clostridia spp [1-5].
#=GF SQ 140
#=GS A0A1C0BUZ3_9FIRM/505-635 AC A0A1C0BUZ3.1
#=GS U6RP73_9BACT/458-591 AC U6RP73.1
#=GS A0A1B1SAN9_9BACT/489-599 AC A0A1B1SAN9.1
#=GS K5YU73_9BACT/455-586 AC K5YU73.1
#=GS R6FHS5_9BACE/460-593 AC R6FHS5.1
#=GS A0A386HRN4_9BACT/456-588 AC A0A386HRN4.1
#=GS A0A4Q0XFA3_9FLAO/480-611 AC A0A4Q0XFA3.1
#=GS A0A0U1KKE7_9BACI/499-628 AC A0A0U1KKE7.1
#=GS A0A6B3L3Z2_9BACT/465-609 AC A0A6B3L3Z2.1
#=GS A0A0F5IUT0_9BACT/458-590 AC A0A0F5IUT0.1
#=GS A0A386PG59_CLOSE/503-633 AC A0A386PG59.1
#=GS A0A176T2Z5_9FLAO/455-586 AC A0A176T2Z5.1
#=GS R7J9B6_9BACT/458-589 AC R7J9B6.1
#=GS A0A1A5WYP7_9BACL/324-429 AC A0A1A5WYP7.1
#=GS A0A1B8W800_9BACI/505-636 AC A0A1B8W800.1
#=GS R5J5E7_9BACE/489-601 AC R5J5E7.1
#=GS A0A7X3LFE6_9BACL/471-605 AC A0A7X3LFE6.1
#=GS A0A3A9J8K6_9FIRM/499-635 AC A0A3A9J8K6.1
#=GS W0ERV8_9BACT/488-598 AC W0ERV8.1
#=GS R6EZS8_9BACT/481-593 AC R6EZS8.1
#=GS A0A6M1UCE8_9BACL/323-428 AC A0A6M1UCE8.1
#=GS A0A1Y3VRM0_9BACT/458-590 AC A0A1Y3VRM0.1
#=GS A0A0U1KMN7_9BACI/501-632 AC A0A0U1KMN7.1
#=GS A0A844LRC1_9BACI/505-635 AC A0A844LRC1.1
#=GS A0A7G6YTZ6_9BACT/459-591 AC A0A7G6YTZ6.1
#=GS A0A1Y0ITS6_9BACL/392-491 AC A0A1Y0ITS6.1
#=GS R6ATL1_9BACT/465-588 AC R6ATL1.1
#=GS A0A264Y6M6_9BACT/490-600 AC A0A264Y6M6.1
#=GS R5PKS8_9BACT/457-586 AC R5PKS8.1
#=GS A0A089IFC7_9BACL/505-636 AC A0A089IFC7.1
#=GS A0A851GCH8_9BACT/468-612 AC A0A851GCH8.1
#=GS R6ZTR2_9BACE/478-591 AC R6ZTR2.1
#=GS A0A0A2DVJ6_9PORP/463-591 AC A0A0A2DVJ6.1
#=GS A0A2V1IXG8_9BACT/458-587 AC A0A2V1IXG8.1
#=GS Q8XKW3_CLOPE/503-632 AC Q8XKW3.1
#=GS B5CLB0_9FIRM/513-643 AC B5CLB0.1
#=GS A0A521EA67_9BACT/479-611 AC A0A521EA67.1
#=GS A0A416GF92_9BACE/459-589 AC A0A416GF92.1
#=GS R6BKI9_9FIRM/104-211 AC R6BKI9.1
#=GS A0A3N2M0D5_9BACT/486-591 AC A0A3N2M0D5.1
#=GS A0A088F1P6_9SPHI/445-579 AC A0A088F1P6.1
#=GS A0A1I0FGC0_9FIRM/501-632 AC A0A1I0FGC0.1
#=GS A0A3L7Z5V0_9BACE/460-593 AC A0A3L7Z5V0.1
#=GS A0A1M6QHD4_9BACT/467-611 AC A0A1M6QHD4.1
#=GS A0A5B7UHU8_9FLAO/461-588 AC A0A5B7UHU8.1
#=GS A0A5C7F2J2_9ACTN/521-596 AC A0A5C7F2J2.1
#=GS A0A1M4TDS2_9BACE/494-627 AC A0A1M4TDS2.1
#=GS A0A4Y9J9N5_9LACT/477-607 AC A0A4Y9J9N5.1
#=GS A0A1H3ZFQ9_9BACT/490-624 AC A0A1H3ZFQ9.1
#=GS A0A1Y4HVB4_9BACT/462-594 AC A0A1Y4HVB4.1
#=GS R5GVV4_9BACT/459-588 AC R5GVV4.1
#=GS A0A7X3LIX7_9BACL/505-636 AC A0A7X3LIX7.1
#=GS R6D9W8_9BACE/485-598 AC R6D9W8.1
#=GS Z4WQS1_9PORP/454-588 AC Z4WQS1.1
#=GS A0A0B7HD93_9FLAO/461-591 AC A0A0B7HD93.1
#=GS R6NST8_9BACE/488-601 AC R6NST8.1
#=GS A6LB41_PARD8/458-590 AC A6LB41.1
#=GS Q5L8V6_BACFN/460-593 AC Q5L8V6.1
#=GS A0A6N1DWQ0_9MOLU/517-647 AC A0A6N1DWQ0.1
#=GS R7PD06_9BACT/451-583 AC R7PD06.1
#=GS A0A374VER7_9BACE/460-587 AC A0A374VER7.1
#=GS A0A3A9I4Q2_9FIRM/520-651 AC A0A3A9I4Q2.1
#=GS R7PAD6_9BACT/502-636 AC R7PAD6.1
#=GS A0A3N2NFE2_9BACT/479-590 AC A0A3N2NFE2.1
#=GS A0A174R002_9BACE/460-590 AC A0A174R002.1
#=GS F3PSW1_9BACE/482-609 AC F3PSW1.1
#=GS A0A7X3LIF4_9BACL/532-662 AC A0A7X3LIF4.1
#=GS A0A3P1ZZM2_9BACE/460-587 AC A0A3P1ZZM2.1
#=GS A0A1Y4HKN9_9BACT/486-600 AC A0A1Y4HKN9.1
#=GS W4P431_9BACE/466-599 AC W4P431.1
#=GS A0A5P8E888_9BACT/457-569 AC A0A5P8E888.1
#=GS R5R199_9FIRM/503-634 AC R5R199.1
#=GS A0A0N7JE82_9SPHI/455-587 AC A0A0N7JE82.1
#=GS A0A060RDN5_9BACT/472-586 AC A0A060RDN5.1
#=GS A0A4S2DS98_9CLOT/533-665 AC A0A4S2DS98.1
#=GS A0A6F9ZCL4_9BACT/458-591 AC A0A6F9ZCL4.1
#=GS A0A2V3PW60_9BACT/485-598 AC A0A2V3PW60.1
#=GS A0A3S1BRH9_9BACL/510-644 AC A0A3S1BRH9.1
#=GS R6QQA7_9CLOT/518-650 AC R6QQA7.1
#=GS F9YSQ8_CAPCC/455-585 AC F9YSQ8.1
#=GS R6YF95_9BACE/459-592 AC R6YF95.1
#=GS A0A1M5BS16_9FLAO/455-586 AC A0A1M5BS16.1
#=GS R7EXG0_9BACT/473-590 AC R7EXG0.1
#=GS R7DI99_9BACT/487-599 AC R7DI99.1
#=GS E6SP84_BACT6/450-584 AC E6SP84.1
#=GS A0A6I1MLV5_9CLOT/503-635 AC A0A6I1MLV5.1
#=GS I3ZYJ0_ORNRL/447-579 AC I3ZYJ0.1
#=GS A0A2V1IWH4_9BACT/489-595 AC A0A2V1IWH4.1
#=GS A0A416G6G2_9BACE/457-591 AC A0A416G6G2.1
#=GS R6DTK6_9BACE/460-593 AC R6DTK6.1
#=GS R6AFC8_9BACT/453-573 AC R6AFC8.1
#=GS A0A168PKE9_9BACL/505-636 AC A0A168PKE9.1
#=GS E6SUN0_BACT6/485-598 AC E6SUN0.1
#=GS I1A4I0_9MOLU/509-640 AC I1A4I0.1
#=GS B2ULA9_AKKM8/440-571 AC B2ULA9.1
#=GS A0A0B7IBM0_9FLAO/433-563 AC A0A0B7IBM0.1
#=GS F0F3I2_9BACT/512-618 AC F0F3I2.1
#=GS A0A0A7G0Y7_9CLOT/508-641 AC A0A0A7G0Y7.1
#=GS A0A2T5BZK7_9BACT/516-653 AC A0A2T5BZK7.1
#=GS R5IRU5_9BACT/487-601 AC R5IRU5.1
#=GS A0A1Y4KUX9_9FIRM/742-868 AC A0A1Y4KUX9.1
#=GS R6RX87_9BACE/460-592 AC R6RX87.1
#=GS L1MFZ6_9BACT/460-596 AC L1MFZ6.1
#=GS R5B081_9BACE/491-597 AC R5B081.1
#=GS A0A168PKD7_9BACL/499-630 AC A0A168PKD7.1
#=GS L1QDW6_9CLOT/1355-1489 AC L1QDW6.1
#=GS A0A368URW5_9BACT/470-608 AC A0A368URW5.1
#=GS A0A0A2E4W9_9PORP/462-589 AC A0A0A2E4W9.1
#=GS A0A383TVX0_9FLAO/437-569 AC A0A383TVX0.1
#=GS A0A4Y1WX61_9BACT/485-594 AC A0A4Y1WX61.1
#=GS A0A4Y9A9P0_9BACI/582-712 AC A0A4Y9A9P0.1
#=GS A0A3P1ZAK1_9BACT/458-600 AC A0A3P1ZAK1.1
#=GS M8DHB3_9BACL/323-428 AC M8DHB3.1
#=GS A0A6I1MSJ0_9CLOT/509-641 AC A0A6I1MSJ0.1
#=GS A0A1T5C4D2_9BACT/460-592 AC A0A1T5C4D2.1
#=GS A0A1H6KQU7_9BACT/429-555 AC A0A1H6KQU7.1
#=GS A0A0X7BE80_9FLAO/485-616 AC A0A0X7BE80.1
#=GS A0A1Y4NGK2_9FIRM/514-647 AC A0A1Y4NGK2.1
#=GS R5CB31_9BACE/460-592 AC R5CB31.1
#=GS A0A4Y8WPS9_9PORP/471-587 AC A0A4Y8WPS9.1
#=GS R5CGB7_9BACE/458-587 AC R5CGB7.1
#=GS A0A0F5JDX6_9BACT/451-582 AC A0A0F5JDX6.1
#=GS A0A416GE76_9BACE/462-587 AC A0A416GE76.1
#=GS A6L220_PHOV8/458-591 AC A6L220.1
#=GS R7LGQ5_9BACT/470-601 AC R7LGQ5.1
#=GS A0A3A1UZA4_9BACL/488-619 AC A0A3A1UZA4.1
#=GS W7YKG7_9BACL/506-637 AC W7YKG7.1
#=GS R5I0U9_9BACT/465-577 AC R5I0U9.1
#=GS A0A1D9ML85_9ACTO/497-628 AC A0A1D9ML85.1
#=GS A0A5B8VJG6_9BACT/508-609 AC A0A5B8VJG6.1
#=GS OGA_BACTN/460-590 AC Q89ZI2.1
#=GS C9MP37_9BACT/502-609 AC C9MP37.1
#=GS A0A1I2K6H8_9CLOT/502-632 AC A0A1I2K6H8.1
#=GS R5W6L0_9BACE/495-609 AC R5W6L0.1
#=GS A0A1Y4N0Z0_9FIRM/554-686 AC A0A1Y4N0Z0.1
#=GS A0A2R7KIX2_9SPHI/461-593 AC A0A2R7KIX2.1
#=GS A0A075R0Z5_BRELA/324-432 AC A0A075R0Z5.1
#=GS A0A386PDR4_CLOSE/508-637 AC A0A386PDR4.1
#=GS A0A1T5C4Z8_9BACT/460-592 AC A0A1T5C4Z8.1
#=GS R5UXJ6_9BACT/460-592 AC R5UXJ6.1
A0A1C0BUZ3_9FIRM/505-635 ..........................ESVELKAKLNEF..KEKL...KQ..N..L....-.V.T..E..A....D.VDQIKAEFETLQKATDVFTAQ....GG......D..ERLLEQMKYWLEC.WKETNDA..AI.NYLNA....I...........KA.....D...L............Nr.dS......S....G...L...L...A.Y.Q...T..K...-.-.-.-.-.AK.E..SFD..Q..S..K..E.......H.AF..Wyv...dhYE.KAEV...GVQHIVPFINT--la........................................................
U6RP73_9BACT/458-591 ..........................ESVALQPVAQSF..TDSY...IK..G..E....K.Y.N..E..N....D.YAALQETFGRMAESGDILLTD....AE......N..TPLVKEMKPWLTQ.FKLLGET..GE.EVLAM....A...........KAy..enG...N............Q...E......L....F...M...R...K.Y.K...H..V...K.A.L.Q.Q.QM.F..QID..Q..T..Y..N.......Q.NP..Y.......QP.GVKT...ATKVIKPLIDQTF..........................................................
A0A1B1SAN9_9BACT/489-599 ..................tstfslne------------..----...--..-..-....-.Y.T..P..E....K.AAAMLAEFEKIEKVPATMEAK....CN......N..QLLMKELKPWLTE.FGKLGKR..GV.EAIGL....I...........EQy..raG...N............D...S......I....F...W...T...G.Y.V...D..A...L.M.T.P.E.ER.K..AY-..-..-..-..-.......-.--..-.......-D.AHKS...GTLKLQPFIE---nal.......................................................
K5YU73_9BACT/455-586 ..........................ESVRNAGYAGAF..LLDF...RQ..-..H....R.Y.N..A..D....A.ADQMNRLFAEIAAAPAAIETS....-R......N..KALIDEIKPWLMQ.FHLLGKA..GQ.AAIRT....A...........EAg..qgQ...D............R...A......A....T...W...Q...S.Y.L...S..L...T.S.L.L.D.SM.R..TID..R..T..Y..N.......Q.NP..Y.......QK.GVKV...GSRVLTPFVQEI-h.........................................................
R6FHS5_9BACE/460-593 ..........................ESVALQPALQAL..LSAY...KE..N..G....T.I.D..E..N....A.FSQVETECRKIVEAADCLMAS....QE......N..MALITEIEPWLMQ.FKLVGQY..GE.SVLRM....L...........QSl..kaS...D............A...E......A....F...D...A...A.Y.A...H..A...K.A.L.Q.M.LM.Y..KID..T..S..Y..N.......Q.NP..Y.......QP.GVKS...GSKELLPTFNALF..........................................................
A0A386HRN4_9BACT/456-588 ..........................ESVQIKPAIDKY..LSDL...SK..K..-....D.Y.H..S..D....S.TEILKSYFSEISKAPVEIRSK....AK......N..KALIKEIDPWLTQ.FHLLGLA..GT.EALQM....V...........GYy..gkG...A............H...K......D....A...W...E...S.Y.L...K..L...E.K.I.F.A.KM.D..SVD..K..N..N..N.......Q.NP..Y.......QK.GVKT...GSLILMPFINNLY..........................................................
A0A4Q0XFA3_9FLAO/480-611 ..........................ESVSFAPKATVF..LQKL...EA..N..Q....Q.I.D..-..-....N.LEAIQNEFQSMVEASYILLNS....TD......N..PVLLDEIRPWVKQ.FQLLGQS..GL.AMLHM....Y...........KAl..edK...Q............T...E......R....F...E...R...S.Y.Q...A..L...K.A.M.K.A.QM.Y..AID..R..T..E..N.......Q.NP..Y.......QP.GVKT...GTLVVSPLIDKGF..........................................................
A0A0U1KKE7_9BACI/499-628 ..........................ESEEIKPLLEQF..NQKY...NA..N..E....S.I.I..D..I....G.-NTLIEEFEKIAKASDTFMQN....SQ......N..ERMKEQVEPFAKS.LKDLAHA..SI.AFINT....Ai........alEN.....N...N............D...N......A....V...W...A...N.F.S...Q..G...K.A.-.-.-.--.-..---..-..-..-..-.......-.--..-.......--.----...-------------aydsskthdrpvingtkkalpgskrlipfaenl.........................
A0A6B3L3Z2_9BACT/465-609 ..........................ESVEIKPAVDKA..LANY...RQ..N..Q....Q.L.S..A..E....D.AQVLLAEFAEITAAADKMITTl..pQT......D..PALWHEIEFWVKS.FKALGDA..GT.AAVKL....A...........SG.....Kg.gD............G...Na...hlA....L...F...S...V.I.A...N..S...K.A.L.Q.Q.DF.Y..DAQ..K..Q..R..HfeetfasD.KQ..W.......AK.GCKV...STLVLTPLVDELF..........................................................
A0A0F5IUT0_9BACT/458-590 ..........................ESARYEKQANRF..LTSY...RN..-..G....S.F.G..E..R....D.GNLLGALFAQIQAAPELIYNQ....GD......N..KRLIEEINPWLMQ.FELLGRC..GT.NALRM....A...........HAw..yeK...D............R...Q......N....T...W...Q...R.F.L...E..V...S.A.V.M.D.SM.K..LIN..R..T..F..N.......Q.NP..Y.......QK.GVKV...GTRVLMPLIEGL-y.........................................................
A0A386PG59_CLOSE/503-633 ..........................ESEEIKPIIEEF..TRML...RA..N..E....S.I.L..E..Y....S.-NVVLAEYNEILDATINFENK....SK......N..ELMKKEIKPWVDS.LKALAES..TI.AYINS....A...........--.....-...-............-...-......-....-...-...-...-.-.-...-..-...-.-.-.-.-.--.-..---..-..-..-..-.......-.--..-.......--.----...-------------iefekgnyekamiyygegadkytlsrsyridlindrkarpepgtkrlipfikdl....
A0A176T2Z5_9FLAO/455-586 ..........................ESVSFSPKATAF..LKQL...KA..G..E....N.I.D..-..-....D.FKAVENEFHAMVEASYILLNS....SD......N..AVLLDEIRPWVQQ.FKLLGQS..GL.GMLHM....Yt........slQA.....K...K............T...D......D....F...E...R...S.Y.N...A..I...I.A.V.K.E.EM.Y..QID..R..T..K..N.......Q.NP..Y.......QP.GVKT...ATLVATPLIDDSF..........................................................
R7J9B6_9BACT/458-589 ..........................ESVRIKPVLDEF..LQQI...LQ..N..A....A.T.F..K..E....D.--EVRTEFENIVYAADLLMAN....ED......N..PYLTAEIDPWFHQ.FKTLGEM..GI.EVMNL....Y...........KA.....W...Qe.........qyQ...E......A....F...L...K...S.Y.R...H..L...R.A.L.Q.H.AW.Y..KYD..M..T..M..N.......Q.EV..Q.......QP.GIKT...GSKVLKPFIDKLF..........................................................
A0A1A5WYP7_9BACL/324-429 ......spalleaflqfrfqflygdr------------..----...--..-..-....-.-.-..Q..A....G.LRMLGRVFADMEETALHLLER....MR......N..RKLAAEIGGWVEK.YRHWAKV..GQ.AVTAM....I...........EA.....G...T............S...G......R....T...L...R...A.A.Y...H..L...L.R.L.K.H.WM.K..RTE..-..-..-..-.......-.--..-.......--.----...-------------rlpqk.....................................................
A0A1B8W800_9BACI/505-636 ..........................ESENIKAELEQF..SSRF...AG..G..Q....S.V.E..G..-....V.GQTLIAEFDHVLQAIESFREK....SQ......N..PSMVEEIDPWLSS.LRYVAES..SK.YAAQS....A...........IS.....L...Q............K...G......E....L...G...A...A.W.E...G..L..aK.A.T.N.A.LS.E..SKK..M..K..I..K.......K.LN..Y......pDV.TVEA...GAKRLVPFAEQL-l.........................................................
R5J5E7_9BACE/489-601 ..................etktfrlt------------..----...--..-..-....D.W.T..E..E....T.AQALEEEFKKIENVPANLEKG....CT......N..KNLLKELRPWLTE.FGKLGTR..GK.RAIEL....A...........RIyr.skQ...D............D...A......L....F...W...S...K.F.-...-..-...-.-.V.Q.N.LM.-..---..-..T..K..E.......E.RK..N.......YD.AHKS...GTMKLQPFYEN--tm........................................................
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A0A6I1MSJ0_9CLOT/509-641 ..........................ESEHIASTLDSF..KNKL...SN..N..E....S.V.V..-..D....D.GERLIQEFQAIKKAGSNIIKN....CS......N..KTLVNEAEQWLQS.FEQLGIA..GE.STVKA....V...........IA.....L...Q............EgeyD......I....W...W...N...N.Y.L...E..A...K.K.A.L.D.EM.A..RID..K..H..N..R.......E.VL..K.......KS.GITV...SSQKLTPFVKSMF..........................................................
A0A1T5C4D2_9BACT/460-592 ..........................ESVESKPVVEKY..LKEL...SG..D..N....-.F.P..Q..K....E.SEVLACLFKQIAETPATIRAK....ST......N..ESLIKEIDPWLIQ.FEHLGLA..GS.VSLKM....A...........SAw..ksK...N............T...N......D....A...E...K...Y.Y.S...E..L...T.S.L.L.E.KM.Q..IID..K..Q..Y..N.......Q.NE..W.......QP.GVKT...GSLVLKPFIIEL-y.........................................................
A0A1H6KQU7_9BACT/429-555 ..........................ESVAIAPTAQAL..LEGL...KS..G..K....-.I.D..E..K....A.KAAMLKEYAGIAASAARIMQS....CD......S..PEFVRETKPWLLS.FEQLGNV..GT.NALKA....L...........DS.....K...D............P...-......-....V...K...E...L.V.A...A..T...T.A.L.D.-.EM.N..RLS..K..L..Y..N.......S.NP..Y.......QP.GVKV...GSLVMTPAA----tevt......................................................
A0A0X7BE80_9FLAO/485-616 ..........................ESVNFKPQADLF..LKNL...EA..N..Q....T.I.-..-..I....N.FESIQNEFQAMVEASDILLNS....TD......N..PVLLTEIRAWAEQ.FKLQGQS..GL.AMLQM....Y...........KAl..qaK...N............T...A......D....F...E...L...S.Y.Q...A..I...K.A.I.K.S.QM.Y..AID..H..T..E..N.......Q.NP..Y.......QP.GIQT...ATLVVAPLIDTGF..........................................................
A0A1Y4NGK2_9FIRM/514-647 ..........................ESEYIKEALESV..EAKI...LN..G..D....D.ItN..D..N....E.VKELLTEFENIINAVDTMKTS....CD......N..QSLIDELTPWFNS.LQNVTAA..AK.SVVEG....V...........IA.....F...Q............S...G......D....T...G...T...A.W.D...M..F...S.Q.A.V.E.QY.D..KYD..S..F..TylN.......G.DG..N.......YS.TALA...GSKRIEPFVSE--vl........................................................
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A0A4Y8WPS9_9PORP/471-587 ...............ieswetetftm------------..----...--..-..E....Q.W.E..P..A....K.VSALNVEFIKIQEAAKCLLSV....GI......N..PLLLSELKPWIIE.LGKLGAR..GQ.RAIEL....G...........QI.....Y...Ndg........hsD...A......L....F...W...N...R.Y.V...A..N...-.-.-.-.-.VM.-..---..S..D..D..E.......V.KN..Y.......Q-.AHKS...GTMKLQPFYDHM-m.........................................................
R5CGB7_9BACE/458-587 ..........................ESECIRPAADRF..VKQY...TQ..S..G....N.W.Q..A..E....D.MQTLKDEFDRMVLAAGELKLA....KS......N..PALTREIAPWITA.FGLWAQM..GQ.EALAL....A...........EV.....A...K............A...Q......E....H...E...Q...S.V.R...I..L...K.-.-.-.-.RM.H..VLQ..R..L..I..E.......Q.ND..Rs....taAG.AASL...GTAVIQPLIKHIM..........................................................
A0A0F5JDX6_9BACT/451-582 .....................esfss-----TDLIDRF..EQSL...IT..G..K....Y.L.K..K..E....A.FE-IADLFIRIKEVPGTIESS....SL......N..KQLIKEIHPWLTQ.TRNVGTA..GC.ATMRM....L...........DLa..skQ...D............T...E......A....C...Q...K...A.Y.R...E..V...K.E.A.L.D.AI.A..VFS..R..P..Y..R.......-.RG..E.......QD.GVRS...GSQVLLPFIQRM-l.........................................................
A0A416GE76_9BACE/462-587 ..........................ESTDLQPTLKAM..----...--..-..K....Q.G.E..Q..K....A.LESVLAECKNLETACDILLAD....TE......N..PYLIEEIRPWLKQ.GKLLGEY..GQ.SVLLM....I...........KAi...qQ...K............D...D......A....F...M...T...H.Y.N...R..A...R.S.L.Q.A.QM.Y..ELD..M..T..E..N.......Q.NP..Y.......QP.GVKV...GSLVLLPSLNEMF..........................................................
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A0A3A1UZA4_9BACL/488-619 ..........................ESENIKEELQAF..LARY...AN..G..Q....S.V.T..E..A....G.-RTLIEEFDRVRGAIESFRAN....SQ......N..PAMLEEIEPWLGS.LVYVLQA..DK.SVVLS....A...........MA.....V...Q............A...G......E....L...D...K...A.W.Q...E..L...A.Q.A.T.S.AM.A..ASK..S..FkiK..K.......L.NA..P.......DV.TVEA...GAKRLVPFAQEL-l.........................................................
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R5I0U9_9BACT/465-577 ......................etet------------..---F...RL..G..E....D.W.T..E..Q....Q.YAALMEDFEEVEKAHARMSEK....CR......N..DALMRELDPWLEE.FTKLGER..GR.RALDL....Mr........myEA.....G...D............N...A......S....F...W...A...A.Y.V...A..-...-.-.-.-.-.--.-..---..-..-..-..-.......-.--..-.......--.----...-------------nlmdpadraayeahksgtlklqpfyeham.............................
A0A1D9ML85_9ACTO/497-628 ..........................ESVELAPKLRAF..LDKL...AA..N..T....F.T.D..-..E....D.ADQIAAEFTLLRHSADTFLAN....PG......T..PVMRDQMRPFLQS.FQDTGDA..AV.SFMNA....L...........KA.....A...Kr.........gdS...A......A....L...M...Q...E.Y.N...K.gL...A.Q.L.N.A.SRsH..TFR..S..K..M..-.......-.-N..Q.......QV.AAEV...GVQHIVPFLNK--vr........................................................
A0A5B8VJG6_9BACT/508-609 ..eswhvsqtidslmamtdqmnhfpi------------..----...--..-..-....E.L.N..Q..F....N.MKALRGALATFAPAATDLLQN....CQ......D..TVLINEIRPWLQH.FKSLGNA..AT.ALTDL....L...........TA.....K...D............A...Qq...ayS....F...L...P...V.Y.K...-..-...-.-.-.-.-.--.-..---..-..-..-..-.......-.--..-.......--.----...-------------rhvt......................................................
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C9MP37_9BACT/502-609 .....................frlad------------..----...--..-..-....-.Y.S..K..E....K.RDKLYQEFQRVAEAPATIEAG....CT......D..SLLLKELKPWLVE.FGKLGER..GK.KAIEL....Md........lyRS.....G...D............A...G......K....F...W...K...A.Y.V...NsgM...T.A.A.D.K.QA.Y..E--..-..-..-..-.......-.--..-.......--.----...-------------ahksgtmklqpfyeham.........................................
A0A1I2K6H8_9CLOT/502-632 ..........................ESEEIKPLLDEF..TNKL...KA..K..E....S.V.T..E..T....G.AK-LLNEMDTIIKACNEFVKA....ST......N..KRMVEQITPFANS.LKDLSSA..IK.FFIQSs.mdL...........ES.....N...N............K...D......S....A...V...Q...N.F.A...E..G...T.T.L.Y.E.NS.-..---..-..K..K..H.......E.RP..V.......IN.GVKKaqpGSKRLVPFVES--vr........................................................
R5W6L0_9BACE/495-609 ................swetqtfrla------------..----...--..-..-....D.W.T..D..E....A.ANALEEEFKKVESAPARLESS....CK......N..AALLNELRPWLTE.FGKLGTR..GK.QAIEL....A...........RIyr.sgK...D............D...A......L....F...W...E...K.Y.I...Q..-...-.-.-.-.-.--.-..---..-..-..-..-.......-.--..-.......--.----...-------------nimtpedrrsyeahksgtlklqpfyenam.............................
A0A1Y4N0Z0_9FIRM/554-686 ..........................ESEELRPFLDEF..TTAL...AG..G..D....A.A.Q.iK..E....K.GDAVVAEFEKIVAALNEYREK....GT......N..ERLKTELEPWLNS.MEYISQA..AI.GFVKTg.iaL...........AE.....G...D............E...E......A....A...C...A...N.Y.L...E..A...S.A.A.L.T.--.-..NSK..N..C..P..V.......Q.NI..S......gPQ.NVEA...GAKRIIPFVT---kls.......................................................
A0A2R7KIX2_9SPHI/461-593 ..........................ESVEIKPAIDVF..FASF...QQ..G..D....-.Y.R..P..D....L.AAQIKAEFSRIIPVAAEIRSK....ST......N..KRLVEQISPWLSQ.FELLGKT..GV.YTMSM....L...........EE.....W...N............A...K......N....Y...TaagS...S.Y.L...K..V...D.Q.L.L.D.SM.K..QLD..K..K..A..N.......S.NP..Y.......QP.GVKT...GSLVLTPFVKNVF..........................................................
A0A075R0Z5_BRELA/324-432 ........apqlleklhqfryhffhg------------..----...--..-..-....-.D.Q..Q..K....A.VEILEHTFSEMESSARHLLNG....MQ......N..ERLYKEIKGWLKK.YAYWAKL..GK.TATRL....I...........DA.....G...R............K...G......Q....T...L...R...-.-.-...-..-...-.-.-.-.-.--.-..---..-..-..-..-.......-.--..-.......--.----...-------------aifyflrmrrrlrqaeklpekvss..................................
A0A386PDR4_CLOSE/508-637 ..........................ESEEIKSLLDEF..NRKY...LA..G..E....S.I.K..E..I....G.-QTLINEYEKIVKAADDFDTK....SK......N..EGLKAEIDPWRQS.LKALAQS..TI.EYIKT....Ai........aiED.....G...N............N...G......E....V...W...S...H.Y.S...E..G...A.-.-.-.-.AK.F..ELS..K..T..F..Q......vQ.NI..H......gKD.YVEA...GYKRLIPFVK---kl........................................................
A0A1T5C4Z8_9BACT/460-592 ..........................ESVQIKPVIDVF..SQSF...KL..G..K....Y.L.E..F..E....-.ASQLNALFSQMAVAPTMIYSQ....SP......N..KRLIRQINPWLRQ.FELVGNA..GK.ETMEM....A...........NAw..inK...D............E...M......S....T...W...Q...N.Y.S...A..V...T.A.L.F.D.SI.Q..EVD..R..N..F..N.......K.ND..F.......QP.GVKT...ASKVIMPFIQQV-y.........................................................
R5UXJ6_9BACT/460-592 ..........................ESVNINPEIRKF..LTAF...RK..G..D....-.I.L..A..E....S.LSKIRTEYQKILTACTQLSTT....PE......N..PDLIREISPWLMQ.FEVLGKA..GL.AATEL....A...........AL.....S...P............R...Qe...lcR....Y...W...D...T.Y.S...A..L...I.G.Y.E.N.ER.L..RID..K..S..Y..N.......Q.NP..Y.......QP.GIKT...GSLVMQPFIDS--vr........................................................
#=GC seq_cons ..........................ES.thps.hpth..hpth...tt..t..t....p.h.s..p..p....s.hptLtpEFpclhpAssplhss....sp......N..ptLlcElcPWLpp.achlGpt..Gp.tslph....h...........ps.....t...p............p...p......t....a...h...p...t.a.t...p..h...p.t.h.p.p.th....thp..p........p.........ps..h.......t..shcs...ushhl.Phhpp............................................................
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