#=GF ID GramPos_pilinD3
#=GF AC PF16570.9
#=GF DE Gram-positive pilin backbone subunit 3, Cna-B-like domain
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE pdb_2l4o
#=GF GA 27.20 27.20;
#=GF TC 27.20 27.50;
#=GF NC 27.00 24.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0287
#=GF RN [1]
#=GF RM 20559564
#=GF RT Supramolecular organization of the repetitive backbone unit of
#=GF RT the Streptococcus pneumoniae pilus.
#=GF RA Spraggon G, Koesema E, Scarselli M, Malito E, Biagini M, Norais
#=GF RA N, Emolo C, Barocchi MA, Giusti F, Hilleringmann M, Rappuoli R,
#=GF RA Lesley S, Covacci A, Masignani V, Ferlenghi I;
#=GF RL PLoS One. 2010;5:e10919.
#=GF RN [2]
#=GF RM 21760959
#=GF RT Structure of the full-length major pilin from Streptococcus
#=GF RT pneumoniae: implications for isopeptide bond formation in
#=GF RT gram-positive bacterial pili.
#=GF RA Paterson NG, Baker EN;
#=GF RL PLoS One. 2011;6:e22095.
#=GF DR INTERPRO; IPR032332;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC GramPos_pilinD3 is one of the major backbone units of
#=GF CC Gram-positive pili, such as those from S.pneumoniae [1]. There
#=GF CC are three major pilin subunits that form the polymeric backbone
#=GF CC of the pilin from S. pneumoniae, constructed of three
#=GF CC transthyretin-like, CnaB, domains along with a crucial
#=GF CC N-terminal domain, D1. The three Cna-B like domains are
#=GF CC stabilised by internal Lys-Asn isopeptdie bonds, Gram-positive
#=GF CC pili are formed from a single chain of covalently linked subunit
#=GF CC proteins (pilins), usually comprising an adhesin at the distal
#=GF CC tip, a major pilin that forms the polymer shaft and a minor
#=GF CC pilin that mediates cell wall anchoring at the base [2].
#=GF SQ 20
#=GS A0A137SVV5_9FIRM/403-538 AC A0A137SVV5.1
#=GS F0GV36_9FIRM/402-543 AC F0GV36.1
#=GS H3NL28_9FIRM/342-463 AC H3NL28.1
#=GS A0A2I1MAW3_9FIRM/378-511 AC A0A2I1MAW3.1
#=GS A0A2U1E4L8_9FIRM/406-535 AC A0A2U1E4L8.1
#=GS Q8DYR6_STRA5/379-514 AC Q8DYR6.1
#=GS G4D2K0_9FIRM/383-513 AC G4D2K0.1
#=GS A0A1I1Z2D6_9FIRM/407-517 AC A0A1I1Z2D6.1
#=GS E4L030_9FIRM/375-503 AC E4L030.1
#=GS A0A7X6MYR7_9STRE/358-478 AC A0A7X6MYR7.1
#=GS C2BGP5_9FIRM/459-600 AC C2BGP5.1
#=GS A4VY77_STRSY/74-199 AC A4VY77.1
#=GS A0A3L9DV59_9STRE/375-503 AC A0A3L9DV59.1
#=GS C7HW59_9FIRM/368-502 AC C7HW59.1
#=GS A0A4R9C2N5_9FIRM/388-533 AC A0A4R9C2N5.1
#=GS A0A1I1YVF2_9FIRM/388-531 AC A0A1I1YVF2.1
#=GS U7UMI0_9FIRM/455-600 AC U7UMI0.1
#=GS E0NIX3_9FIRM/385-522 AC E0NIX3.1
#=GS B0S004_FINM2/423-582 AC B0S004.1
#=GS H3NQ15_9FIRM/339-460 AC H3NQ15.1
A0A137SVV5_9FIRM/403-538 .............................................t-GELKVKK..NWS.DT...V...E....NRS..TKVRYIL-EKD-GKTVAQVYTnGKDVVV................K.ADEGIKFKADDTDK....YSGTFT...G...LDKDATYKFREFVNGYEA--..KY..........DT.Q...TK.GQIT..IENKFD-.-PSRKTPEP.PKVTTYDAKFVKTDGA....G.KKLAGAEFYV.
F0GV36_9FIRM/402-543 ..............................................KGELKVTK..TWS.DG...T...T....KDV..-QVVYTLSNGT---KSYAVMMdGNKTSG................T.VDLGDGITFEITGA....YAGTFK...GealKDANTEWTISERVAGYDETI..DA..........TT.T...-A.GTAA..ITNTKDEeNPTPLNPTE.PKVVYYGKRFVKADLN...sG.ERLQGAEFVV.
H3NL28_9FIRM/342-463 ..............................................NGEITATK..TWA.EG...E...A....PEG..VKVEFVLYNAQTGKEVARYTL.QD---G................-.-------------E....TSHKFT...G...LDNDTEYKVVETFNGYSA--..EY..........ST.E...GN.GQIG..VKNWKDN.NPKPVNPEE.PKVETFGKKFVKANDS....N.ERLQGAQFVV.
A0A2I1MAW3_9FIRM/378-511 ..............................................EGKLTVNKefTGA.EG...D...W....KDD..EKVTVTLIDAHTGKP---VKF.TDGQEA................T.VELTKGTKTEH---....---TWT...G...LDNDKQYIVKETFKAGDE-V..TY..........IK.Q...ED.GSIK..IEDKKTD.NPSPKDPQE.PEVVTYGHRFQKIDQS...tK.EGIEGAKFIV.
A0A2U1E4L8_9FIRM/406-535 ............................................nk--QITVNK..TWSvDGkesN...A....PSG..VRVVYTLQVQD-GDKWKDVES.V-EKTG................-.------------TN....FSHTFT...G...LDDNKTYRVVETVSGYDP--..EY..........KS.F...EG.GVVT..INNNTDSdNPKPLEPTD.PKVITGGKKFVKTNQD...kS.ERLAGAEFYV.
Q8DYR6_STRA5/379-514 ..............................................KGEVTVAK..TWS.DG...I...A....PDG..VNVVYTLKDKD--KTVASVSL.TKTSKG................T.IDLGNGIKFEVSGN....FSGKFT...G...L-ENKSYMISERVSGYGSAI..NL..........EN.G...--.-KVT..ITNTKDSdNPTPLNPTE.PKVETHGKKFVKTNEQ....G.DRLAGAQFVV.
G4D2K0_9FIRM/383-513 ............................................gt--EVKVEK..TWA.DG...SsnqA....PAD..AKVTYYLYKKGSGD------F.STDTLV................-.---DSVIK---TKD....FSHTFS...N...L-EDGDYYVKEFVQGYT--P..EY..........TT.S...EN.GTIK..LNNNKKP.-GTPLVPKT.PEIVTGGKKFVKTNDKagneL.KRLAGAEFVI.
A0A1I1Z2D6_9FIRM/407-517 .............................eitlslqvydpqgnkws--------..---.--...-...-....---..---------------------.------................-.-DVNSQNKTLNSTT....TSGEWT...G...LDNNKQYRVIEKD-VKGWVP..NY..........AV.Q...ED.GILK..IVNKKND.NPEPITPEP.VIVRTGGKKFVKTNED....GkERLNGAEFII.
E4L030_9FIRM/375-503 ..............................................NGEMEFTK..SWD.-G...E...A....PAN..ASVTVQLYNANTGKAVGEAKT.--LNAG................-.------------NS....WKATWT...G...LDNDTEYKVVETA-VAGYEA..EY..........SK.G...DGlGKLG..VKNWKSD.NPTPLNPSE.PKVVNGGKKFVKTNEKegkeL.ERLAGAEFYV.
A0A7X6MYR7_9STRE/358-478 .............................................s-GELVITK..TWG.VG...-...-....ANK..VSVMFDVYEELTGTKVATVTL.QAGEQ-................-.--------------....-SVTVS...G...LEDGKKYVVREQK-TQKTLP..DY..........KP.N...GA.GQLT..VNNEENY.NPEPIRPKE.PKVITYGRRFVKVNDQ....N.DILAGAEFVV.
C2BGP5_9FIRM/459-600 ..............................................DGEITVSK..TWA.DG...T...A....PTG..VKVKYVLLDEN-NNALADVTF.TDKSTV...............dQ.TDLGHGITFEKTGD....FAGKFKfknE...EDKAKQYKIKEIVDGYEPEY..VV..........DN.N...-S.GKVT..VNNKKT-.-PDSITPTP.PQVTVGGKKFVKVDSE...tG.DRLAGAQFVI.
A4VY77_STRSY/74-199 ..............................................DGEIIVNK..TWD.TG...V...N....QTE..--VVFGVYEKGTGVRVGEIKLaAGVNTG................-.--------------....---KLT...G...LDGAKEYIVIEETIVSGSLP..SY..........SN.G...DT.GTIR..IENKKNP.NPTPLTPED.PKVVTYGKRFVKTDDKdldsS.EKLLGAEFIV.
A0A3L9DV59_9STRE/375-503 ............................................nk--QIIVEK..QFS.DG...K...F....PED..VDVQVTLYNAQTGKAVEPRQV.ATLTKQ................-.-------------Q....PTHTFI...G...LDNDTEYKVIETNLSGYS-A..EY..........KKvN...QN.GQII..IVNWKDN.NPPPLTPEE.PKIVTGGQRFRKVDKVh..dN.KALKGAEFVV.
C7HW59_9FIRM/368-502 ............................................dq--KIKVSK..TWAaDGp.eI...T....EADrhVKAVFTLQEKQ----------.---NDG................S.WKDVAEYESNYKEN....FEHEFT...G...LDNAKTYRVVESVSGYEP--..QY..........QKtT...ED.GKVV..IVDKIDNdNPKTLKPTT.PKVVNGGRRFVKTDSEd..tP.NRLAGAEFYV.
A0A4R9C2N5_9FIRM/388-533 ..............................................DKELIVSK..TWY.NG...K...TpkdsPDN..VKVVYSLYKQD--KQVVAVTL.DKNTKG................T.FDLGNGILFEAQGK....FNGKFI...G...LDENEKWKLFERVSGYDGFI..TS..........T-.-...EN.GKAD..IKNIKDIdNPTPLKPTS.PEVVVGGKKFVKTNDStaenS.ERLLGATFIV.
A0A1I1YVF2_9FIRM/388-531 ............................................nk--ELTVTK..TWA.NGttgT...A....PDD..VSVTYVLKKG--GQNKAAVTLdKSTTSG................T.FDLGNDIKFSVTGE....FSGKFT...G...LEDSNDWKISERVAGYTP--..SY..........ES.V...SN.GTVT..VKNKKDTdNPTPLNPTE.PKVVTGGKKFVKTDSSd..aP.VRLAGAKFVV.
U7UMI0_9FIRM/455-600 ............................................nk--EIPVTK..TWA.DG...K...V....PTG..VRVKYVLLDAE-GNPVADVTF.TEAQKV................DyTELGNGITFEVTGD....FSGKFKfakD...EDATKQYMIKEIVYGYEGFT.gGY..........EP.TytvSG.STVT..VKNTK--.VPESITPTP.PQVTVGGKKFVKTDKD....G.NRLAGAEFII.
E0NIX3_9FIRM/385-522 kteinvnksfvsgdgtgtetwpadmtitlklekwdqatntwsevsg--------..---.--...-...-....---..---------------------.------................-.----KTLTL-NSTT....TSGKFD...K...LNKDEKYRVVEQE-VKGWVP..NY..........SH.D...TQ.GNLV..IKNKKNP.NPNPITPPE.VTVTSGGIRFVKTDDNt.seF.KRLVGGKFL-i
B0S004_FINM2/423-582 ..............................................DGEMNVTK..TWA.DG...V...P....AAG..EWAEFTLYNAQTGKKVGTVKF.TTDANGttttytpnddykatgsE.KPQGPSKKTDGTANdkttWKFTWT...G...LDKDIQYKVVEKNNMNET-A..TY..........GK.G...AN.GEIT..ITNNKWN.NPEPINPNE.PKVVTYGAKFVKTDTE....G.KRLQGAEFVV.
H3NQ15_9FIRM/339-460 ..............................................NGEITATK..TWA.EG...E...A....PEG..VKVEFVLYNAQTGKEVARYTL.QD---G................-.-------------E....TSHKFT...G...LDNDTEYKVVETFNGYSA--..EY..........ST.E...GN.GQIG..VKNWKDN.NPKPVNPEE.PKVETFGKKFVKANDS....N.ERLQGAQFVV.
#=GC seq_cons ...............................................tElpVsK..TWu.-G...p...s....sss..spVhasLhptp.Gptlstlph.sptspu.....................s.thp...psp....aotpFT...G...LDssppY+VhEpstGYss....sY..........ss.s...ps.Gpls..IpNpKss.NPsPlsPp-.PKVlTtGKKFVKTscs...ts.-RLsGAEFlV.
//
