#=GF ID HCV_NS2
#=GF AC PF01538.22
#=GF DE Hepatitis C virus non-structural protein NS2
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Swiss-Prot
#=GF GA 25.00 25.00;
#=GF TC 219.20 218.00;
#=GF NC 22.00 21.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 9224925
#=GF RT The nonstructural proteins of the hepatitis C virus: structure
#=GF RT and functions.
#=GF RA Neddermann P, Tomei L, Steinkuhler C, Gallinari P, Tramontano A,
#=GF RA De Francesco R;
#=GF RL Biol Chem 1997;378:469-476.
#=GF RN [2]
#=GF RM 9261354
#=GF RT In vitro study of the NS2-3 protease of hepatitis C virus.
#=GF RA Pieroni L, Santolini E, Fipaldini C, Pacini L, Migliaccio G, La
#=GF RA Monica N;
#=GF RL J Virol 1997;71:6373-6380.
#=GF DR INTERPRO; IPR002518;
#=GF DR MEROPS; C18;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC The viral genome is translated into a single polyprotein of
#=GF CC about 3000 amino acids. Generation of the mature non-structural
#=GF CC proteins relies on the activity of viral proteases. Cleavage at
#=GF CC the NS2/NS3 junction is accomplished by a metal-dependent
#=GF CC autoprotease encoded within NS2 and the N-terminus of NS3 [1,2].
#=GF SQ 2
#=GS O41892_PEGIA/743-939 AC O41892.1
#=GS POLG_HCV77/811-1005 AC P27958.3
O41892_PEGIA/743-939 DWSDYWWCVAGVVSWALVTMGLLTHGGKEVKLRWYRTWCVFYQKVRLRLLDTPIGNR-PRRPLCKLWLVAAwfwPDIAAEVCVFLILIFGFLdvvdFCLEVSLVSSPNLVRLAQMFDSLVM----AGERLGATHLAERLRRRGVFLFEHAGHVTRPAAERLREWGFALEPVAVKPEDCAIVRDAARVLGCGQRVNGVPVVAR
#=GR O41892_PEGIA/743-939 pAS ....................................................................................................................................................*........................................*............
POLG_HCV77/811-1005 DTEVAASCGGVVLVGLMALTLSPYYKRYISWCMWWLQYFLTRVEAQLHVWVPPLNVRGGRDAVILLTCVVH...PALVFDITKLLLAIFGPL....WILQASLLKVPYFVRVQGLLRICALARKIAGGHYVQMAIIKLGALTGTCVYNHLAPLRDWAHNGLRDLAVAVEPVVFSRMETKLITWGADTAACGDIINGLPVSAR
#=GR POLG_HCV77/811-1005 AS ....................................................................................................................................................*........................................*............
#=GR POLG_HCV77/811-1005 sAS ........................................................................................................................................................................*.................................
#=GC seq_cons Dhpshh.CsusVlshhhshhh..hatth.shhhWahpahlhh.cspL+lhssPlssR.sRcslhhLhhVst...Pslsh-lshhLlhIFG.L....ahLpsSLlpsP.hVRltthhc.hsh....AGt+hsthtlhchhthpGshlapHhu.lpc.AtptLR-huhAlEPVshp..-stllp.uAcshuCGphlNGlPVsAR
//
