#=GF ID HCV_NS4a
#=GF AC PF01006.24
#=GF DE Hepatitis C virus non-structural protein NS4a
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_315 (release 3.0)
#=GF GA 27.00 27.00;
#=GF TC 66.10 66.10;
#=GF NC 26.70 25.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 9568891
#=GF RT Complex of NS3 protease and NS4A peptide of BK strain hepatitis
#=GF RT C virus: a 2.2 A resolution structure in a hexagonal crystal
#=GF RT form.
#=GF RA Yan Y, Li Y, Munshi S, Sardana V, Cole JL, Sardana M,
#=GF RA Steinkuehler C, Tomei L, De Francesco R, Kuo LC, Chen Z;
#=GF RL Protein Sci 1998;7:837-847.
#=GF RN [2]
#=GF RM 9514871
#=GF RT Complex formation of NS5B with NS3 and NS4A proteins of
#=GF RT hepatitis C virus.
#=GF RA Ishido S, Fujita T, Hotta H;
#=GF RL Biochem Biophys Res Commun 1998;244:35-40.
#=GF RN [3]
#=GF RM 9261364
#=GF RT The hepatitis C virus NS4A protein: interactions with the NS4B
#=GF RT and NS5A proteins.
#=GF RA Lin C, Wu JW, Hsiao K, Su MS;
#=GF RL J Virol 1997;71:6465-6471.
#=GF RN [4]
#=GF RM 9224925
#=GF RT The nonstructural proteins of the hepatitis C virus: structure
#=GF RT and functions.
#=GF RA Neddermann P, Tomei L, Steinkuhler C, Gallinari P, Tramontano A,
#=GF RA De Francesco R;
#=GF RL Biol Chem 1997;378:469-476.
#=GF DR INTERPRO; IPR000745;
#=GF DR SCOP; 8ohm; fa;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC NS4a forms an integral part of the NS3 serine protease, as it
#=GF CC is required in a number of cases as a cofactor of cleavage
#=GF CC [1,3]. It has also been reported that NS4a interacts with NS4b
#=GF CC and NS3 to form a multi-subunit replicase complex [3].
#=GF SQ 2
#=GS O41892_PEGIA/1590-1657 AC O41892.1
#=GS POLG_HCV77/1658-1711 AC P27958.3
O41892_PEGIA/1590-1657 GPVLLVGLAMAGGALLAHWTGSIVVVTTWEVNGGGnpllyqtrrgvptsgsPvVVVPPCE---G-GERYPCD
POLG_HCV77/1658-1711 STWVLVGGVLAALAAYCLSTGCVVIVGRIVLSGKP................-.AIIPDREVLYQEFDEMEEC
#=GC seq_cons ushlLVGhshAuhAhhsh.TGslVlVsph.lsGts..................sllPspE...t.h-ch.ps
//
