#=GF ID   HEF_HK
#=GF AC   PF19191.4
#=GF DE   HEF_HK domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Bellieny-Rabelo D;0000-0003-2544-7899
#=GF SE   Daniel Bellieny-Rabelo
#=GF GA   24.10 24.10;
#=GF TC   24.10 24.20;
#=GF NC   24.00 23.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF DR   INTERPRO; IPR043836;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a dimerization and histidine phosphotransfer (DHp)
#=GF CC   domain found in Histidine Kinases (HK). This domain is belongs
#=GF CC   to the His_Kinase_A (CL0025) clan. HK domain architectures
#=GF CC   typically contain DHp domains adjacent to GHKL domains, such as
#=GF CC   HATPase_c (Pfam:PF02518) and HATPase_c_3 (Pfam:PF13589) which
#=GF CC   comprise the ATP-binding regions.
#=GF SQ   76
#=GS A0A401FRK8_9DELT/757-823  AC A0A401FRK8.1
#=GS A0A2V4NCH5_9RHOB/774-840  AC A0A2V4NCH5.1
#=GS A0A1I7NAT6_9HYPH/780-846  AC A0A1I7NAT6.1
#=GS A0A073J7D0_9RHOB/154-220  AC A0A073J7D0.1
#=GS A0A4Q2ZQI0_9SPHI/779-845  AC A0A4Q2ZQI0.1
#=GS A0A8J6IS87_9ALTE/776-842  AC A0A8J6IS87.1
#=GS A0A0M2VK55_9GAMM/781-842  AC A0A0M2VK55.1
#=GS I2B9G8_SHIBC/773-839      AC I2B9G8.1
#=GS A0A2M9CM40_9MICO/753-819  AC A0A2M9CM40.1
#=GS A0A4Y9PSQ3_9ACTN/144-210  AC A0A4Y9PSQ3.1
#=GS A0A419R1L3_9SPHN/580-644  AC A0A419R1L3.1
#=GS B3EB45_TRIL1/770-836      AC B3EB45.1
#=GS A0A143B5Y9_9DELT/776-842  AC A0A143B5Y9.1
#=GS E8T9T6_MESCW/774-836      AC E8T9T6.1
#=GS A0A7W6CBB5_9SPHN/760-822  AC A0A7W6CBB5.1
#=GS A0A0G3XIF1_9SPHN/580-644  AC A0A0G3XIF1.1
#=GS F9RCY1_VIBSN/774-840      AC F9RCY1.1
#=GS A0A5R8Y7E7_9HYPH/774-840  AC A0A5R8Y7E7.1
#=GS A0A2H5AUD0_9ACTN/775-841  AC A0A2H5AUD0.1
#=GS A0A4R5C4D0_9FLAO/778-844  AC A0A4R5C4D0.1
#=GS A0A1Y5KMI5_9BACL/828-893  AC A0A1Y5KMI5.1
#=GS A0A1V0PZ18_9RHOB/772-838  AC A0A1V0PZ18.1
#=GS Q26DQ0_FLABB/753-817      AC Q26DQ0.1
#=GS A0A081NMD6_9GAMM/776-842  AC A0A081NMD6.1
#=GS A0A1G6U7F9_9PROT/777-843  AC A0A1G6U7F9.1
#=GS A0A6F8PTB5_9GAMM/922-988  AC A0A6F8PTB5.1
#=GS A0A8J8B2C9_9FIRM/805-870  AC A0A8J8B2C9.1
#=GS A0A1M6P449_9FLAO/749-813  AC A0A1M6P449.1
#=GS A0A174GGL2_9BACE/743-809  AC A0A174GGL2.1
#=GS A0A562VI46_9DELT/777-843  AC A0A562VI46.1
#=GS A0A3A1P5X9_9SPHN/580-644  AC A0A3A1P5X9.1
#=GS A0A2S9Q836_9HYPH/770-830  AC A0A2S9Q836.1
#=GS A0A0A8WQV3_9DELT/771-837  AC A0A0A8WQV3.1
#=GS A0A1H8XAJ4_9SPHI/753-817  AC A0A1H8XAJ4.1
#=GS A0A0Q5P0G9_9SPHN/316-382  AC A0A0Q5P0G9.1
#=GS D4E4H5_SEROD/784-850      AC D4E4H5.1
#=GS A0A1M6C664_9BACT/768-830  AC A0A1M6C664.1
#=GS A1BCM2_CHLPD/771-837      AC A1BCM2.1
#=GS A0A6H9WX01_9MICO/763-829  AC A0A6H9WX01.1
#=GS F9ZBK1_ODOSD/745-811      AC F9ZBK1.1
#=GS A0A4S4BG91_9BACL/814-879  AC A0A4S4BG91.1
#=GS A0A1G7BUJ5_9FLAO/752-816  AC A0A1G7BUJ5.1
#=GS A0A1B5FPD5_9CAUD/356-418  AC A0A1B5FPD5.1
#=GS A0A2H1E9S9_9FLAO/751-815  AC A0A2H1E9S9.1
#=GS A0A1U9Z2P8_9HYPH/774-840  AC A0A1U9Z2P8.1
#=GS A0A248JZ66_9PROT/754-816  AC A0A248JZ66.1
#=GS A0A1W2EGA8_9SPHI/749-813  AC A0A1W2EGA8.1
#=GS A0A3S9A1C0_9BACL/588-653  AC A0A3S9A1C0.1
#=GS A0A084A0Z0_9GAMM/769-835  AC A0A084A0Z0.1
#=GS A0A5C8JFU5_9BACT/769-835  AC A0A5C8JFU5.1
#=GS N2AA52_9FIRM/814-879      AC N2AA52.1
#=GS A0A3N2KPC1_9BACT/171-237  AC A0A3N2KPC1.1
#=GS T2GC91_MEGG1/766-832      AC T2GC91.1
#=GS A0A0M7AVG7_9HYPH/140-206  AC A0A0M7AVG7.1
#=GS A0A1R4HZJ9_9GAMM/192-258  AC A0A1R4HZJ9.1
#=GS N0E3Z6_9MICO/763-829      AC N0E3Z6.1
#=GS A0A7J0AZN2_9BACT/777-843  AC A0A7J0AZN2.1
#=GS A0A7Y5NUP4_9DELT/761-827  AC A0A7Y5NUP4.1
#=GS A0A1M6J3P0_9BACT/756-822  AC A0A1M6J3P0.1
#=GS A0A381H2K4_CITKO/260-324  AC A0A381H2K4.1
#=GS A0A8J8NAS2_HALGN/692-754  AC A0A8J8NAS2.1
#=GS A0A502BP06_9HYPH/774-835  AC A0A502BP06.1
#=GS A0A6I5YGP5_9SPHN/769-830  AC A0A6I5YGP5.1
#=GS A0A852RF63_9ACTN/763-829  AC A0A852RF63.1
#=GS A0A850ENI2_9BACL/477-543  AC A0A850ENI2.1
#=GS A0A1X1MQ44_9VIBR/792-858  AC A0A1X1MQ44.1
#=GS A0A7Y6ZXR8_9ALTE/773-834  AC A0A7Y6ZXR8.1
#=GS A0A068QRF2_9GAMM/772-835  AC A0A068QRF2.1
#=GS H2CGF7_9LEPT/753-817      AC H2CGF7.1
#=GS A0A6L6UAB7_9FLAO/751-815  AC A0A6L6UAB7.1
#=GS A0A444J6D6_9DELT/666-732  AC A0A444J6D6.1
#=GS F8X1T7_9BACT/760-826      AC F8X1T7.1
#=GS A0A2W2AF67_9BACT/778-844  AC A0A2W2AF67.1
#=GS A0A6N0X144_9SPHN/769-830  AC A0A6N0X144.1
#=GS A0A4U1IER0_9DELT/765-825  AC A0A4U1IER0.1
#=GS A0A6F9ZA26_9BACT/777-843  AC A0A6F9ZA26.1
A0A401FRK8_9DELT/757-823             .QLGLSVEIIDHELNRLYQGIKAGLQRLKQMVRRAPNARKTVEDIGVNFQHLEQKYQLMSPLYRGTYR.....
A0A2V4NCH5_9RHOB/774-840             .QIGMALNTINHEFGKTAGSLRDGLRRMKSWAHANPDMKRLYDDMRVNFDHLDSYLALFNPLDRKLQ-s....
A0A1I7NAT6_9HYPH/780-846             .QLGLAVAIINHEFSASIKRVRRSIQELGQISRRSDGLRPLYESIRSNFEHLDGHLNLFTPLQRRLQR.....
A0A073J7D0_9RHOB/154-220             .QIGMALNTINHEFGKTAGGLRDGLRRMKSWAHANPEMKSLYDDMRVNFDHLDSYLALFNPLDRKLQ-s....
A0A4Q2ZQI0_9SPHI/779-845             .QLGLAVNIINHEFHSTVKSIRTSIRDLKAWVDVNDKLETIYTNIKINFEHLDKYLGLFTPLNRRMYR.....
A0A8J6IS87_9ALTE/776-842             .QLGLAVSIIHHEFNSTVRSVRSSLKDLKAWSDVNQDLEGVYKNIKINFEHLDGYLNLFTPLNRRLSR.....
A0A0M2VK55_9GAMM/781-842             .QLGVTVEILGHELNSNERMVREGIRQIKNSGDISGTH-L----VVEGFEAISHQLEFLSPLKI----sgar.
I2B9G8_SHIBC/773-839                 .QMGMSVGILQHEFESSIKGIRSAMVRFKPWADKNAPLSPIYMDLRVHIERLDGYLKALDPLGRRMHR.....
A0A2M9CM40_9MICO/753-819             .QLGQAVQVISHEFEASIASVRNGLRGLDPWARATPPLAPLVRDIRAAFTHLDGYLRLFTPLQRRLYR.....
A0A4Y9PSQ3_9ACTN/144-210             .QLGQAVQVVSHEFESTIKSVRFGLRQLDPWARANPQLRDVVQDIKSGFQHLDGYLRLFTPLQRRLYR.....
A0A419R1L3_9SPHN/580-644             g-VGLMVEVVAHELARSAEDALDTLNKLQR-KNVPEEVRSRLESLRASMKAISKRLRILDPLS-----vsgr.
B3EB45_TRIL1/770-836                 .QLGLAVGVIHHEFTSTAQAIRENIKDLKMLSDVNEKYESLYKNLRANFEHLDNYLSLFTPLDRRMYR.....
A0A143B5Y9_9DELT/776-842             .QMGMGVGILQHEFEKSARNMRLAVRDLKPWADGTPELKKVYTRLRNSFDHLDGYLKMLDPLGRRIRR.....
E8T9T6_MESCW/774-836                 .QLGIAVEIVGHELQAYDDIIGSALRRLPD----EVRNSKAVQDIEFGYDGLTDQLRFLSPLR-----lagqr
A0A7W6CBB5_9SPHN/760-822             .QMGIAIEIIGHELDTMDAEVRRNLHRLPQEIKKSDAFRLAF----EAHTAITERLRFLAPLR-----lagyr
A0A0G3XIF1_9SPHN/580-644             g-VGLMVEVVAHELARSAEDALDTLNKLQR-KNVPEEVRSRLESLRASMKAISKRLRILDPLS-----vsgr.
F9RCY1_VIBSN/774-840                 .QLGLAVGVIHHEFNSTVRSIRHSLKDLKAWSDVNEDLDGVYKNIKVNFEHLDGYLNLFTPLNRRLSR.....
A0A5R8Y7E7_9HYPH/774-840             .QIGMALNTINHEFGKTAGSLRDGLRRMKSWAHANPDMKRLYDDMRVNFDHLDSYLALFNPLDRKLQ-s....
A0A2H5AUD0_9ACTN/775-841             .QLGRAIELINHEFASSIKAVRRNLRALRPWGNRNPKLGEIERELAAAFEHLDNYLALFTPLQRRLYR.....
A0A4R5C4D0_9FLAO/778-844             .QLGLAVGILHHEFSSTVRSIRGSIKDLKAWSDVNQQLDSVYKNIKVNFEHLDGYLNLFTPLNRRLNR.....
A0A1Y5KMI5_9BACL/828-893             .NMGMAAEIVNHEFNQLLVNVEDGIKNIKN-ANLSPTQSYWIRQIEAGFKAIGTRHSQLSPMYRSYN-l....
A0A1V0PZ18_9RHOB/772-838             .QLGLAVAIINHEFESAIKGVRRSLRELRPWASSNDELAGLYQDIRNNFDHLDGHLNLFTPLQRRLYR.....
Q26DQ0_FLABB/753-817                 .QLGVAVEIIDHEFNQLYAKINSSIDKLSEVNLFTDVEQFNF--LKQNFKQLEDKYDLLSPLYRIS--gv...
A0A081NMD6_9GAMM/776-842             .QVGMALGIVQHEFNSTVRKIKRNIRQLQVWAKGTPPLRQLYKELSSGFMHLEEYLRLFAPMDRRLNR.....
A0A1G6U7F9_9PROT/777-843             .QMGMGLGILQHEFTHVAADFREAMQAIKPWADRTPGLDNAYSQLRSNFESLDGYLKVLDPLGRRLNR.....
A0A6F8PTB5_9GAMM/922-988             .QIGTAINIINHEFDSSIRTVRRNLSRLKAWADVNENLHEIYHDVRASFEHIDGYLTLFSPLNRRLYR.....
A0A8J8B2C9_9FIRM/805-870             .NVGLAAEVVDHEFNQYFTNVKYAINNLST-SIKDNNQKYWLNQIYVGFNAISNRHSQLSPTYRSK--nl...
A0A1M6P449_9FLAO/749-813             .QLGIAVEIIDHEFNQLYAKINNQLGVLGNNEVVNSIKEFRF--LEKNFKQLEDKYALLSPLYRIS--ga...
A0A174GGL2_9BACE/743-809             .QLGISVEINDHEFHVLYSQMANSINFLKEYAYNHTEIKDQFLQFQTAFQHMETNYKMLQPLYRTTRR.....
A0A562VI46_9DELT/777-843             .QMGMAVGILQHEFEKTARNMRVAVRDLKPWADGTPDLKKVYTRLRNSFDHLDGYLKLLDPLGRRLNR.....
A0A3A1P5X9_9SPHN/580-644             g-VGLMVEVVAHELARSAEDALDTLNKLQR-KNVPEEVRSRLESLRASMKAISKRLRILDPLS-----vsgr.
A0A2S9Q836_9HYPH/770-830             .QLGITVEIIAHELEMLDSEVTRNLDRLPPEIRNDRAFGQAV----AAHQALTEKLRFLSPLQ-----lag..
A0A0A8WQV3_9DELT/771-837             .QLGLAVAIINHEFVAAIKGIRLKLRELGSWARTNADLVPLYQEIRTNFDHLDAHLNLFTPLQRRLQR.....
A0A1H8XAJ4_9SPHI/753-817             .QLGIAVEIIDHEFNVLYSQINSVIDKLDS--EMPQKANSLFNNLKRSFKSLEDKYGLLSPLYRIS--gv...
A0A0Q5P0G9_9SPHN/316-382             .QVGMALGIVQHEFQSTANSINDAIGRLQPWSRANADLAKLVRDVSGGFEHLEGYLRLFAPMSRRLNR.....
D4E4H5_SEROD/784-850                 .QLGLAVSIIHHEFNSTVRSIRTSLKDLKAWSDVNEDLEGVYKNIKINFEHLDGYLNLFTPLNRRLQR.....
A0A1M6C664_9BACT/768-830             .-IGLILETATHEYENQVSLVRNSIRSLKR--KLHNGEAETLAVLADAFEIIDHRIRMFDPIVRR---rs...
A1BCM2_CHLPD/771-837                 .QLGLAVAVINHEFVAAIKMIRGQLRELRSWAMVNKDLLPVYQEIRTNFDHLDAHLNLFTPLQRRLYK.....
A0A6H9WX01_9MICO/763-829             .QIGMAVNIVTHEFENSVKSVRDNLRRLRSWAQQNAGLRPLYSDLRVSFDHLDGYLKLFTPLHRRLYR.....
F9ZBK1_ODOSD/745-811                 .QLGISVEIIDHEFNVLYAKMAQSVNFLRDYAGEHPEIQDICSQLQISFQHMEANYKMLKPLYRTTRR.....
A0A4S4BG91_9BACL/814-879             a-VGLAAELTSHEFNALYKSIRDQLGLLQK-SLANTSILPVVEKTGAAFRSLERLHQRMNPLYRQVR-a....
A0A1G7BUJ5_9FLAO/752-816             .QLGVAVEIIDHEFNQLYAKINGSLEKLTNGNLFADEEQFQF--LTQNFKQLENKYELLSPLYRVA--gv...
A0A1B5FPD5_9CAUD/356-418             .QLGISVEIISHELEEMDSMVTRGLNSLPTSVKEHPGFSLAL----NAHRSLTQQIRFLSPLKI----sgyq.
A0A2H1E9S9_9FLAO/751-815             .QLGVAVEIIDHEFNQLYAKINNSISKLSSENLFTDVEQFQF--LTQNFKQLEDKYDLLSPLYRIS--gv...
A0A1U9Z2P8_9HYPH/774-840             .QIGLAISAVNHEFDKTVHALRDGFRRLEGWAKANDDLAELYQSMFSSFEHLNGFLSLFTQMDIRFNR.....
A0A248JZ66_9PROT/754-816             .QVGITVEIIGHELETLDAEVRRNLSRLPDEIRRSTAFKLAY----DAHHALTERLRFLSPLK-----vagyr
A0A1W2EGA8_9SPHI/749-813             .QLGIAVEIIDHEFNQLYAKINNQLTVLGNNFAVNSIKEFGF--LEKNFKQLEDKYALLSPLYRIS--ga...
A0A3S9A1C0_9BACL/588-653             .NIGMAAEIVNHEFNQLMTNVEDGISNIKN-ANLSSIQNYWVKQIEAGFRAISTKHSQLSPMYRS---nhl..
A0A084A0Z0_9GAMM/769-835             .QLGMALGVLGHEFNSNILSIRRALNEMQPFAVRSERFKLVYDRVRTGFDHLDASLKTLMPLTRRMGR.....
A0A5C8JFU5_9BACT/769-835             .QLGMAIEVINHEFDSSIRGIRHDLRRLKAWADVNQSLSSVYNNLRTSFDHLDGYLTLFTPLHRRLYR.....
N2AA52_9FIRM/814-879                 .NLGLAAEIVNHEFNQLFTNVYDSINHMKL-YRLPADVKYYLKQVEVGFRAISDRQNQLSPMYRS---ksl..
A0A3N2KPC1_9BACT/171-237             .QLGISAEIIDHELYSLHAQMANSLNYFKEYSRIHTETASQYKQLSVAFEHMEANYKMLQPLYRTAK-k....
T2GC91_MEGG1/766-832                 .QLGMAIEVINHEFDANIRAIRANVRRLKSWADVNPDLQDLYAGIRNSFEHLDGYLTLFTPLHRRLYR.....
A0A0M7AVG7_9HYPH/140-206             .QMGQAIGIVHHEFNSVIRSVRRNVRRLEPWAQRNEKLRKLYEEISESYAHLDSYLSLFAPLSRRLS-q....
A0A1R4HZJ9_9GAMM/192-258             .QMGMSVGILQHEFEGAARGIRSAMSELKPWADKNPPLAKIYKKLRDHIEHLDGYLKVLDPLGRRMHR.....
N0E3Z6_9MICO/763-829                 .QIGMAVNIVTHEFENSIKSVRDNLRRLRSWAQQNAGLRPLYTDLRVSFDHLDGYLKLFTPLHRRLYR.....
A0A7J0AZN2_9BACT/777-843             .QLGLAVGILHHEFNGTVNSIRHSLKDLKAWSDVDIKLEGIYKNIKVNFEHLDGYLNLFTPLNRRLNR.....
A0A7Y5NUP4_9DELT/761-827             .QLGSAVEIISHEFGASVKAVRRGIRRLKPWAEANAELAALYRDLRAAFEHLDAYLGLFVPLSRRLG-s....
A0A1M6J3P0_9BACT/756-822             .QMGMAIEVINHEFDSSIRSIRDQLRLLRNWADVNKGLDKVYQGLRTSFDHLDGYLTLFTPLHRRLYR.....
A0A381H2K4_CITKO/260-324             .QLGITVEIIGHELDGLDQELTYALKVIKD-DQLTPTQAKNIDVALNCHNSLIDKLKFLSPLK-----lsgk.
A0A8J8NAS2_HALGN/692-754             .QVGITVEIIGHEFEALESEVRRNLSKLPA--SIKQTAAFQV-AL-RSHQALADRLRFLAPLKI----ggyr.
A0A502BP06_9HYPH/774-835             .QLGIAVEIVGHELQAYDDIIGAALRRLPDE----VRESKAAKDIAFGYEGLTDQLRFLSPLR-----lagq.
A0A6I5YGP5_9SPHN/769-830             .QLGITVEIIGHELEALDSEVSRNLEKLPDTAKKTLAFTRAM----DAHRSLTEKLRFLSPLQ-----laga.
A0A852RF63_9ACTN/763-829             .QIGMAVNIVTHEFENSIRSVRDNLRRLRAWAQQNTGLRPLYSDLRASFDHLDGYLKLFTPLHRRLYR.....
A0A850ENI2_9BACL/477-543             g-IGIAAERTTHEIGHLVNKLKATIQELRKLVLNSDEGLNLVETMLNYTSALDSELKLLNPLFK----anrl.
A0A1X1MQ44_9VIBR/792-858             .QLGMSLGIIQHEFSSTARSVRSSIKSLKPWADRNPKLGDLYKNISHSFSHLDGYLKMFTPLNRRLYR.....
A0A7Y6ZXR8_9ALTE/773-834             .QLGVTVEILGHELNSNERMIREGIRQIKNNG-DIPGTNLVV----EGFEALSHQLEFLSPLKI----sgsr.
A0A068QRF2_9GAMM/772-835             .QLGITVEVIGHEVEALDSTISRGLNSLRN-ASFTEQEKRIFDDINYAQQSLSDKWRFLSPLK-----lsg..
H2CGF7_9LEPT/753-817                 .QLGLIVEGIDHEYRTLFSQAKKDFKTLRS--GKNTVDSETFDHLYSVFNAINEKIESLAPLYRAG--rr...
A0A6L6UAB7_9FLAO/751-815             .QLGVAVEIIDHEFNQLYAKINSSIDKLSEVNLFTDVEQFNF--LKQNFKQLEDKYDLLSPLYRIS--gv...
A0A444J6D6_9DELT/666-732             .QLGLAVAVINHEFEAAIKGIRVNLRELGSWARASDDLVPLYQEIRTNFDHLDAHLNLFTPLQRRLQR.....
F8X1T7_9BACT/760-826                 .QMGIAVEIIDHQFNALYSQVAYAITQINDHLPTDEKAQRNYLSLKTAFEHLEDKYKLMSPLYRTTG-k....
A0A2W2AF67_9BACT/778-844             .QLGLAVGVIHHEFNSTVKSIRGSLKDLRAWADVNEKLEGVYKNIKVNFEHLDKYLNLFTPLNKRLNR.....
A0A6N0X144_9SPHN/769-830             .QLGITVEIIGHELEALDSEVSRNLEKLPDTAKKTLAFTRAM----DAHRSLTEKLRFLSPLQ-----laga.
A0A4U1IER0_9DELT/765-825             .QLGVTVEIVGHEFESLDAEVRRGLSRLPKEAQ----ATDAFQLIKHSHLSLMQKLRFLTPLK-----lsg..
A0A6F9ZA26_9BACT/777-843             .QLGLAVGILHHEFNGTVNSIRHSLKDLKAWSDVDIKLEGIYKNIKVNFEHLDGYLNLFTPLNRRLNR.....
#=GC seq_cons                        .QLGlAVpIlsHEFsshhpsl+pulccLcshuphssphpthapplcsuFcpL-shLplhoPLpRph.......
//