#=GF ID HEPN_Toprim_N
#=GF AC PF18871.5
#=GF DE HEPN/Toprim N-terminal domain 1
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Burroughs AM;0000-0002-2229-8771
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF SE Iyer LM
#=GF GA 25.00 25.00;
#=GF TC 25.10 25.70;
#=GF NC 24.60 23.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 23768067
#=GF RT Comprehensive analysis of the HEPN superfamily: identification
#=GF RT of novel roles in intra-genomic conflicts, defense,
#=GF RT pathogenesis and RNA processing.
#=GF RA Anantharaman V, Makarova KS, Burroughs AM, Koonin EV, Aravind L;
#=GF RL Biol Direct. 2013;8:15.
#=GF DR INTERPRO; IPR041487;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Alpha + beta domain. Fused to two distinct HEPN families:
#=GF CC MAE_28990 and ERFG_01251 families, TOPRIM and a Mrr-like REase
#=GF CC domain [1].
#=GF SQ 84
#=GS A0A2V5LHS7_9MICC/1-157 AC A0A2V5LHS7.1
#=GS A0A0D3V796_9BACL/1-213 AC A0A0D3V796.1
#=GS A0A0J8VM15_9ENTR/1-238 AC A0A0J8VM15.1
#=GS A0A0H3KTW5_BURM1/1-221 AC A0A0H3KTW5.1
#=GS A0A1Q2CU33_9ACTN/1-191 AC A0A1Q2CU33.1
#=GS A0A7G5YZB4_9SPHN/1-199 AC A0A7G5YZB4.1
#=GS A0A1E3G812_9GAMM/1-226 AC A0A1E3G812.1
#=GS H8MHT8_CORCM/1-238 AC H8MHT8.1
#=GS A0A1R3U1E1_9HYPH/1-197 AC A0A1R3U1E1.1
#=GS A0A3T1D6V4_9BACL/1-200 AC A0A3T1D6V4.1
#=GS A0A850QCW5_9BURK/1-196 AC A0A850QCW5.1
#=GS A0A4Q5VAX4_9GAMM/2-191 AC A0A4Q5VAX4.1
#=GS A0A6M8HXQ9_9PROT/9-227 AC A0A6M8HXQ9.1
#=GS A4JM28_BURVG/1-221 AC A4JM28.1
#=GS D4Z4D8_SPHJU/1-230 AC D4Z4D8.1
#=GS U5W7N9_9ACTN/1-199 AC U5W7N9.1
#=GS A0A840HWZ7_9SPHN/1-231 AC A0A840HWZ7.1
#=GS A0A4U8Z3Z1_METTU/1-196 AC A0A4U8Z3Z1.1
#=GS A0A6J4FDQ4_9PROT/1-230 AC A0A6J4FDQ4.1
#=GS A0A2C7A9V2_9PROT/1-207 AC A0A2C7A9V2.1
#=GS A0A430ARV5_9ENTE/1-213 AC A0A430ARV5.1
#=GS A0A2V4AE32_9PSEU/1-227 AC A0A2V4AE32.1
#=GS A0A1I0FNY9_9FIRM/8-156 AC A0A1I0FNY9.1
#=GS A0A7W4W1A8_9ACTN/1-191 AC A0A7W4W1A8.1
#=GS A0A1G6VZA6_9BURK/1-229 AC A0A1G6VZA6.1
#=GS V4JPW1_9GAMM/1-222 AC V4JPW1.1
#=GS F0GXH3_9FIRM/1-203 AC F0GXH3.1
#=GS B2JT78_PARP8/94-260 AC B2JT78.1
#=GS A0A2U3I473_9BURK/1-226 AC A0A2U3I473.1
#=GS A0A1G6LBN8_9BURK/1-230 AC A0A1G6LBN8.1
#=GS B2JT78_PARP8/1-78 AC B2JT78.1
#=GS A0A226HN01_9FLAO/1-217 AC A0A226HN01.1
#=GS Q88LL1_PSEPK/1-225 AC Q88LL1.1
#=GS A0A0Q3QUF4_9BACI/1-202 AC A0A0Q3QUF4.1
#=GS E0RWT1_BUTPB/1-153 AC E0RWT1.1
#=GS A0A7L4ZS80_9BACT/1-84 AC A0A7L4ZS80.1
#=GS A0A1M6EM45_9FIRM/1-221 AC A0A1M6EM45.1
#=GS B2JT79_PARP8/6-63 AC B2JT79.1
#=GS B2JT77_PARP8/1-216 AC B2JT77.1
#=GS A0A6J5H4F7_9BURK/1-172 AC A0A6J5H4F7.1
#=GS A0A840CUH3_9BACT/1-200 AC A0A840CUH3.1
#=GS A0A6J5H1K1_9BURK/1-227 AC A0A6J5H1K1.1
#=GS A0A1I5UN61_9SPHN/1-228 AC A0A1I5UN61.1
#=GS A0A0Q4J2X7_9SPHN/1-229 AC A0A0Q4J2X7.1
#=GS A0A369LHD8_9ACTN/1-221 AC A0A369LHD8.1
#=GS A5G5I6_GEOUR/1-230 AC A5G5I6.1
#=GS A0A6N8TFG2_SHIZO/1-225 AC A0A6N8TFG2.1
#=GS A0A5J6Q9X4_9PSED/1-229 AC A0A5J6Q9X4.1
#=GS A0A285E9E1_9ACTN/1-196 AC A0A285E9E1.1
#=GS A0A2S8B2J0_9SPHN/1-223 AC A0A2S8B2J0.1
#=GS S0FUC4_RUMCE/1-215 AC S0FUC4.1
#=GS A0A3N1XR98_9FIRM/1-221 AC A0A3N1XR98.1
#=GS A0A8A8D2K5_9BURK/1-190 AC A0A8A8D2K5.1
#=GS A0A2C8ZVU9_9MICO/1-118 AC A0A2C8ZVU9.1
#=GS A0A4U8Z7Z7_METTU/1-212 AC A0A4U8Z7Z7.1
#=GS A0A1H8BNA9_9FIRM/1-220 AC A0A1H8BNA9.1
#=GS A0A368JR12_9BACT/1-216 AC A0A368JR12.1
#=GS Q6LR51_PHOPR/1-226 AC Q6LR51.1
#=GS A0A8J3EFY0_9RHOB/1-106 AC A0A8J3EFY0.1
#=GS A0A859RIG4_9ENTR/1-234 AC A0A859RIG4.1
#=GS A0A7W9F2Y7_9SPHN/12-239 AC A0A7W9F2Y7.1
#=GS A0A126T4E2_9GAMM/1-223 AC A0A126T4E2.1
#=GS A0A1M5L8F5_9HYPH/1-196 AC A0A1M5L8F5.1
#=GS A0A4U0RML6_9ACTN/1-198 AC A0A4U0RML6.1
#=GS A0A3N9U8A7_9GAMM/1-229 AC A0A3N9U8A7.1
#=GS J7Q4E0_METSZ/1-201 AC J7Q4E0.1
#=GS A0A2K8X941_9FLAO/1-178 AC A0A2K8X941.1
#=GS A0A1U7P0N3_9DEIO/1-223 AC A0A1U7P0N3.1
#=GS A0A840YTI5_9SPHN/1-201 AC A0A840YTI5.1
#=GS A0A178MHL2_9PROT/1-225 AC A0A178MHL2.1
#=GS A0A0S2W1E3_9FIRM/1-193 AC A0A0S2W1E3.1
#=GS A0A8J3UTS8_9ACTN/1-192 AC A0A8J3UTS8.1
#=GS A0A4U1IEL4_9DELT/1-201 AC A0A4U1IEL4.1
#=GS A0A4R7I0X0_9ACTN/1-210 AC A0A4R7I0X0.1
#=GS A0A316TM42_9ACTN/1-191 AC A0A316TM42.1
#=GS A0A7H8IR64_9ACTN/1-184 AC A0A7H8IR64.1
#=GS A0A7T2LMD3_9SPHN/1-152 AC A0A7T2LMD3.1
#=GS A0A7Y2SSR5_9CHLR/1-213 AC A0A7Y2SSR5.1
#=GS A0A8J2YS03_9PROT/1-227 AC A0A8J2YS03.1
#=GS A0A4R3V9Q7_9BURK/1-227 AC A0A4R3V9Q7.1
#=GS A0A0R1J6A0_9LACO/5-177 AC A0A0R1J6A0.1
#=GS A0A370G667_GLULI/1-224 AC A0A370G667.1
#=GS A0A419VY56_9BACT/1-219 AC A0A419VY56.1
#=GS A0A4Z0LU43_9GAMM/1-229 AC A0A4Z0LU43.1
A0A2V5LHS7_9MICC/1-157 msskwwlhrgatqiqwqrneeplelltifteadkytddawlqaidrlegygry--.-------------.------..--------SPEDEEQQRLDEILVE-...................ESNGKDV....LGYRARVSRIRARLALMGFTANACRHELSLAIDEm......laDDEPGD........TLEVA.DKD........gEAVETIPRSEI......L...-DRG...LAAWENE-----..----...-----------...--------------..................----------...........---.------.------------.--------------------------------kpyrslg........................................................
A0A0D3V796_9BACL/1-213 .....................................................MG.SYCGLTINGVGLF.SVKNTF..SETHLKLFSPLEF--IKYKE---DL...................DGEDYER....YVFRTTVKKAMTRLEILGCSNKKLITYFNNGLEY.........QKSYYA........KPDDE.YDKr.......yEYYERLTFDNY......S...---N...ALRSILES--ESidIYDD...NIKNKHPK-IS...TDIISRLIVEKLSSg...............nlLNPFFYDDIY...........ENE.EHLIDHmLDIYMCII--NC.NEDSVVEYDLSSVVDGGWVDESDAL-------effd...........................................................
A0A0J8VM15_9ENTR/1-238 .....................................................MP.TWVALEIDGFAVRdYVTHHD..----TWYFHEHDRVREVLSVDTKD-...................EMSPDDF....IGYRASAATIRRRMTLAGYDLQACDAHFREYLDK.........VISEAQdiigfrvdSLQNG.GHPeeanaqmilDIEMYQKFIDA......I...KDTV...LEDWIALFPQAV..KLQR...ETMPLWDNWRE...VKWFEGSNVPLVCAm...............lsNIPLYPEYPV..........tYSL.NFPADH.PDYFITAYLASC.PDDAVCELNIAELIRAGYEADFTDLEEIQQG-t..............................................................
A0A0H3KTW5_BURM1/1-221 ..............................................mqctahs--.-----TIGGYPIA.STVDSC..---NRWQFMPEDRIIRFRRRCERNQltygp........pideldRDVIDTQ....YVYSITADTLRRRLGRAGYNRASLENEFQDYEKS.........TGKRLH........-LTGE.---.........---FAEAHDEA......F...-PGS...LYDWLDALAK--..TVKA...GVTPARRAAEG...LKPTGNLLVDIITG.................sDKPAFNDVEP..........eHGLpGFPCSS.FNNMAIALLEVT.AGNAVCELDVTSFILHQ---------------gditfddmlgrrne.................................................
A0A1Q2CU33_9ACTN/1-191 .....................................................MG.TEITLSLNGVDID.YGKNRY..WKSHHWLFPPGSLTDIEYRYA----...................NDAVETK....PGFQTTLNETGFRLRHLGYSLQETRTKFDAAVRR.........WNRTAD........-----.---.........---LQLSFEDF......R...----...-----SALT---..SIDF...GTLTPADM-KT...FIWDFRSYVR---S..................LLATWDTDDA..........gLED.FIASLD.FAITLRALADRAaSGPLPLRWHHQDLVESGWVALEDLT-------didrqt.........................................................
A0A7G5YZB4_9SPHN/1-199 .....................................................MG.SSCNVSIDGFSFW.GTKSYV..DDATLSVFHERDRQKRRMRRPQYG-...................GRKLEKT....IIYAVDAQAMRERLDAMGYTVAHARADYARGLSE.........--EYEL........YLGAG.---.........--FSKTDRKRV......-...KDWT...YDRWCAAV----..--AR...LVPQGFQVWSA...DKFPGDPDAE--RI..................SDGLR-----...........SGL.GSYFSD.PRYMLRGLLDAL.PGAQEAILDVTDLIDAGYYEGAEAICDEAR--rg.............................................................
A0A1E3G812_9GAMM/1-226 .....................................................MG.TEITLRIENITLT.YSKNDI..GDDHSSIFQEKDHMPVTSDQINYDYfk..............eagKSPGHME....AALVRSLKEIKPRLKLLGFNLQHAEDEYNKKIKE.........ADDNLI........YEEID.F--.........NKKERPTFTEF......C...-KLI...TQRPVSSFSDEY.iDYED..qEKEMYKIRGRL...TNCKFKSLPSFERA..................EADSYSESSY...........FSY.LIGFID.PYSILIILAENEeNLEARVIWQYGPLVYAGWASKSDFISGSNRNE...............................................................
H8MHT8_CORCM/1-238 .....................................................MS.WSVYLRIGSLLEV.WHEEM-..PSSVALLFGPEDFVTEGVPELE---...................SDAPSPS....SAFRSTVGRCKRRLSALGYDWSLFLASYREGVSGrv.....tlAMAMGCla....viDMDAA.ERL........pALFEATSPEED......L...AALG..rVCMWQAREDSHR.eEGAI..lQELPGGGEERG...YQQHFDMVLQWARDrp..............eaYDVLFAARAVef......iiwLRR.QSPDFG.WLFFVRAILEAF.QDDEFIEFDIAGRIRQFIEDGREVEPNDFA--sa.............................................................
A0A1R3U1E1_9HYPH/1-197 .....................................................MG.TYSDLKIGKFTVE.ESGNFS..TTRHQSIFLPSHSKTIIREG-----...................RDDQKPV....EVFQAPLRDLVTRLELMGSTLPAIERRFSDPYVT.........YDQPHD........-----.---.........-----VSFSDA......L...-ELV...RNADLDTIPEFD.mSSDS..pGILPPEYHDRL...RGPNYLGGFS----..................LGPGWD----...........LTS.LLERLN.AEDMLRVLVERPeNLDLMVVWDFMDVVENGYFEREDFTVGSAGQ-s..............................................................
A0A3T1D6V4_9BACL/1-200 .....................................................MG.SYASIGINGFHFS.LSKNHV..SPIWLTLYRENDKKIESVQD-----...................EDNEERL...iCEYCTTVKNIKLRLDILGFTIDKAKKEFISYNES.........-VQYCS........YLSGE.G--.........----F-VEIEI......-...NNYT...FDNWLKSLE---..----...CIINSPYSHYL...YYKDNIVITDYPMQy...............fmMNADYEGESI...........FGF.ISS--D.MRYVFRAILELY.GDDENCVIDFSSLVDGGWCSENDRICE-----etl............................................................
A0A850QCW5_9BURK/1-196 .....................................................MG.SYSGLNLGPFSIT.ESKNEF..ISYHSELFQAQDLVVSPLH------...................-EETTPE....EHYERPLRLVLERLELLGHTLERARREFERPNPY.........--SFAD........-----.---.........--PLPFTFDQV......L...EILQ...GIDVSKLS----..SRYS...EEFNDDIVSPL...EILQTVRTVQVPHD.................vETNHWD----...........LYA.LIRNFD.PYTLLRIFAENPvNLDLPVIWFFNDVVKGGWVERDHIQAGI----seha...........................................................
A0A4Q5VAX4_9GAMM/2-191 .....................................llldtlslslapddpk--.-------------.------..-ENHAALFRPGDRKIMTFPE-----...................GGDLNPE....HVFATTLPQIIQRLDLLGYSFESIKSEYESSTDY.........WSENWG........-----.CTPie.....kiSFERLVSLIES......N...-SLN...-----KLFSIHL..---P...ETSSDSITSED...TEISAQVFRRIMSV..................VEKEYPEQIKdgflagsnpsaFGL.LRRHLC.PYSILKLLSKSDsNQSLELIW------------------------rl.............................................................
A0A6M8HXQ9_9PROT/9-227 .....................................................MG.SMIHLTLGRIELD.WGKNSG..FSDHSALFRPDDLTTIPYYYAG-DSddlecahlpliqrredfsyRLITEMK....EGYSAPLKVVARRLLLLGHTDAYCRQEFQ-----.........WHAEDG........YLHHD.---.........-----FTFDEL......K...AILA...TADFS-------..--DA...HLSPEKGSESL...AEFLLTHVFPKYGPea.............pqrLQISWP----...........DGG.EVDGLS.AYTVIRLLADNPtAQELPITWQFVDVADGGWAPRAAFD-------aplrqss........................................................
A4JM28_BURVG/1-221 ..............................................mqctahs--.-----TIGGYPIA.STVDSC..---NRWQFMPEDRIIRFRRRCERNQltygp........pideldRDVIDTQ....YVYSITADTLRRRLGRAGYNRASLENEFQDYEKS.........TGKRLH........-LTGE.---.........---FAEAHDEA......F...-PGS...LYDWLDALAK--..TVKA...GVTPARRAAEG...LKPTGNLLVDIITG.................sDKPAFNDVEP..........eHGLpGFPCSS.FNNMAIALLEVT.AGNAVCELDVTSFILHQ---------------gditfddmlgrrne.................................................
D4Z4D8_SPHJU/1-230 .....................................................MG.TEIQLKLGGLGLT.YAKNHR..GPDHGALFQPADRQRIRSDQVDYEYce..............eegEDPSPME....WAFARKLKHVVPRLQLLGFTIDLAREAYSNWVVD.........WKEERE........SLQDD.DDP.........PIPEPLSFDEF......C...-AFA...TRQSILDL----..--DD...TFLSGDEEWRD...RRKPKGRFASDMAIierip........igfdhDDMAWSERSY...........FGS.RVNILH.PYLMLQILAGNAaNLETDVTWQYGPLVENGYTAAAAFTPSARRTE...............................................................
U5W7N9_9ACTN/1-199 .....................................................MG.SYGYLKVDSLVLG.TYKNGV..PAELLAIFRNDMFGTRQVSRTD--Yfdd.............adeDEGVLDV....VEFRAPAAVIADRLDVMGFEPAAALTLLEEALDR.........HKLLDT........DPGMD.V--.........RSEYSRAWSEA......L...RPLT...ADRWVTQL----..---A...AAVPGTGSAHE...QGRVISSAAWL---..................LDLLDEEYDP...........---.-----D.GRFLLRLVLLA-.RPAGEVILDVTDLAGGGWVPER----------paelp..........................................................
A0A840HWZ7_9SPHN/1-231 .....................................................MG.TEIELTVEGIALD.WSKNMM..GIDHGVLFQEGNRARRRAEEIDYYYfe..............qnqLDAAPYE....AAFVRPLARVLPRLNLLGHGLDGARFAYEAAVQS.........AIELAE........DVTSV.E--.........LPTDFMSFDDF......C...-AFC...RRYPLSSLGDHV.vASDA...EGEAEVPP-GR...FAAHADEIRRIPKEidp...........ypwlGGYDQSERRY...........FAS.VACILD.AYSMLQVLGRDGaNADAEVIWQYGPLVKNGWEDASSFVPGAPR--hk.............................................................
A0A4U8Z3Z1_METTU/1-196 .....................................................MG.SYCEIYFDKTEVC.GAKSAV..PDHFCALFQESDRVVRPSDD-----...................EDDESPD....VVYEACRAVVLSRLDLLGCTANVARERLMAWLAA.........TRETWE........EYRSD.GAW.........AEETAVA----......L...RSFS...VDEWYRRAPE--..----...-VLATLYS--R...EDATDEVDRHMRDR..................NGDGWL----...........---.WFDGYG.SLMSLRALLDAC.ADVRSVTLDITALIGGGWIEPDARVCEDRRA-s..............................................................
A0A6J4FDQ4_9PROT/1-230 .....................................................MG.TEIHLELGGLALS.WAKNHC..GPDHGALFQEGDRRAVRSDQIDYAYfq..............eenEDPTPME....MAFVRKLKQIVPRLDLLGFTLEQARSVYDHWAVQ.........WKEERE........ANADS.EGS.........PIPEPLSFKEY......C...-TFA...NRQSVTELDDTF.hDDNA...SLMSRTKCKGR...FIDDEATLERIPCSf...............dhDDQYWSERSY...........FGS.RINILH.PYLMLRILAGNAvNLETDVVWQYGPLVEAGWATAAEFMPLARRTE...............................................................
A0A2C7A9V2_9PROT/1-207 .....................................................MG.SYCEIQFDELSVC.SVKWYV..PDEWAALFQESDRRCRFCSDEDTDL...................EGSARPV....VDYCTDRPTFLWRLALLGATDTTVRSAFEKWLESar.....atWREYRD........SWTGE.---.........EQMGAARICTA......L...DTLD...FNEWKHQAN---..----...KAIHARYGSDA...AKPTDP--------..................FEQRFHDYDD...........SFL.HFAGYG.SLVGLRALLEAC.PEAKEVSLDVGDLVDAGHYEEDERICDQARS-r..............................................................
A0A430ARV5_9ENTE/1-213 .....................................................MG.TIINLSINNLCID.WGKNYF..YNAHSWLYESKEFQK---KYDDYNY...................---YEGG....LAISEKLIDVKFRLNNLGYSLNEVESKFNHQLNI.........WSKNHD.......cILTFE.LLK.........SIVMNIDLDKI......T...DRFL...SEDWENRYND--..NFYS...WLANDIKANED...YISIKRKYLNDNEK.................nKDEFYDGL--...........EDF.ILIKMD.RYIILRLFCENEsNLKYDLNWFCYDLIESGWVTIED---------inyfddkn.......................................................
A0A2V4AE32_9PSEU/1-227 .....................................................MG.TEITLDVAGVSVT.YSKNHR..GTDHGSIFQEQDRKAIKSDQINYDWye..............endEDPTPSE....AAFTRPLKYVVPRLELLGFNLEHVRREYDAVAQN.........WLEERK........YLQIG.DEE.........LVPDLMNFVEF......V...-AFA...AAYPLDSLDDTF.vPYAD...DAGKARIQARF...KEVQVERIPADRPS..................GIQVHSEQNF...........FGS.LVNILH.PYSVLRLLAEIEaNKDAPVVWQYGPLVQAGWATEREFMPDARRTE...............................................................
A0A1I0FNY9_9FIRM/8-156 .....................................................-G.SMISLGVGTMEID.WERNSY..FKDHSALFKPEDVKLIPYYYVGDDD...................KPLIIEK....EGYSKKLKYVKKRLDLLEYTLNEIDVMYDEIKCD.........------........-----.---.........-----------......-...----...------------..----...-----------...--------------..................----------...........---.------.------------.--------------------------------alchelqillsfddfaniiktinvnkintpklavefeengydfgefarrciisekeiydklle
A0A7W4W1A8_9ACTN/1-191 .....................................................MG.TQIMLSLNDINID.YGKNRY..WKSHYWLFPPGSEANVPTEYV----...................-SGVRLQ....PGYEASLADVRFRLCHLGYSYAETRAKFETYVHR.........WQRTDD........DLQ--.---.........-----ITYDEF......H...-DTM...TGIEFATLTS--..--DD...---LKSYIWDF...RDFVIDRLAT----..................-TQRD---KY..........vLED.FIYGLD.FSTTLRTLCDRQdNLQLPVRWQTQDLIDSGWVTLED-LKDIDR--qt.............................................................
A0A1G6VZA6_9BURK/1-229 .....................................................MS.TPITLTVGDIELT.YNTGYV..GMDHGMLFQERDRQRRRHPSINYDYyeq.............hpeEDVVQSE....MCFCRTLGSMVSRLELLGYTLSAVKAAYEIQSAL.........DSDRYA........GSEAD.DTP.........ARPIRLTFEQF......V...-TFI...RAHAVRDLKDEY..NDGY...DAEHAQGRGRF...ASEPAIALLPE--Gdp..............drDMGGYSERSH...........FGA.LISFLD.PYSTLRILAENPaNLDLEVVWDYGNFVAAGWAENGDFVAGARRTQ...............................................................
V4JPW1_9GAMM/1-222 .....................................................MG.SIATLYFSGYPVE.DTKNRL..---DQWIFKESDKRVFERKLSERNDltwg...........eiadEGEVETA....YVFEATVETIINRLEVLGYTLEACKRDFIETIKE.........--ELRKl......pELQEY.---.........DAEFVRSHRAI......C...ANFG..kFEQWLEAFS--V..IVRD...RPKEVFYMSEP...ERVHEDDLINYMLN..................PSPVWSEDWH..........pCGF.QYPSRN.FNFFARAFLESC.DRRSSVQLDATDLVNGGWYEGFEHLEDV----vkp............................................................
F0GXH3_9FIRM/1-203 .....................................................MG.SMITLRIGKMELD.WGKNNM..FNNHSCLFQKKDIKMVPYFYS----...................DDNIEYR....KGLSKNIKSVKRRLDLLGYSLHDIEEIFNEDLKS.........------........-----.---.........----INELDNI......S...IPIS...FNDYYNTVK---..NIDI...NSINMTSEEYD...YKYDLGEYVRKCVIse..............inKLSTFSEYEYy.........dIRE.FLQNLH.PYITLRILSENKkNHNLDIIWEYADVVENGWILEEDIIPKLTTQE...............................................................
B2JT78_PARP8/94-260 ...................................................ky--.-------------.------..-------------------------...................-------....-----------------GQDMTSLRSEFERYRSAmiadkaptfYASASD........YYGEE.ADA.........VRKHVPERADA......L...RETT...LDDWLLALKEVV.eSGAT...RAKGFTSPPMP...KGPTFD---TKALA..................DIILTDQHPCncdl...rpwhDLW.GFPCSL.LEHLAVAMLEVI.PPNAECVLDVTELVENDCVYCFEDLILA----ned............................................................
A0A2U3I473_9BURK/1-226 .....................................................MD.CIVHATIGGFPIA.STVNSY..---NRWRFRPEDRIIRCRRRDQRDPliygt........pideldAEVVDTQ....FVYSTTADTLRRRLGRAGFNRASLEKEQWEYYERv.......cHMSEGR........NLHFT.GES.........AEAHGGAFSDA......M...----...LDDWLDALAH--..AVKD...GVTPARRAAEG...FKPTGNPLVDIITG.................sDKPPFEELEPe.........hGLI.GFPCSS.FNNLAVALLEVT.AGNPVCELDVTSFILH----------------rgditfddmlgrrd.................................................
A0A1G6LBN8_9BURK/1-230 .....................................................MS.TPITLSIGDIDLT.YNTGHM..GIDHGHLFQEIDRKRRRRPTIDYSYfeq.............hpeDDLAQME....MCLVRPLITMLPRLELLGHTLDTVKEEYELRAAE.........HQERKM........YDAED.PGA.........CDMPLLGFDHF......L...-DFV...RMHAICDL----..---S...NELPDDVGDAD...RDGKFGRFSSDAVSaflpk........lewwdAGNSYSERSH...........FGS.LLDFLH.PYSVLRVLAENPaNLELDVVWDYGAFVSAGWEKNEHFITGARRA-q..............................................................
B2JT78_PARP8/1-78 ..............................................mtfrayy--.-----MFNGYPVC.WEQESY..---FRWLFTRKDRVIRHRTKGERNAlihdl........penraeWDEPETD....YLYVVTAEELRRRLSL------------------.........------........-----.---.........-----------......-...----...------------..----...-----------...--------------..................----------...........---.------.------------.--------------------------------i..............................................................
A0A226HN01_9FLAO/1-217 .....................................................MG.SFCALTLNGYEID.QSKSYI..STFWSCFFNEDDRRSRSVPYDLYYTqp...............itDNNNVPT....FEYSASVDTMKLRLEIMGYTLDKVKLKYADGIEI.........ALKSRQ........QYNAE.LFN........tVENSDEKHLNI......L...KNGG...FEYWLKLIKY--..IFDN...KITNFSDNLEL...HDDIYSFILD----..................-YNDVDEDLY...........--L.GYPNIG.IGYFLRGALEAV.EPRSELILDITSVVDSGYYKEDEPVCASTA--qm.............................................................
Q88LL1_PSEPK/1-225 .....................................................MG.SVAQITICGYPIY.ETKNYY..---GRWYFRKKDRVIRIRKKSERNPliwc...........aaeaEEMHEEEt..dYLYTIPGSVLRRRLELDGFNRETLEREFSEYITQ.........QVTRME........ELCEA.DTE.........WAQTLIPRIAM......L...QNSN...LNDWLQRLKT--..AFDD...GIVNWRWSDCE...QNYTDPLLHHWFG-..................HGSFTEEASV...........HDT.GFPCQS.LESMAVAMLEIL.PVDAECTLDITDLIGGGWTNSFEDMIEYNK--df.............................................................
A0A0Q3QUF4_9BACI/1-202 .....................................................MG.HYATLTVNGFQLY.SSKSYV..YPELMTLFRESDKQIQNWIDE----...................DNEEFIS....YRYVNSVKNIKLRLDIMGFNLNNSHNDFMTNNDY.........--EYNV........PVYED.EQI.........-------DDQV......L...SGYT...FDSWLKAMKSII..FNKL...SIYELKDKFCN...FKKNNSPIETY--I..................LNEHFDGESF...........FG-.-FESSD.IRFIIRSLLELF.SDEDKFILDYTDLIDGGYCDETDEL-------skesi..........................................................
E0RWT1_BUTPB/1-153 .....................................................MG.EYVSITIGNYDFL.QRKNTF..-GDLLSIFDKKELIIKETQDE----...................EGKKYIQ....RYFCTSIKNAKMCLDVMGHTISQAKVLFDNLKEA.........EIDYLE........---DS.---.........--TENIDLEQY......K...KEFD...FDSWRNAVLK--..----...-----------...--------------..................----------...........---.------.------------.--------------------------------yakilendiykefkylnlekerqkkvpfsegiqkshrhi........................
A0A7L4ZS80_9BACT/1-84 .....................................................MG.SMITLRVNGLQLD.WGKNHG..YRDYSNLFLPSDRKKVPYSYA----...................DEVEEHK....LASACKLKDVKARLDLIGYSLAKLESIYEV----.........------........-----.---.........-----------......-...----...------------..----...-----------...--------------..................----------...........---.------.------------.--------------------------------nlryi..........................................................
A0A1M6EM45_9FIRM/1-221 .....................................................MG.SYCELSINGIELY.ANKNYF..DEVILNMFSPNEIVTERIEI-----...................DGEFIDI....HLLRTTVKKAKRRFEILGCSEKKLKEYFVKGVDY.........MKYEYD........SSKID.LNK.........--LDPIELEEFn....yY...KQLTfdnYNDAIKKVLSYE..NLDYyetGIFNKFIELET...NILTKHI------Inklk..........sghyLNPFFWN-GI...........YEN.EEHIIN.PMLDLYICLFNS.KEQYIVEFDLTSIINGGWIEESDIT-------nyykn..........................................................
B2JT79_PARP8/6-63 ............................................lteerpqpt--.-------------.------..-------------------------...................-------....----------------------------------.........------........-----.---.........-----------......-...----...------------..----...-----------...--------------..................----------...........---.-LPCTE.FGNSAVVVLEVV.PRNAECVLDVTELVQNKRVYCFDDLVLA----segt...........................................................
B2JT77_PARP8/1-216 .....................................................MGmPSAFITINGYGLK.TTRLGY..---RRWRFKREDRAI----------...................RPMDRRE....YVYVTSAAVMRKRLTEAGYNRPALELEYLRTLQK.........ISAEGAe......sYFRTR.CCI.........GRYTSTQRAEA......C...RRAS...LNDWLFALKENI.tNRKA...RISNPPDRVDD...RGRPAEVDVLI---..................DTLAYSESTIypi....ktehLLN.AFPCAS.LDCMAIAMLEVV.PDTAECILDVTDLVNHELVYCFDDLKKVDET-t..............................................................
A0A6J5H4F7_9BURK/1-172 ....................................................m--.-------------.------..-------------------------...................-------....----TTAAELRQRLRRAGFTRESLEREFLEYKDK.........VVHFTD........LQHLR.DTP.........--EEAHRRAHS......V...QYAA...LDDWLCALGLLQ.hCIAA..gQFTDAR----F...YEYRASDPLID--Iqml...........tqciSLSR-----YigetrdalprhNRF.GFPCAS.LECLAVAMLEVV.EDDAPCELDVTDFVRYEGSRAFDDVTRRE---gqe............................................................
A0A840CUH3_9BACT/1-200 .....................................................MG.SMITLGIGEMEVD.WGKNWY..FNDYSNLFLPADEKDIPYYYA----...................YDIIEYK....PGYSRKMSKIKDRLELLGYSIHNLRNIYQKYLID.........YFEDYS........-----.---.........--AVSLTYEEL......LnifSNIS...IKDYRENLDD--..AVRK...YAIEHILNHKL...FEPLRKPYS-----..................DDFAFD----...........SDH.FFENFD.VKFLLRLLMENPqNLDLDLEWRTADVIEGGYVDEDSMCIGID---dsd............................................................
A0A6J5H1K1_9BURK/1-227 ...................................................mp--.-YASIEIAGSTIS.EMF---..YGYRRWFFVRGDMVVRTVTDAH---...................DHSSKLQ....YLYVVTAAELRQRLEMTGFTRASLERDFNRYADK.........VENFTKl......pYRADT.P--.........--DVASRRADT......V...RRAN...LDDWLAALKA--..---S...HRLDGAGDGKF...AEPYQASNDF-VDIdlladsisncwmslpggpNDARDRGSSDtl......lqiNSL.AFPCTS.LECAAVAILELA.PCNAECVLDVSSLVKEGMVYCFDDLAEQ----ag.............................................................
A0A1I5UN61_9SPHN/1-228 .....................................................MG.TSIELTVCGVSLS.YAKNHM..GLDFGYLFQDADLTRRPCRGIDYEYyreh...........petmADLIESE....LTFVRALCRVIPRLNVLGHSLEGARAEYEAVIAE.........AASLDD........PEPDT.D--.........-QERYLSFEEF......C...-HLA...NLLPLTEL----..--SD...RFVDLPSD-ER...EIEAQGRFAAHAGLfarl.........pltdnSDLYWSEASY...........VSA.RLCILS.ASSMLLIFALNPeNARAEVMWQFGDIVNAGWVARDAFVAGARRNQ...............................................................
A0A0Q4J2X7_9SPHN/1-229 .....................................................MG.TIIDLTIDGLELC.WSKNSM..GIDFGTLFQKGDQARRRSDQVDYASd.................eADDEEPF...dAAFVRSLGRTLPRLNLLGADIEAARAGYEAAVSQ.........AIETAR........DITSV.S--.........LPTEFMSFEEF......C...-AFC...SRYPLSSLD---..---T...RRIPPGLEGEE...TT-PPGRFAAHADEvrripte....pdyypwmREEGQSEKSF...........FAS.TVMILD.PYPMMQVLGHNGaNADAEIVWLYGPLVENGWEKASSFVPGIGR--ys.............................................................
A0A369LHD8_9ACTN/1-221 .....................................................MG.SYVNLSIEGCEVL.EFKNQI..PPEIMSIFQEGDKKKRIYNTETERYedy............lrepREDEITS....VVYTASREVVLARLDVMGFTHAALKADFERGVTK........eLNSLME........DLPPD.YRNd.......eFYDHQAEHIDI......L...QDFT...FDAFVCGGKEIL..EKDL...KSWNDDHN---...RNDIAASTSYM---..................LDEHYE----...........MLY.GYPGTD.IRFIIRMFCEVA.QEGSNVSVDLSDIIGGGWVKED----------iafaseakkn.....................................................
A5G5I6_GEOUR/1-230 .....................................................MG.TEIEFEIGGASLS.WSKNSR..GMDHGMLFQAKDRKRLHSDQIDYDYft..............engQDPGLME....MALCRPLKEIVPRIELLGFTLNEVEREYKKCTES.........WLEQCQ........MMAHE.VEE........fSEPDVMTFQEF......C...-AFV...AAHPIQTL----..--DH...SFISSFDNAES...ERKIQGRFDAMPEIrrip.........yfpsaIDNTYSERSY...........FAG.LVNFMH.PYSTLRLLAQNMsNLNADVVWQYGPLVENGWASESEFIPDARRNQ...............................................................
A0A6N8TFG2_SHIZO/1-225 .....................................................MG.TEITLDVAGVSIT.YSKNHR..GIDHGPIFQEQDRKAVKSDQLDYDWye..............kegEDPTPSE....MAFTRQLRDVVPRLELLGFDLERVRREYDAVVQN.........WLEERQ........SLQDE.EDG.........PVPDAMSFLEF......M...-EFV...NAHPLDRLDDTF.iSGSD...DASEAKIRGRF...AGMQLERFPFYRPY..................DSQAYSERTF...........FGG.LIDILH.PYSVLRMLADA-.NGDAPVVWQYGPLVENGYAPEREFVPHARRTE...............................................................
A0A5J6Q9X4_9PSED/1-229 .....................................................MG.TSIELKVGNVSLD.YAKNSM..GNDYGFLFQEDDLTRIKREGIDYEYyaeh...........peegAELEISE....LAFVRPLARVIPRLDLLGHTLESAKIEYQSLINE.........ENSLWD........EVSIA.H--.........EKKDFLTFEEF......C...-LLA...NLFPLDDLANEY.vDFSD...R--------ER...EKVAQGRFAEHYADfsrl.........pslgsYNSYWSESSY...........LSD.KICILS.AESMLQVFYQNPeNSDAEVVWEFGSIVSAGWVNQDMFQAGAGRQQ...............................................................
A0A285E9E1_9ACTN/1-196 .....................................................MG.WIARLRIRDLEAFsWYDDV-..EPTFLFLFTSSDVVREPRDPEELD-...................DYPDAYA....TVLVATAGILADRLDFLGLGKKASERVFGCNLDQ.........WLEWQK........ALLPE.--I.........GEELLQPEIDA......L...EGLE...LSGWVDLVA---..----...EALPAPKLGTA...RRRGSPV-------..................--SLDS----...........LLR.IWQDDD.PRLLLRALVMAL.DPADDVRLDVSP--------------------mregnhidaafnpqaaat.............................................
A0A2S8B2J0_9SPHN/1-223 .....................................................MG.TAIELEVGDVSIS.YAKNHM..GMDFGYLFQRGDETRRKSDAINYDYyeeh...........peekDELVVHE....AAFVRPLSRMLPRLFLFGSSIESARFEYEAIIAE.........AREFAS........---YG.EPP.........DETDFLSFEEY......C...-ALI...RRYPLSSLGG--..---G...TEFHDKEKAKGrlaADKDFDRL-PWTDN..................SDSFWSESSF...........IAA.KLAILS.PESMLHVFALNPdNLDAEVKWEFGPLVVAGWASRENFEPGARRM-q..............................................................
S0FUC4_RUMCE/1-215 .....................................................MG.EIVSISIGSYSFL.SYKNTF..-GDLLTIFCPEDRCVKESTDD----...................DGEPYTN....YSYITTVERAKKCLDCLGFTVEAARNSFEKSKQE.........EIEYLD.......eYFDEK.YHSyd.....skTIRRKFTFDKW......C...SAAK...RYALILSK----..---D...RFTKKCQYTNL...ERQRKRKRLSVADRiv..............ldSLPFEHNEHF...........FGI.YFEYTS.RWEIFRVLLDAF.EPKTQIVLEYTSLFNGGWCNEF----------peedefc........................................................
A0A3N1XR98_9FIRM/1-221 .....................................................MG.SMITLGIGRMEID.WGKNNS..FTDHSSLFKLSDIKPIPYYYVDFDT..................dEPLVEMK....NGCARKLSSVKKRLDLLGYDIESIRGMFEDTIRQ.........HEKYGY........-----.---.........--KIKLSFDVF......Y...-DVL...RVIDVSEMD---..TVQF...SVEFEQNGYDF...GEYARRCVLEAPQIkdkil.......veyegdGDIEYRNPQF..........eVSE.FLENLD.PYITLRILAENPnNADQEVRWSFADVVENGWVQMDEVVQ------vldskk.........................................................
A0A8A8D2K5_9BURK/1-190 .....................................................MG.SMISLSVGSIDID.WGKNEF..FENHAHLFQPGDESENDYHYVKEDG...................SPIVKVQ....QCLKRPLGRVVPRLELLGYTLPSCAAKLTAWLGD.........EDETGP........-----.---.........--ASMTAFRHA......L...TTFQ...WRECGEYV----..----...---------DF...EEAFRAAYAAAPDS..................NVPPDQDSQF...........VAW.ERPI-D.PYLVLRVLGDMPeYVDLPVCWNFADVLEGEYVDSETFEP------sp.............................................................
A0A2C8ZVU9_9MICO/1-118 .....................................................MG.SWWNIEIGGRAAPiWGKNYV..GDDLMLLFNDDDFHVSAAKLE---Aledde........pssidtDDPSASRrtdlMGYSSNAGALRQRLQLQGFSTQWVRRLTAAYFDD.........------........-----.---.........-----------......-...----...------------..----...-----------...--------------..................----------...........---.------.------------.--------------------------------qedewrdeggnlrglfpn.............................................
A0A4U8Z7Z7_METTU/1-212 .....................................................MG.SMISLAVGRLEVD.WGKNNG..FVDHSALFQSDDTAQIPYYYAGQEIegad..........gapdwEVITELK....EGLSKPLAQVIERINLLGHTHSVCDAEFAALAEF.........------........-----.---.........-----NGFDAT......-...-TFS...FSDLREALAS--..-IDV...SSLSPNYG--E...GSEDFGKFFR-RQIlprl..........glkaSGPDPMELGC...........IAE.GMENLS.AYTILHLLAENPtARGLNVQWAFNDVEDGGWAKRSDFVKPVDQS-s..............................................................
A0A1H8BNA9_9FIRM/1-220 .....................................................MD.SMITLGIGQMEID.WGKNSS..YKDHSALFQLSDIKQIPYYYVDTDT..................eRPIVKMR....EGVSRKLKNMKSRLDLLGYDIASIRERFMEIVRE.........HEDHSC........-----.---.........--TVMLSFDTF......-...----...YNAFKEINVSEA.nTVKY...EVEGFENGYDL...GEYVSECILKIPDIk...............dkLFGEFPNDDFerrs...lindLAI.FLENMD.PYITLRILAENPaNLDLEVQWNFSEAIDCGWANRIDLLKEIDPK-s..............................................................
A0A368JR12_9BACT/1-216 .....................................................MS.KYIDLSIGKILIG.SFKINF..DLDLLSLFDRSDIVQ-HYSTLEEEGlveey.........shraiVNPHLTV....FYFKSSLSIIKDRLEIMGYTSEVAKEGFNKSIEY.........LVSNRE........YEISK.EDF.........IDTSDQYPISF......F...TQLT...VEKWLDKFKYIA.fDRDK..yDTINTNHNSNE...--------------..................----------...........---.------.------------.--------------------------------dllesyiasrqwfgypgndiliflrlvidffdpndqliynfteylydqvddeyefihelea..
Q6LR51_PHOPR/1-226 .....................................................MG.SYADINIKNHELLsWKNTYD..----EWYFSKQDRVREITE------...................EDDSKSF....IGYRVDVRTLRRRLQLAGHDLRSAERDFKDTRML.........WIEEMKe.....slQRHRA.HQEkkpdrfrveMIEEITSELEV......L...QAHG...FNDWLLALPLVL.sKSKD...NLEQGIYDQKV...HIENEPLLSFMLSS.................lSGVYDDNQGF...........AGS.TFPCRY.IETYAVALLEIS.NDDDACELDITDLVNGGWVDDFNDIAQVQAG-e..............................................................
A0A8J3EFY0_9RHOB/1-106 .....................................................--.-------------.------..-------------------------...................-------....----------------------------------.........------........-----.---.........-----MPFKEA......L...-ELV...RNVDLASLKEGT.rDNHG...GLLPAEYQKRL...EEPLTDHYG-----..................RAPGWD----...........LST.LLDRLM.PYDILRMLAERPaNLDLIVQWDFMDVVESGYFEREDFSVGVD---de.............................................................
A0A859RIG4_9ENTR/1-234 .....................................................MG.TEISLKVSGATLD.WSKNSL..GVDHGALFQSTDHIMIPQHE-RYDLeet............deidEERRLQW....TVLRKPLAAVAERVELLGFSLTAIRAEYENLVKH.........EVYQRN........EMIEAyPDNw.......ePLENLFSFDEF......L...-GLL...KSYDLGELNDKD.iDFDN...SKKTENDNFIL...KLFPNDILKR---Iply............dpyNNFYWSEKTA...........FFS.VINILH.PYSMIKLLSENKhNLSEYVEWDYGEIVANGWVHINQIKTEINR--en.............................................................
A0A7W9F2Y7_9SPHN/12-239 .....................................................MG.TEINLIVGGISLS.FSKNHM..GIDFGHLFQEGDRTRHKMEEISYDYyeen...........pdeiADLEVSE....MVFARRLDRIVSRLELLNHSLDAARAEYAVIVAE.........TIEMAL........Y---S.ESP.........EDPSILSFEEF......C...-ALA...CRYPIDVLKDAY..----...--IEYETP-DR...DKVAQGRFAEDADEfarl.........pgdryNNLYYSEKSY...........LSA.SLCILS.AESMLRVFALNPdNADIEIVWEFGPLVNNGWANKNDFNPGARR--vq.............................................................
A0A126T4E2_9GAMM/1-223 .....................................................MG.TEITLDVAGVSVT.YSKNHR..GIDHGSIFQEKDRKAIESDQLNYDWyr..............engEDPTLSE....MAFIRPLKHVAPRLELLGFNMERVRREYDAVAKS.........WLEERQ........SFQDD.E--.........PIPDLMSFAEF......C...-KFV...TSHPLDSLDDTF.iIGTD...SASEKMIRGRF...DGMQFERIPAYRSY..................DNHAYSERSF...........FGG.LVSILH.PYSVLRVLAEA-.NEDASVVWQYGPLVEAGWATEREFVPHARRTE...............................................................
A0A1M5L8F5_9HYPH/1-196 .....................................................MG.TYSDLKLGKFVVE.QSGNFS..TSTHQSIFLPKHSTFVRREG-----...................REDEDPV....EIFQAPLRDLVTRLELMGSTLPAIERRFSNPWVT.........YDEPHD........-----.---.........-----ISFGET......L...-DLV...RNADLSLIPDWE.gDDDN..fGILPQHYYGHL...IEKVGVHFL-----..................ASPAWD----...........LTA.LLERLS.AEDMLRVLAERPeNLDLMVVWDFMDIVESGYFERKDFSVGCGNQ-s..............................................................
A0A4U0RML6_9ACTN/1-198 .....................................................MG.HHSYLVAGDCQFL.YTRGHY..DEELAALFNETDRKLIVADGSDVTPg................deWDESEDA....LGYYTTANALRQRLNVQGFTSRRALADLAEGIAH.........WRKIYD........SQSQL.-RE.........RQARGESLFET......L...-ARP...PREPAELL----..----...AAIGEAIRPHR...PEKSFATFQEWFQY..................EDEFGETVTD...........VEE.LRCFVE.ERSLIRLIIDQA.PDDTRVGLNLGEL-------------------tgc............................................................
A0A3N9U8A7_9GAMM/1-229 .....................................................MG.TSIELCVGKVSLS.YSKNFK..GEDYGFLFQEGDLFRRRTDAINYDYcekc...........peekEELAEAE....ELFARKLSRILPRLDILGFTLETARAEYQMLVAE.........AEEISS........YINVE.E--.........SKKECLTFEEF......C...-NLA...CRYPLGDLKS--..----...DYIEYDTPDRD...T-ISQGRFAADVDVferi.........pwsgiSDSYWSEASF...........FSA.RVCILS.AESMLQVFALNTaNAEVEVTWEFGPIVHAGWVQREAFRPGALQ--kq.............................................................
J7Q4E0_METSZ/1-201 .....................................................--.-------------.------..------MFQEQDRKRVRGKQIDYDYfe..............etgKSPVAME....MALSRPLKDVVPRLQLLGFSLERVKREYERTAEA.........WREERR........SLADD.EQE.........PLPDLMSFDEF......-...RQFV...TRHPLRSLDETF.vSGTG...KANEASVRGRF...NNE--GITARLPRYs...............pfDFQAYSERTY...........FGE.LVNIMH.PYSVMRLLAECKaNEDDEVIWHYGPLVDAGWANESDFVPNARRTE...............................................................
A0A2K8X941_9FLAO/1-178 .....................................................MG.TYCKLKVNGYDIF.EIKNDY.qSEVINLIFDESDFLVKQFDG-----...................--DDYIS....KKFISTAGICKKKLEIYGNNLSKTKNDFNIALKK.........YKDEYE........-----.---.........-----VIFNNE......S...-EIS...FKNYQKIIE---..---T...SINKGIKNYGD...CDDYFSLNF-----..................QEFITS----...........NNF.GIPNQK.LECLLWSIFDSI.DEDIEIVYDLTFIIEAGWIT------------nnpe...........................................................
A0A1U7P0N3_9DEIO/1-223 .....................................................MG.AYAELYFDSSRML.SIKNGV..PYDLLSVFSDREREVLSPTDFHLKApfi.............pfdLEMECSY....YIYQTQASFIKDRLDLMGINLKNLEVMFNEGWKD.........HKEFKS........AEGEN.PNP........iLQELRVKYNSEndlkddL...HIYN...FDYWKNLVKL--..AVES...NISLDNHTYGR...FDFLGS--------..................ETFSYHQDQY...........-GF.PNYYLD.FRYLLRILLEYL.PGTQLITLDYTDLALNDYESADEMLCERVI--es.............................................................
A0A840YTI5_9SPHN/1-201 .....................................................MG.SPIHLAVGRFEVD.WGKNNM..FTMHGEMFQPGDVHLVPYAYWDEDA...................EAIIDDL...kEGASRSLRRVLPRLALLGHSITTAKAEFASIEGQ.........SGEPLS........-----.---.........--ITFDQLAEA......L...TAFD...VSSPIVDESE--..--DH...GFGEFFAREIY...VRLGLD---RF---..................GGERWVAREL...........-GY.ALENLS.PASVMVLLGLNPkNLDAPVTWQFADVIEGGWAGRESIID------slgrv..........................................................
A0A178MHL2_9PROT/1-225 .....................................................MG.TEITLDVAGVSVT.YSKNYR..GIDHGSIFQEPDRKPVKSAQIDYDCye..............kdrEYRALDE....MAFTRPLKHVVPRLELLGFNLEHIRREYDVVAQN.........WQEERL........SLLDE.DDK.........TIPELMSFEEF......-...RAFA...AAHPLDGLDNTF.iAGTD...DASEAKMVGRF...DSVQLERLPTYRPY..................DIQAYSERSF...........FGE.LVNILH.PYSVLRLLAET-.NEDAPVVWQYGPLVQAGWATEREFVPNARRTE...............................................................
A0A0S2W1E3_9FIRM/1-193 ...................................................mt--.-------------.-SKNSF..-GELLLPFSSRDLRIEDAFDE----...................DGEQYTR....RYFSSTVSRLKLILDSYGFTIEVAKQNFATLKTE.........KLDFIQ........YCLES.DGE.........--TFGLSQEDV......A...TNFT...FENWYQAA----..-LRY...AEVLANGQYEL...DQFRTE-NLSIAEKi...............llDSLPYGEG-Y...........WGF.TDVEFN.VWSVFRTLLDAF.PSEMDVILDYTDLYESGWCDE-----------ypteedyd.......................................................
A0A8J3UTS8_9ACTN/1-192 .....................................................MG.TAITLSLNGIDID.WGKNRS..WKSHFWLFPPGSLTDVEYLYA----...................NDVIETK....PGFQTTLNEAYFRLRHLGYSQQETKTKFDDAVAR.........WNRTAD........-----.---.........---LRLTFADF......R...SALT...SVDFASLTP---..----...-ADLEPYVWDF...RAFVVNLLA-----..................---AWDTDGA..........lLKD.FIAGLD.FALTLRVLADRVeSRSLPLRWHHQDLVDSGWVTVEDLTG------idrrtf.........................................................
A0A4U1IEL4_9DELT/1-201 .....................................................MG.SLISLGLASLELD.WGKNDF..FRNHSALFLPGDVKLATYYYA----...................GGITEQK....RAFVRSLRSVARRLEMLGYTLQDCKRRYDEAVSD.........VPSYYP........-----.--A.........PILSYAQFANV......L...KNVN...VG----------..---A...VGIPEEGDYDL...GEYASKAIMNDPQFt...............ktEQILGSIRSD...........EGT.FFENVD.PYITLRLLAENPqNLNQDVVWRIADVVEGGWVEEDSLYEGVPRT-e..............................................................
A0A4R7I0X0_9ACTN/1-210 .........................mssyattyladgrpicsfrdgvdqlfyt--.-------------.------..------LFMRSDWVELHGQE-AYELapks...........fvdfDPEEAVI....IGFRVAAGSLRDRLDVMGVDRETVRSELEVLLEE.........QTDRKS........HLVES.FAT.........SPDVVAQIETD......I...---G...AWAAVDSE-SWF.vQLGE...RIQAGDHVDRP...GQRTPG-SAS----..................---------W...........LMS.LWDYHD.PRYRLRAVLEVL.PADLEITLDLADLIEGGWLGPDD---------dprtvas........................................................
A0A316TM42_9ACTN/1-191 .....................................................MG.TQIMLSLNDINID.YGKNRY..WKSHYWLFPPGSEANVPTEYV----...................-SGVRLQ....PGYEASLADVRFRLCHLGYSYAETRAKFETYVHR.........WQRTDD........DLQ--.---.........-----ITYDEF......-...HDTM...TGIEFATLTS--..---D...D--LKPYIWDF...RDFVIDRLAT----..................-TQRDK--YV...........LED.FIYGLD.FSITLRTLCDRQdNLQLPVRWQTQDLIDSGWVTLED-LKDIDR--qt.............................................................
A0A7H8IR64_9ACTN/1-184 .....................................................MG.HYSYLVVGDCQFF.YFRNHY..DEQLAALFDEAERECVAPN------...................EATGEGK....FGYFTTAHALRQRLDVQGFTSRRAQADLAEGLLQ.........WRKSYE........DEREE.---.........-----AAKDEW......-...----...VREPRTREPR--..ESAD...LLAGIGRAVRP...HRKSFETIGEYLQY..................ENQFVETVQD...........VDE.LRGIVE.VRSLIRLLLDQA.PDETRVGLDLSEL-------------------tgc............................................................
A0A7T2LMD3_9SPHN/1-152 .....................................................MG.TEIEIYVGRTAVP.-DANYMgwQNCTDHVFYEADFFRRPRNSTHKVVrdvs...........dqyyIEPPETY....RYFLAPAEVVRKRLMIQGYTPEFCAHSWEVSRLH.........QVETYQ........KFARG.EDS.........----QISADLA......L..mASTS...LSDWLELVRRQE.kASPD...KVITGR-----...--------------..................----------...........---.------.------------.--------------------------------hqpwhi.........................................................
A0A7Y2SSR5_9CHLR/1-213 .....................................................MG.TYTDFYISGYSLF.STKSDV..DFSLMTIFREADKRVIHEEVE----...................DDQQLSE....YRYVTTIRSAKDRLEVMGFTLEKAKKEINYGISIkl.....qvLEEQIS.......eTSSSG.--Yq.......lLIEEWTRERDL......L...KGAL...FEDWISAFSY--..IIQH...NLQPYYEKSDI...FDNTPPLAL-----..................YILDTS--SD...........HPF.NLPTGD.LRFVVRIILEAC.SSDEEIYQDVTELIMAGFYQADDPICEMA---vhe............................................................
A0A8J2YS03_9PROT/1-227 .....................................................MG.TAITLDVAGVSVT.YSKNHR..GIDHGSIFQEQDRRAVKSDQLDYDWyq..............ekgEDPTSSE....MAFTRPLKDVVPRLELLGFNLDRVEREYAAVARH.........WLDQRS........TLQGE.DDQ.........PGPDLMSFAEF......F...-AFV...TAHPLDSLDDTF.iSSTD...DATESKIRGRF...AAMPLERIPNYRSY..................DVNAYSERSF...........FGE.LVGILD.PYSVLRILAEAQaNKDVPVIWQYGPLVQGGYAAEREFAPHARRTE...............................................................
A0A4R3V9Q7_9BURK/1-227 .....................................................MG.TEITLDVAGVSVT.YSKNHR..GIDHGSIFQEQDRKAIKSNQLNYDWye..............ekgEDPTPSE....MAFTRPLKHVVPRLELLGFNLERVRREYDVVVQG.........WLEERQ........SLQDY.DDE.........PIPDLMSFAEF......C...-AFA...TAHPLDSLDDTF.iSGTD...DASEKKVRGRF...DGMQFERIPGYRSY..................DLHAYSERSF...........FGG.LIDILH.PYSVLRLLAEAKaNEDAPVVWQYGPLVQAGWATEREFMPHARRTE...............................................................
A0A0R1J6A0_9LACO/5-177 ....................................................n--.SYLFFSIGNFEID.FNKGYM.sDENYCPLFTSSDKKLVKYIYD----...................NNNYEMK....MGYSKIGFDVKERLNMLGYTFQNTKKKYEEYINS.........YSNSII........-----.---.........---DKIDFESL......V...----...KILYKINI----..KEKY...NYSEDDNPQYL...DHSEIPWDVSE---..................KLNIFNINH-...........YDE.FLLNID.PLIILRILLEVKkNCNFFVTL------------------------rh.............................................................
A0A370G667_GLULI/1-224 .....................................................MG.TEINLMVGGISLS.YAKNHM..GIDFGHLFQEGDQTQRRIEEIDNDNnsen...........pekeEDREISG....MVFVRTLRRIVPRLELLNHSLDTARMEYEAVIAG........sAVPPRD........-----.---.........NESSFLTFEDF......C...-LLA...CRYPISSMS---..---D...EYIEDETQ-DW...ERAAQGRFAVYADDfsrl.........pgdqlDNLYYSEGSY...........FSS.YICILS.AESMLQVFALNPeNLDIEVSWEFGPLVSNGWASIHDFQPNARR--pq.............................................................
A0A419VY56_9BACT/1-219 .....................................................MG.SYCELYIKDYPIA.TTKNEI..DPFLLSLFQTSDLNVFERKIGDRIQvlyg...........reneEEEEEKA....IQYFNSAKNIRDRLNVMGFTLTRTIERFEESKEEsl.....vrLRERIE.......dKTFND.SDR.........MNKILTNEIQI......L...ENNS...FDDFIEAVK---..----...EIFEHNYGFAV...KKENLP--DKINP-..................IIPYLLDYGY..........gLDR.FPYDYD.QRTLLRALLEAT.EPDAIITYDITELLESGYYEG-----------epeev..........................................................
A0A4Z0LU43_9GAMM/1-229 .....................................................MG.TAIELCLGDVSLS.YSKNHM..GIDYGFLFQDSDLKQQKSKSINYEYyeen...........pdekYELDEAE....EVFSRTLSRVLPRLNLLGFTLEAARAEYQAVVAE.........AEEISR........EIDIE.G--.........SGKEFLTFEEF......S...-NLA...CRYPLRELNN--..--DSi.eYETPDRDRVSM...GRFA-----ADIDLfdri.........pgyedSDLYWSEASY...........LSA.KICILS.AESMLQVFAQHEaNAEIEVTWEFGPIVHAGWVQRDAFLAGARQR-q..............................................................
#=GC seq_cons .....................................................MG.o.hpLplsshpls.hsKNph....shthlFpppDpphhthpt.t......................cs..t.p....hsaspslpplh.RLclhGaohpps+pcapphhpp.........h.c.tp............t.................hhsap-h......h....shs...hpt.lptlt.......tt...phhtttht.ph...tp...thh.t......................tt.hasp.th...........hs..hhshhs..h.hl+hlh-s..s.sh.lhhphssllpsGahpttp.........t..............................................................
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