#=GF ID   HSV_VP16_C
#=GF AC   PF12149.12
#=GF DE   Herpes simplex virus virion protein 16 C terminal
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Gavin OL;
#=GF SE   pdb_2k2u
#=GF GA   27.00 27.00;
#=GF TC   30.80 29.60;
#=GF NC   25.00 19.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   18630911
#=GF RT   NMR structure of the complex between the Tfb1 subunit of TFIIH
#=GF RT   and the activation domain of VP16: structural similarities
#=GF RT   between VP16 and p53.
#=GF RA   Langlois C, Mas C, Di Lello P, Jenkins LM, Legault P, Omichinski
#=GF RA   JG;
#=GF RL   J Am Chem Soc. 2008;130:10596-10604.
#=GF DR   INTERPRO; IPR021051;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in viruses, and is about 30 amino acids in
#=GF CC   length. It is found in association with Pfam:PF02232. This
#=GF CC   domain is the C terminal of the HSV virion protein 16. This
#=GF CC   protein is a transcription promoter. The C terminal domain is
#=GF CC   the carboxyl subdomain of the acidic transcriptional activation
#=GF CC   domain. The protein binds to DNA binding proteins to carry out
#=GF CC   its function. Such proteins include TATA binding protein, CBP,
#=GF CC   TBP-binding protein, etc.
#=GF SQ   8
#=GS K9MG49_9ALPH/460-489      AC K9MG49.1
#=GS VP16_HHV2H/461-490        AC P68336.1
#=GS VP16_HHV11/461-490        AC P06492.1
#=GS L0N4A8_HHV1/461-490       AC L0N4A8.1
#=GS A0A060Q1W6_9ALPH/455-482  AC A0A060Q1W6.1
#=GS J9QQT3_9ALPH/493-516      AC J9QQT3.1
#=GS Q9ELS1_CHV16/462-491      AC Q9ELS1.1
#=GS Q805Y1_CHV1/458-487       AC Q805Y1.1
K9MG49_9ALPH/460-489                 ..DPVPYGALDVADFEFEQMFTDALGIDDFGG..
VP16_HHV2H/461-490                   ..DPVSYGALDVDDFEFEQMFTDAMGIDDFGG..
VP16_HHV11/461-490                   ..DSAPYGALDMADFEFEQMFTDALGIDEYGG..
L0N4A8_HHV1/461-490                  ..DSAPYGALDMADFEFEQMFTDALGIDEYGG..
A0A060Q1W6_9ALPH/455-482             eg--AAYEALDPADFEFEQMFADALGID----gl
J9QQT3_9ALPH/493-516                 gf-----SALDADDMDFEQMFADALGID----s.
Q9ELS1_CHV16/462-491                 ..DDAAYASLDMADFEFEQMFTDALGIDEFGG..
Q805Y1_CHV1/458-487                  ..DAAAYASLDMADFEFEQMFTDALGIDDIGG..
#=GC seq_cons                        ..DsAsYuALDhADFEFEQMFTDALGID-aGG..
//