#=GF ID HTH_54
#=GF AC PF18607.5
#=GF DE ParA helix turn helix domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF07900
#=GF GA 32.30 32.30;
#=GF TC 32.40 32.30;
#=GF NC 32.20 31.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0123
#=GF RN [1]
#=GF RM 19461582
#=GF RT Structural basis for ADP-mediated transcriptional regulation by
#=GF RT P1 and P7 ParA.
#=GF RA Dunham TD, Xu W, Funnell BE, Schumacher MA;
#=GF RL EMBO J. 2009;28:1792-1802.
#=GF DR INTERPRO; IPR041250;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The accurate segregation of DNA is essential for the faithful
#=GF CC inheritance of genetic information. Segregation of the
#=GF CC prototypical P1 plasmid par system requires two proteins, ParA
#=GF CC and ParB, and a centromere. When bound to ATP, ParA mediates
#=GF CC segregation by interacting with centromere-bound ParB, but when
#=GF CC bound to ADP, ParA fulfills a different function: DNA-binding
#=GF CC transcription autoregulation. ParA consists of an elongated
#=GF CC N-terminal alpha-helix which mediates dimerization, a winged-HTH
#=GF CC and a Walker-box containing C-domain. This entry describes the
#=GF CC N-terminal alpha helix domain combined with the winged HTH
#=GF CC region [1].
#=GF SQ 58
#=GS A0A077SL49_9CAUD/14-105 AC A0A077SL49.1
#=GS A0A485C5A7_KLUCR/1-39 AC A0A485C5A7.1
#=GS A0A081MYR5_9GAMM/16-107 AC A0A081MYR5.1
#=GS A0A1Q8YLF0_9ENTR/14-105 AC A0A1Q8YLF0.1
#=GS A0A6G9QQY9_9GAMM/13-102 AC A0A6G9QQY9.1
#=GS E1PKR1_PANVC/15-106 AC E1PKR1.1
#=GS A0A1C3EBM2_9GAMM/15-106 AC A0A1C3EBM2.1
#=GS A0A2S0VYC3_9ALTE/15-104 AC A0A2S0VYC3.1
#=GS W1DLS8_KLEPN/14-105 AC W1DLS8.1
#=GS A0A1B0VAC0_9CAUD/14-105 AC A0A1B0VAC0.1
#=GS U3AMH9_9VIBR/9-101 AC U3AMH9.1
#=GS D6YRG7_PANVC/15-106 AC D6YRG7.1
#=GS A7N814_VIBC1/10-101 AC A7N814.1
#=GS A6TJ30_KLEP7/14-105 AC A6TJ30.1
#=GS D8MJZ5_ERWBE/15-106 AC D8MJZ5.1
#=GS A0A379LSE4_ENTAG/15-106 AC A0A379LSE4.1
#=GS A6TIP7_KLEP7/15-106 AC A6TIP7.1
#=GS Q71TA9_BPP1/14-105 AC Q71TA9.1
#=GS A0A0C2IRX3_THEKT/15-98 AC A0A0C2IRX3.1
#=GS A0A6I4V6Y1_9GAMM/15-106 AC A0A6I4V6Y1.1
#=GS A0A859PWJ1_9ENTR/15-106 AC A0A859PWJ1.1
#=GS E1PL33_PANVC/15-106 AC E1PL33.1
#=GS W1IYW9_9GAMM/15-106 AC W1IYW9.1
#=GS A0A485CBH7_KLUCR/15-80 AC A0A485CBH7.1
#=GS Q87FC7_VIBPA/10-101 AC Q87FC7.1
#=GS Q99Q38_SHIFL/14-105 AC Q99Q38.1
#=GS A0A485C400_KLUCR/14-105 AC A0A485C400.1
#=GS D4GFN4_PANAM/15-106 AC D4GFN4.1
#=GS Q9KKJ2_VIBCH/12-103 AC Q9KKJ2.1
#=GS D4E9W6_SEROD/45-136 AC D4E9W6.1
#=GS A0A6M8UWE0_9GAMM/14-105 AC A0A6M8UWE0.1
#=GS A0A427K2N8_9GAMM/15-106 AC A0A427K2N8.1
#=GS A0A663AMR7_9ENTR/14-105 AC A0A663AMR7.1
#=GS A0A380SB69_YERRU/25-116 AC A0A380SB69.1
#=GS A0A2I8QGF9_9ENTR/14-105 AC A0A2I8QGF9.1
#=GS U3C421_9VIBR/13-104 AC U3C421.1
#=GS Q327G4_SHIDS/14-105 AC Q327G4.1
#=GS A0A653CJ44_CALMS/14-105 AC A0A653CJ44.1
#=GS Q9RIC6_YERPE/15-106 AC Q9RIC6.1
#=GS A0A0Q4MPZ6_9GAMM/15-106 AC A0A0Q4MPZ6.1
#=GS D0I2R2_GRIHO/15-106 AC D0I2R2.1
#=GS A0A085S0Z4_VIBCL/10-101 AC A0A085S0Z4.1
#=GS B2VB64_ERWT9/15-106 AC B2VB64.1
#=GS Q93GQ8_SALTY/14-105 AC Q93GQ8.1
#=GS A0A499QL86_9CAUD/14-105 AC A0A499QL86.1
#=GS A0A0H3H607_KLEPH/14-105 AC A0A0H3H607.1
#=GS A0A6I4V800_9GAMM/15-106 AC A0A6I4V800.1
#=GS A0A8J6ULS2_9GAMM/15-106 AC A0A8J6ULS2.1
#=GS J2LLI0_KLEPN/14-105 AC J2LLI0.1
#=GS A0A1I5B8F4_9GAMM/14-105 AC A0A1I5B8F4.1
#=GS Q1MVJ3_BPP7/17-108 AC Q1MVJ3.1
#=GS A0A1W6BBG0_9GAMM/13-104 AC A0A1W6BBG0.1
#=GS A0A377YWA7_KLEPO/14-105 AC A0A377YWA7.1
#=GS A0A7Y7BB33_STRMO/15-106 AC A0A7Y7BB33.1
#=GS A0A071LQD7_9ENTR/14-105 AC A0A071LQD7.1
#=GS W1DMV1_KLEPN/1-42 AC W1DMV1.1
#=GS A0A1T4W7T4_9GAMM/15-106 AC A0A1T4W7T4.1
#=GS A0A379LTE9_ENTAG/5-73 AC A0A379LTE9.1
A0A077SL49_9CAUD/14-105 .....ANRMLNVLTEQVQLQKDEL....HANEFYQVYAKAALAKLPLLTRANVDYAVSEMEEKGYVFDKRPAGSSMKYAMSIQNIIDIYEHRGVPKYRDRY.
A0A485C5A7_KLUCR/1-39 ..mgt-------------------....-------------------------------------SSTRNRSVTFEQYALTIQNVIDIYAHRKIPKYRDIH.
A0A081MYR5_9GAMM/16-107 .....SERMLQKLVRDIDKQKKEL....GIGGYYRTYSKGELTSELGISKRIAETTLNAMQDSGIALHRDETKATRPYKLTIEDVAEFYQFRGEPRLRDQY.
A0A1Q8YLF0_9ENTR/14-105 .....AGKLLTSLSESIRQQKEEL....KLTEFYQEYSKAALYKLPKLSKGSVEYAVAEMEAGGYIFKKKPSGNTMKYAMTIQNVIDLYNHRKVPKYRDRF.
A0A6G9QQY9_9GAMM/13-102 ....a-DTYLDGINKHVNDYKDEF....RKPDFHMRYSKKTVESMPYLSRNAVEKAMAQLEEAGYEFKRKANGNLDSF--SFEDVIAIYEQRKVPKYRDQH.
E1PKR1_PANVC/15-106 .....ANSMLHGLSDHIEQQRQEF....NQTGFYQTFSRNAVANMPLLSKHAVVAAISDMEAAGYQFGKKQTGSTSQYALTIQNVVDIYQHRKVPKYRDRH.
A0A1C3EBM2_9GAMM/15-106 ....s-LRMLSALTEQINSQKAEL....DATEYHQTFTKATVAKMPRLSKAIVDKTVSEMEEAGYEFAKRQAGSTRVYAMTIQNIIDIYRHRKVPSYRER-r
A0A2S0VYC3_9ALTE/15-104 .....AHKMLEDLTQIISQQKDEV....GIGQYTKRYSKTNLHSMPSLSKAIVEKTVSDMEKEGYVFERK--GDSNFYSITSDDVIKIYEKRGEKKYRDKY.
W1DLS8_KLEPN/14-105 .....AGKLLTSLSESIRQQKEEL....KLTEFYQEYSKAALYKLPKLSKGSVEYAVSEMEAGGYIFKKKPSGNTMKYAMTIQNVIDLYNHRKVPKYRDRF.
A0A1B0VAC0_9CAUD/14-105 .....ANRMLNVLTEQVQLQKDEL....HANEFYQVYAKAALAKLPLLTRANVDYAVSEMEEKGYVFDKRPAGSSMKYAMSIQNIIDIYEHRGVPKYRDRY.
U3AMH9_9VIBR/9-101 .nlle----LAELTQQVQADRIEIvleeRSDNYFPPMSKALMETRSGLTRRKLDEAIGKMEAEGHQFTKNNA---NHYSISLEEAHMLMDAAEIPKFHER-k
D6YRG7_PANVC/15-106 .....SERMLLSLTDQIQAQKQEL....HENTYYQVYAKAALAKLPKLTRASVDYAVNEMEESGYQFDKRAAGSSVKYAMSIQNIIDIYHHRGVPKYRDRH.
A7N814_VIBC1/10-101 ..lqe----LAELTQQVQADRIEIvleeRSDNYFPPMSKAMMETRSGLTRRKLDDAIGKMEAEGHQFTKNNA---NHYSITLEEAHMLMDAAEVPKFHER-k
A6TJ30_KLEP7/14-105 .....AGKLLTSLSESIRQQKEEL....KLTEFYQEYSKAALYKLPKLSKGSVEYAVAEMEAGGYIFKKKPSGNTMKYAMTIQNVIDLYNHRKVPKYRDRF.
D8MJZ5_ERWBE/15-106 .....ANAMLRSMSDDIIDKRHEF....GLDRYYQTFTRNSVANMPKLSRRAVEQAIDEMEMQGHQFGKKDAGNARHYALTVEDVVDIYAHRKVPKYRDLH.
A0A379LSE4_ENTAG/15-106 .....ANSMLHGLSNHIEQQRQEF....NQTGFYQTFSRNAVANMPLLSKHAVVAAIGDMEAAGYQFGKKQTGSTSQYALTIQNVVDIYQHRKVPKYRDRH.
A6TIP7_KLEP7/15-106 ....a-GILLESMSRDIEDQRKEF....NLTEYFQTFTRNAVAKLPKLSRRIVEQAIKEMEDAGYDFNKKRVGNVEQYALTVQNVIDIYAHRKIPKYREIH.
Q71TA9_BPP1/14-105 .....ANRMLNVLTEQVQLQKDEL....HANEFYQVYAKAALAKLPLLTRANVDYAVSEMEEKGYVFDKRPAGSSMKYAMSIQNIIDIYEHRGVPKYRDRY.
A0A0C2IRX3_THEKT/15-98 .....ASAMLRSMSDDISLRRNEF....GLDQYYQTFTRNSVANLPKLSRRAVEQAIDEMEAQGHVFGRK--------ALTIKDVVDIYAHRKVPKYRDLH.
A0A6I4V6Y1_9GAMM/15-106 .....SERMLLSLTEQIQAQKQEL....HENTYYQVYAKAALAKLPKLTRASVDYAVNEMEESGYQFDKRAAGSSVKYAMSIQNIIDIYHHRGVPKYRDRH.
A0A859PWJ1_9ENTR/15-106 .....SERMLVSLTEQIKAQKEEF....EETSFYQVYAKAALAKLPKLTRASVDYAVSEMEQAGYNFEKKPAGTSTKYAMSIQNIIDIYHHRGVPKYRDRH.
E1PL33_PANVC/15-106 .....ASAMLRSMSDDISLRRNEF....GLDQYYQTFTRNSVANLPKLSRRAVEQAIDEMEAQGHVFGRKDAGNTRHYALTIKDVVDIYAHRKVPKYRDLH.
W1IYW9_9GAMM/15-106 .....AELMLQGLSDQIEQQRIEL....DQTEYYQTFTKNSVAKMPMLNRRAVDQAIIEMEEHGYEFSRRQTGSTSQYALTLQNVIDIYKHRNIPTYRDKW.
A0A485CBH7_KLUCR/15-80 ....a-SALLKAMSQDIEDQRKEF....NQTEYYQTFTRNAVAKLPKLSRRIVEQAIKEMEDDGYQFNKKQVGN---------------------------v
Q87FC7_VIBPA/10-101 ..lqe----LAELTQQVQADRIEIvleeRSDNYFPPMSKAMMETRSGLTRRKLDEAIGKMEAAGHQFTKNNA---NHYSITLEEAHMLMDAAEVPKFYER-k
Q99Q38_SHIFL/14-105 .....ADKMLLALTKQIQEQKQEF....QADVFYQVYSKSAVAKLPKLTRASVDGAVGEMEAQGYQFEKRPAGTATKYALTIQNIIDIYAHRGIPKYRDRY.
A0A485C400_KLUCR/14-105 .....AGKLLTSLSESIRQQKEEL....KLTEFYQEYSKAALYKLPKLSKGSVEYAVSEMEAGGYIFKKKPSGNTMKYAMTIQNVIDLYNHRKVPKYRDRF.
D4GFN4_PANAM/15-106 .....SERMLLSLTEQIQAQKLEL....QENSYYQIYAKAALAKLPKLTRASVDYAVNEMEESGYQFDKRAAGSSVKYAMSIQNIIDIYHHRGVPKYRDRH.
Q9KKJ2_VIBCH/12-103 ..lyq----LAQLTQQVQADRIEIvleeRRDEHFPPMSKALMETRSGLTRRKLDEAIAKMEEAGHQFTKNNA---NHYSISLSEAHMLMDAAGVPKFHER-k
D4E9W6_SEROD/45-136 .....AEKMLSALTEQIQLQKEEL....KENEYFQVYSKAAVAKFPKLTRANVDYTVSEMENGGYVFEKRAAGSSTKYAMTVQNIVDIYHHRGVPKYRDRH.
A0A6M8UWE0_9GAMM/14-105 .....SEKMLASLTDQIQTQKDEL....QKNDFYQVYAKAALSKLPKLTRANVDYAVSEMEAGGYIFDKRPAGSTLKYAMSIQNIVDIYAHRGVPKYRDRY.
A0A427K2N8_9GAMM/15-106 ....a-SSLLQAMSRDIEEQRKEF....NLTEYHQTYTRNAVAKLPKLSRRIVEQSMKEMEEQGYDFNKKQVGNVEQYALTIQNVIDIYAHRKIPKYRDIH.
A0A663AMR7_9ENTR/14-105 .....AGKLLTSLSESIRQQKEEL....KLTEFYQEYSKAALYKLPKLSKGSVEYAVAEMEAGGYIFKKKPSGNTMKYAMTIQNVIDLYNHRKVPKYRDRF.
A0A380SB69_YERRU/25-116 .....SEHMLTLLTKQIKEQKEEL....EETTYFQTYAKAAVAKLPKLTRASVDYAVTEMEEQGYTFLKKPAGTSIKYAMSLQNIIDIYHHRGVPKYRDRH.
A0A2I8QGF9_9ENTR/14-105 .....AHKMLTSLSEHVREEKQEL....KQNEFYQVYSKASLYKLPKLSKGSVEYAVNEMESDGYEFNKKPSGNTVKYAMTLQNVIDLYRHRGVPKYRDRH.
U3C421_9VIBR/13-104 .....SVRMLSALTDEINNHKAEF....DVVDFYQHYSKANVAKLPKLSKAIVDKSVAEMEEAGYTFSKRKAGSTHVYAMSIQNIIDIYKHRDIPKYRDRH.
Q327G4_SHIDS/14-105 .....ADKMLLALTKQIQEQKQEF....QADVFYQVYSKSAVAKLPKLTRASVDGAVGEMEAQGYQFEKRPAGTATKYALTIQNIIDIYAHRGIPKYRDRY.
A0A653CJ44_CALMS/14-105 .....AGKLLTSLSESIRQQKEEL....KLTEFYQEYSKAALYKLPKLSKGSVEYAVAEMEASGYIFKKKPSGNTMKYSMTIQNVIDLYFHRKVPRYRDRF.
Q9RIC6_YERPE/15-106 ....a-SALLQAMSRDIEEQRKEF....NLTEYHQTYTRNAVAKLPKLSRRIVELAVKEMEESGYEFNKKQVGNVEQYALTIQNVIDIYAHRQIPKYRDIH.
A0A0Q4MPZ6_9GAMM/15-106 .....AGKMLTSLTEHIQAQKEEL....RENEYFQVYAKAALAKLPKLTRANVDYAVSEMEENGYAFDKRAAGSSSKYAMTIQNIVDIYHHRGVPKYRDRH.
D0I2R2_GRIHO/15-106 ....s-IRMLSALTDQINNQKEEF....DANHFHQSYTKATVAKLPKLSKAIVDKTVSEMEESGYQFAKRKAGSTQVYAMSIQNIIDIYAHRQVPRYRDRY.
A0A085S0Z4_VIBCL/10-101 ..lyq----LAQLTQQVQADRIEIvleeRRDEHFPPMSKALMETRSGLTRRKLDEAIAKMEEAGHQFTKNNA---NHYSISLSEAHMLMDAAGVPKFHER-k
B2VB64_ERWT9/15-106 .....AGKMLTALTEQIRAQKQEL....HEDVYFQVYAKAALSKLPKLTRANVDYAVSEMEENGYKFDKRSAGSSTKYAMNLQNIIDIYHHRGVPKYRDRH.
Q93GQ8_SALTY/14-105 .....AGKLLTSLSESIRQQKEEL....KLTEFYQEYSKAALYKLPKLSKGSVEYAVAEMEASGYIFKKKPSGNTMKYAMTIQNVIDLYFHRKVPKYRDRF.
A0A499QL86_9CAUD/14-105 .....ANRMLNVLTEQVQLQKDEL....HANEFYQVYAKAALAKLPLLTRANVDYAVSEMEEKGYVFDKRPAGSSMKYAMSIQNIIDIYEHRGVPKYRDRY.
A0A0H3H607_KLEPH/14-105 .....AGKLLTSLSESIRQQKEEL....KLTEFYQEYSKAALYKLPKLSKGSVEYAVAEMEAGGYIFKKKPSGNTMKYAMTIQNVIDLYNHRKVPKYRDRF.
A0A6I4V800_9GAMM/15-106 .....ANSMLHGLSNHIEQQRQEF....NQTGFYQTFSRNAVANMPLLSKHAVVAAINDMEEAGYQFGKKQTGSTSQYALTIQNVVDIYQHRKVPKYRDKH.
A0A8J6ULS2_9GAMM/15-106 aaskv-----KLLSSDIEAQRKEF....SESGYYRTFSRSQLYDLPGFTKAIVEKAVREMEEQGYTFGKRQAGKNEVYCITVDQVRDIYKHRGIETYKERF.
J2LLI0_KLEPN/14-105 .....AGKLLTSLSESIRQQKEEL....KLTEFYQEYSKAALYKLPKLSKGSVEYAVAEMEAGGYIFKKKPSGNTMKYAMTIQNVIDLYNHRKVPKYRDRF.
A0A1I5B8F4_9GAMM/14-105 .....AGKLLISLNDSISQQKNEL....EQNVFYLEYSKASLYKLPKLSKGSVEYAVTEMEAAGYVFKKKPSGNTMKYAMTIQNVIDLYFHRKVPKYRDRF.
Q1MVJ3_BPP7/17-108 ....a-SALLKAMSQDIEDQRKEF....NQTEYYQTFTRNAVAKLPKLSRRIVEQAIKEMEDDGYQFNKKQVGNVEQYALTIQNVIDIYAHRKIPKYRDIH.
A0A1W6BBG0_9GAMM/13-104 .....AERMLHSLTEQIQAQKEEF....HENEYFQVYAKAALAKLPKLTRANVDYAVSEMEANGYEFEKRPAGSSMKYAMTLQNIIDIYQHRGVPKYRDRY.
A0A377YWA7_KLEPO/14-105 .....AGKLLTSLSESIRQQKEEL....KLTEFYQEYSKAALYKLPKLSKGSVEYAVAEMEAGGYIFKKKPSGNTMKYAMTIQNVIDLYFHRKVPKYRDRF.
A0A7Y7BB33_STRMO/15-106 ....a-SALLQAMSRDIEEQRKEF....NLTDYHQTYTRNAVAKLPKLSRRIVELAMKEMEEDGYIFNKKQIGNVEQYALTIKNVIDIYAHRQIPKYRDIH.
A0A071LQD7_9ENTR/14-105 .....SGKMLVSLTEQIQSQREEL....NEHEFYQVYAKAALSKLPKLTRANVDYAVSEMEAEGYVFDKRPAGSSTKYAMSIQNIIDIYCHRGIPKYRDRY.
W1DMV1_KLEPN/1-42 .....-------------------....-------------------------------MEAGGYIFKKKPSGNTMKYAMTIQNVIDLYNHRKVPKYRDRF.
A0A1T4W7T4_9GAMM/15-106 ....s-LRMLSALTDQINNQKEEL....DAQHFHQSYTKATVAKLPKLSKAIVDKTVSEMEEAGYEFAKRKAGSTKVYAMSIQNIIDIYRHRQVPRYRDRH.
A0A379LTE9_ENTAG/5-73 ..tir-------------------....-------SIAKAALAKLPKLTRASVDYAVNEMEESGYQFDKRAAGSSVKYAMSIQNIIDIYHHRGVPKYRDRH.
#=GC seq_cons .....ut+hLpuLo-pIppQKpEl....ctscaYQsYoKAAluKLPKLo+usV-hAVuEMEtsGYtFsK+suGsoh+YAhTIQNlIDIYpHRtVPKYRDRa.
//
