#=GF ID   HcgF
#=GF AC   PF06787.15
#=GF DE   FeGP cofactor biosynthesis protein HcgF
#=GF PI   UPF0254;
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   SWISS-PROT
#=GF GA   25.00 25.00;
#=GF TC   25.10 132.60;
#=GF NC   24.50 20.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RC   Paper describing PDB structure 3wva
#=GF RN   [1]
#=GF RM   25882909
#=GF RT   Protein-pyridinol thioester precursor for biosynthesis of the
#=GF RT   organometallic acyl-iron ligand in [Fe]-hydrogenase cofactor.
#=GF RA   Fujishiro T, Kahnt J, Ermler U, Shima S;
#=GF RL   Nat Commun. 2015;6:6895.
#=GF DR   INTERPRO; IPR009625;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This archaeal family includes the iron guanylylpyridinol (FeGP)
#=GF CC   cofactor biosynthesis protein HcgF which catalyses  the
#=GF CC   transesterification of AMP-GP to afford a Cys (HcgF)-S-GP
#=GF CC   thioester [1].
#=GF SQ   21
#=GS R9SGS1_9EURY/1-168      AC R9SGS1.1
#=GS A0A2U1S613_9EURY/1-168  AC A0A2U1S613.1
#=GS A0A315XLV5_9EURY/1-168  AC A0A315XLV5.1
#=GS Y1251_METJA/1-162       AC Q58649.1
#=GS A0A1D2WD34_9EURY/1-162  AC A0A1D2WD34.1
#=GS F6BCQ6_METIK/5-166      AC F6BCQ6.1
#=GS D7DTZ9_METV3/35-195     AC D7DTZ9.1
#=GS Y1148_METTH/1-156       AC O27216.1
#=GS Y1743_METLZ/1-159       AC A2SU98.1
#=GS E3GZ34_METFV/1-159      AC E3GZ34.1
#=GS L0HD12_METFS/1-159      AC L0HD12.1
#=GS Q2FR48_METHJ/2-160      AC Q2FR48.1
#=GS A0A328PCK6_9EURY/1-159  AC A0A328PCK6.1
#=GS Y935_METMP/1-158        AC Q6LYQ3.1
#=GS E1RJE4_METP4/1-159      AC E1RJE4.1
#=GS A0A8J7YHJ5_9EURY/1-158  AC A0A8J7YHJ5.1
#=GS A0A1R1MJF8_9BACT/6-157  AC A0A1R1MJF8.1
#=GS D3E1A1_METRM/1-182      AC D3E1A1.1
#=GS Y012_METKA/1-161        AC Q8TZC1.1
#=GS Y668_META3/1-160        AC A6UUT0.1
#=GS F0S2C1_DESTD/6-157      AC F0S2C1.1
R9SGS1_9EURY/1-168                 .MIRIATAECFTHGKIGREIHALAQSYEG.NFGRDYik..............npkEFGDFDYNDIGLVCGLFIPTIDAVKTVLQVENPPEPKTL.IKGIKVYDEEGDKKVSKIMAEAVKNITDSDIAIGTTAGIGRGGICILTDDYSIVTTTDVF.SDLRENNSEELYNRQEDGIRKALRILLYLL.
A0A2U1S613_9EURY/1-168             .MIKIATAECFTHGKIGNELHALGQSYEG.KFGCEYik..............npeKYGGFNYSEISVTCSLFIPTIDAVKTILRVPNPPEPKEL.IKGIKVYDEYGDKEVSKVMAKAVKKLTNCDIAIGTTAGIGRGGISVVTDELEITTTTNIN.ADLRENNSFDLLKRQESGIKKAIEIILLL-l
A0A315XLV5_9EURY/1-168             .MIKIATAECFTQGKIGRELHAIAQGYTG.DFGREYvk..............dleSYGDFDYNELSVTCSLFIPTIEAVVKILNVKNPPKPDKL.IKGIKVYDEKGDLQVSKIMAHAIKDLTDCDIAIGTTAGIGHGGICIITDEYEISTTTDVY.ADLCENNSEGLFQRSQNGIRKTLEILLLL-l
Y1251_METJA/1-162                  .MITVATAECFTHANIGLTIHKAAAGYED.-FEFKYl................fsEEDLKLMKNVRVISAMFVPSIIGVEKLLDIKLPEPDFN-.YKYAKAYSEEKDLEVAKLMAEGLKKKLNVNISIGSTAGVGRGAICILTDNNRYLFTSDVY.ANLITF--ENIKERQKNGIEKGIKRFLEIL.
A0A1D2WD34_9EURY/1-162             .MIKVATAECFTHGHIAREIHGFSQGYDG.EFGPNY...................NLLNGIPYDLSVVCGIFAPTLSALQKVLKVD-PPEPLKL.IRGIKVYDEENDKKVAVIMAKAVKDLLGANIGIGTTAGIGRGGIAVSTDEYTVVASSGFY.ADITTHDSSRLLKRQECGIKKALSIFVDV-i
F6BCQ6_METIK/5-166                 k-ISVGTAECFTHAKIGITIHKAASGYKD.-FEFKEi................fdKEELRMMSNVRVLASMFIPSIYAAEKLLNIKLPEPDYD-.YAYAKAYTEKNDLKVAYLMAKGLKDILNCNIAIGTTAGIGRGGICILTDKNKYLFTTDVY.GNLLKH--ENILERQRNGIEKGLRKFIEIL.
D7DTZ9_METV3/35-195                .LITIATVECFTLGKIGIYIHKIASKYPElDYFLNK...................NPEYIILHSSKVLTAMFMPSKEIAETFLNIALPNSDYD-.YNYSKAYSQENDELVAELMAKGLKNITKCNIAIGTTAGIGKGAICIITDKKVYNFTSDVE.ADLLTK--QNVSERQKNAIEKTIKKILDIL.
Y1148_METTH/1-156                  .MIRVATAECFTHGFVAREIHAYSMGYPG.GYSWSV...................D------SDVVLVAGLFIPTLSGIRSILKFE-PPEPSAT.LNDIKVYTEEEDERVALMMARSVRELTSADLGIGTTAGIGRGGIAVVSENREEVINSDVE.ADLRFSGAEEILMRQRSGIRCALELLESFL.
Y1743_METLZ/1-159                  .MPTISTAECFTHGKVANELHAFARGYPH.EYLFSI...................DRKKVD---ISVVAGMFIPTLTGVRTLLHFE-PLEPRLV.IDTVKVYEQDQDCIMACRMAEAVMRVTGADIGIGTTAGIGKGAVAIASQDKIYSKVTRID.ADFRTSDAKKLMQREKSGVFTALRLFEEFL.
E3GZ34_METFV/1-159                 .MIRVATAECFTHGKIGREIHAFAQGYPL.NYDWSI...................KREDYK---ISLVAALFIPTISGLKTILKIK-PLTPDHV.LGDIKVYNEKSDKKMALKMAKSIKRITNADIGIGTTAGVGRGGIAIVTNKSEIITDSGVH.ADLRFSEPKKILERQAHGIKRCLKLFEKVL.
L0HD12_METFS/1-159                 .MIRIATAECFTHGLVGKEIHALSRGYPL.DFGWRP...................D---PALPCVSLVAALFIPTLSGVHHILGIR-PVPPFEV.IDDIKVYDQQGDEMMALKMAEAVREITQADIGIGTTAGIGKGGIAVVTTEIKLLTTSGID.ADLRSSPAGRILERQAHGVKKTLHTLECLL.
Q2FR48_METHJ/2-160                 .VIRVALAECFTHGLISREIHAFSMGYPL.TYHWST...................DPEDFP---ISVIAGLFIPTLSGIRTILHFE-PLPPAEV.INDIKIYNQDQDLLMAFLMAQAVKNLTCADIGIGTCAGVGKGGIALVYEKGSEVITSEHY.ADLRFSSACEIMSRQKSGVVMCLRHFESIL.
A0A328PCK6_9EURY/1-159             .MIRIATAECFTHGKIAREIHAFSQGYPL.SYKWTI...................SPKDYR---LSLIAGLFIPTISGIRKILKFE-PLPPTEV.VDDIKVYDESADKKMAKRMAEAIKDITRADIGIGTTAGVGRGGIAIIADNMKVISSSDVY.ADLRSSPATEIMKRQKSGVERALKLLEVIL.
Y935_METMP/1-158                   .MISVATAECFTHGKIGTKIHKIACGYKE.-FEKDS...................NYD-MIHGNVYVMASMFLPSKKGIESLLDVNLPKP-DYV.FKYSKAYNQENDILVAKLVAKALKNKLNCNIAISSTAGIGNGAVCIVTDYNDYVFSSDIY.GDLLKG--QNIIKRQESGIEKAYNTFIDIL.
E1RJE4_METP4/1-159                 .MIRIATAECFTHGRIGLEIHAISRGYYM.NISHTL...................NFEPSR---LSLTASLFIPTLSGVKSILGFE-PLEPDDL.LDGIKVYNDEKDKIMAVKMAEAVRSITGADIGIGSTAGIGKGAIAVADERTVLTGSSGVY.ADLRTSGADIIMKRQESGIEEAFVLLEKIL.
A0A8J7YHJ5_9EURY/1-158             .MLSIATAECFTHGRIGNILHKMAMGYDD.VKDHPY...................--YRVFNGNIYVMASMFMPLKSTVESILDITLPTPNYE-.YRYGKAYNEENDLKVAYLMAKGIKNKLNCNIGIGTTAGIGKGGICILTDNNKYLFTTDVY.GNLLSK--KNIVERTINGIDKTLDKLVEIL.
A0A1R1MJF8_9BACT/6-157             i-LTFASVECFTHCEIGMGLHKLSAPYVE.N-----...................------RLPVSVSAVMFLPSVYSIEEVLDIRLPAPKAH-.INGVKVYDEIGNMNVALILSRVLKEKMGVDISVASSAGNGRGTVCLRFNKETFIIRTTNEvRNFPFTDAEKVYRRKAEAVDKTLLLLKAL-i
D3E1A1_METRM/1-182                 .MITIATAECFTHGILAREIHALAQDYDD.IFASSYwglvnkvqkdcikdailedKCSIFDLRDLSVSCGLFIPTLDAVKSVLKIENPLEPLTL.IDGIKVYDDDGDREMAILMAEAAKKVSGSDIGIGTTAGIGYGGIAIVDDDIVISTSSDVY.ADLVNVDSDDLYMRQRSGIEKTLKILIYYL.
Y012_METKA/1-161                   .MLRVATAECFTHGFVGREIHASASGYTG.ELGSEI...................LGTELE-GKVSVVAACFIPTVSGLRSLLGID-PPEPDEVsKSGAKAYREETDRKVAVMMARAVRERTGADVGIGTTAGIGRGAICLDDGEITLLGRTDVH.ANLLKP-DERIRKRQLQGIKRSLVMFRAY-f
Y668_META3/1-160                   .MITVATAECFTLGKIGTTIHKIASGYEE.CKNHRY...................--YNIINGNVKIISSSFIPSIEGAEKLLNLGAPLPKCDYeYSYSKAYTEKNDLKVAHILAKGLKNSLNCNIAIATTAGVGRGGICIISDKNEYLFTTDIE.GDLISK--KNIIQRQKNGIDKTINKFVEIL.
F0S2C1_DESTD/6-157                 i-LTFASVECFTHCEIGMTIHKRSAPYVK.N-----...................------RWNIAVVFSSFLPSINIAKKLFNVNLPSPNKE-.INGIKIYNEEGDTEVSLVLSKHIKALLNVDITIASSAGEGRGAVVVRFKNKCFLVRSLFSiPSFEKATEKDIKRRKYSAKKRTIRLIESLI.
#=GC seq_cons                      .MIplATAECFTHG+IGpEIHuhupGYst.sathph...................p.t.h...sluVluuhFIPTlsulcplLplc.P..Ptcl.lsslKlYsE-sDpcVAhlMA+ulKclossDIuIGTTAGIG+GGIsllo-ctphlhoo-la.ADLhpsssccIhcRQcsGIcKsLchhhplL.
//