#=GF ID   Hemolysin_N
#=GF AC   PF12563.12
#=GF DE   Hemolytic toxin N terminal
#=GF AU   Gavin OL;
#=GF SE   Prosite
#=GF GA   22.50 22.50;
#=GF TC   22.80 65.40;
#=GF NC   22.40 22.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Hemolysin
#=GF CL   CL0636
#=GF RN   [1]
#=GF RM   12479411
#=GF RT   Purification, characterization and molecular cloning of Vibrio
#=GF RT   fluvialis hemolysin.
#=GF RA   Han JH, Lee JH, Choi YH, Park JH, Choi TJ, Kong IS;
#=GF RL   Biochim Biophys Acta. 2002;1599:106-114.
#=GF DR   INTERPRO; IPR022220;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This domain family is found in bacteria, and is approximately
#=GF CC   190 amino acids in length. The family is found in association
#=GF CC   with Pfam:PF07968, Pfam:PF00652. This family is a bacterial
#=GF CC   virulence factor - hemolysin - which forms pores in erythrocytes
#=GF CC   and causes them to lyse.
#=GF SQ   12
#=GS A0A0H6SZL4_VIBCL/3-187  AC A0A0H6SZL4.1
#=GS HLY1_AERHH/9-196        AC P55870.2
#=GS D0YYQ7_PHODD/4-185      AC D0YYQ7.1
#=GS A0A0Q2MKS2_VIBFU/1-163  AC A0A0Q2MKS2.1
#=GS A0A2T3N0F1_9GAMM/1-182  AC A0A2T3N0F1.1
#=GS A0A4P9VNA6_9GAMM/8-198  AC A0A4P9VNA6.1
#=GS C9P680_VIBME/3-187      AC C9P680.1
#=GS HLYA_VIBCH/3-187        AC P09545.2
#=GS A0A090ICS3_9GAMM/1-185  AC A0A090ICS3.1
#=GS E3BMX3_9VIBR/30-194     AC E3BMX3.1
#=GS A0A178K7H8_9GAMM/7-195  AC A0A178K7H8.1
#=GS D0Z5B0_PHODD/4-185      AC D0Z5B0.1
A0A0H6SZL4_VIBCL/3-187             ......................kl---NRCAIAIFTILSAISSPTLLANINEPS.G.EAADIISQVADSHAIKYYNAADWQAEDNALPSLA--ELRDLVINQQKRVLVDFSQISDAEGQAEMQAQFRKAYGVGFANQFIVITEHKGELLFTPFDQAEEVD----P.QLLEAPRTARLLARSGFASPAPANS....ETNTLPHVAFYISVNRAISDEECTFNNS...
HLY1_AERHH/9-196                   ........................FITQAPTLSLLA-LALLAGSVQAEDIGERT.D.QGTAMLASLQSEQGLIYLNADVWLKRQGATPLMTRDQLRERVLARGERLFIDFSAVTDQSERQQTRKAMEQLAGISFDADWVLVSGYKGELLFTPLGGVDDPAFYQVM.ERVESLEGQGKRHKRSLTQPPAAE-....--AGLPHVAFYLNVNRKISDAECTFPRS...
D0YYQ7_PHODD/4-185                 .................rklysci----------LLGLSSLSASAIADVDNYST.GaDVISILSSVQNPDRIVYVNMK-----QEEISTY--NRILEDIIYNDKQYIFDLS-FDNNEEKEKLQKKFKDLMGVKFDSNFIVVTGYKNQLMYTPIADANDRMVSVLD.HEARSNDISKYPMALALRSGNATSD....QSISLPHVSFYLNVNKEITDQECTFRNS...
A0A0Q2MKS2_VIBFU/1-163             .......................m-----------------------ADIHDPV.G.EAVSILSQVSDSSQINYFNAQYWQGNDSDMPTLA--QLRQFVVQEKQRILMDFSQIENNEERAVMQALFRQQYGMSFASRFILVTEHKGELLFTPFDVADDVN----P.ALLEAPAAKRVRRSLSDTQRVSGG-....EANTLPHVAFYINVNRAISDEECTFDNS...
A0A2T3N0F1_9GAMM/1-182             ....................mirk-----TNLITLAMMGLMATTTWAAGIDEPA.G.SAINMLSSLQDVSSVNYINAEYLLDNDVMPLSLT--EIKTQVLNEDKRYFIDFSNIATEVDKNTAKSKLRHSMGIGLTGDMIIISAYKGELMFSQLDGEDDPN----I.TLLEGEPKRASRNKRSTTQLSNPD-....--NSIPNVAFYLHANRRISDRECNL---twn
A0A4P9VNA6_9GAMM/8-198             ...mlccalgslastcfsynnsyn-------------------------QHNYS.P.SATLILQNTTLNNQVKYINFSSITEEKLDYKNFK--IIENDILENNTIYWIDFTQSISQNGEHLNHEKVKKLFGIVYQEDMLLISSYKGKLLYTPFNSANSTLFSQLTnQLLNNSHSSRKRVARDVTTNTSKEStvsdDKKAPPNVSFYINVFRPITDEECTFKRS...
C9P680_VIBME/3-187                 .......................i--YNNKTIALAAILSGLVWNTAYADVQQPQ.G.VAVEMLSTLQDDSQVSYLNAAELLVEEGTVPTLS--DVRDSVLRQHQRYLIDFSNISDEQGKTQAKALLRGQLGVALSSDFWLITEHKGELLFTGLDDENDPS----I.QLLEAQPVTYSRQRRSIDSRTNATS....EANSLPHVAFYVNVHRPISDEECTFKNS...
HLYA_VIBCH/3-187                   ......................kl---NRCAIAIFTILSAISSPTLLANINEPS.G.EAADIISQVADSHAIKYYNAADWQAEDNALPSLA--ELRDLVINQQKRVLVDFSQISDAEGQAEMQAQFRKAYGVGFANQFIVITEHKGELLFTPFDQAEEVD----P.QLLEAPRTARLLARSGFASPAPANS....ETNTLPHVAFYISVNRAISDEECTFNNS...
A0A090ICS3_9GAMM/1-185             .................mlstlll-----------ASSAVLSQPF--EVTNNMT.D.GAVNIVKQLTNSQNVVYFNAASLLKEGGELQKLTLQEIEQEVVGNKNKYLLDFSSLTSPEQKQRALDKVSKITGISFEQDFLVISAFKGSLLYTPVSSPEDPNVSALE.TANITTLPAPLTIQKRQGSPQAIQ-....KSQGSPALSFYVSANRPISDGECSFS--sg.
E3BMX3_9VIBR/30-194                ..........lavfhhfpvfahpm----------------------------QS.D.TALLIMQSVYSPSNINYINLNEVSD-DALEKSLP--AVNDNVINENKKYLLDFSQLEDNDKIERYQKQIQSRIGMSIVTPFLAITNYQGSMLFTPISDSLDPQIQRLN.EDN--SRPSSSRKRRSVQKISP---....-----PKLSFYVSLNKQFSESDCLFPR-v..
A0A178K7H8_9GAMM/7-195             faltplaailfscsvqasqyheae----------------------AFSMYEPV.G.DAVNIVSRINDPEGLRYINAKYWLNDNDDL-SLGFDRVDQIVKDEGGRYLIDFTEIFDYSDKIKAKKLFSRIFGISFDADYVAITKYKESLLFTELTGSGDQN-VTIL.NRTYEPMALALMSDDPYQPLVPK--....-QIPVPNVAFYVNASRQISDQDCKI---ewn
D0Z5B0_PHODD/4-185                 .................rklysci----------LLGLSSLSASAIAEVDNYSTpA.DVVSILSSVKNPDRIVYINMKQ-----EE--LSTYDSILEDIINNDKQYIFDLSFDSD-EEKANIQKKFKDLMGVKFDSNFIVVTGYKNQLMYTPISDTNDRMISILD.HEAKSDDISKFPRALALSSGKVASD....QSISLPHVSFYLNVNKEITDQECTFRNS...
#=GC seq_cons                      ......................hh...........h..u.hs.sh.htshppso.u.sAlsIlSplpsspplpYlNAp.h.tppsth.oLs..plcppVlsppp+YllDFSplsstpp+tphppph+chhGluFsssFllITtaKGpLLFTPlssssDss......phhcustssthhtppuhss.sssp.....pttslP+VuFYlsVNRtISDpECTFppS...
//