#=GF ID   Herpes_BBRF1
#=GF AC   PF04793.16
#=GF DE   BRRF1-like protein
#=GF AU   Waterfield DI;0000-0003-2885-5126
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_6247 (release 7.5)
#=GF GA   25.00 25.00;
#=GF TC   26.80 27.70;
#=GF NC   23.10 22.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF DR   INTERPRO; IPR006878;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Family of herpesvirus proteins including Epstein-barr virus
#=GF CC   protein BBRF1.   
#=GF SQ   21
#=GS U5NIF1_9GAMA/18-299      AC U5NIF1.1
#=GS VG49_SHV21/20-298        AC Q01032.1
#=GS VG49_EHV2/17-302         AC Q66651.1
#=GS Q53CY8_9GAMA/17-298      AC Q53CY8.1
#=GS A0A2Z5U655_9GAMA/17-299  AC A0A2Z5U655.1
#=GS Q2VSJ2_9GAMA/34-309      AC Q2VSJ2.1
#=GS Q9YTL6_ATHV3/20-299      AC Q9YTL6.1
#=GS Q993G9_9GAMA/19-300      AC Q993G9.1
#=GS A0A3Q8J4F6_9GAMA/32-256  AC A0A3Q8J4F6.1
#=GS BRRF1_EBVA8/22-302       AC P0C723.1
#=GS BRRF1_EBVB9/22-302       AC P03207.1
#=GS P88987_MHV68/5-280       AC P88987.1
#=GS A0A060CU28_9GAMA/32-311  AC A0A060CU28.1
#=GS Q8UZH2_9GAMA/21-301      AC Q8UZH2.1
#=GS A0A0M4LR31_9GAMA/19-259  AC A0A0M4LR31.1
#=GS A0A0B5CYF8_9GAMA/17-298  AC A0A0B5CYF8.1
#=GS ORF49_HHV8P/18-299       AC Q2HR83.1
#=GS E9M5N2_9GAMA/5-274       AC E9M5N2.1
#=GS A0A1Z1NE88_9GAMA/22-295  AC A0A1Z1NE88.1
#=GS O40934_HHV8/18-299       AC O40934.1
#=GS Q99CZ1_BHV4/16-296       AC Q99CZ1.1
U5NIF1_9GAMA/18-299                 ......................................................................................................................................................YHYPAWDQIIQELETLSVTTHN...PDFCLPALHVEKALYLAKTLQILVQHRYSERFLVPVACSNLT...YSLNRLHKLSCDKIRGVI...NGILPL..VDA.C.CIGIQ...NELAIELPKILALHYPHAIP.......-.TN.APDPAAKy.....vaWCVAHMvgisNRIK.Q....E.IK..D-..-CL.C.PSRG.DGVPSFQWLAGIVKRVYLV.ENVIYED.YQDTEFNVQFNLCLLWSAVLYVYQKCIYEQKLLDLLGTALNLLKQTAREFFAW....-----YDQNDPNLGSEALVKYTEHRIRSLNQDSSDVEL.GEICSHL---HHCKHSLF........................................................
VG49_SHV21/20-298                   ......................................................................................................................................................FHYVDVSVIQSEFKNVILKTVV...PKLSQPATHLEKGDFLLKICQLLMIHREEEQQILNKVKSNII...YFLNELWSAEYGKVQEQV...KNILCEvkLDK.T.DSELS...TYLAQEIPKLTVLKYPTHFK.......V.CE.ETIPNGR........WCLHNL....LGIE.Q....Y.YK..DF..SNI.V.LHDPeTSLGSVQAYSRLSKLLFWC.DSFMNKI.YPCNAFNSSINQVVLWSTMFHFYSVAHCNDCISESISFTEALLKQEVSAFYEWc..lE--EEYEEDR-------MAKFMKFSADQITILSTHTDL.QNLAEYI---YSYKKCLI........................................................
VG49_EHV2/17-302                    ......................................................................................................................................................YHIPDEAAVLREYKGISVTDPRh.hPSLSKAKTCLDRSIYMLKICVALFANRQREMDILQAVTDNVR...YFLGRVRDAA-GGCDEAL...RDLIRE..TAR.Y.SPHIS...PRIGERLLAVLRVRYPGYAPsggpwegL.ME.DSIPV--........WCSHHM....TQLR.D....E.ER..VL..ECF.V.ERSG.-TVYSLSKFCSLASELFYE.DSLWHR-.LPDPEFIRPYNLAVFWVGVMKKFESVLAKKLVDDHLTCYTTVAKYDIAAAC--....EAVRRCGERRASGVTLELVDWLRWKLRDFGVDSNDSHA.SEIISVLQILRGNHL---v.......................................................
Q53CY8_9GAMA/17-298                 ......................................................................................................................................................FHYPPLGMIVGEMNTLTVNARN...PLYQAATLRVERALYLSKILQVLMQHRQGERFIVPQCRSNMV...YCLKELHKITNDRIRGLI...NSVLPL..VDA.G.CVGFD...EELVRILPEILKLEYPHVHE.......L.LP.PHDPTSPl......sWCLSHM....VGVT.KtfkgE.VK..EM..--IdT.FHDL.-SVPSFQYLASLVKKFFLV.EEVIYED.YQDTQFNVFLNLCFFWTTVIKMYQSCIFKDKLLDTIKACIELLKGEARQFFGW....-----YDLNTPNLGSAALVKYTEHLIRALSVDSSAIPI.GEICSHL---HHCKHAL-l.......................................................
A0A2Z5U655_9GAMA/17-299             ......................................................................................................................................................YHIPDEETVLKECKSIDIRDTK..nPVYSKPKTHLEKAVFYLRICDNLIRNKQQEPCILEEIVGNIN...YFLRQLLEVA-SEYSVMI...SPLIEL..TSR.Y.SSSIS...PNIGGALLQILKQKYPALDT.......-.-S.RDPPGGSl.....atWCHHHM....TQIH.D....A.KN..YI..RDS.F.ISKG.NAVYSMSKFSFVSVNLFHQ.DFVWEK-.YPDIIFNQPYNLVVFWATVLRKYEMVISNAEVEYSLYIYTSLMKDEVKGMVTF....-LLSDPKNKIKMKTLIKTVDFLYWKLQRMTPASTCTSLpQEIISLIQKLR-------wnyi....................................................
Q2VSJ2_9GAMA/34-309                 ....................................................................................................................................................yf--YADPGQLRAMLEDVAIPRSTrcrRDSKHLILCLKRCMFILKVYKVFAERKTSERGIVPCILVNLR...YHLEGIKGVVGEESQMWI...EPLLEA.lYRQ.G.AFNLE...KAIEEGLPGLLAAEY-ALIP.......-.-D.QGVSLSQgc....htWVSGRL...lPTVRgS....A.RR..SI..SAL.F.SDYH.LSVPSITALSVASKKLFDK.RNTSTKE.LTHRTFNLHYNHIVFWTAVLKMYQDALWENELLKRMDLLRDMLHIELKPFLE-....--------------------------------------.------------------skpspgskkspvaelckcihylmtdllanhsemiavqlfa................
Q9YTL6_ATHV3/20-299                 ......................................................................................................................................................YHYVDINVIKAELKNVKLDTVV...TKFSQPATHLERGDFLLRMCQLLMIHREEEQEIINKAKSNII...YFMNEILNTEYGEVKELA...KNILCDveIPK.P.NCELS...AYLATTIPKLIVLKYPTHFR.......V.CE.EITPNGR........WCLRNL....LGIE.P....Y.YK..YI..SDT.V.LLDPeISLGSVHAFSRLSKCLFWC.ESFMNKV.YPSTAFNSSINQVVLWSTMFYLYSIAHYNEYVNESIGFTEALLKQEVTAFYNWc..lE-QEDYEADR-------MAKFIQFSANQITLTSTHTDL.QGMAEYM---YSYKKCF-i.......................................................
Q993G9_9GAMA/19-300                 ......................................................................................................................................................KHYPDTMDVIHLINTVPTKPGV...KWSDSPMCIIQRATILAKTLQVVHQHKLSEETAIPKILEKLK...CFLKLLHHYSDPYEQKFI...RETLDHisVSR.-.DMFLE...CNLWTLVRHLSKIHHPSSVN.......-.VE.VTHPDRA.......aWALQYF....DGLD.S....S.VR..CA..VAS.T.FTEGyNSMPSLTAVVNLAQVILEA.SAPSHEP.CTWTSF---FNQVVIWTLALDKFHNCFYNRHIEGSIASLSQLLHIELKSLCHWmlsvNGLSIFCHRRPLLTLWESVAATKDITDIIP-------L.PDATEILHLLRHTRN---lia.....................................................
A0A3Q8J4F6_9GAMA/32-256             eecilseldaiggpqspneltlaclcrqavvtlyiydcfriraeeeltvieditgyiklnavalaqaaglprglcwtrgiwehveafgadglvetmsrclegllehrypemyasrgvrdlkgnpmgwlkanlvdvdypllyriwkafdva----------------------...------------------------------------------...------------------...------..---.-.-----...--------------------.......-.--.-------........------....----.-....-.--..--..---.-.---GvPSAPSISKLHELSAELQVC.TR-HNTD.KKRAAFNVYYNRLVLWAVALTMYTDIVVQRVASARMSRI--------------....--------------------------------------.------------------skrmlrlfn...............................................
BRRF1_EBVA8/22-302                  ......................................................................................................................................................KHYPEVGDVVHLLNTIGVDCDL...PP-SHPLLTAQRGLFLARVLQAVQQHKLLEDTIVPKILKKLA...YFLELLSYYSPKDEQRDI...AEVLDHlkTNR.-.DLGLD...DRLWALIRKLRQDRH--HAS.......-.VN.VLMPGSDy.....taVSLQYYdgisIGMR.K....V.IA..D-..---.V.CRSGyASMPSMTATHNLSHQLLMA.SGPSEEP.CAWRGF---FNQVLLWTVALCKFRRCIYYNYIQGSIATISQLLHLEIKALCSWiisqDGMRLFQHSRPLLTLWESVAANQEVTDAIT-------L.PDCAEYIDLLKHTKHVLE........................................................
BRRF1_EBVB9/22-302                  ......................................................................................................................................................KHYPEVGDVVHLLNTIGVDCDL...PP-SHPLLTAQRGLFLARVLQAVQQHKLLEDTIVPKILKKLA...YFLELLSYYSPKDEQRDI...AEVLDHlkTNR.-.DLGLD...DRLWALIRKLRQDRH--HAS.......-.VN.VLMPGSDy.....taVSLQYYdgisIGMR.K....V.IA..D-..---.V.CRSGyASMPSMTATHNLSHQLLMA.SGPSEEP.CAWRGF---FNQVLLWTVALCKFRRCIYYNYIQGSIATISQLLHLEIKALCSWiisqDGMRLFQHSRPLLTLWESVAANQEVTDAIT-------L.PDCAEYIDLLKHTKHVLE........................................................
P88987_MHV68/5-280                  ......................................................................................................................................................FYYPSLESVVHTFCVIDTREHN...----RVSACLCKLQVLCKICQTLRHNLDTEPFLLPHLRELII...RHLTLLERLSTTSKFQRI...LDYMKL.sLEA.N.DSNLL...QDLAIGTVNLLGCQSPEILS.......IpYD.KDQPVHE........WCACFL....TSVD.E....EaLR..KI..SSM.L.DNKH.-----FSYMYNF--KTFLK.YSLELET.AADFDLSTGLNVLVYWVSVFKLFSVCVQSQFLLDSLVAFNALFKNHVKELE--....--------------------------------------.------------------aivesdtnllcystsvvwaklsnlnhllhrlqtsnntlvfdeiliclrglqiyikc
A0A060CU28_9GAMA/32-311             ....................................................................................................................................................wl--YTEPKEILDMLESVTLPDTTkcmPENKHVILWLKRCMFLIKVYKVVAERKNSESGLLPCLMFNLK...YHLEKLQWVASAESKVLL...EEVLTF..INL.YgDVNIE...SHIESALHTILKDNY-TMAA.......-.-F.GAPPR-KlseykyveWFNDSL...iPVIR.D....R.TR..HD..LCA.V.FPDYrQCVPSITSLTITSKKLLDR.RDMSDEF.YGHKSFNYHYNQVVFWTTALKMYHGALWKNLLEVHMDYIRDLIKRELEAFMDW....-VSRNEDESCPLHSICD---------------------.------------------ymtalmetlefqghnemlatqlft................................
Q8UZH2_9GAMA/21-301                 ......................................................................................................................................................KHYPEVGDVVHLLNTIGVDCDL...PP-GHPLLTAHRGLFLARVLQAVQQHRLLEDAIIPKILKKLA...YFLELLSYYSPKDEQRAI...AEVLDHlnMSR.-.DMGLD...DKLWALIRTLRQERH--HAS.......-.VN.VVLPESDy.....taLSLQYYegisLGMR.K....V.VA..DI..---.-.CRSGyASMPSMTAIHNLSHQLLMA.SGPSEEP.CAWRGF---FNQVVLWTVALSKFHRCLYYNYIHGSIATLSQLLHLEIKALCGWiisqEGMRIFHRNRPLLTLWESVAADQEVTDAIP-------L.PDCSEYIDLLKHTKHVLE........................................................
A0A0M4LR31_9GAMA/19-259             ....................................................................................................................................iapkcmildkytlkkcdf----------------------...-------------IYILKIYKILLNNRITSYKIIPDIFTVLK...KATVHLATYT-RNLHFKL...K-LLDL..QQK.-.CTDIQeltRLLPYILQNLKQDHGQCIYN.......L.FV.NIYPCLK........WYKSAL....IGLK.P....C.IK..E-..EVI.Q.ILKCdENVYCLSYLKKICKRLVCNtNNYIQSDlLLDLTFSIAFNQTVFWIAVAKLYEKTLNDELLDEQITEIYSLLNFGIRRFM--....--------------------------------------.------------------ntfvsplnhtttlrdienlicylenmhn............................
A0A0B5CYF8_9GAMA/17-298             ......................................................................................................................................................FHYPPLGMIVGEMNTLTVNARN...PLYQAAALRLERALYLSKILQVLMQHRKGERFIVPQCRSNMV...YCLKELHKITNDRIRRLI...NSVLPL..VDA.G.CLGFD...EELVRILPEILKLEYPHVHE.......L.LP.PHDPTSPl......sWCLSHMvgvtNAFK.G....E.VK..EM..--I.D.TFHD.TSVPSFQYLASLVKKFFLV.EGVIYED.YQDTQFNVFLNLCLFWTTVIKMYQSCIFKDKLLDTIKACIELLKGEARQFFGW....-----YDLNTPDLGSAALVKYTEHLIRSLSVDSSNIPI.GEICSHL---HHCKHALI........................................................
ORF49_HHV8P/18-299                  ......................................................................................................................................................YHYPSWDQILQELDTLSVATLN...PDCHVPALNVEKTLYLAKTIQILVQHRQSEPYLVPAARANLA...YSLQQLYKLGNDKIRGVI...NGMLPL..VDA.G.CIGFE...RELIKGLPRVLTLQYPHTAP.......-.LE.SEPPTADc.....teWCLSHFvgasGRLR.S....E.VR..DI..--L.T.THNG.TCAPSFQWMASVVKKFFLV.ETVIYED.FQDTDFNVQLNLCFFWTAVVQMYQRCIYEQKLVHIISTSLTLLKSTARSFFAW....-----YDLYRPNLGSAALVKYTEHLIRALTPDCSDVEL.GELCSHL---HHCKHALF........................................................
E9M5N2_9GAMA/5-274                  .....................................................................................................................................................f-YLPDMDKCLHEMDQLALSAAS...PD----LALVGRVQYAVSVCRTLRLNMDLEPRILPYIKQVILrqlWFLEALYPKG--RPRRAIqagKHSLQH..ENM.D.ELSLI...RDMSMCAVCLAGYERPEVLQ.......C.PFiETPPH-I........WCTNFL....IDVS.E....HtAK..KV..QSF.LdTKDF.KTMYSIEACFRFIQNLNLP.HSDEAK-.---R--KSAVNVLLFWVAVYRAFYSCIHSQYLLDCIISMDGILKLQLSQLIN-....--------------------------------------.------------------hlvnkhhpipkacllhlahihkhydmlssyfltcdissycktlqk...........
A0A1Z1NE88_9GAMA/22-295             ......................................................................................................................................................YHYPRIGAIVDMLHSVDCEVAN...PVYKEQAVRLSRVLALAKVLQTLVNHQMLEPFIIPRILDILS...HYISKMQTHYSGKISAAM...AKVAKH..IDAhG.DDQLE...AVLDFALYTSRRAQYTEDDS......eW.VP.ITKPIGE........WVITNS....RGLD.D....G.IRaaVY..SNW.A.YGTG.-QIPSMAFLATISKRIFLN.EELNFTH.EEDNYFNTLFNQLILWTAALRVFRMAIHEGALLNVTNQTAGLLVEEMKAFFAW....FAS-----------------------------------.------------------ggyewvstvamldylfqlvnglheklldfevveiytlv..................
O40934_HHV8/18-299                  ......................................................................................................................................................YHYPSWDQILQELDTLSVATLN...PDCHVPALNVEKTLYLAKTIQILVQHRQSEPYLVPAARANLA...YSLQQLYKLGNDKIRGVI...NGMLPL..VDA.G.CIGFE...RELIKGLPRVLTLQYPHTAP.......-.LE.SEPPTADc.....teWCLSHFvgasGRLR.S....E.VR..DI..--L.T.THNG.TCAPSFQWMASVVKKFFLV.ETVIYED.FQDTDFNVQLNLCFFWTAVVQMYQRCIYEQKLVHIISTSLTLLKSTARSFFAW....-----YDLYRPNLGSAALVKYTEHLIRALTPDCSDVEL.GELCSHL---HHCKHALF........................................................
Q99CZ1_BHV4/16-296                  ......................................................................................................................................................YHFPDLSQIVKEKDKLSFNSGE...TNYEKPITALERALFLTDVAQILIQHKNQEKSIMVLIQDIIK...YMITSLNELNNADAQCST...PQLLHF..LVS.D.DQMLG...VHLIKLLPEILLCKYPNFST.......-.--.SPINSGDmd...yieWCLHHM....LAIS.E....T.DQ..NLlrNTL.S.TREW.TLMPSIQVLCHIMQQLFLS.QTHCPE-.YKDHEFNLFFNQAIFWTTVLKMFQECIRQDMVGDHIQCVIALLKNEVRQFFLW....-----YDINKIHFKPMAMVKYLEHLVNSITYESSDILL.FQA--RL-LLSHCKLIL-q.......................................................
#=GC seq_cons                       ......................................................................................................................................................hHYPchspllp.hpslslssss...P..ppshhplcRslaLsKlhQsLhpH+ppE.tIlPplhsslt...YaLppLpphssschpthI...pplLsh..hst...shslp...pcLhthl.plhphcYPphhs.........hp.st.Psuc.......tWslpah....hslc.p....t.h+..ch...sh.s.hpps.tshPShphhssls+pLahs.csh.tcs.htcpsFNh.aN.llhWosslchappslapphl.cpIsshtsLLK.El+shhsW.........hp.pp..h...t.sth.p..hpths.......l..ph.phl...ht.+............................................................
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