#=GF ID   Herpes_ICP4_C
#=GF AC   PF03585.18
#=GF DE   Herpesvirus ICP4-like protein C-terminal region
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_1422 (release 7.0)
#=GF GA   25.00 25.00;
#=GF TC   130.80 63.70;
#=GF NC   22.80 22.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11739685
#=GF RT   Identification of a motif in the C terminus of herpes simplex
#=GF RT   virus regulatory protein ICP4 that contributes to activation of
#=GF RT   transcription. 
#=GF RA   Bruce JW, Wilcox KW; 
#=GF RL   J Virol 2002;76:195-207.
#=GF DR   INTERPRO; IPR005205;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The immediate-early protein ICP4 (infected-cell polypeptide 4)
#=GF CC   is required for efficient transcription of early and late viral
#=GF CC   genes and is thus essential for productive infection.  ICP4 is a
#=GF CC   large phosphoprotein that binds DNA in a sequence specific
#=GF CC   manner as a homodimer.  ICP4 represses transcription from LAT,
#=GF CC   ICP4 and ORF-P that have high-affinity a ICP4 binding site that
#=GF CC   spans the transcription initiation site. ICP4 proteins have two
#=GF CC   highly conserved regions, this family contains the C-terminal
#=GF CC   region that probably acts as an enhancer for the N-terminal
#=GF CC   region [1].
#=GF SQ   35
#=GS ICP4_VZVD/750-1187          AC P09310.1
#=GS L0N6C0_HHV1/1-439           AC L0N6C0.1
#=GS A0A077B9T3_9ALPH/875-1302   AC A0A077B9T3.1
#=GS A0A1L5JKJ4_9ALPH/889-1298   AC A0A1L5JKJ4.1
#=GS Q2QBA3_CHV16/711-1142       AC Q2QBA3.1
#=GS ICP4_GAHVM/1861-2284        AC Q9DGT6.1
#=GS ICP4_HHV2H/858-1276         AC P90493.1
#=GS A0A060PYC4_9ALPH/740-1154   AC A0A060PYC4.1
#=GS E6Y373_9ALPH/1142-1551      AC E6Y373.1
#=GS Q9DH52_MEHV1/1711-2139      AC Q9DH52.1
#=GS A7KQA2_9ALPH/1861-2284      AC A7KQA2.1
#=GS Q7T401_CHV1/732-1146        AC Q7T401.1
#=GS A0A0Y0C415_9ALPH/780-1194   AC A0A0Y0C415.1
#=GS Q5PP75_9ALPH/1033-1370      AC Q5PP75.1
#=GS D1FXY1_FHV1/907-1331        AC D1FXY1.1
#=GS L0N3J4_HHV1/1-439           AC L0N3J4.1
#=GS G9CUK7_9ALPH/1861-2284      AC G9CUK7.1
#=GS A0A172DSP4_9ALPH/901-1320   AC A0A172DSP4.1
#=GS K9MHE7_9ALPH/810-1227       AC K9MHE7.1
#=GS J9QYQ8_9ALPH/489-614        AC J9QYQ8.1
#=GS Q5PP75_9ALPH/973-1036       AC Q5PP75.1
#=GS A0A1L5JKK3_9ALPH/893-1299   AC A0A1L5JKK3.1
#=GS E2IUH2_SHV1/901-1316        AC E2IUH2.1
#=GS Q77LS1_CHV9D/719-1155       AC Q77LS1.1
#=GS F8TC94_9ALPH/1568-1999      AC F8TC94.1
#=GS Q2QBB7_CHV16/711-1142       AC Q2QBB7.1
#=GS ICP4_EHV1B/993-1418         AC P28925.1
#=GS A0A089N6G1_9ALPH/853-1268   AC A0A089N6G1.1
#=GS A0A1R3TFR1_9ALPH/1240-1669  AC A0A1R3TFR1.1
#=GS A0A286MM89_9ALPH/895-1339   AC A0A286MM89.1
#=GS A0A1S6JLQ4_HSVA1/894-1310   AC A0A1S6JLQ4.1
#=GS J9R0A4_9ALPH/1-329          AC J9R0A4.1
#=GS A0A068EPP2_9ALPH/1192-1605  AC A0A068EPP2.1
#=GS A0A1V0M8R0_9ALPH/1192-1605  AC A0A1V0M8R0.1
#=GS ICP4_HHV11/812-1253         AC P08392.1
ICP4_VZVD/750-1187                     ........GGFRRIPRGALHTPVPSDQARKAYCTPETIARLVDDPLFPTAWRPALSFDPGALAEIAAR----RP......GGGD------------.RRFGPPSGVEALRRRCAWMR.QIPDPEDVRLLIIYDPLPGEDin......gpLEST.L...A.T..DP..G...P.....SWSPSR.GGLSVVLAALSNR.LCL.PSTHAWAGNWTGPPDVSALNARGVLLLSTRDLAFAGAVEYLGSRLASARRRLLVLDAVALERWPRDGPALSQYHV.YVRAPARPDAQAVVRWPdsaVTEGLARAVFASSRTFGPASFARIET.AFANLYPGEQPLCLCRGGNVAYTVCTRAGPKTRVPLSPREYRQYVLPGFDGCKDL.ARQS.RGLGLGAADFVDEAAHSHRAANRWGLGAALRPVFLPEGRR.PG...A..AGPEAGDVPTwARVFCRHALLEPDPAAEPLVLPPVAGRSVALyaSADEARNALPPI.PRVMWPPGFGAAETV.............................
L0N6C0_HHV1/1-439                      ........------PPGPSHTAAPAAAALEAYCSPRAVAELTDHPLFPVPWRPALMFDPRALASIAARCAGPAPaaqaacGGGDDDDNPHPHGAAGgRLFGPLRASGPLRRMAAWMR.QIPDPEDVRVVVLYSPLPGED..........LADG.G...A.S..GG..P...P.....EWSAER.GGLSCLLAALANR.LCG.PDTAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLASAGDRRLIVVNTVRACDWPADGPAVSRQHA.YLACELLPAVQCAVRWP...AARDLRRTVLASGRVFGPGVFARVEA.AHARLYPDAPPLRLCRGGNVRYRVRTRFGPDTPVPMSPREYRRAVLPALDGRAAA.SGTT.DAMAPGAPDFCEEEAHSHRACARWGLGAPLRPVYVALGRE.AV...R..AGPARWRGP-.RRDFCARALLEPDDDAPPLVLR---G---DD..DDDDGPGALPPAlPGIRWASATGRSGT-v............................
A0A077B9T3_9ALPH/875-1302              ........GGFRRVPRGESHTPAPGEAARAAYCSPETVAELVDHPLFPEAWRPALTFDPAALATVAARRTGPPA......-------------REG.ARFGALAPSGPLRRRAAWMR.QVPDPEDVRIVVLYHPLPGEDll......ggLPAG.G...A.AgrEG..G...P.....RWSERK.GGLSALLAALGNR.LLT.RGSHCWAGNWTGPPDVSALNRQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVLDAVDPEDWPADGPAVGQYHL.YMRARLTPRAACAVRWP...AERDLSRAVLTSGSVFGPVFFARVEA.AFARLHPGLEAPRLCRAGNVAYVVETRAGERTRVPMPPRDYRQRVLPVYDGCKDM.GAQS.RGLAVFDPDFDEGAARSHRAANRWGLGAPLRPLYLAAGRR.GAldeS..AAPADLLPPA.LREFCRVALLEPDLEAGPTVLRVGE------..------------.---------------elparaphvewepgfgarsta........
A0A1L5JKJ4_9ALPH/889-1298              ........GGFRRVPPGEYHTPAPSAAALAAYCRPEVAARLADHPLFPEPWRPALAFDPEALAEIAAR-RRAGP......----------------.--AGALAASAPLRRRVAWMS.QIADPEDVRVVVLYDPLPGEA..........LAAP.P...G.E..DErrR...P.....EWPPRR.GGLSHALAALGNR.LLLsADSHAWAGTWTGAPDVSALGAQGVLLLATRDLAFRGAVEYLCLRLAAARRRLIVIDAVDPANWPRDGPAVGQAHV.YLRAAVLPAAQCAARWP...ERRALARAVLASRRVFGPGAFARAEA.AYARLYPGAPPLRLCRGANVRYTVATRLGPRTAVPVPPREYRQRVLPRLDGRKDM.AAQG.AALGLGEPDFAEGEAASHRAANRWGLGAPLRPVYLACGRR.AL...E..LAPDELPA-A.AVAFCAAALLEPHAEAPPLVLEAAAAAAP--..------------.---------------apgaapggagga.................
Q2QBA3_CHV16/711-1142                  ........GGWRRAPPGPAHTPAPAAAALEAYCEPRLVAELTDHPLFPEPWRAALAFDPRALASLAARCGPPEP......GSG-------------.RALGPLRASGPLRRAAAWMR.QVPEPEDVRVLVLYAPLPGEE..........LGGV.-...-.S..PA..P...P.....AWTAAR.GGSPSCLAALGNR.LCG.PDTAAWAGNWTGPPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLAAAAGRRLVVVDAVPPEEWPDDGPVVARRHV.YLPCAVLPAAQCDLRWP...AARDLRRAVLASGRVFGPGLFARVEA.ACARLYPDAPPPRLGRGANVRYRVRTRLGPDTAVPLPPREYRRAVLPALDGRAAD.SPAR.AAAAAGAPDFRRGEAHSHRACARWGLAAPLRPVYLALDRA.AA...R..AGPDALPA-A.LRAFCARALPEPDPDAAPLVLR---------..-ADAEPPDPAAA.PRVRWAA--G-----radtlladaedaaavelaaap........
ICP4_GAHVM/1861-2284                   ........AAFRQFPVGTVIGQTPPQSVLNAYCPNGAFVELVEFARIPEPWQEVLRYSPEAMADI-ARVANALP......--GKYNSNEIITSAAS.EAFH--TATSKLRARTAWMRyQQESPDDVSIVVLYSPLPGEH..........LFCV.P...A.P..DT..P...Pg..glKFDNKR.GGLSFLLAAFSNR.LCL.PKSSAWAGRWKAAPDISPLTRMGVLFLSTEDLGYQGAVEYLQRQCMKRKKKLIIMDTVEDRYRLPNGPCIIEEATrYMKCIISPRSQCCVRWP...GLLDFGTTIITSRDVVGPLTLMDLEQyYYCEIGIEDSTINLCCTGNVRYTVETRLEDVSCVPTTPLFYFAAVKHV-------.----.------RPDFLCGETYSNRAARKWGLCAPLRPIYVIESKM.NA...I..VSPSFLH-PT.ARNLCRSVILPPDPEARPVVVHIPEGTCSAL..AEDMVASIRSSC.--ITWGQ---HEEG-gpe..........................
ICP4_HHV2H/858-1276                    ........GGWRRQPPGPSHTPAPSAAALEAYCAPRAVAELTDHPLFPAPWRPALMFDPRALASLAARCAAPPP......GGAP------------.AAFGPLRASGPLRRAAAWMR.QVPDPEDVRVVILYSPLPGED..........LAAG.R...A.G..GG..P...P....pEWSAER.GGLSCLLAALGNR.LCG.PATAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLAGACDRRLIVVNAVRAADWPADGPVVSRQHA.YLACEVLPAVQCAVRWP...AARDLRRTVLASGRVFGPGVFARVEA.AHARLYPDAPPLRLCRGANVRYRVRTRFGPDTLVPMSPREYRRAVLPALDGRAAA.SGAG.DAMAPGAPDFCEDEAHSHRACARWGLGAPLRPVYVALGRD.AV...R..GGPAELRGP-.RREFCARALLEPDGDAPPLVLR---------..--DDADAG--PP.PQIRWASAAGRAG--tv...........................
A0A060PYC4_9ALPH/740-1154              ........GGWRRQPPGPSHTPAPGQAALDAYCPPAVVAELTEHALFPSAWRAALMFDPSALASLAARSAASEP......GSG-------------.RLFGPLRVSGPLRRAAAWMR.QIPDPEDVRVVVLYAPLPGEE..........LG-G.P...A.P..-S..P...P.....AWTTER.GGLSFLLAALGNR.LCG.PDTAAWAGRWTGPPDVRALGAQGVLLLSVRDLAFTGAVEFLGLLASASERRLIVINAVPEAEWPADGPTISQQHV.YLPCSVTPRAQCDLRWP...DAPDLARAALTSGRVFGPGVFARAEA.AFARLYPGEAPLRLARARNVRYCVDSRLGEQTAVPLSPREYRRAILPALDSRAAS.SRLG.DAMGPGAPDFCEGEAHSHRACLRWGLGAPLRPVYLALPRG.AA...A..EGPAAVPA-A.LRDFCARALLEPEEDAAPYRLK---------..----AGDALPPA.PGVRWASAVGRLDT-v............................
E6Y373_9ALPH/1142-1551                 ........GGYRRVPTGITHTPLPTESARSTYCQPDIVAELLDDPMFPPNWKPALMFDPEALARVAAR------......RGGS--------HVEG.RLYGPLRVTDPLRKQCAWMN.QIPDPEDVKVVIMYCPLVGEE..........LSAA.P...V.A..SC..M...P.....MWSDEK.GGLSFLLAALCDR.LCS.YGSHAWAGNWTGVPDISALNSRGVLLLSVRDLGFAGAVEYLCLRLGSAHKRLIFLDTIDTVDWPADGPAISSYHS.YIKATITPQAHGAHRWP...DCEAMSRVVMTSRGIVGPGVFARVEA.AFAQLYPNEPPLQLMRGDNVKYVVETKAGRTTRVPMTPREYRGLVLPQYD-RKDM.AFQA.DGLSISGPDFLEGAAYNHRAANRWGLGAPLRPLYLTESRK.HP...F..ETPDDIP-EV.VRSYCAAALLEPQMEGNVCVVNP--------..------------.---------------ntiqrgqrpptitwelc............
Q9DH52_MEHV1/1711-2139                 ......sg--GRRCPVGRLVPETTLPTDIRAYCPPAAAAALMDFAKIPGPWRPAMLYAPECLAEIAA-VANEVP......--------PRATSTVGgGNAE--PSLETLKRHTAWMHhQQHSPEDVKIVVLYKALKGEH..........LFCV.P...T.P..DA..AygwP.....RFETTK.GGLSFLLAAMSNR.LCL.PSSAAWAGRWKAAPDISPLTQAGVLFLSVGDWGWVGALEYLQHLNIERHHKLIVVDTVDENSRPQGGPQFISEAVrYYRCWIDPLNQCCLRWP...DAPGLDTAVMTSKEVLGPVLLTEVAL.-QCTAEFSCPQPKLCCSANVRYVVDTHLGDDMPVPTSAVFYCAATRQA------S.AQPN.EHDPFSQPDFLGGEAHSHRAARRWGLGAPLLPIYLTEAGR.RA...I..ASPSLIS-KV.VRYMCGNTVLPPDPHGTPVVINVPEGTSETM..AELTVAHVGRRS.--IGWSTS-------ewhsati......................
A7KQA2_9ALPH/1861-2284                 ........AAFRQFPVGTVIGQTPPQSVLNAYCPNGAFVELVEFARIPEPWQEVLRYSPEAMADI-ARVANALP......--GKYNSNEIITSAAS.EAFH--TATSKLRARTAWMRyQQESPDDVSIVVLYSPLPGEH..........LFCV.P...A.P..DT..P...Pg..glKFDNKR.GGLSFLLAAFSNR.LCL.PKSSAWAGRWKAAPDISPLTRMGVLFLSTEDLGYQGAVEYLQRQCMKRKKKLIIMDTVEDRYRLPNGPCIIEEATrYMKCIISPRSQCCVRWP...SLLDFGTTIITSRDVVGPLTLMDLEQyYYCEIGIEDSTINLCCTGNVRYTVETRLEDVSCVPTTPLFYFAAVKHV-------.----.------RPDFLCGETYSNRAARKWGLCAPLRPIYVIESKM.NA...I..VSPSFLH-PT.ARNLCRSVILPPDPEARPVVVHIPEGTCSAL..AEDMVASIRSSC.--ITWGQ---HEEG-gpe..........................
Q7T401_CHV1/732-1146                   ........GGWRRVPPGPSHTPAPSAAALEAYCAPRVVAELTDHPLFPEAWRAALAFDPRALASLAARCGPPEP......GSG-------------.RAFGPPRASGPLRRAAAWMR.QVADPEDVRVLVLYAPLPGEE..........L--G.G...A.S..PA..P...P.....AWTDAR.GGLSFLLAALGNR.LCG.PDTAAWAGNWTGPPDVSALGAQGVLLLSTRDLAFAGAVEYLGLLAAAAGRRLVVVDAVPPEEWPADGPAVARRHV.YLPCAVLPAAQCDVRWP...AARDLRRAVLASGRVFGPGVFARVEA.ACARLYPDAPPPRLGRGANVRYRARTRLGPDTPVPLPPREYRRAVLPALDGRAAD.SPAR.EAAAAGAPDFRRGEAHSHRACARWGLAAPLRPVYLALDRD.AA...R..AGPDALP-PA.LRAFCARALLEPDPDAAPLVLR---------..ADADADP--AAA.PRVRWAAGRG-----dtl..........................
A0A0Y0C415_9ALPH/780-1194              ........GGWRRQPPGPSFTPGLSPSALDTYCPPSMAEALTAHELFPEPWRTALLFDPKALASLAAR--HDPP......TGPD------------.QIIGPLGVSGPLRRMTAWMR.QIPEPEDVRVLILYSPHPNES..........LWRV.G...L.S..--..R...P.....QWDPKRqGGLSFLLAALSNR.LCG.PETAAWAGNWEAAPDISALNAQGVLLLSTDDLGFTGAVEFLCLEASTSDRRLIIINTIQPSEWPEDGPTISQRHT.YFPCGVLATAQCFLRWP...RATQLSRAVLTSSRVFGPKVFAMAEE.AFAKLYPQLPPLRLCRGSNVRYRIHTHVGDNLLVPLPPKEYRRAVLPALDSRAAA.SSIG.KAMGPGAPDFEEWESYSHRACLRWGLKAALRPIYLSLPRG.AA...R..AGPEAVPQD-.LKDFCARAILEPDPAARPVLIE---------..-H---DRHLPPL.PGICWSSPTGRM---ttv..........................
Q5PP75_9ALPH/1033-1370                 .....rga------------------------------------------------------------------......----------------.----------PLRRRAAWMR.QIADPEDVRVVVLYDPLPHEE..........LCAE.P...A.E..GA..P..rP.....AWDPRR.GGLSALLAAFAHR.LCT.PDSHAWAGNWTGRPDIGRLNAQGVLLLSARDLGFAGAVEYLCSRLGAARRRLIVLDTIE--DWPADGPAVGDYHV.YVRVRLDPAAQCAVRWP...GCRELRAAVLDSSSIVGPACFARVEA.SFARLHPGAEPLRLCRQDNVRYTVSTRAGPRTPVPLPPRAYRQRVLPTVDGCKDM.ARQR.SALGLGDPDFDAGAAFGHRAANRWGLGAPLRPVFVSCGRR.GL...AelRGPEGLPAE-.LRAFCAAALLEPDAEAAPLVLTPGA------..------------.---------------vaaagappavlwdfap.............
D1FXY1_FHV1/907-1331                   ........GGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAITFDPGALATIAARCTGPRR......QEGT------------.-GLGGLVVSAPLRRASAWMT.QIADPEDVKVVVLYNPLPHEH..........LAHQ.NpnrD.S..RH..T...P.....AWSETK.GGLSTLLAALGNR.LLS.PESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPEDWPATGPAVSHYHL.YIRATVTPTAYCAVRWP...ALEDLSRAVLTSSAIFGPGSFARVEA.AFERLYPNCDGLRLCASGNVGYTVRTDAGDRTPVPMLPREYRQRVLPAYDGCKDM.EAQS.AGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRR.AL...-..ASTDPTRIPAvVRAFCRTALLAPDTEAPPLILT---------..PADPQSAIIENI.PGVTWDSGFGKQETV.............................
L0N3J4_HHV1/1-439                      ........------PPGPSHTAAPAAAALEAYCSPRAVAELTDHPLFPVPWRPALMFDPRALASIAARCAGPAPaaqaacGGGDDDDNPHPHGAAGgRLFGPLRASGPLRRMAAWMR.QIPDPEDVRVVVLYSPLPGED..........LADG.G...A.S..GG..P...P.....EWSAER.GGLSCLLAALANR.LCG.PDTAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLASAGDRRLIVVNTVRACDWPADGPAVSRQHA.YLACELLPAVQCAVRWP...AARDLRRTVLASGRVFGPGVFARVEA.AHARLYPDAPPLRLCRGGNVRYRVRTRFGPDTPVPMSPREYRRAVLPALDGRAAA.SGTT.DAMAPGAPDFCEEEAHSHRACARWGLGAPLRPVYVALGRE.AV...R..AGPARWRGP-.RRDFCARALLEPDDDAPPLVLR---G---DD..DDDDGPGALPPAlPGIRWASATGRSGT-v............................
G9CUK7_9ALPH/1861-2284                 ........AAFRQFPVGTVIGQTPPQSVLNAYCPNGAFVELVEFARIPEPWQEVLRYSPEAMADI-ARVANALP......--GKYNSNEIITSAAS.EAFH--TATSKLRARTAWMRyQQESPDDVSIVVLYSPLPGEH..........LFCV.P...A.P..DT..P...Pg..gpKFDNKR.GGLSFLLAAFSNR.LCL.PESSAWAGRWKAAPDISPLTRMGVLFLSTEDLGYQGAVEYLQRQCMKRKKKLIIMDTVEDRYRLPNGPCIIEEATrYMKCIISPRSQCCVRWP...GLRDFGTTIITSRDVVGPLTLTDLEQyYYCEIGVEDSTINLCCTGNVRYTVETRLEDVSCVPTTPLFYFAAVKHV-------.----.------RPDFLCGETYSNRAARKWGLCAPLRPIYVIESKM.NA...I..VSPSFLH-PT.ARNLCRSVILPPDPEARPVVVHIPEGTCSAL..AEDMVASIRSSC.--ITWGQ---HEEG-gpe..........................
A0A172DSP4_9ALPH/901-1320              ........GGFRRIPSGDCHTPVPRDIVKSIYCSPETVKELTDHPLFPEAWRTALSFDPQALSTIASRCTGQTS......---D-----------D.RKFGSLVVSGPLKRRVAWMH.QILDPEDVKVVILYNPLPFED..........LAQE.NpnqD.K..QK..V...P.....RWSTTK.GGLSTLLAALGNR.IFS.EKSHAWAGNWTGKPVIDSLNSQGVLLLSTKDLAFAGCVEYLCLRLGSARRRLIVFDTVDPEDWPELGPAVSNYHL.YIRAKLSPAAYCSIRWP...EDKDLNRTVLASSSLVGPGSFARVEA.AFARLYPNSDPLKLCSSKNVSYTVKTAAGERTVVPLNPRDYRHKVLPAYDGCKDM.TTQR.VGLKLDDPDFVDGTAFSHRACNRWGLGASLCPIYLASGRK.AL...E..TT-NMEHIPInVRKFCNEAILEPCADSTPMIINPSQ------..------S-----.---------------lpskvpsiiwehgfghigt..........
K9MHE7_9ALPH/810-1227                  ........GGWRRQPPGPSHTPAPSAAALEAYCAPRAVAELTDHPLFPVPWRPALMFDPRALASLAARCAGAPP......GGPA------------.-TFGPLRASGPLRRAAAWMR.QVPDPEDVRVVILYSPLPGED..........LASG.R...A.G..GG..P...P....pEWSAER.GGLSCLLAALGNR.LCG.PDTAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLAGASDRRLIVVNAVRAADWPADGPVVSRQHA.YLACEVLPAVQCAVRWP...AARDLRRTVLASGRVFGPGVFARVED.AHARLYPDAPPLRLCRGANVRYRVRTRFGPDTLVPMSPREYRRAVLPALDGRAAV.SGAG.DAMAPGAPDFCEDEAHSHRACARWGLGAPLRPVYVALGRD.AV...R..GGPAELRGP-.RREFCARALLEPDGDAPPLVLR---------..--DDADAG--PP.PQIRWASATGRAGT-v............................
J9QYQ8_9ALPH/489-614                   garrarar------------------------------------------------------------------......----------------.--------------------.---------------------..........----.-...-.-..-A..P...X.....SXTTER.GGLSFLLAALANR.RCT.PDSAAWAGNWTGPPDVSALNARGVLLLSTRDLAFAGAVEFLGLLAGAAGRKLVVVNAVPADAXARGRP-------.-----------------...--------------------------.-------------------------------------------------------.----.----------------------------------------.--...-..----------.-------------------------------..------------.---------------grlraarvpglrgaprgpvrralar....
Q5PP75_9ALPH/973-1036                  ........GGFRRVPAGETHTPRPSEAALAAYCPPEVARALVDQEVFPELWRPALTFDPAALAHIAARR-----......----------------.--------------------.---------------------..........----.-...-.-..--..-...-.....------.-------------.---.---------------------------------------------------------------------------.-----------------...--------------------------.-------------------------------------------------------.----.----------------------------------------.--...-..----------.-------------------------------..------------.---------------gap..........................
A0A1L5JKK3_9ALPH/893-1299              ........GGFRRVPPGEYHTPAPSAAALAAYCRPEVAARLADHPLFPEPWRPALAFDPEALAEIAAR-RRAGP......----------------.--AGALAASAPLRRRVAWMS.QIADPEDVRVVVLYDPLPGEA..........LAAP.P...G.E..DErrR...P.....EWPPRR.GGLSHALAALGNR.LLLsADSHAWAGTWTGAPDVSALGAQGVLLLATRDLAFRGAVEYLCLRLAAARRRLIVIDAVDPANWPRDGPAVGQAHV.YLRAAVLPAAQCAARWP...ERRALARAVLASRRVFGPGAFARAEA.AYARLYPGAPPLRLCRGANVRYTVATRLGPRTAVPVPPREYRQRVLPRLDGRKDM.AAQG.AALGLGEPDFAEGEAASHRAANRWGLGAPLRPVYLACGRR.AL...E..LAPDELPA-A.AVAFCAAALLEPHAEAPPLVLEAAAAA----..------------.---------------ppapaaapgga..................
E2IUH2_SHV1/901-1316                   ........GGWRRQPPGPSHTPAPGAAALEAYCPPERVAELADRPLFPAPWRAALMFDPGALAALAARCAPPEP......GSG-------------.RAFGPLRVSAPLRRAAAWMR.QVPDPEDVRVLVLYHPLPGEE..........LGGP.P...G.P..E-..P...P.....AWTADR.GGLSFLLAALANR.RCT.PDSAAWAGNWTAAPDVSALNAQGVLLLSTRDLAFAGAVEFLGLLAGASGRRLVVLDAVEPADWPADGPAVALRHV.YVPCSVRPGAQCDLRWP...GCEELRRAVLVSPRVAGPGSFARAEA.AYARLYPDAPPLRLARAGNVRFAVRTRLGPRTSVPVPPRAYRRAVLPALDGRAAA.SRLAgAAMGRGAPDFCGDETFSHRACDRWGLGAALRPLYLALGRG.PA...P..RRPDDVP--AaLRAFCAAALLEPDDDAAPLLVGPDADP----..------------.---------------aaapgvrwasasgrvgt............
Q77LS1_CHV9D/719-1155                  ........GCFRRVPAGALHTPVPSEAARRAYCAPNVIESLVDEPMFPPAWRPVLRFDPAAVAEISAR----GH......GG------------VD.RRFGPPSGVDALRRRCAWMH.QVADPEDVRLVIIYDPLPGES..........LCGP.T...C.M..EG..G...Asr.dvHWSDCR.GGLSVVLAALSNR.LCL.PDTHAWAGNWSGPPDVSQLNARGILLLSTRDLAFAGAVEYLGSRLASAGRRLLILDAVAPERWPRDGPAISQYHV.YVKAPARPDAQAVVRWPr.aTEAGLARAVFASSRTFGPGSFARVET.AFSNLYPNEQPIRLCRGANVCYVVATRAGPRTRVPLSPRDYRQYVLPGFDGCKDI.ARQA.QGLAVGAADFVDDAAYSHRAANRWGLGAPLRPVYLPEGRR.PG...S..AGPRPSDVPLwARVFCRHALPEPDPEAEPIILPPVAGRSVAVfsCMSEARESLPPI.PRILWPPGFGSGET-a............................
F8TC94_9ALPH/1568-1999                 ........AAFRKPPIGTPIAGYAGPPHLDAYCPGEGVDELTSFAQIPTLWRQPLARSPEAMAEI-ARVAS-TP......----SHVSRSPDTAAS.EGVLCRTAVVSLRARTAWMRhQQASPEDVALVILYTANPGEH..........LFCV.P...A.P..GS..P...Pg..gpRFDPNR.GGLSFLLAALANR.LCL.PESAAWAGRWRAAPDVSALTAAGVMFLSPQDLGFAGVLEHLQRLCLKREKRLVVLDTLEDQDRPENGPRLVEEAVrYVRCTVSPRSQCSVRWP...GHPDLATTVITSRDVLGPVVLRELET.HFRRENPAAGDISLCCGSNVRYKVATRLDRVATVPMTALSYLAASSALVAGRQR-.----.----PPGPDFLAGESHSHRAALKWGLYAPLRPVYVLEPKK.NA...I..VSPDFLN-RT.VCDVCRSVVLPPDPHAQPVVVHVPEATCSLL..AREMLAHLRSSS.--VVWLEGDG-----gppett.......................
Q2QBB7_CHV16/711-1142                  ........GGWRRAPPGPAHTPAPAAAALEAYCEPRLVAELTDHPLFPEPWRAALAFDPRALASLAARCGPPEP......GSG-------------.RALGPLRASGPLRRAAAWMR.QVPEPEDVRVLVLYAPLPGEE..........LGGV.-...-.S..PA..P...P.....AWTAAR.GGLSFLLAALGNR.LCG.PDTAAWAGNWTGPPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLAAAAGRRLVVVDAVPPEEWPDDGPVVARRHV.YLPCAVLPAAQCDLRWP...AARDLRRAVLASGRVFGPGLFARVEA.ACARLYPDAPPPRLGRGANVRYRVRTRLGPDTAVPLPPREYRRAVLPALDGRAAD.SPAR.AAAAAGAPDFRRGEAHSHRACARWGLAAPLRPVYLALDRA.AA...R..AGPDALPA-A.LRAFCARALPEPDPDAAPLVLR---------..-ADAEPPDPAAA.PRVRWAA--G-----radtlladaedaaavelaaap........
ICP4_EHV1B/993-1418                    ........GGFRRVPRGDCHTPRPSDAACAAYCPPELVAELIDNQLFPEAWRPALTFDPQALATIAARCSGPPA......RD-------------G.ARFGELAASGPLRRRAAWMH.QIPDPEDVKVVVLYSPLQDED..........LLGGlP...A.S..RP..G...GsrrepLWSDLK.GGLSALLAALGNR.ILT.KRSHAWAGNWTGAPDVSALNAQGVLLLSTGDLAFTGCVEYLCLRLGSARRKLLVLDAVSTEDWPQDGPAISQYHI.YMRAALTPRVACAVRWP...RERHLSRAVLTSSTLFGPGLFARAEA.AFARLYPDSAPLRLCRSSNVAYTVDTRAGERTRVPLAPREYRQRVLPDYDGCKDM.RAQA.EGLGFHDPDFEEGAAQSHRAANRWGLGAWLRPVYLACGRRgAG...A..VEPSELLIPElLSEFCRVALLEPDAEAEPLVLPITEA-----..------------.---------------prrraprvdwepgfgsrst..........
A0A089N6G1_9ALPH/853-1268              ........GGFRRVPPGDYHTPAPSAAALAAYCRPEVAARLADHPLFPEPWRPALAFDPEALAEIAAR-RRAGP......----------------.--AGALAASAPLRRRVAWMS.QIADPEDVRVVVLYDPLPGEA..........LAAP.P...G.E..DErrR...P.....EWPPRR.GGLSHALAALGNR.LLLsADSHAWAGRWTGAPDVSALGAQGVLLLSTRDLAFRGAVEYLCARLAAARRRLIVLDAVDPENWPRDGPAVGQAHV.YLRAAVLPAAQCAARWP...ERRALARAVLASRRVFGPGAFARAEA.AYARLYPEAPPLRLCRGGNVRYTVATRLGPRTAVPVPPREYRQRVLPALDGRKDM.AAQG.AALGLGEPDFVEGEAASHRAANRWGLGAPLRPVYLACGRR.AL...E..LAPDELPA-A.AVAFCAAALPEPRAEAPPLVLEAAAAPPA--..------------.---------------aaapgvdwdadqgpretl...........
A0A1R3TFR1_9ALPH/1240-1669             ........GGYRRIPGGDLYTPVPSASVRNVYCDPDIVAELVDDPLFPQNWRPALMFDPNALATIAARRGAARDd....eAGERYTNNNNNNKNSC.PRFGRLSVTTPLRRQTEWMR.QINDPEDVRVIILYNPLPNED..........LAGD.P...SkS..GQ..E...P.....QWSDTK.GGLSFLLAALSDR.LCT.PKSHAWAGNWTGRPDISVLNKKGVLLLSTGDLGFTGAVEYMCLRTGSARRKLIVLDAVDPADWPSDGPAIGHYHV.YVQASVSPRSHCAVRWP...ECRDLSRTVMASRNVFGPGSFARVEA.AYALLYPTDSPLGLAKGENVSYVVETRAGPQTRVPMAPRDYRSAVLPRLDGCKDM.LAQS.SELALRDPDFVDGAAYSHRAANRWGLGAALRPVYLAEGRR.VG...W..NSPDDIPD-N.IRRFCREAVREPAPG----------------..------------.---------------eastgfvdttgqiptdtprvyweaghg..
A0A286MM89_9ALPH/895-1339              ........GGFRRVTPGRYYTPAPSRAALDAYCGPEIVDGLVHHEILPEKWRAAFAFDPEALAALAARCTSPRV......GGGG----PGP-----.GGLGRLVVTDPLRARLAWTR.QIEDPEDVRVVFMYAPLPGESlagpparaasAAAA.A...A.D..DD..E...Pad.gpRWPPAR.GGLSHLLAALGNRaLVG.PGDQAWAGRWTAPPDVSALNARGVLLLSTRDVGFVGAVEYLCARFAAARRPLIVADAVAPEDWPRDGPAVPEGHV.YLRAALRPEAHCALRWP...EAPELGPVVLTACRVVGPGFFERVER.EHARLYPGAPPLALCRGANVTFVVATRAGPRTPVPLAPREYRGRVLPALDGCKDM.AAQS.GALGLGAPDFANGETVSDRAANRWGLGATLRPVYLPVGRD.FD...R.lRGPGDLD-PA.VAAFAAAARLLPDPDAPPFALP--AGLAGDAdpEARAAARARVP-.---------------apppqavwdrp..................
A0A1S6JLQ4_HSVA1/894-1310              ........GGWRRQPPGPSHTPPPGAAALEAYCPPDRVAELTERALFPPAWRGALMFDPAALAALAARCAPPEP......GSG-------------.RAFGPLRVSAPLRRAAAWMR.QVADPEDVRVLVLYCPLPGEN..........LAGP.P...A.P..E-..P...P.....AWTAER.GGLSFLLAALANR.RCT.PDSAAWAGNWTGAPDVAALNAQGVLLLSTRDLAFAGAVEFLGLLAGASDRRLIVLNAVEPEDWPPDGPAVALRHV.YVPCSVLPRAQCDLRWP...GCAALRRAVLVSPRVAGPGSFARVEA.AHARLYPGAAPLRLARGANVRYTVATRLGPATAVPAPPRAYRRAVLPVLDGRAAA.SRLAgAAMARGAPDFRGDEAFSHRACGRWGLAAPLRPLYLALGRG.AA...L..RAPEDVP--ArARAFCAAALLEPDDAAAPFLVGPDADPAA--..-----------A.PGVRWASASGR----vdtl.........................
J9R0A4_9ALPH/1-329                     ........------------------------------------------------------------------......----------------.------------------MR.QVPDPDDVRVLVLYAPLPGEE..........LGG-.L...A.P..-A..P...P.....EWTTER.GGLSFLLAALANR.RCT.PDSAAWAGNWTGPPDVSALNARGVLLLSTRDLAFAGAVEFLGLLAGAAGRKLVVVNAVPADAWPEDGPAVSAQHE.FLACAVRPEAQCDVRWP...GADDLRGAVLAAPAVFGPGLFARVEA.AHARANPGAPPLRLGRAGDVRFCVRTRVGEATRVPLAPREYRLAAAPALDSRAAAtSAAA.EAMAPGAADFRDGAAHSHRACARWGLGAALRPVYLALPRG.AA...R..AGPEAVPA-A.LRAFCAAALLEPDPEAAPLVLAA--------..GED-----PPPP.PSIRWASAAGR----lgta.........................
A0A068EPP2_9ALPH/1192-1605             ........GGFRRVPPEYSHTPRPSVTLDAAYCDPETTAELIDQPMFPRKWRHALMFDPGALCDIAAA----RK......-GGP------------.-------AADRLARRAAWMK.QIQDPEDVKVVILYCPLPGED..........LTGP.V...A.N..EK..S...P.....TWSDRK.GGLSLLLAALSNR.LCT.RDSHAWAGNWTGPPNVSALNNRGVLLLSTGDLCFAGAVEYLCLRAGSARRKLAIVDTVEAQDWPSDGPAVGESHF.YVRARLEPRSQCCLRWP...DDRDLRRVVLSSSVIFGPGVFVRVEN.LYQSLYPEESPLCLCRGSNVTYTVHTRVDPRTVVPLSARDYRDAVLPRFDLCKDM.NAQS.SGLGLDEADFRGAETHGHRAVNRWGLGTPFRPIYVAQARR.RP...F..AHPLEIPEE-.TRQFCGEVLLAPDLSAGPSIVDPL-------..------------.---------------appdrlrvrlhrlaeqtvtwgpgdgpett
A0A1V0M8R0_9ALPH/1192-1605             ........GGFRRVPPEYSHTPRPSVTLDAAYCDPETTAELIDQPMFPRKWRHALMFDPGALCDIAAA----RK......-GGP------------.-------AADRLARRAAWMK.QIQDPEDVKVVILYCPLPGED..........LTGP.I...A.N..EK..S...P.....TWSDRK.GGLSLLLAALSNR.LCT.RDSHAWAGNWTGPPNVSALNNRGVLLLSTGDLCFAGAVEYLCLRAGSARRKLAIVDTVEAQDWPSDGPAVGESHF.YVRARLEPRSQCCLRWP...DDRDLRRVVLSSSVIFGPGVFVRVEN.LYQSLYPEESPLCLCRGSNVTYTVHTRVDPRTVVPLSARDYRDAVLPRFDLCKDM.NAQS.SGLGLDEADFRGAETHGHRAVNRWGLGTPFRPIYVAQARR.RP...F..AHPLEIPEE-.TRQFCGEVLLAPDLSAGPSIVDPL-------..------------.---------------appdrlrvrlhrlaeqtvtwgpgdgpett
ICP4_HHV11/812-1253                    ........GGWRRQPPGPSHTAAPAAAALEAYCSPRAVAELTDHPLFPVPWRPALMFDPRALASIAARCAGPAPaaqaacGGGDDDDNPHPHGAAGgRLFGPLRASGPLRRMAAWMR.QIPDPEDVRVVVLYSPLPGED..........LAGG.G...A.S..GG..P...P.....EWSAER.GGLSCLLAALANR.LCG.PDTAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLASAGDRRLIVVNTVRACDWPADGPAVSRQHA.YLACELLPAVQCAVRWP...AARDLRRTVLASGRVFGPGVFARVEA.AHARLYPDAPPLRLCRGGNVRYRVRTRFGPDTPVPMSPREYRRAVLPALDGRAAA.SGTT.DAMAPGAPDFCEEEAHSHAACARWGLGAPLRPVYVALGRE.AV...R..AGPARWRGP-.RRDFCARALLEPDDDAPPLVLR---------..GDDDGPGALPPApPGIRWASATGRSGT-v............................
#=GC seq_cons                          ........GGaRRhPsGssHTPsPusuALpAYCsPcslAELsDaPLFPpsWRsALhFDPpALAslAARhssstP.......ts..............thhGsLtuouPLRRtsAWMR.QlsDPEDVRVVVLYsPLPGEc..........Lsus.s...u.s..ss..s...P.....pWoscR.GGLShLLAALuNR.LCs.P-StAWAGNWTGsPDVSALsApGVLLLSTRDLAFAGAVEaLsLhsuuucRRLIVlDsVcsp-WPsDGPAVuptHs.YltstlhPtuQCslRWP...ssc-LpRsVLsSscVFGPGsFARVEA.AaARLYPsssPLRLCRGuNVRYsVcTRhGscTsVPhsPR-YRpAVLPshDGptsh.usts.suhuhGsPDFtcGEAaSHRAssRWGLGAPLRPVYLAhuRc.ss...t..suPstls..s.hRsFCupALLEPDs-AsPlVlp.......................................ss...........................
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