#=GF ID   Herpes_US12
#=GF AC   PF05363.16
#=GF DE   Herpesvirus US12 family
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_62991 (release 7.8)
#=GF GA   21.00 21.00;
#=GF TC   21.20 21.20;
#=GF NC   20.90 20.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Infected_cell_protein_47
#=GF RN   [1]
#=GF RM   10521276
#=GF RT   Structure of the active domain of the herpes simplex virus
#=GF RT   protein ICP in water/sodium dodecyl sulfate solution determined
#=GF RT   by nuclear magnetic resonance spectroscopy. 
#=GF RA   Pfander R, Neumann L, Zweckstetter M, Seger C, Holak TA, Tampe
#=GF RA   R; 
#=GF RL   Biochemistry 1999;38:13692-13698.
#=GF DR   INTERPRO; IPR008026;
#=GF DR   SCOP; 1qlo; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   US12 a key factor in the evasion of cellular immune response
#=GF CC   against HSV-infected cells. Specific inhibition of the
#=GF CC   transporter associated with antigen processing (TAP) by US12
#=GF CC   prevents peptide transport into the endoplasmic reticulum and
#=GF CC   subsequent loading of major histocompatibility complex (MHC)
#=GF CC   class I molecules [1]. US12 is comprised of three helices and is
#=GF CC   associated with cellular membranes [1].
#=GF SQ   8
#=GS A0A1G7FIS8_9PROT/79-141  AC A0A1G7FIS8.1
#=GS ICP47_HHV11/1-82         AC P03170.2
#=GS L0N6D1_HHV1/1-82         AC L0N6D1.1
#=GS A0A5M6IIV1_9PROT/78-141  AC A0A5M6IIV1.1
#=GS ICP47_HHV2H/1-86         AC P14345.2
#=GS Q2QBA4_CHV16/1-76        AC Q2QBA4.1
#=GS K9MG74_9ALPH/1-86        AC K9MG74.1
#=GS A0A5J6Q5E7_9SYNE/17-86   AC A0A5J6Q5E7.1
A0A1G7FIS8_9PROT/79-141             .....lldl-----------------------------LRRQREAREAAREATEDPGEPILSlPPWLVPDVRA..-----------------------elraivqelsryararqpgfavla
ICP47_HHV11/1-82                    .........MSWALEMADTFLDTMRVGPRTYADVRDEINKRGREDREAARTAVHDPERPLLR.SPGLLPEIAP..----NASLGVAHRRTGGTVTDSP........................
L0N6D1_HHV1/1-82                    .........MSWALEMADTFLDNMRVGPRTYADVRDEINKRGREDREAARTAVHDPERPLLR.SHGLLPEIAP..----NASLGVAHRRTGGTGTDSP........................
A0A5M6IIV1_9PROT/78-141             ...glmdry------------------------------RQEREAREAARRAAEDPGEPLLAvPPTLMPNVREelRRVVQELSRYARSRD--------pgfavla.................
ICP47_HHV2H/1-86                    .........MSWALKTTDMFLDSSRCTHRTYGDVCAEIHKREREDREAARTAVTDPELPLLC.PPDVRSDPAS..RNPTQQTRGCARSNERQDRVLAP........................
Q2QBA4_CHV16/1-76                   .....mssl---YLAEVDAFLQSPRTRHRTCADLRRELDAYADEERREAAKAIAHPDRPLLA.PPSAPPDRSR..----PAPRG--------------tahppaa.................
K9MG74_9ALPH/1-86                   .........MSWALKTTDRFLDLSRGTHLTYGDVCAEIHKREREDREAARTAVNDPELPLLR.PPVVRSDPAI..RNPTQQTCGCTTSNTRQGRLLA-l.......................
A0A5J6Q5E7_9SYNE/17-86              sgrpfrsrw-------------------------RSDIHRRKRGSRSSHRSRAASPSIPAQM.DTPSSSSPPT..TNPIERTIGIAASRIRGMTTTSP........................
#=GC seq_cons                       ............hLt.sDhFLp..Rst.hThuDlpsEIp+RpRE-REAARoAlpDP-cPLLp.PPslhP-sus......ptohGhApppptt.hh.u.........................
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