#=GF ID   Herpes_gE
#=GF AC   PF02480.20
#=GF DE   Alphaherpesvirus glycoprotein E
#=GF AU   Mian N;0000-0003-4284-4749
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_849 (release 5.4)
#=GF GA   26.70 26.70;
#=GF TC   26.70 73.40;
#=GF NC   26.60 24.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0159
#=GF RN   [1]
#=GF RM   10881679
#=GF RT   Epitopes on glycoprotein E and on the glycoprotein
#=GF RT   E/glycoprotein I complex of bovine herpesvirus 1 are expressed
#=GF RT   by all of 222 isolates and 11 vaccine strains. 
#=GF RA   Rijsewijk FA, Kaashoek MJ, Langeveld JP, Maris-Veldhuis MA,
#=GF RA   Magdalena J, Verschuren SB, Meloen RH, van Oirschot JT; 
#=GF RL   Arch Virol 2000;145:921-936.
#=GF RN   [2]
#=GF RM   16646632
#=GF RT   Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a
#=GF RT   mechanism for antibody bipolar bridging.
#=GF RA   Sprague ER, Wang C, Baker D, Bjorkman PJ;
#=GF RL   PLoS Biol. 2006;4:e148.
#=GF DR   INTERPRO; IPR003404;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Glycoprotein E (gE) of Alphaherpesvirus forms a complex with 
#=GF CC   glycoprotein I (gI) (Pfam:PF01688), functioning as an
#=GF CC   immunoglobulin G (IgG) Fc binding protein. gE is involved in
#=GF CC   virus spread but is not essential for propagation [1]. This
#=GF CC   entry represents the Ig-like domain of gE, identified as the
#=GF CC   Fc-binding domain [2].  
#=GF SQ   35
#=GS A0A0K1R1R8_9ALPH/188-366  AC A0A0K1R1R8.1
#=GS GE_CHV1/211-383           AC P30816.2
#=GS Q0PEE1_ILTV/183-355       AC Q0PEE1.1
#=GS A0A1L5JKK2_9ALPH/243-420  AC A0A1L5JKK2.1
#=GS Q77L56_MEHV1/182-357      AC Q77L56.1
#=GS Q77LR5_CHV9D/320-493      AC Q77LR5.1
#=GS GE_PSHV1/210-385          AC Q6UDF4.1
#=GS GE_HHV2H/215-387          AC P89475.1
#=GS A0A0Y0DAC9_9ALPH/198-370  AC A0A0Y0DAC9.1
#=GS A0A1S6JLR8_HSVA1/281-455  AC A0A1S6JLR8.1
#=GS Q2QBA9_CHV16/212-384      AC Q2QBA9.1
#=GS A0A068EPF3_9ALPH/205-377  AC A0A068EPF3.1
#=GS A0A286MM87_9ALPH/197-373  AC A0A286MM87.1
#=GS O41526_9ALPH/184-359      AC O41526.1
#=GS A0A060Q505_9ALPH/223-395  AC A0A060Q505.1
#=GS E2IUI0_SHV1/284-459       AC E2IUI0.1
#=GS F8TC91_9ALPH/213-387      AC F8TC91.1
#=GS GE_EHV1B/196-372          AC Q6S6V7.1
#=GS GE_GAHVM/182-357          AC Q77MP7.1
#=GS Q9DH41_MEHV1/20-194       AC Q9DH41.1
#=GS L0N6C7_HHV1/220-392       AC L0N6C7.1
#=GS J9QWN5_9ALPH/185-359      AC J9QWN5.1
#=GS A0A089N879_9ALPH/219-396  AC A0A089N879.1
#=GS C6ZD38_9ALPH/195-371      AC C6ZD38.1
#=GS A0A1V0M8P2_9ALPH/205-377  AC A0A1V0M8P2.1
#=GS Q6UK11_9ALPH/222-387      AC Q6UK11.1
#=GS A0A0B5LBJ9_9ALPH/219-396  AC A0A0B5LBJ9.1
#=GS G9CUK5_9ALPH/182-357      AC G9CUK5.1
#=GS GE_HHV11/220-392          AC P04488.1
#=GS GE_VZVD/337-511           AC P09259.1
#=GS A0A077B9G3_9ALPH/194-371  AC A0A077B9G3.1
#=GS Q66930_FHV1/188-363       AC Q66930.1
#=GS Q69288_9ALPH/182-357      AC Q69288.1
#=GS A0A1R3TEQ0_9ALPH/201-377  AC A0A1R3TEQ0.1
#=GS K9MG68_9ALPH/213-385      AC K9MG68.1
A0A0K1R1R8_9ALPH/188-366             ...................re--STVGVMA.SNTLIMYPGSTLVTTAEIVD.TIYD-.PEFNLTIGWYHFT.IP.S..TCQSIVLYPTCLELNGQSECETAEHlSECSITSLSSSTVVVYRIYNRCT..H..AT...SWRtDC.MHVDF..ND...PKL.GNRIS..mQDDGNIAIHPAGDEDSGLYLVVVMYNGRFApgSLGYVSVSSKTDIRPVLLKSGIP-s
GE_CHV1/211-383                      .....................RGVTVSLRT.QTAILFAPGDTVHTDVSVMP.IAHDD.DPYVMEVVWVRFD.VP.E..ECGEMRIYEPCLYHPQLPECRSPAD.APCAASV--WTERLAVRRYGPCS..R..GV...PPP.RC.PSDAA..ME...SRA.GLGWY...GHTVNLQLRDASEASGGLYVCVVYVNGHVH..AWGHVVISTASRYRNAVVERSPPR.
Q0PEE1_ILTV/183-355                  ahahvelqmlpfhelndnspt---------.------------YVTPVLKVfPPTEH.VKFNVTYSWYGFD.VK.E..ECEEVKLFEPCVYHPTDGKCQFPATnQRCLIGSVLMAEFLGAASLLDCS..R..-D...TLE.DC.HENRV..PN...LRF.DSRLS...ESRAGLVISPLIAIPK--VLIIVVSDGDIL..GWSYTVLG-KRNSPRVVVETHMP-s
A0A1L5JKK2_9ALPH/243-420             ....................h-GARFRVQP.YRSHVYTPGDSFTLSVRLQS.EFFDE.APFSAGIDWYFLR.PA.G..DCALVRIYETCIFHPEAPACLHPVD.ARCAFASPYRSETAYSRLYERCR..P..ASadrWPR.EC.EGAAY..EA...PVA.HLRPA...NNSVDLVFDGAPASASGLYVFVLQYNGHVE..AWDYSLVVTSDRLVRAVTDHTRP-e
Q77L56_MEHV1/182-357                 ....................t-RVDLTFKN.FNAFLFNAGDTVDASVTAHL.TNWA-.GAFSLEFKLLFLP.YN.S..KCLYLTVYEPCIFHPSESECQMVPEhAECRFAANMDVMQLASARTDGCR..V..--...DVR.GC.TFQTS..VD...ESV.QGKLAfleSDVPSFRLANAQPTDAGLYVIVGLYNGRPL..AWTYVYLSTLETILNVFEDVHKP-g
Q77LR5_CHV9D/320-493                 ....................k-GAEFHTWH.YHSHVFSVGETFSLPMHLQY.KIHD-.TPFDLLLEWLYVP.IN.P..TCQPMRLYSACVYHETVPSCLSPEN.PECTFASPHIARRVANTVYQNCE..H..VN...YTA.DC.LAVSH..VE...PGS.GLEIQ...NGGSALLFVNAAESMSGLYVFIIHFNGHVE..TVAYTVVSTIENFVNAIEEHGFP-p
GE_PSHV1/210-385                     ....................d-RDHVFVSM.PRMHVAWPHGTTVLHPKMII.AAASWrPEYNFTYEWYAVP.YD.G..YCATMRLFEACLYHPSAPACLDPAGhRGCVVGTMTHDDLVGRVLMARCR..G..S-...DLR.TCePHVIH..IK...QKP.MVSLG...RAVPELRVESAAHIPS-LYILVVKIDDSVA..GWAYTELMAEGSSPRVVIDIHMPR.
GE_HHV2H/215-387                     .....................RGVTVHMET.LEAILFAPGETFGTNVSIHA.IAHDD.GPYAMDVVWMRFD.VP.S..SCADMRIYEACLYHPQLPECLSPAD.APCAVSS--WAYRLAVRSYAGCS..R..TT...PPP.RC.FAEAR..ME...PVP.GLAWL...ASTVNLEFQHASPQHAGLYLCVVYVDDHIH..AWGHMTISTAAQYRNAVVEQHLPQ.
A0A0Y0DAC9_9ALPH/198-370             ....................y-GVTVSLVT.PNSLLFREGSSFHTDVNIYP.AAHDT.QEYSLDIVWAYHP.MD.P..RCGEMHIYESCLHHPHLPECMYPAN.AACSIGT--ISNILGIKQYMGCS..A..DD...TPP.NC.PSTSK..FH...TTP.GLTWL...DHSINLQFTNASRSASGVYLCVVYIDEHVS..AWGYIVISTAEQYRNVVVEPNLP-v
A0A1S6JLR8_HSVA1/281-455             ...................av---GVRMDT.HSALLFQAGETVSTRVGIRF.VATDG.WPYDVDVVWFRAP.IP.D..GCAEMHIYEPCLRHPRLPECLNPAD.APCAFGA--PTHHVAAKHFRDCA..A..TR...TPP.NC.NAPTT..GElsgRVR.GLSWH...HHSTNLQFVNATEAVNGVYLCAVYIDGHLC..AWRHVVVSTANGFRGALVEHTLPR.
Q2QBA9_CHV16/212-384                 .....................RGVTVSLRT.QTAILFSPGDTVHTAVSIVP.LAHDD.DPYVMEVVWVRFD.VP.E..ECGEMRIYEPCLYHPRLPECRSPAD.APCAASV--WTERLAVRRYGPCS..R..RA...PPP.RC.PADAA..ME...ARP.GLGWY...GHTVNLQLRDASEASGGLYVCVVYVNGHVH..AWGHVVVSTAARYRNAVVERSLPR.
A0A068EPF3_9ALPH/205-377             ..................pnl-----SVVS.TGSVLFHIGEDARTNVAIKG.DNIP-.NLREISFTWYFVK.HE.R..GCYSLRIHEPCIFHPSEPECISPKD.SKCTVTSTLNAQIIATRIYWNCT..E..--...KWR.TC.NYVET..VD...ELL.QGHLDwlnETDPNFKITQTTHDDSGLYILVVEVNNKVL..SWGHVHLSTIDAYVSVIEDSHKP-d
A0A286MM87_9ALPH/197-373             ....................h-GAHFSTRG.YHSHLYAVGEAFNVSVHLES.SIYDS.DGFTANLEWYFVK.PD.D..SCPLLTIYEPCLYHPNVPACLHPHN.ARCAFASPYRATTLFSRLYIQCD..R..RTr.dWTA.AC.VGTVY..AH...PRD.YVVQA...PNNVDLIFRRTPDAASGTYVFVLRYNDHVE..TWSYVTVTTSEHLVNAEVVRHLP-a
O41526_9ALPH/184-359                 .................hggf----FHVKN.YHSHVFVPNDSFKIELNLES.EIYD-.SEFSASIDWYYMK.TS.S..ECSVFHIYETCIFHPHANSCLNPIN.PLCSFTSPLRATSLINRFYFRCKpeG..KN...WTT.DC.INTFS..IN...ADK.HIKQH...SNNVDLIFLNTPTNASGLYVFILKYNGHPE..AWTYTLVSTVKNFMNVIKDMTRP-l
A0A060Q505_9ALPH/223-395             .....................RGVSVSLST.PNTLLFTEGQSFNTDVVIHA.ISHDD.QQYSMEIVWIQHP.FP.A..GCSEMQIFEACLYHPRLPECLEPAD.ARCAISS--WTHYLGTQRYLGCS..R..RA...TPP.NC.PSESM..LD...RGS.GITWH...GTSTNLHFHNASASTSGVYLCVVYIDGHVA..AWSYITITTTEKFIPVHVETRLPR.
E2IUI0_SHV1/284-459                  ...................cr--VGVSMTT.HAALLFMEGQTVHTDVSVDF.SADTA.RPYDVDIMWFFVP.TP.D..SCVEMRIYEPCLRHPRALECLDPAD.APCAFGA--KARRLGTKSFRGCS..R..SR...TPP.NC.AAPTAefLD..rRTP.GLSWH...HYSTNLQFANATSTANGVYLCAAYIDGRLC..AWRHVVVSTAGGFRGAVVEHVLPK.
F8TC91_9ALPH/213-387                 ...................hk--FQISLKN.FKTFLYQVGDTVTISITTRL.ETTV-.RAFKLEFRVMFLP.YS.P..NCKSFTIYEPCIFHPKEPECISPSElSECRFASNAQVLEIAAARSVNCS..A..G-...--R.AC.HYDAE..VD...ESM.QQRFAflySEIPSFTIGNAGPGDAGLYVVVALCDERPT..TWTHVYLSTLDKILDVHEIAHKP-g
GE_EHV1B/196-372                     ..................tht---DFVVHG.YHSRVYADGESFELSVNLES.HIVE-.PSFSAEIQWYYMN.TSsS..SCDLFRVFETCIFHPTAMACLHPEQ.HTCSFTSPIRATKILHRVYGNCS..D..HGn.sWPS.RC.HSTLL..GN...RLY.FIQPA...QNRVDLLFKDTPASATGLYVFVLLYNGHPE..AWTYTLLSTANHFMNVLTDVTRPR.
GE_GAHVM/182-357                     ....................a-DIKLSLKN.FKALVYHVGDTINVSTAVIL.GPSP-.EIFTLEFRVLFLR.YN.P..TCKFVTIYEPCIFHPKEPECITTAEqSVCHFASNIDILQIAAARSENCS..T..--...GYR.RC.IYDTA..ID...ESV.QARLTfiePGIPSFKMKDVQVDDAGLYVVVALYNGRPS..AWTYIYLSTVETYLNVYENYHKP-g
Q9DH41_MEHV1/20-194                  ..................tcd----LTFKN.FNAFLFNAGDTVDASVTAHL.TNWA-.GAFSLEFKLLFLP.YN.S..KCLYLTVYEPCIFHPSESECQMVPEhAECRFAANMDVMQLASARTDGCR..V..--...DVR.GC.TFQTS..VD...ESV.QGKLAfleSDVPSFRLANAQPTDAGLYVIVGLYNGRPL..AWTYVYLSTLETILNVFEDVHKP-g
L0N6C7_HHV1/220-392                  .....................RGVTVRMET.PEAILFSPGEAFSTNVSIHA.IAHDD.QTYAMDVVWLRFD.VP.T..SCAEMRIYESCLYHPQLPECLSPAD.APCAAST--WTSRLAVRSYAGCS..R..TN...PPP.RC.SAEAH..ME...PVP.GLAWQ...AASVNLEFRDASPQHSGLYLCVVYVNDHIH..AWGHITISTAAQYRNAVVEQPLPQ.
J9QWN5_9ALPH/185-359                 ..................rgi---DVDLRMeQHSVLFRPGDSFGTSAHLHA.VAHDD.STYTIEVVWTRIG.LT.D..SCVEMRLYELCLYHPNLPGCLDPAD.APCAIGS--QARRVGSRKYAGCS..R..TT...PPP.NC.DGTSF..LE...ADR.GISWA..gPSGINLQFDDATESMSGVYLCVVYVDAHVA..AWTYAVISTAARYHNVITDRSVP-a
A0A089N879_9ALPH/219-396             ....................h-GARFRVLP.YHSHVYTPGDSFLLSVRLQS.EFFDE.APFSASIDWYFLR.TA.G..DCALIRIYETCIFHPEAPACLHPAD.AQCSFASPYRSETVYSRLYEQCR..P..DPagrWPH.EC.EGAAY..AA...PVA.HLRPA...NNSVDLVFDDAPAAASGLYVFVLQYNGHVE..AWDYSLVVTSDRLVRAVTDHTRP-e
C6ZD38_9ALPH/195-371                 ..................mda---EAIISL.YKTVLFHAGEDMNVTADLSI.YHIQ-.GPYNMTIQWFMKPiVD.N..TCPILSLYEPCLFHPSERECLFPEN.ANCAFASTLNASIVGERKISNCN..E..TG..aGWA.SCqSEQLD..GD...NNA.AIQVM...QKGIGLRLTNPQNTDSGLYVVIITIDDKIT..SWAYTLLSTIDLFVGVTIETHKP-a
A0A1V0M8P2_9ALPH/205-377             ..................pnl-----SVVS.TGSVLFHIGEDARTNVAIKG.DNIP-.NLREISFTWYFVK.HE.R..GCYSLRIHEPCIFHPSEPECISPKD.SKCTVASTLNAQIIATRIYWNCT..E..--...KWR.TC.NYVET..VD...ELL.QGHLDwlnETDPNFKITQTTHDDSGLYILVVEVNNKVL..SWGHVHLSTIDAYVSVIEDSHKP-d
Q6UK11_9ALPH/222-387                 .................hepr----FHALG.FHSQLFSPGDTFDLMPRVVS.DMGDSrENFTATLDWYYAR.AP.P..RCLLYYVYEPCIYHPRAPECLRPVD.PACSFTSPARARLVARRAYASCS..P..L-...---.--.LGDRW..LT...ACP.FDAFG...EEVH----TNATADESGLYVLVMTHNGHVA..TWDYTLVATAAEYVTVIKELTAP-a
A0A0B5LBJ9_9ALPH/219-396             ....................h-GARFRVLP.YHSHVYTPGDSFLLSVRLQS.EFFDE.APFSASIDWYFLR.TA.G..DCALIRIYETCIFHPEAPACLHPAD.AQCSFASPYRSETVYSRLYEQCR..P..DPagrWPH.EC.EGAAY..AA...PVA.HLRPA...NNSVDLVFDDAPAAASGLYVFVLQYNGHVE..AWDYSLVVTSDRLVRAVTDHTRP-e
G9CUK5_9ALPH/182-357                 ....................a-DIKLSLKN.FKALVYHVGDTINVSTAVIL.GPSP-.EIFTLEFRVLFLR.YN.P..TCKFVTIYEPCIFHPKEPECITTAEqSVCHFASNIDILQIAAARSENCS..T..--...GYR.RC.IYDTA..ID...ESV.QARLTfiePGIPSFKMKDVQVDDAGLYVVVALYNGRPS..AWTYIYLSTVETYLNVYENYHKP-g
GE_HHV11/220-392                     .....................RGVTVRMET.PEAILFSPGETFSTNVSIHA.IAHDD.QTYSMDVVWLRFD.VP.T..SCAEMRIYESCLYHPQLPECLSPAD.APCAAST--WTSRLAVRSYAGCS..R..TN...PPP.RC.SAEAH..ME...PVP.GLAWQ...AASVNLEFRDASPQHSGLYLCVVYVNDHIH..AWGHITISTAAQYRNAVVEQPLPQ.
GE_VZVD/337-511                      .....................RGAEFHMWN.YHSHVFSVGDTFSLAMHLQY.KIHE-.APFDLLLEWLYVP.ID.P..TCQPMRLYSTCLYHPNAPQCLSHMN.SGCTFTSPHLAQRVASTVYQNCE..H..AD..nYTA.YC.LGISH..ME...PSF.GLILH...DGGTTLKFVDTPESLSGLYVFVVYFNGHVE..AVAYTVVSTVDHFVNAIEERGFPP.
A0A077B9G3_9ALPH/194-371             ....................r-HSEFHVRS.YHSHVYRVGDTFDVSVHLES.EIVG-.FEFNAEIRWYYMD.TS.KsrSCNLFHVYETCIFHPSARACLYPEN.PKCSFTSPLRATQISNRVYRSCR..S..NAs.sWTI.QC.HSTPW..FK...APD.YIEEA...KNNVDLVFKNAPAPATGLYVFMLMVNGHPE..AWTYTLVSTADDFLNVITDTTRPR.
Q66930_FHV1/188-363                  ....................h-GAHFHVRN.YHSHVYIPGDKFLLEMHLKS.DIYD-.PEFSATIDWYFME.TD.I..KCPVFRIYETCIFHPHAASCLHPED.PSCSFTSPLRAVSLINRFYPKCD..HryAD...WTS.RC.INTPS..IN...HMP.YIEQP...ANNVDLKFINVPTNASGLYVFILRYNGHPE..EWTYTLISTGAKFLNVIRDLTRPR.
Q69288_9ALPH/182-357                 ....................a-DIKLSLKN.FKALVYHVGDTINVSTAVIL.GPSP-.EIFTLEFRVLFLR.YN.P..TCKFVTIYEPCIFHPKEPECITTAEqSVCHFASNIDILQIAAARSENCS..T..--...GYR.RC.IYDTA..ID...ESV.QARLTfiePGIPSFKMKDVQVDDAGLYVVVALYNGRPS..AWTYIYLSTVETYLNVYENYHKP-g
A0A1R3TEQ0_9ALPH/201-377             ....................h-GAEFISKN.YHTQLFSAGDSFTTTTFLKW.AIHD-.SSFNITVSWFFLP.IN.T..WCSMYKVYEICLYHSNETSCRNPAEgPNCVFTSPENAKEVATRQYINCK..D..NE..nWPK.TC.TRTES..ID...RDHkYLSMV...NETINLCFSNTPESASGLYVMLLKYNGRIE..TWTYTMISTSSLFRSVVEYFDAP-e
K9MG68_9ALPH/213-385                 .....................RGVTVHMET.PGAILFAPGETFGTNVSIHA.IAHDD.GPYAMDVVWMRFD.VP.S..SCAEMRIYEACLYHPQLPECLSPAD.APCAVSS--WAYRLAVRSYAGCS..R..TT...PPP.RC.FAEAR..ME...PVP.GLAWL...ASTVNLEFQHASPQHAGLYLCVVYVNDHIH..AWGHIIISTAAQYRNAVVEQHLPQ.
#=GC seq_cons                        ....................t.tsphplps.acuhlFpsG-ohssslslps.tsa-..ssashslsWhahs.hs.s..sCs.h+IYEsClaHPptPECLsPs-.utCuFuSshpupplusRtYtsCs..p..ss...hst.pC..ssst..h-...tss.tlphs...sssssLphpsAssssoGLYVhVlhhNGHlp..AWsYshlSTsspahsVlh-pphP..
//